KR840000554A - 헤테로 아릴- 및 디벤족세핀- 알카노산의 제조방법 - Google Patents

헤테로 아릴- 및 디벤족세핀- 알카노산의 제조방법 Download PDF

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Publication number
KR840000554A
KR840000554A KR1019820002844A KR820002844A KR840000554A KR 840000554 A KR840000554 A KR 840000554A KR 1019820002844 A KR1019820002844 A KR 1019820002844A KR 820002844 A KR820002844 A KR 820002844A KR 840000554 A KR840000554 A KR 840000554A
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South Korea
Prior art keywords
heated
mol
carbon atoms
carboxylic acid
acid
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KR1019820002844A
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English (en)
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밀리처 한스
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하인리히 벡커/베른하르트 벡크
훽스트 아크티엔 게젤샤프트
베른하르트 벡크
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Publication of KR840000554A publication Critical patent/KR840000554A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)

Abstract

내용 없음

Description

헤테로 아릴- 및 디벤족세핀-알카노산의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 다음 일반식 (Ⅱ)의 화합물을, 임의로 할로겐화한 지방족 탄소수 2 내지 5의 카복실산 무수물 또는 탄소수 2 내지 5의 카복실산 할리드 및 강산의 촉매량 존재하에, 50 내지 150℃로 가열시킴을 특징으로 하는 다음 일반식 (Ⅰ)의 헤테로아릴-벤족세핀-알카노산 및 6,11-디하이드로-11-옥소-디벤즈 [b,e]옥세핀-알카노산의 제조방법.
  3. 상기식에서
  4. X는 연결되는 탄소원자와 함께 벤젠환 또는 1 내지 2개의 산소, 질소 또는 유황원자를 함유하는 5- 또는 6-원헤테로 아릴환이고, R1및 R2는 각각 수소 또는 메틸이며,
  5. R3는 탄소수 1 내지 4의 알킬 또는 알콕시, 할로겐 또는 트리플루오로메틸이고,
  6. n은 0, 1, 2 또는 3이다.
  7. 제 1 항에 있어서, 일반식 (Ⅱ)의 화합물 1몰을 농인산 1 내지 10몰% 존재하에 불활성 유기용매 중에서, 지방족 탄소수 2 내지 5의 카복실산 무수물 또는 지방족 탄소수 2 내지 5의 카복실산 할라이드 1 내지 1.5몰과 가열하는 방법.
  8. 제 1 및 2항에 있어서, 용매 없이 카복실산 무수물 또는 할라이드 과량 존재하에 가열하는 방법.
  9. 제 1 및 2항에 있어서, 일반식 (Ⅱ)의 화합물 1몰을, 농인산 1 내지 10몰% 존재하에 방향족 탄화수소 중에서, 아세트산 무수물 1 내지 1.5몰 또는 아세틸클로라이드 1 내지 1.5몰과 가열하는 방법
  10. 제 1 내지 4항에 있어서, 반응 혼합물을 100 내지 140℃로 가열하는 방법.
  11. 제 1 내지 4항에 있어서, 반응 혼합물을 불활성 담체물질 존재하에 가열하는 방법.
  12. 제 6 항에 있어서, 담체물질이 규조토, 알칼리금속-알루미늄 실리케이트 또는 활성탄인 방법.
  13. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019820002844A 1981-06-27 1982-06-25 헤테로 아릴- 및 디벤족세핀- 알카노산의 제조방법 KR840000554A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19813125374 DE3125374A1 (de) 1981-06-27 1981-06-27 Verfahren zur herstellung von heteroaryl- und dibenzoxepinalkansaeuren
DEP3125374.1 1981-06-27

Publications (1)

Publication Number Publication Date
KR840000554A true KR840000554A (ko) 1984-02-25

Family

ID=6135538

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019820002844A KR840000554A (ko) 1981-06-27 1982-06-25 헤테로 아릴- 및 디벤족세핀- 알카노산의 제조방법

Country Status (10)

Country Link
EP (1) EP0068370A1 (ko)
JP (1) JPS588077A (ko)
KR (1) KR840000554A (ko)
DE (1) DE3125374A1 (ko)
DK (1) DK288182A (ko)
ES (1) ES8304962A1 (ko)
FI (1) FI822277L (ko)
GR (1) GR81394B (ko)
NO (1) NO822164L (ko)
PT (1) PT75124B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7687646B2 (en) 2006-03-28 2010-03-30 Azad Pharmaceutical Ingredients, Ag Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof
JP4841482B2 (ja) * 2007-03-26 2011-12-21 安藤建設株式会社 配管カバー装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU204274A (en) * 1973-07-24 1982-06-30 Hoechst Ag Process for preparing new dibenzoxepin derivatives
US4585788A (en) * 1973-09-06 1986-04-29 American Hoechst Corporation 6,11-dihydrodibenz[b,e]oxepin-acetic acids and derivatives
DE2600768C2 (de) * 1975-02-04 1983-10-27 Hoechst Ag, 6230 Frankfurt Verfahren zur Herstellung von 6,11-Dihydro-11-oxodibenz[b,e]-oxepin-alkansäuren
US4025640A (en) * 1975-08-26 1977-05-24 American Hoechst Corporation Oxothienobenzoxepin-acetic acids, precursors and derivatives thereof
US4282365A (en) * 1978-11-24 1981-08-04 Merck & Co., Inc. Dibenz[b,e]oxepin compounds

Also Published As

Publication number Publication date
FI822277L (fi) 1982-12-28
ES513344A0 (es) 1983-03-16
FI822277A0 (fi) 1982-06-24
ES8304962A1 (es) 1983-03-16
PT75124B (de) 1985-01-07
JPS588077A (ja) 1983-01-18
PT75124A (de) 1982-07-01
DE3125374A1 (de) 1983-01-13
DK288182A (da) 1982-12-28
GR81394B (ko) 1984-12-11
NO822164L (no) 1982-12-28
EP0068370A1 (de) 1983-01-05

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