KR840002770A - 아세토페논유도체의 제조방법 - Google Patents

아세토페논유도체의 제조방법 Download PDF

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Publication number
KR840002770A
KR840002770A KR1019820005547A KR820005547A KR840002770A KR 840002770 A KR840002770 A KR 840002770A KR 1019820005547 A KR1019820005547 A KR 1019820005547A KR 820005547 A KR820005547 A KR 820005547A KR 840002770 A KR840002770 A KR 840002770A
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South Korea
Prior art keywords
organic solvent
hydrophilic organic
alkali metal
compound
acid acceptor
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KR1019820005547A
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English (en)
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KR870000247B1 (ko
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미츠노리 가이노 (외 3)
Original Assignee
마츠하라 이치로오
다나베 세이야쿠 가부시기가이샤
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Publication of KR840002770A publication Critical patent/KR840002770A/ko
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Publication of KR870000247B1 publication Critical patent/KR870000247B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음.

Description

아세토페논유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 구조식(II)의 할로게노 아세토페논 유도체를 산수용체 존재하의 비친수성 유기용매와 물의 2상 용매계에서 3,4-디메톡시펜에 틸아민파 축합시키고 필요하면 그 산물을 산부가염으로 전환시키는 것으로 구성되는 구조식(I)의 아세토페논 유도체나 그의 산부가염을 제조하는 발법.
    상기 구조식에서 R은 히드록시기의 보호기이고 X는 할로겐원자이다.
  2. 제1항에 있어서, 비 친수성 유기 용매가 방향족 탄화수소, 할로게노탄화수소, 에테르로 구성되는 기에서 선택되고, 산수용체가 알칼리금속 수산화물, 알칼리 금속 수산화물, 알칼리 금속탄산염, 알칼리 금속중 탄산염으로 구성되는 기에서 선택되는 방법.
  3. 제1항에 있어서, 비 친수성 유기 용매가 벤젠, 톨루엔, 염화메틸렌, 클로로포름, 디에틸 에테르나 디이소프로필에테르이고, 산 수용체가 수산화나트륨, 수산화 칼륨, 수산화칼슘, 탄산나트륨, 탄산칼륨, 중탄산나트륨인 방법.
  4. 제1항 내지 제3항중 어느하나에 있어서, 축압반응이 0℃-실온에서 수행되는 방법.
  5. 제4항에 있어서, 축합반응이 0℃-10℃에서 수행되는 방법.
  6. 제1항 내지 제3항에 있어서, 비친수 성유기용매가 화합물(II)를 용매하기에 충분한 만큼의 양이 사용되고, 물이 산 수용체를 용해하기에 충분한 양이 사용되는 방법.
  7. 제1항 내지 제3항에 있어서, 화합물(II) 1mole 당 3,4-디에톡시펜에틸아민 1.2-2mole, 화합물(II)중량부당 비 친수성 유기용매 5-10 체적부, 화합물(II) 1mole 당 산 수용체 1.1-3mole을 각각 사용하는 방법.
  8. 제6항에 있어서, 산 수용체 중량부당 2중량부의 물을 사용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8205547A 1981-12-11 1982-12-10 아세토페논 유도체의 제조방법 KR870000247B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56200536A JPS58103344A (ja) 1981-12-11 1981-12-11 アセトフエノン誘導体の製造法
JP200536 1981-12-11

Publications (2)

Publication Number Publication Date
KR840002770A true KR840002770A (ko) 1984-07-16
KR870000247B1 KR870000247B1 (ko) 1987-02-21

Family

ID=16425933

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8205547A KR870000247B1 (ko) 1981-12-11 1982-12-10 아세토페논 유도체의 제조방법

Country Status (10)

Country Link
JP (1) JPS58103344A (ko)
KR (1) KR870000247B1 (ko)
AT (1) AT382613B (ko)
CA (1) CA1211126A (ko)
CH (1) CH649759A5 (ko)
DK (1) DK158643C (ko)
ES (1) ES518106A0 (ko)
HU (1) HU187806B (ko)
IT (1) IT1191242B (ko)
SE (1) SE454776B (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200740779A (en) 2005-07-22 2007-11-01 Mitsubishi Pharma Corp Intermediate compound for synthesizing pharmaceutical agent and production method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2784193A (en) * 1955-01-19 1957-03-05 Merck & Co Inc Phenalkylamines
AU501137B2 (en) * 1975-12-11 1979-06-14 Tanabe Seiyaku Co., Ltd. Benzyl alcohol derivatives

Also Published As

Publication number Publication date
DK158643B (da) 1990-06-25
DK550482A (da) 1983-06-12
IT8268462A0 (it) 1982-12-13
DK158643C (da) 1990-11-19
ATA449782A (de) 1986-08-15
JPS6335619B2 (ko) 1988-07-15
SE8207080L (sv) 1983-06-12
KR870000247B1 (ko) 1987-02-21
ES8402256A1 (es) 1984-01-16
ES518106A0 (es) 1984-01-16
CH649759A5 (en) 1985-06-14
CA1211126A (en) 1986-09-09
SE454776B (sv) 1988-05-30
SE8207080D0 (sv) 1982-12-10
IT1191242B (it) 1988-02-24
AT382613B (de) 1987-03-25
JPS58103344A (ja) 1983-06-20
HU187806B (en) 1986-02-28

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