KR840005725A - 융합 4h-1,4-벤조티아진의 제조방법 - Google Patents
융합 4h-1,4-벤조티아진의 제조방법 Download PDFInfo
- Publication number
- KR840005725A KR840005725A KR1019830003619A KR830003619A KR840005725A KR 840005725 A KR840005725 A KR 840005725A KR 1019830003619 A KR1019830003619 A KR 1019830003619A KR 830003619 A KR830003619 A KR 830003619A KR 840005725 A KR840005725 A KR 840005725A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- formula
- alkoxy
- optionally substituted
- compound
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 다음 일반식(Ⅱ)의 2-아미노티오페놀과 다음 일반식(Ⅲ)의 화합물을 디메틸술폭사이드내에서 반응시켜 다음 일반식(Ⅰ)의 화합물을 제조함을 특징으로 한 융합 4 H-1,4- 벤조티아진의 제조방법.
-
- 상기 일반식에서, R1은 수소 및 임의로 치환된 알킬을 나타내며, R2와 R3는 수소, 임의로 치환된 알킬, 할로겐, 니트로, 시아노, 알킬술포닐, 히드록실, 알콕시 또는 아실옥시(R2또는 R3가 브롬을 나타내지 않거나 또는 R2또는 R3둘다가 수소를 나타내지 않는 조건하에서 R2와 R3는 서로 동일하거나 다를 수 있다)를 나타내며, X는 알킬, 알콕시, 아릴, 플루오르 또는 알콕시카보닐 등에 의해 한번 또는 여러번 치환될 수 있는 알킬렌(2 내지 4개의 탄소원자를 가지고 있다)을 나타내며 또한 알킬렌 브리지의 메틸렌 그룹이 O, S, SO2, SO, NH 또는 N-알킬로 치환될 수 있다.
- 임의로 촉매량의 산을 사용하여, 다음 일반식(Ⅲ)의 디카보닐 화합물과 다음 일반식(Ⅳ)의 디술파이드를 반응시켜 다음 일반식(Ⅰ)의 화합물을 제조함을 특징으로한 융합 4H-1,4- 벤조티아진의 제조방법.
-
- 상기 일반식에서, R1은 수소 및 임의로 치환된 알킬을 나타내며, R2와 R3는 수소, 임의로 치환된 알킬할로겐, 니트로, 시아노, 알킬술포닐, 아릴술포닐, 히드록실, 알콕시 또는 아실옥시(R2또는 R3가 브롬을 나타내지 않거나 또는 R2와 R3둘다가 수소를 나타내지 않는 조건하에서 R2와 R3는 서로 동일하거나 다를 수 있다)를 나타내며, X는 알킬, 알콕시, 아릴, 플루오르 또는 알콕시카보닐등에 의해 한번 또는 여러번 치환될 수 있는 알킬렌(2 내지 4개의 탄소원자를 가지고 있다)을 나타내며 또한 알킬렌 브리지의 메틸렌 그룹이 O, S, SO2, SO, NH 또는 N-알킬로 치환될 수 있다.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP3229122,1 | 1982-08-04 | ||
DE19823229122 DE3229122A1 (de) | 1982-08-04 | 1982-08-04 | Anellierte 4h-1,4-benzothiazine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
KR840005725A true KR840005725A (ko) | 1984-11-16 |
Family
ID=6170117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019830003619A KR840005725A (ko) | 1982-08-04 | 1983-08-02 | 융합 4h-1,4-벤조티아진의 제조방법 |
Country Status (16)
Country | Link |
---|---|
US (1) | US4636497A (ko) |
EP (1) | EP0101898A1 (ko) |
JP (1) | JPS5944370A (ko) |
KR (1) | KR840005725A (ko) |
AU (1) | AU1741483A (ko) |
DE (1) | DE3229122A1 (ko) |
DK (1) | DK354583A (ko) |
ES (1) | ES524713A0 (ko) |
FI (1) | FI832784A (ko) |
GR (1) | GR79355B (ko) |
HU (1) | HU189314B (ko) |
IL (1) | IL69388A0 (ko) |
NO (1) | NO832625L (ko) |
PH (1) | PH18784A (ko) |
PT (1) | PT77097B (ko) |
ZA (1) | ZA835673B (ko) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3484745D1 (de) * | 1983-10-05 | 1991-08-01 | Merck Frosst Canada Inc | Inhibitoren fuer die leukotrien-biosynthese. |
JPS60139680A (ja) * | 1983-12-27 | 1985-07-24 | メルク フロスト カナダ,インコ−ポレ−テツド | 3h−フエノチアジン−3−オン類の製法 |
EP0155623A3 (en) * | 1984-03-19 | 1985-12-27 | Merck & Co. Inc. | Use of lipoxygenase inhibitors for the preparations of cytoprotective pharmaceutical compostions and process for the preparation of a cytoprotective pharmaceutical composition |
US4500708A (en) * | 1984-04-23 | 1985-02-19 | G. D. Serle & Co. | Benzothiazine derivatives |
