KR830002764A - 10,11-디하이드로-5H-디벤조[a,d]사이클로헵텐-5,10-이민의 제조방법 - Google Patents
10,11-디하이드로-5H-디벤조[a,d]사이클로헵텐-5,10-이민의 제조방법 Download PDFInfo
- Publication number
- KR830002764A KR830002764A KR1019800002072A KR800002072A KR830002764A KR 830002764 A KR830002764 A KR 830002764A KR 1019800002072 A KR1019800002072 A KR 1019800002072A KR 800002072 A KR800002072 A KR 800002072A KR 830002764 A KR830002764 A KR 830002764A
- Authority
- KR
- South Korea
- Prior art keywords
- general formula
- reacted
- following general
- cycloheptene
- dibenzo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Luminescent Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (12)
- 본문에 상술한 바와 같이, 다음 일반식(2)의 화합물을 티타늄 테트라클로라이드의 존재하에 가스상 암모니아와 반응시키고, 얻어진 다음 일반식(3)의 아민을 산수용체의 존재하에 아실화제와 반응시키고, 얻어진 다음 일반식(4)의 아실이민을 일반식 R2Li의 유기티튬과 반응시키고, 얻어진 다음 일반식(5)의 아실아미드를 산 또는 염기와 반응시켜서 다음 일반식(6)의 아실아민을 제조하고, 이를 강산 또는 염기와 반응시키거나 또는 Ac가 아릴설포닐기일때는 강산 또는 환원제와 반응시켜 다음 일반식(1)의 10, 11-디하이드로-5H-디벤조[a, d]사이클로헵텐-5, 10-이민의 제조방법.
-
- 식중
- R1및 R2는 각각
- (1) C1-5알킬,
- (2) C2-5알케-,
- (3) 페닐-C1-3알킬,
- (4) C3-6사이클로알킬, 또는
- (5) C3-6사이클로알킬-C1-3알킬이고 ; 및
- R3는 수소 또는 할로겐이며,
- Ac는 아실이다.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/045,494 US4232158A (en) | 1979-06-04 | 1979-06-04 | 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines |
US45494 | 1993-04-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830002764A true KR830002764A (ko) | 1983-05-30 |
KR840000077B1 KR840000077B1 (ko) | 1984-02-08 |
Family
ID=21938211
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019800002072A KR840000077B1 (ko) | 1979-06-04 | 1980-05-26 | 10,11-디하이드로-5H-디벤조[a, d]사이클로 헵텐-5, 10-이민의 제조방법. |
Country Status (16)
Country | Link |
---|---|
US (1) | US4232158A (ko) |
EP (1) | EP0019866B1 (ko) |
KR (1) | KR840000077B1 (ko) |
AR (1) | AR230282A1 (ko) |
AT (1) | ATE6651T1 (ko) |
CA (1) | CA1142516A (ko) |
DK (1) | DK238280A (ko) |
ES (1) | ES492115A0 (ko) |
FI (1) | FI64939C (ko) |
GR (1) | GR68427B (ko) |
HU (1) | HU181709B (ko) |
NO (1) | NO152786C (ko) |
PL (1) | PL124031B1 (ko) |
PT (1) | PT71305B (ko) |
SU (1) | SU1025328A3 (ko) |
YU (1) | YU147180A (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4477668A (en) * | 1982-04-07 | 1984-10-16 | Merck & Co., Inc. | Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine |
NZ221626A (en) * | 1986-09-08 | 1989-11-28 | Merck & Co Inc | Dibenzo(a,d cycloheptene derivatives and pharmaceutical compositions |
US6017910A (en) * | 1989-04-14 | 2000-01-25 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | PCP receptor ligands and the use thereof |
US5011834A (en) * | 1989-04-14 | 1991-04-30 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | PCP receptor ligands and the use thereof |
US5196415A (en) * | 1989-05-09 | 1993-03-23 | The United States Of America As Represented By The Department Of Health And Human Services | 5-aminocarbonyl-5H-dibenzo[a.d]cyclohepten-5,10-imines for treatment of epilepsy and cocaine addiction |
US5831095A (en) * | 1995-09-26 | 1998-11-03 | Research Triangle Institute | Synthesis of 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imine |
WO2005030720A1 (ja) * | 2003-09-25 | 2005-04-07 | Shionogi & Co., Ltd. | Nmda受容体拮抗作用を有するピペリジン誘導体 |
