KR840005725A - Method for preparing fused 4H-1,4-benzothiazine - Google Patents

Method for preparing fused 4H-1,4-benzothiazine Download PDF

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Publication number
KR840005725A
KR840005725A KR1019830003619A KR830003619A KR840005725A KR 840005725 A KR840005725 A KR 840005725A KR 1019830003619 A KR1019830003619 A KR 1019830003619A KR 830003619 A KR830003619 A KR 830003619A KR 840005725 A KR840005725 A KR 840005725A
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South Korea
Prior art keywords
alkyl
formula
alkoxy
optionally substituted
compound
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KR1019830003619A
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Korean (ko)
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니머 엑케하르드 (외 4)
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칼-루드빅 쉬미트, 귄터 슈마허
바이엘 아크티엔 게젤샤프트
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Application filed by 칼-루드빅 쉬미트, 귄터 슈마허, 바이엘 아크티엔 게젤샤프트 filed Critical 칼-루드빅 쉬미트, 귄터 슈마허
Publication of KR840005725A publication Critical patent/KR840005725A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

내용 없음No content

Description

융합 4H-1,4- 벤조티아진의 제조방법Method for preparing fused 4H-1,4-benzothiazine

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (7)

다음 일반식(Ⅱ)의 2-아미노티오페놀과 다음 일반식(Ⅲ)의 화합물을 디메틸술폭사이드내에서 반응시켜 다음 일반식(Ⅰ)의 화합물을 제조함을 특징으로 한 융합 4 H-1,4- 벤조티아진의 제조방법.Fused 4H-1, characterized in that the compound of formula (I) is prepared by reacting 2-aminothiophenol of formula (II) with a compound of formula (III) in dimethyl sulfoxide 4-Benzothiazine Preparation Method. 상기 일반식에서, R1은 수소 및 임의로 치환된 알킬을 나타내며, R2와 R3는 수소, 임의로 치환된 알킬, 할로겐, 니트로, 시아노, 알킬술포닐, 히드록실, 알콕시 또는 아실옥시(R2또는 R3가 브롬을 나타내지 않거나 또는 R2또는 R3둘다가 수소를 나타내지 않는 조건하에서 R2와 R3는 서로 동일하거나 다를 수 있다)를 나타내며, X는 알킬, 알콕시, 아릴, 플루오르 또는 알콕시카보닐 등에 의해 한번 또는 여러번 치환될 수 있는 알킬렌(2 내지 4개의 탄소원자를 가지고 있다)을 나타내며 또한 알킬렌 브리지의 메틸렌 그룹이 O, S, SO2, SO, NH 또는 N-알킬로 치환될 수 있다.Wherein R 1 represents hydrogen and optionally substituted alkyl, and R 2 and R 3 represent hydrogen, optionally substituted alkyl, halogen, nitro, cyano, alkylsulfonyl, hydroxyl, alkoxy or acyloxy (R 2 or R 3 does not represent a bromine or R 2 or R 3 both are under the conditions that do not represent hydrogen R 2 and R 3 represents a may be the same or different from each other), X is alkyl, alkoxy, aryl, fluorine or alkoxycarbonyl Alkylene (which has 2 to 4 carbon atoms), which may be substituted once or several times by, for example, nil, and the like, and the methylene group of the alkylene bridge may be substituted with O, S, SO 2 , SO, NH or N-alkyl. have. 임의로 촉매량의 산을 사용하여, 다음 일반식(Ⅲ)의 디카보닐 화합물과 다음 일반식(Ⅳ)의 디술파이드를 반응시켜 다음 일반식(Ⅰ)의 화합물을 제조함을 특징으로한 융합 4H-1,4- 벤조티아진의 제조방법.Fused 4H-1 characterized in that a compound of formula (I) is prepared by reacting a dicarbonyl compound of formula (III) with a disulfide of formula (IV): , 4-Benzothiazine. 상기 일반식에서, R1은 수소 및 임의로 치환된 알킬을 나타내며, R2와 R3는 수소, 임의로 치환된 알킬할로겐, 니트로, 시아노, 알킬술포닐, 아릴술포닐, 히드록실, 알콕시 또는 아실옥시(R2또는 R3가 브롬을 나타내지 않거나 또는 R2와 R3둘다가 수소를 나타내지 않는 조건하에서 R2와 R3는 서로 동일하거나 다를 수 있다)를 나타내며, X는 알킬, 알콕시, 아릴, 플루오르 또는 알콕시카보닐등에 의해 한번 또는 여러번 치환될 수 있는 알킬렌(2 내지 4개의 탄소원자를 가지고 있다)을 나타내며 또한 알킬렌 브리지의 메틸렌 그룹이 O, S, SO2, SO, NH 또는 N-알킬로 치환될 수 있다.Wherein R 1 represents hydrogen and optionally substituted alkyl, and R 2 and R 3 represent hydrogen, optionally substituted alkylhalogen, nitro, cyano, alkylsulfonyl, arylsulfonyl, hydroxyl, alkoxy or acyloxy denotes a (R 2 or R 3 is under the condition does not represent a bromine or R 2 and R 3 both do not represent hydrogen R 2 and R 3 may be the same or different from each other), X is alkyl, alkoxy, aryl, fluorine Or alkylene (which has 2 to 4 carbon atoms) which may be substituted once or several times by alkoxycarbonyl and the like, and the methylene group of the alkylene bridge is O, S, SO 2 , SO, NH or N-alkyl. Can be substituted. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019830003619A 1982-08-04 1983-08-02 Method for preparing fused 4H-1,4-benzothiazine KR840005725A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823229122 DE3229122A1 (en) 1982-08-04 1982-08-04 FELLED 4H-1,4-BENZOTHIAZINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
DEP3229122,1 1982-08-04