DE3426564A1 (de) * | 1984-07-19 | 1986-01-30 | Bayer Ag, 5090 Leverkusen | Verwendung von 4h-1,4-benzothiazinen bei der prophylaxe und therapie von erkrankungen der atemwege, entzuendungen/rheuma, thromboembolischen erkrankungen, ischaemien und infarkten, herzrhythmusstoerungen, arteriosklerose und dermatosen, arzneimittel zu diesem zweck sowie wirkstoffe, die in diesen arzneimitteln enthalten sind |
DE3540702A1 (de) * | 1985-11-16 | 1987-05-21 | Bayer Ag | 1h-pyrido-(2,3-b) (1,4)-thiazine |
DE3545097A1 (de) * | 1985-12-19 | 1987-07-02 | Bayer Ag | 1-h-pyrido-(3,2-b)(1,4)-thiazine |
US4921838A (en) * | 1987-06-16 | 1990-05-01 | Trustees Of Boston University | Angiogenic and blood perfusion inducing properties of amphiphilic compounds |
US5981294A (en) * | 1995-11-29 | 1999-11-09 | Metrika, Inc. | Device for blood separation in a diagnostic device |
US5994349A (en) * | 1997-10-27 | 1999-11-30 | Howard University | 3-carboalkoxy-2, 3-dihydro-1H-phenothiazin-4[10H]-one derivatives |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1088055B (de) * | 1958-05-16 | 1960-09-01 | Chem Fab Promonta Ges Mit Besc | Verfahren zur Herstellung von Hexahydrophenthiazin-9-dioxyden |
DE1151802B (de) * | 1960-04-28 | 1963-07-25 | Chem Fab Promonta Ges Mit Besc | Verfahren zur Herstellung von cycloalkylierten 2,3-Dihydro-1,4-benzthiazinen |
US3422101A (en) * | 1967-05-05 | 1969-01-14 | Mcneilab Inc | Tetrahydrothienobenzothiazines |
US4512990A (en) * | 1982-02-18 | 1985-04-23 | Syntex (U.S.A.), Inc. | Benzthiazine analogs as antiinflammatory agents |
-
1982
- 1982-08-04 DE DE19823229122 patent/DE3229122A1/de not_active Withdrawn
-
1983
- 1983-07-19 NO NO832625A patent/NO832625L/no unknown
- 1983-07-22 EP EP83107175A patent/EP0101898A1/de not_active Withdrawn
- 1983-07-25 PT PT77097A patent/PT77097B/pt unknown
- 1983-07-29 AU AU17414/83A patent/AU1741483A/en not_active Abandoned
- 1983-08-01 JP JP58139537A patent/JPS5944370A/ja active Pending
- 1983-08-01 IL IL69388A patent/IL69388A0/xx unknown
- 1983-08-02 GR GR72112A patent/GR79355B/el unknown
- 1983-08-02 FI FI832784A patent/FI832784A/fi not_active Application Discontinuation
- 1983-08-02 KR KR1019830003619A patent/KR840005725A/ko not_active Application Discontinuation
- 1983-08-03 ZA ZA835673A patent/ZA835673B/xx unknown
- 1983-08-03 HU HU832742A patent/HU189314B/hu unknown
- 1983-08-03 DK DK354583A patent/DK354583A/da not_active Application Discontinuation
- 1983-08-03 ES ES524713A patent/ES524713A0/es active Granted
- 1983-08-04 PH PH29350A patent/PH18784A/en unknown
-
1985
- 1985-08-29 US US06/770,895 patent/US4636497A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PT77097B (en) | 1986-03-12 |
DE3229122A1 (de) | 1984-02-09 |
ES8404607A1 (es) | 1984-05-01 |
NO832625L (no) | 1984-02-06 |
US4636497A (en) | 1987-01-13 |
HU189314B (en) | 1986-06-30 |
ES524713A0 (es) | 1984-05-01 |
AU1741483A (en) | 1984-02-09 |
ZA835673B (en) | 1984-04-25 |
FI832784A (fi) | 1984-02-05 |
FI832784A0 (fi) | 1983-08-02 |
GR79355B (ko) | 1984-10-22 |
IL69388A0 (en) | 1983-11-30 |
DK354583A (da) | 1984-02-05 |
JPS5944370A (ja) | 1984-03-12 |
DK354583D0 (da) | 1983-08-03 |
PT77097A (en) | 1983-08-01 |
PH18784A (en) | 1985-09-25 |
EP0101898A1 (de) | 1984-03-07 |
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