ES8105317A1 - Un procedimiento para la preparacion de 10, 11-dihidro-5-h- dibenzo (a,d) ciclohepten -5,10-iminas - Google Patents

Un procedimiento para la preparacion de 10, 11-dihidro-5-h- dibenzo (a,d) ciclohepten -5,10-iminas

Info

Publication number
ES8105317A1
ES8105317A1 ES492115A ES492115A ES8105317A1 ES 8105317 A1 ES8105317 A1 ES 8105317A1 ES 492115 A ES492115 A ES 492115A ES 492115 A ES492115 A ES 492115A ES 8105317 A1 ES8105317 A1 ES 8105317A1
Authority
ES
Spain
Prior art keywords
hours
temperature
time
treatment
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492115A
Other languages
English (en)
Other versions
ES492115A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8105317A1 publication Critical patent/ES8105317A1/es
Publication of ES492115A0 publication Critical patent/ES492115A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE 10,11-DIHIDRO-5-H-DIBENZENO{A,D}CICLOEPTEN-5,10-IMINAS. CONSTA DE LAS SIGUIENTES ETAPAS: 1. TRATAMIENTO DE UNA CETONA CON AMONIACO GASEOSO EN PRESENCIA DE TETRACLORURO DE TITANIO; LA TEMPERATURA DE REACCION OSCILA DE -10 A 50GC, EMPLEANDOSE DE 2 A 10 HORAS. 2. ACILACION DE LA IMINA LIBRE POR TRATAMIENTO DE (I) CON UN HALURO DE ACILO; EL TIEMPO DE REACCION ES DE 1 A 6 HORAS A UNA TEMPERATURA DE 0 A 50GC. 3. ADICION DEL COMPUESTO R ELEVADO A 2 H SOBRE EL DOBLE ENLACE IMINICO; LA TEMPERATURA ES DE 0G A 50GC DURANTE UN TIEMPO DE 0,5 A 4 HORAS. 4. ADICION DEL GRUPO ACILAMINO SOBRE EL DOBLE ENLACE CONJUGADO; LA TEMPERATURA ES DE 150 A 170GC, EL TIEMPO, DE 24 A 48 HORAS. 5. DESACILACION DEL GRUPO IMINO POR HIDROLISIS ACIDA O BASICA A UNA TEMPERATURA DE 25 A 150GC DURANTE UN TIEMPO DE 2 A 48 HORAS. LOS COMPUESTOS QUE SE OBTIENEN TIENEN DE FORMULA GENERAL II. AGENTES ANSIOLITICOS: TRATAMIENTO DE TRASTORNOS EXTRAPIRAMIDALES (ENFERMEDAD DE PARKINSON). *FORMULA*
ES492115A 1979-06-04 1980-06-03 Un procedimiento para la preparacion de 10, 11-dihidro-5-h- dibenzo (a,d) ciclohepten -5,10-iminas Granted ES492115A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/045,494 US4232158A (en) 1979-06-04 1979-06-04 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines

Publications (2)

Publication Number Publication Date
ES8105317A1 true ES8105317A1 (es) 1981-05-16
ES492115A0 ES492115A0 (es) 1981-05-16

Family

ID=21938211

Family Applications (1)

Application Number Title Priority Date Filing Date
ES492115A Granted ES492115A0 (es) 1979-06-04 1980-06-03 Un procedimiento para la preparacion de 10, 11-dihidro-5-h- dibenzo (a,d) ciclohepten -5,10-iminas

Country Status (16)

