SU496721A3 - Способ получени 1-(2,5-дихлорфенокси)-3-трет.бутиламино-2-пропанола - Google Patents
Способ получени 1-(2,5-дихлорфенокси)-3-трет.бутиламино-2-пропанолаInfo
- Publication number
- SU496721A3 SU496721A3 SU1758614A SU1758614A SU496721A3 SU 496721 A3 SU496721 A3 SU 496721A3 SU 1758614 A SU1758614 A SU 1758614A SU 1758614 A SU1758614 A SU 1758614A SU 496721 A3 SU496721 A3 SU 496721A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- dichlorophenoxy
- butylamino
- tert
- obtaining
- propanol
- Prior art date
Links
- -1 2,5-dichlorophenoxy Chemical group 0.000 title 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N 2-propanol Substances CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 description 2
- 239000004593 Epoxy Substances 0.000 description 1
- 229920000180 alkyd Polymers 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
- C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
(54) СП(ЮОР ПОЛУЧЕНИЯ 1-(2.5-ДИХЛОРФЕНОКСИ)-3 ТРЕТ-БУТИЛАМИНО-2-ПРОП4НОЛА
спсжоб получени нового, не описашюго ранее д хпорпроизводного формулы 1,/ XlСН„ ОСИ . сн СИ - N и -, ..,. ,- t л шш его солей, Обладающего биологической активностью, которое может найти прим ненне в фармацевтшеской промьпцленнос и . Известен споооб долучени монохлорпроИзврдных аминосоеданвний общей фс.рму . . Л.9«А осн„« сн - сн «i N и G сн & iJLI где R J и g - соответственно водород , алкйп с атомами-углерода или галоген, или..5 :: сопей 7закпюча1ощййс e...TOMi что производное эпоксипропана общей формулы 3 СН - сн. и R 2 имеют указанные ни , подвергают взеввиодействиго с трвт-бутв амином . Однако предлагаемым способом были получены новые сбединенв , содержащие два атома хлора в бензольном дре об ладаюшие аначитально большей бнологиче-; ской активностью по сравнению с иэвест аыми соединени ми обшей формулы 2. Предлагаемый способ заключаетс в том, что 1(2,5 д11хлорфенокс} 2,3«д11Оксипропан подвергают взаимодействи с трет-бутиламином. Целевой продукт выдел ю вэагст ым способом в виде основани влн сопи, в
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUGO001156 | 1971-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU496721A3 true SU496721A3 (ru) | 1975-12-25 |
Family
ID=10996691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1758614A SU496721A3 (ru) | 1971-03-17 | 1972-03-13 | Способ получени 1-(2,5-дихлорфенокси)-3-трет.бутиламино-2-пропанола |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS5310581B1 (ru) |
| AT (1) | AT316515B (ru) |
| AU (1) | AU461159B2 (ru) |
| BE (1) | BE780719A (ru) |
| CA (1) | CA1002537A (ru) |
| CH (1) | CH569692A5 (ru) |
| CS (1) | CS163270B2 (ru) |
| DK (1) | DK133872B (ru) |
| ES (1) | ES401235A1 (ru) |
| FI (1) | FI55025C (ru) |
| FR (1) | FR2130284B1 (ru) |
| GB (1) | GB1337921A (ru) |
| IL (1) | IL38870A (ru) |
| NL (1) | NL170626C (ru) |
| NO (1) | NO134836C (ru) |
| PL (1) | PL88985B1 (ru) |
| SE (1) | SE384021B (ru) |
| SU (1) | SU496721A3 (ru) |
| YU (1) | YU35435B (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU172137B (hu) | 1976-03-02 | 1978-06-28 | Gyogyszerkutato Intezet | Sposob poluchenija zamehhjonnykh proizvodnykh fenoksi-propanolamina |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1236523C2 (de) * | 1962-02-15 | 1975-06-12 | Sanol-Arzneimittel Dr. Schwarz Gmbh, 4019 Monheim | Verfahren zur herstellung von basischen phenylaethern und deren salzen |
-
1972
- 1972-02-29 CH CH283272A patent/CH569692A5/xx not_active IP Right Cessation
- 1972-03-01 AT AT170072A patent/AT316515B/de not_active IP Right Cessation
- 1972-03-02 IL IL38870A patent/IL38870A/xx unknown
- 1972-03-06 AU AU39659/72A patent/AU461159B2/en not_active Expired
- 1972-03-07 CS CS1504A patent/CS163270B2/cs unknown
- 1972-03-08 FI FI611/72A patent/FI55025C/fi active
- 1972-03-10 YU YU639/72A patent/YU35435B/xx unknown
- 1972-03-11 ES ES401235A patent/ES401235A1/es not_active Expired
- 1972-03-13 SU SU1758614A patent/SU496721A3/ru active
- 1972-03-14 NL NLAANVRAGE7203323,A patent/NL170626C/xx not_active IP Right Cessation
- 1972-03-15 FR FR7209048A patent/FR2130284B1/fr not_active Expired
- 1972-03-15 SE SE7203354A patent/SE384021B/xx unknown
- 1972-03-15 BE BE780719A patent/BE780719A/xx not_active IP Right Cessation
- 1972-03-15 PL PL1972154080A patent/PL88985B1/pl unknown
- 1972-03-16 CA CA137,222A patent/CA1002537A/en not_active Expired
- 1972-03-16 DK DK123772AA patent/DK133872B/da not_active IP Right Cessation
- 1972-03-16 JP JP2692872A patent/JPS5310581B1/ja active Pending
- 1972-03-16 GB GB1233472A patent/GB1337921A/en not_active Expired
- 1972-03-16 NO NO855/72A patent/NO134836C/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU63972A (en) | 1980-06-30 |
| SE384021B (sv) | 1976-04-12 |
| DE2213044A1 (de) | 1972-09-28 |
| NL170626C (nl) | 1982-12-01 |
| JPS5310581B1 (ru) | 1978-04-14 |
| YU35435B (en) | 1981-02-28 |
| IL38870A0 (en) | 1972-05-30 |
| AT316515B (de) | 1974-07-10 |
| FI55025C (fi) | 1979-05-10 |
| FR2130284B1 (ru) | 1975-10-10 |
| DE2213044B2 (de) | 1977-05-26 |
| GB1337921A (en) | 1973-11-21 |
| DK133872B (da) | 1976-08-02 |
| BE780719A (fr) | 1972-07-03 |
| FR2130284A1 (ru) | 1972-11-03 |
| AU3965972A (en) | 1973-09-13 |
| AU461159B2 (en) | 1975-04-29 |
| NL7203323A (ru) | 1972-09-19 |
| ES401235A1 (es) | 1975-02-16 |
| PL88985B1 (ru) | 1976-10-30 |
| NO134836C (ru) | 1976-12-21 |
| NO134836B (ru) | 1976-09-13 |
| CS163270B2 (ru) | 1975-08-29 |
| FI55025B (fi) | 1979-01-31 |
| CH569692A5 (ru) | 1975-11-28 |
| NL170626B (nl) | 1982-07-01 |
| CA1002537A (en) | 1976-12-28 |
| DK133872C (ru) | 1976-12-27 |
| IL38870A (en) | 1975-08-31 |
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