KR20240013282A - 암을 치료하기 위한 변형된 nk-92 세포 - Google Patents

암을 치료하기 위한 변형된 nk-92 세포 Download PDF

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KR20240013282A
KR20240013282A KR1020247001893A KR20247001893A KR20240013282A KR 20240013282 A KR20240013282 A KR 20240013282A KR 1020247001893 A KR1020247001893 A KR 1020247001893A KR 20247001893 A KR20247001893 A KR 20247001893A KR 20240013282 A KR20240013282 A KR 20240013282A
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티엔 리
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이뮤너티바이오, 인크.
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KR1020247001893A 2015-06-10 2016-06-10 암을 치료하기 위한 변형된 nk-92 세포 Ceased KR20240013282A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257004508A KR20250027585A (ko) 2015-06-10 2016-06-10 암을 치료하기 위한 변형된 nk-92 세포

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562173701P 2015-06-10 2015-06-10
US62/173,701 2015-06-10
US201662337044P 2016-05-16 2016-05-16
US62/337,044 2016-05-16
PCT/US2016/036991 WO2016201304A1 (en) 2015-06-10 2016-06-10 Modified nk-92 cells for treating cancer
KR1020237013832A KR102627811B1 (ko) 2015-06-10 2016-06-10 암을 치료하기 위한 변형된 nk-92 세포

Related Parent Applications (1)

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KR1020237013832A Division KR102627811B1 (ko) 2015-06-10 2016-06-10 암을 치료하기 위한 변형된 nk-92 세포

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KR1020257004508A Division KR20250027585A (ko) 2015-06-10 2016-06-10 암을 치료하기 위한 변형된 nk-92 세포

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KR20240013282A true KR20240013282A (ko) 2024-01-30

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Application Number Title Priority Date Filing Date
KR1020247001893A Ceased KR20240013282A (ko) 2015-06-10 2016-06-10 암을 치료하기 위한 변형된 nk-92 세포
KR1020187000382A Active KR102526538B1 (ko) 2015-06-10 2016-06-10 암을 치료하기 위한 변형된 nk-92 세포
KR1020257004508A Pending KR20250027585A (ko) 2015-06-10 2016-06-10 암을 치료하기 위한 변형된 nk-92 세포
KR1020237013832A Active KR102627811B1 (ko) 2015-06-10 2016-06-10 암을 치료하기 위한 변형된 nk-92 세포

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KR1020187000382A Active KR102526538B1 (ko) 2015-06-10 2016-06-10 암을 치료하기 위한 변형된 nk-92 세포
KR1020257004508A Pending KR20250027585A (ko) 2015-06-10 2016-06-10 암을 치료하기 위한 변형된 nk-92 세포
KR1020237013832A Active KR102627811B1 (ko) 2015-06-10 2016-06-10 암을 치료하기 위한 변형된 nk-92 세포

