KR20250044796A - Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법 - Google Patents

Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법 Download PDF

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KR20250044796A
KR20250044796A KR1020257008859A KR20257008859A KR20250044796A KR 20250044796 A KR20250044796 A KR 20250044796A KR 1020257008859 A KR1020257008859 A KR 1020257008859A KR 20257008859 A KR20257008859 A KR 20257008859A KR 20250044796 A KR20250044796 A KR 20250044796A
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asthma
antibody
week
dupilumab
patients
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Korean (ko)
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니킬 아민
네일 그레이엄
지안루카 피로치
아리엘 테이퍼
Original Assignee
사노피 바이오테크놀로지
리제너론 파아마슈티컬스, 인크.
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Application filed by 사노피 바이오테크놀로지, 리제너론 파아마슈티컬스, 인크. filed Critical 사노피 바이오테크놀로지
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/445—Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020257008859A 2017-10-30 2018-10-29 Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법 Pending KR20250044796A (ko)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US201762579120P 2017-10-30 2017-10-30
US62/579,120 2017-10-30
US201862710381P 2018-02-16 2018-02-16
US62/710,381 2018-02-16
US201862647368P 2018-03-23 2018-03-23
US62/647,368 2018-03-23
EP18305566 2018-05-04
EP18305566.4 2018-05-04
US201862742736P 2018-10-08 2018-10-08
US62/742,736 2018-10-08
KR1020247026403A KR102785099B1 (ko) 2017-10-30 2018-10-29 Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법
PCT/US2018/058039 WO2019089473A1 (en) 2017-10-30 2018-10-29 Methods for treating or preventing asthma by administering an il-4r antagonist

Related Parent Applications (1)

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KR1020247026403A Division KR102785099B1 (ko) 2017-10-30 2018-10-29 Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법

Publications (1)

Publication Number Publication Date
KR20250044796A true KR20250044796A (ko) 2025-04-01

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KR1020257008859A Pending KR20250044796A (ko) 2017-10-30 2018-10-29 Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법
KR1020207015223A Active KR102694419B1 (ko) 2017-10-30 2018-10-29 Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법
KR1020247026403A Active KR102785099B1 (ko) 2017-10-30 2018-10-29 Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법

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KR1020207015223A Active KR102694419B1 (ko) 2017-10-30 2018-10-29 Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법
KR1020247026403A Active KR102785099B1 (ko) 2017-10-30 2018-10-29 Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법

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US (2) US11034768B2 (enExample)
EP (2) EP4344706A3 (enExample)
JP (3) JP7315545B2 (enExample)
KR (3) KR20250044796A (enExample)
CN (1) CN111526920A (enExample)
AU (2) AU2018359219B2 (enExample)
CA (1) CA3079946A1 (enExample)
ES (1) ES2969049T3 (enExample)
HU (1) HUE064655T2 (enExample)
IL (1) IL274134A (enExample)
MX (2) MX2020004467A (enExample)
PL (1) PL3703818T3 (enExample)
WO (1) WO2019089473A1 (enExample)

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