JP2009506988A (ja) * | 2005-08-19 | 2009-02-19 | エラン ファーマシューティカルズ,インコーポレイテッド | ガンマセクレターゼの架橋n−環状スルホンアミド阻害剤 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3542787A (en) * | 1968-06-25 | 1970-11-24 | American Home Prod | 10,11-dihydro-5,10-(iminomethano)-5h-dibenzo(a,d)cyclohepten-13-imine |
US3597433A (en) * | 1968-08-19 | 1971-08-03 | Ayerst Mckenna & Harrison | 10,11 - dihydro - 5,10 - (iminomethano)-5h-dibenzo(a,d)cycloheptene and derivatives thereof |
US3641038A (en) * | 1968-10-29 | 1972-02-08 | Ayerst Mckenna & Harrison | 10,11-dihydro - 10 5 - (iminomethano)-5h-dibenzo( ad)cyclohepten - 10 01acid addition salts the reofand process |
NL7007464A (ko) * | 1969-05-30 | 1970-12-02 | ||
US3716541A (en) * | 1970-07-23 | 1973-02-13 | Ayerst Mckenna & Harrison | Substituted derivatives of 10,11-dihydro-5,10-(iminomethano)-5h-dibenzo, cycloheptenes and preparation thereof |
BE794904A (fr) * | 1972-02-04 | 1973-08-02 | Roussel Uclaf | Nouveaux derives du dibenzocycloheptene et leur preparation |
US4052508A (en) * | 1974-08-19 | 1977-10-04 | Merck & Co., Inc. | Heterocyclic dihydroanthracen imines |
US4064139A (en) * | 1975-04-07 | 1977-12-20 | Merck & Co., Inc. | Substituted 9,10-dihydroanthracen-9,10-imines |
US4123546A (en) * | 1977-07-01 | 1978-10-31 | E. I. Du Pont De Nemours And Company | Antidepressant compounds |
NL191488C (nl) * | 1977-09-19 | 1995-08-04 | Merck & Co Inc | Op de 5-plaats gesubstitueerde 10,11-dihydro-5H-dibenzo£a,d|cyclohepteen-5,10-iminen en farmaceutische preparaten die deze bevatten. |
-
1979
- 1979-06-04 US US06/045,494 patent/US4232158A/en not_active Expired - Lifetime
-
1980
- 1980-05-20 FI FI801622A patent/FI64939C/fi not_active IP Right Cessation
- 1980-05-21 AR AR281138A patent/AR230282A1/es active
- 1980-05-22 GR GR62025A patent/GR68427B/el unknown
- 1980-05-23 SU SU802925102A patent/SU1025328A3/ru active
- 1980-05-23 EP EP80102868A patent/EP0019866B1/en not_active Expired
- 1980-05-23 AT AT80102868T patent/ATE6651T1/de not_active IP Right Cessation
- 1980-05-25 PT PT71305A patent/PT71305B/pt unknown
- 1980-05-26 KR KR1019800002072A patent/KR840000077B1/ko active
- 1980-06-02 CA CA000353229A patent/CA1142516A/en not_active Expired
- 1980-06-02 PL PL1980224699A patent/PL124031B1/pl unknown
- 1980-06-03 ES ES492115A patent/ES492115A0/es active Granted
- 1980-06-03 HU HU801391A patent/HU181709B/hu unknown
- 1980-06-03 DK DK238280A patent/DK238280A/da not_active Application Discontinuation
- 1980-06-03 YU YU01471/80A patent/YU147180A/xx unknown
- 1980-06-03 NO NO801659A patent/NO152786C/no unknown
Also Published As
Publication number | Publication date |
---|---|
AR230282A1 (es) | 1984-03-01 |
GR68427B (ko) | 1981-12-30 |
PT71305A (en) | 1980-06-01 |
US4232158A (en) | 1980-11-04 |
CA1142516A (en) | 1983-03-08 |
PL224699A1 (ko) | 1981-05-08 |
HU181709B (en) | 1983-11-28 |
YU147180A (en) | 1983-04-30 |
NO152786C (no) | 1985-11-20 |
KR840000077B1 (ko) | 1984-02-08 |
DK238280A (da) | 1980-12-05 |
NO152786B (no) | 1985-08-12 |
FI64939B (fi) | 1983-10-31 |
PL124031B1 (en) | 1982-12-31 |
NO801659L (no) | 1980-12-05 |
SU1025328A3 (ru) | 1983-06-23 |
ES8105317A1 (es) | 1981-05-16 |
ES492115A0 (es) | 1981-05-16 |
ATE6651T1 (de) | 1984-03-15 |
FI64939C (fi) | 1984-02-10 |
PT71305B (en) | 1981-09-21 |
EP0019866B1 (en) | 1984-03-14 |
EP0019866A1 (en) | 1980-12-10 |
FI801622A (fi) | 1980-12-05 |
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