KR830008969A - 퀴논 유도체의 제법 - Google Patents

퀴논 유도체의 제법 Download PDF

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Publication number
KR830008969A
KR830008969A KR1019820000537A KR820000537A KR830008969A KR 830008969 A KR830008969 A KR 830008969A KR 1019820000537 A KR1019820000537 A KR 1019820000537A KR 820000537 A KR820000537 A KR 820000537A KR 830008969 A KR830008969 A KR 830008969A
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KR
South Korea
Prior art keywords
following formula
hydroxyl group
protected
represented
peroxide
Prior art date
Application number
KR1019820000537A
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English (en)
Other versions
KR880000760B1 (ko
Inventor
마사즈미 와따나베
이스께 이마다
Original Assignee
구라바야시이꾸시로
다께다야꾸힝 고오교 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 구라바야시이꾸시로, 다께다야꾸힝 고오교 가부시기가이샤 filed Critical 구라바야시이꾸시로
Publication of KR830008969A publication Critical patent/KR830008969A/ko
Application granted granted Critical
Publication of KR880000760B1 publication Critical patent/KR880000760B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/205—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
    • C07C43/2055—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring containing more than one ether bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

퀴논 유도체의 제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 하기식(I)로 표시되는 퀴논류의 제법에 있어서, 하기식(III)으로 표시되는 화합물을 하기식(II)로 표시되는 카르복실산의 과산화물 또는 카르복실산의 산무수물의 과산화물과 반응시킴을 특징으로 하는 제조방법.
    여기서, R은 그의 말단에 보호될 수 있는 히드록실기를 갖는 탄소원자수 1~22의 알킬기를 나타냄.
  2. 제1항에 있어서, 반응이 50℃~150℃범위의 온도에서 수행됨을 특징으로 하는 방법.
  3. 제1항에 있어서, 반응이 유기 용매의 존재하에서 수행됨을 특징으로 하는 방법.
  4. 제1항에 있어서, 과산화물이 2,3-디메톡시-5-메틸-1,4-벤조퀴논의 몰당 1~2몰의 양으로 2,3-디메톡시-5-메틸-1,4-벤조퀴논과 접촉됨을 특징으로 하는 방법.
  5. 제4항에 있어서, 반응이 50℃~150℃범위의 온도에서 수행됨을 특징으로 하는 방법.
  6. 하기식(IV)으로 표시되는 퀴논류의 제법에 있어서, 하기식(VII)의 화합물을 산화시킴을 특징으로 하는 방법.
    여기서, R2는 그의 말단에 임의로 보호되는 히드록실기를 갖는 탄소원자수 1~2의 알킬기를 나타내고, X는 수소 또는 보호될 수 있는 히드록실이고, Y는 보호될 수 있는 히드록실임.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR828200573A 1981-02-09 1982-02-09 퀴논 유도체의 제법 KR880000760B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP18319 1981-02-09
JP56018319A JPS57131735A (en) 1981-02-09 1981-02-09 Preparation of quinones
JP18319/81 1981-02-09

Publications (2)

Publication Number Publication Date
KR830008969A true KR830008969A (ko) 1983-12-16
KR880000760B1 KR880000760B1 (ko) 1988-05-06

Family

ID=11968284

Family Applications (1)

Application Number Title Priority Date Filing Date
KR828200573A KR880000760B1 (ko) 1981-02-09 1982-02-09 퀴논 유도체의 제법

Country Status (11)

Country Link
US (1) US4831265A (ko)
EP (1) EP0058057B1 (ko)
JP (1) JPS57131735A (ko)
KR (1) KR880000760B1 (ko)
AT (1) ATE10735T1 (ko)
CA (1) CA1211455A (ko)
DE (1) DE3261489D1 (ko)
DK (1) DK52082A (ko)
ES (2) ES509410A0 (ko)
HU (1) HU192944B (ko)
PT (1) PT74398B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4808339A (en) * 1982-04-13 1989-02-28 Takeda Chemical Industries, Ltd. Benzoquinone derivatives
JPS58177934A (ja) * 1982-04-13 1983-10-18 Takeda Chem Ind Ltd ベンゾキノン誘導体
DE3680023D1 (de) * 1985-04-08 1991-08-08 Takeda Chemical Industries Ltd Benzochinonderivate, ihre herstellung und verwendung.
DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
JPH0713146B2 (ja) * 1990-05-22 1995-02-15 信越化学工業株式会社 オルガノポリシロキサンの製造方法
EP1694623A4 (en) * 2003-12-05 2007-01-17 Zymes Inc PRACTICAL, COST-EFFECTIVE SYNTHESIS OF UBICHINONES
EA016226B1 (ru) * 2005-06-01 2012-03-30 Эдисон Фармасьютикалз, Инк. Редокс-активные терапевтические соединения для лечения митохондриальных заболеваний
ES2823728T3 (es) * 2005-09-15 2021-05-10 Ptc Therapeutics Inc Variantes de cola de agentes terapéuticos con actividad redox para el tratamiento de enfermedades mitocondriales y otras afecciones y la modulación de biomarcadores de energía
EP1986636B1 (en) 2006-02-22 2013-04-24 Edison Pharmaceuticals, Inc. Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases
JP2012502064A (ja) 2008-09-10 2012-01-26 エジソン ファーマシューティカルズ， インコーポレイテッド 酸化還元活性治療剤を用いての広汎性発達障害の処置
WO2017106803A1 (en) 2015-12-17 2017-06-22 Bioelectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2398418A (en) * 1943-08-27 1946-04-16 Louis F Fieser Introduction of organic radicals into quinones
US2553648A (en) * 1948-01-08 1951-05-22 Research Corp Naphthoquinone compounds
GB1065313A (en) * 1962-11-27 1967-04-12 Lucas Industries Ltd Road vehicles
JPS5919930B2 (ja) * 1974-05-02 1984-05-09 武田薬品工業株式会社 キノン酸誘導体の製造法
JPS51128932A (en) * 1975-04-30 1976-11-10 Takeda Chem Ind Ltd Organic compounds
EP0021841B1 (en) * 1979-06-28 1984-10-24 Takeda Chemical Industries, Ltd. 2,3-dialkoxy-1,4-quinone derivatives; method of producing 1,4-quinone derivatives
JPS56140943A (en) * 1980-04-07 1981-11-04 Takeda Chem Ind Ltd Preparation of organic compound
JPS56150014A (en) * 1980-04-21 1981-11-20 Takeda Chem Ind Ltd Antiallergic agent

Also Published As

Publication number Publication date
DE3261489D1 (en) 1985-01-24
KR880000760B1 (ko) 1988-05-06
JPH0133456B2 (ko) 1989-07-13
ES8308826A1 (es) 1983-10-01
ES522240A0 (es) 1984-08-16
CA1211455A (en) 1986-09-16
ATE10735T1 (de) 1984-12-15
ES8406996A1 (es) 1984-08-16
US4831265A (en) 1989-05-16
EP0058057B1 (en) 1984-12-12
DK52082A (da) 1982-08-10
EP0058057A1 (en) 1982-08-18
ES509410A0 (es) 1983-10-01
PT74398B (pt) 1983-07-05
HU192944B (en) 1987-08-28
PT74398A (en) 1982-03-01
JPS57131735A (en) 1982-08-14

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