Country Link
US (1) US4232158A (es)
EP (1) EP0019866B1 (es)
KR (1) KR840000077B1 (es)
AR (1) AR230282A1 (es)
AT (1) ATE6651T1 (es)
CA (1) CA1142516A (es)
DK (1) DK238280A (es)
ES (1) ES492115A0 (es)
FI (1) FI64939C (es)
GR (1) GR68427B (es)
HU (1) HU181709B (es)
NO (1) NO152786C (es)
PL (1) PL124031B1 (es)
PT (1) PT71305B (es)
SU (1) SU1025328A3 (es)
YU (1) YU147180A (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4477668A (en) * 1982-04-07 1984-10-16 Merck & Co., Inc. Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine
NZ221626A (en) * 1986-09-08 1989-11-28 Merck & Co Inc Dibenzo(a,d cycloheptene derivatives and pharmaceutical compositions
US6017910A (en) * 1989-04-14 2000-01-25 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon PCP receptor ligands and the use thereof
US5011834A (en) * 1989-04-14 1991-04-30 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon PCP receptor ligands and the use thereof
US5196415A (en) * 1989-05-09 1993-03-23 The United States Of America As Represented By The Department Of Health And Human Services 5-aminocarbonyl-5H-dibenzo[a.d]cyclohepten-5,10-imines for treatment of epilepsy and cocaine addiction
US5831095A (en) * 1995-09-26 1998-11-03 Research Triangle Institute Synthesis of 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imine
WO2005030720A1 (ja) * 2003-09-25 2005-04-07 Shionogi & Co., Ltd. Ｎｍｄａ受容体拮抗作用を有するピペリジン誘導体
JP2009506988A (ja) * 2005-08-19 2009-02-19 エラン ファーマシューティカルズ，インコーポレイテッド ガンマセクレターゼの架橋ｎ−環状スルホンアミド阻害剤

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3542787A (en) * 1968-06-25 1970-11-24 American Home Prod 10,11-dihydro-5,10-(iminomethano)-5h-dibenzo(a,d)cyclohepten-13-imine
US3597433A (en) * 1968-08-19 1971-08-03 Ayerst Mckenna & Harrison 10,11 - dihydro - 5,10 - (iminomethano)-5h-dibenzo(a,d)cycloheptene and derivatives thereof
US3641038A (en) * 1968-10-29 1972-02-08 Ayerst Mckenna & Harrison 10,11-dihydro - 10 5 - (iminomethano)-5h-dibenzo( ad)cyclohepten - 10 01acid addition salts the reofand process
NL7007464A (es) * 1969-05-30 1970-12-02
US3716541A (en) * 1970-07-23 1973-02-13 Ayerst Mckenna & Harrison Substituted derivatives of 10,11-dihydro-5,10-(iminomethano)-5h-dibenzo, cycloheptenes and preparation thereof
BE794904A (fr) * 1972-02-04 1973-08-02 Roussel Uclaf Nouveaux derives du dibenzocycloheptene et leur preparation
US4052508A (en) * 1974-08-19 1977-10-04 Merck & Co., Inc. Heterocyclic dihydroanthracen imines
US4064139A (en) * 1975-04-07 1977-12-20 Merck & Co., Inc. Substituted 9,10-dihydroanthracen-9,10-imines
US4123546A (en) * 1977-07-01 1978-10-31 E. I. Du Pont De Nemours And Company Antidepressant compounds
NL191488C (nl) * 1977-09-19 1995-08-04 Merck & Co Inc Op de 5-plaats gesubstitueerde 10,11-dihydro-5H-dibenzo£a,d|cyclohepteen-5,10-iminen en farmaceutische preparaten die deze bevatten.

Also Published As

Publication number Publication date
KR830002764A (ko) 1983-05-30
AR230282A1 (es) 1984-03-01
GR68427B (es) 1981-12-30
PT71305A (en) 1980-06-01
US4232158A (en) 1980-11-04
CA1142516A (en) 1983-03-08
PL224699A1 (es) 1981-05-08
HU181709B (en) 1983-11-28
YU147180A (en) 1983-04-30
NO152786C (no) 1985-11-20
KR840000077B1 (ko) 1984-02-08
DK238280A (da) 1980-12-05
NO152786B (no) 1985-08-12
FI64939B (fi) 1983-10-31
PL124031B1 (en) 1982-12-31
NO801659L (no) 1980-12-05
SU1025328A3 (ru) 1983-06-23
ES492115A0 (es) 1981-05-16
ATE6651T1 (de) 1984-03-15
FI64939C (fi) 1984-02-10
PT71305B (en) 1981-09-21
EP0019866B1 (en) 1984-03-14
EP0019866A1 (en) 1980-12-10
FI801622A (fi) 1980-12-05

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