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US (3) US10738279B2 (enExample)
EP (3) EP4424326A3 (enExample)
JP (4) JP2018517415A (enExample)
KR (4) KR20240013282A (enExample)
CN (2) CN107709552B (enExample)
AU (1) AU2016275030B2 (enExample)
CA (1) CA2987290C (enExample)
ES (1) ES2958720T3 (enExample)
IL (2) IL309167A (enExample)
WO (1) WO2016201304A1 (enExample)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102463529B1 (ko) 2014-04-10 2022-11-07 시애틀 칠드런즈 호스피탈 디/비/에이 시애틀 칠드런즈 리서치 인스티튜트 약물 관련 트랜스진 발현
EP3805371A1 (en) 2014-05-15 2021-04-14 National University of Singapore Modified natural killer cells and uses thereof
EP4424326A3 (en) 2015-06-10 2024-11-13 ImmunityBio, Inc. Modified nk-92 cells for treating cancer
JP7162530B2 (ja) 2015-08-07 2022-10-28 シアトル チルドレンズ ホスピタル (ディービーエイ シアトル チルドレンズ リサーチ インスティテュート) 固形腫瘍を標的とする二重特異性car t細胞
CA3025667A1 (en) * 2016-06-08 2017-12-14 Intrexon Corporation Cd33 specific chimeric antigen receptors
IL267543B2 (en) * 2017-01-06 2024-07-01 Immunitybio Inc Modified nk-92 cells and compositions thereof for use in the treatment of cancer and methods of preparation thereof
SG11201906213UA (en) * 2017-01-10 2019-08-27 Intrexon Corp Modulating expression of polypeptides via new gene switch expression systems
CA3051866A1 (en) * 2017-02-01 2018-08-09 Nant Holdings Ip, Llc Calreticulin-mediated cancer treatment
US20210130471A1 (en) * 2017-02-20 2021-05-06 Dragonfly Therapeutics, Inc. Proteins binding cd33, nkg2d and cd16
JP7098648B2 (ja) * 2017-03-08 2022-07-11 イミュニティーバイオ インコーポレイテッド 臨床のための、改変されたNK-92 haNK003細胞
CA3056630A1 (en) 2017-03-15 2018-09-20 Pandion Therapeutics, Inc. Targeted immunotolerance
EP3601538A4 (en) * 2017-03-27 2021-03-10 Nantcell, Inc. ANK AND IL-12 COMPOSITIONS AND METHODS
SG11201908337VA (en) 2017-03-27 2019-10-30 Nat Univ Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
CA3056439A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy
KR102009040B1 (ko) * 2017-04-05 2019-08-08 한국생명공학연구원 Nk 세포 활성화 융합 단백질, nk 세포 및 이들을 포함하는 약제학적 조성물
EP4317422A3 (en) * 2017-04-13 2024-05-01 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
JP2020521452A (ja) 2017-05-24 2020-07-27 パンディオン・セラピューティクス・インコーポレイテッド 標的化免疫寛容
TWI676483B (zh) * 2017-08-06 2019-11-11 強普生技股份有限公司 醫藥套組及其用途
CA3079264A1 (en) * 2017-10-18 2019-04-25 Intrexon Corporation Polypeptide compositions comprising spacers
US12053490B2 (en) 2017-10-26 2024-08-06 St. Jude Children's Research Hospital, Inc. Methods and compositions for treating CD33+ cancers and improving in vivo persistence of chimeric antigen receptor T cells
EP3703735A1 (en) * 2017-11-01 2020-09-09 Nantkwest, Inc. Nk-92 cells to stimulate anti-cancer vaccine
JP2021503954A (ja) * 2017-11-24 2021-02-15 オーエヌケイ セラピューティクス リミテッド 腫瘍細胞を標的とする改変されたナチュラルキラー細胞およびナチュラルキラー細胞株
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
WO2019127215A1 (en) * 2017-12-28 2019-07-04 Nanjing Legend Biotech Co., Ltd. Multispecific chimeric receptors comprising an nkg2d domain and methods of use thereof
CN110028589B (zh) * 2018-02-07 2023-07-21 阿思科力(苏州)生物科技有限公司 嵌合抗原受体、表达该嵌合抗原受体的nkg2d car-nk细胞及其制备方法和应用
SG11202007156QA (en) 2018-02-09 2020-08-28 Nat Univ Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