Publications (1)

Publication Number Publication Date
KR840005725A true KR840005725A (en) 1984-11-16

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KR1019830003619A KR840005725A (en) 1982-08-04 1983-08-02 Method for preparing fused 4H-1,4-benzothiazine

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Country Link
US (1) US4636497A (en)
EP (1) EP0101898A1 (en)
JP (1) JPS5944370A (en)
KR (1) KR840005725A (en)
AU (1) AU1741483A (en)
DE (1) DE3229122A1 (en)
DK (1) DK354583A (en)
ES (1) ES8404607A1 (en)
FI (1) FI832784A (en)
GR (1) GR79355B (en)
HU (1) HU189314B (en)
IL (1) IL69388A0 (en)
NO (1) NO832625L (en)
PH (1) PH18784A (en)
PT (1) PT77097B (en)
ZA (1) ZA835673B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0138481B1 (en) * 1983-10-05 1991-06-26 Merck Frosst Canada Inc. Leukotriene biosynthesis inhibitors
EP0149297B1 (en) * 1983-12-27 1987-11-25 Merck Frosst Canada Inc. Process for preparing 3h-phenothlazin-3-ones
EP0155623A3 (en) * 1984-03-19 1985-12-27 Merck & Co. Inc. Use of lipoxygenase inhibitors for the preparations of cytoprotective pharmaceutical compostions and process for the preparation of a cytoprotective pharmaceutical composition
US4500708A (en) * 1984-04-23 1985-02-19 G. D. Serle & Co. Benzothiazine derivatives
DE3426564A1 (en) * 1984-07-19 1986-01-30 Bayer Ag, 5090 Leverkusen USE OF 4H-1,4-Benzothiazines FOR PREVENTION AND TREATMENT OF RESPIRATORY DISORDERS, inflammation / RHEUMA, THROMBOEMBOLIC ILLNESSES AND ischemia infarcts, HERZRHYTHMUSSTOERUNGEN, ATHEROSCLEROSIS AND dermatoses, PURPOSE AND ACTIVE DRUGS TO THIS IN THESE PRODUCTS CONTAIN
DE3540702A1 (en) * 1985-11-16 1987-05-21 Bayer Ag 1H-PYRIDO- (2,3-B) (1,4) THIAZINE
DE3545097A1 (en) * 1985-12-19 1987-07-02 Bayer Ag 1-H-PYRIDO- (3,2-B) (1,4) THIAZINE
US4921838A (en) * 1987-06-16 1990-05-01 Trustees Of Boston University Angiogenic and blood perfusion inducing properties of amphiphilic compounds
US5981294A (en) * 1995-11-29 1999-11-09 Metrika, Inc. Device for blood separation in a diagnostic device
US5994349A (en) * 1997-10-27 1999-11-30 Howard University 3-carboalkoxy-2, 3-dihydro-1H-phenothiazin-4[10H]-one derivatives

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1088055B (en) * 1958-05-16 1960-09-01 Chem Fab Promonta Ges Mit Besc Process for the production of hexahydrophenthiazine-9-dioxides
DE1151802B (en) * 1960-04-28 1963-07-25 Chem Fab Promonta Ges Mit Besc Process for the preparation of cycloalkylated 2,3-dihydro-1,4-benzothiazines
US3422101A (en) * 1967-05-05 1969-01-14 Mcneilab Inc Tetrahydrothienobenzothiazines
US4512990A (en) * 1982-02-18 1985-04-23 Syntex (U.S.A.), Inc. Benzthiazine analogs as antiinflammatory agents

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ES524713A0 (en) 1984-05-01
GR79355B (en) 1984-10-22
PT77097B (en) 1986-03-12
FI832784A (en) 1984-02-05
EP0101898A1 (en) 1984-03-07
HU189314B (en) 1986-06-30
DE3229122A1 (en) 1984-02-09
JPS5944370A (en) 1984-03-12
DK354583A (en) 1984-02-05
AU1741483A (en) 1984-02-09
NO832625L (en) 1984-02-06
ZA835673B (en) 1984-04-25
DK354583D0 (en) 1983-08-03
PT77097A (en) 1983-08-01
US4636497A (en) 1987-01-13
ES8404607A1 (en) 1984-05-01
PH18784A (en) 1985-09-25
FI832784A0 (en) 1983-08-02
IL69388A0 (en) 1983-11-30

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