WO2019177986A1 (en) * 2018-03-12 2019-09-19 Nantkwest, Inc. Use of cd33car modified high affinity nk cells (t-hank) to reduce myeloid-derived suppressor cells suppressor activity (or reduce negative impact on nk cell activity)
KR102226918B1 (ko) * 2018-03-23 2021-03-11 주식회사 에스엘바이젠 신규 키메라 항원 수용체 암호화 유전자가 형질도입된 유전자 변형 nk 세포주 및 그의 용도
SG11202008976YA (en) 2018-04-02 2020-10-29 Nat Univ Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
IL321548A (en) * 2018-05-22 2025-08-01 Immunitybio Inc Recombinant NK cells expressing a chimeric antigen receptor (CAR) for epsilon-FC and uses thereof
US12498363B2 (en) 2018-08-01 2025-12-16 Immunitybio, Inc. Combined invasion and cytotoxicity assay using chemokine secreting target cells
IL296050B2 (en) * 2018-08-01 2024-12-01 Immunitybio Inc A quadricistronic system comprising a homing receptor or a cytokine, and chimeric antigen receptor for genetic modification of immunotherapies
KR102839381B1 (ko) 2018-08-29 2025-07-28 내셔널 유니버시티 오브 싱가포르 유전적으로 변형된 면역 세포의 생존 및 확장을 특이적으로 자극하는 방법
KR20250024868A (ko) * 2018-10-31 2025-02-19 난트퀘스트, 인크. Cd19-car 발현 nk 세포에 의한 cd19-양성 림프성 악성종양의 제거
US11077143B2 (en) * 2018-10-31 2021-08-03 Nantkwest Inc. Elimination of PD-L1-positive malignancies by PD-L1 chimeric antigen receptor-expressing NK cells
WO2020096646A1 (en) 2018-11-06 2020-05-14 Nantkwest, Inc. Chimeric antigen receptor-modified nk-92 cells
US12109238B2 (en) 2018-11-06 2024-10-08 Immunitybio, Inc. Chimeric antigen receptor-modified NK-92 cells
WO2020112669A1 (en) * 2018-11-26 2020-06-04 Nantkwest, Inc. Il-2 dependent nk-92 cells with stable fc receptor expression
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
US11364265B1 (en) 2019-03-15 2022-06-21 Nantcell, Inc. Recombinant erIL-15 NK cells
CA3141327A1 (en) 2019-05-20 2020-11-26 Pandion Operations, Inc. Madcam targeted immunotolerance
AU2020320187B2 (en) * 2019-07-26 2024-04-18 Immunitybio, Inc. Antibody pre-loaded CD16+NK-92 cells as an effective therapeutic product for tumor lysis
EP4007809A4 (en) * 2019-08-01 2023-02-22 ImmunityBio, Inc. NK-92 CELLS MODIFIED BY CHIMERIC ANTI-B7-H4 ANTIGEN RECEPTOR
CN115151635A (zh) * 2019-09-18 2022-10-04 斯比根公司 用编码新的嵌合抗原受体的基因转导的基因修饰nk细胞系及其用途
US20210106619A1 (en) * 2019-10-10 2021-04-15 Nantkwest, Inc. NK-92 Bone and Brain targeting
WO2021101467A1 (en) * 2019-11-19 2021-05-27 Acibadem Mehmet Ali̇ Aydinlar Üni̇versi̇tesi̇ A method for redesign and expansion of nk92 cells for use in immunotherapy
CN115190910A (zh) 2019-11-20 2022-10-14 免疫生物公司 细胞介导的免疫增强分子到肿瘤微环境中的瞬时递送
US20210169931A1 (en) * 2019-12-09 2021-06-10 Nantkwest, Inc. Screening of cell clones expressing polygenic transgenes through non-antibiotic dependent positive selection
US11230699B2 (en) 2020-01-28 2022-01-25 Immunitybio, Inc. Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors
EP4097219A4 (en) * 2020-01-28 2023-10-11 ImmunityBio, Inc. CHIMERIC ANTIGEN RECEPTOR-MODIFIED NK-92 CELLS TARGETING EGFR SUPER-FAMILY RECEPTORS
US20230172982A1 (en) * 2020-01-30 2023-06-08 Immunitybio, Inc. Elimination of BCMA-positive malignancies by CAR expressing NK cells
WO2021168079A1 (en) 2020-02-21 2021-08-26 Pandion Operations, Inc. Tissue targeted immunotolerance with a cd39 effector
KR20220162157A (ko) * 2020-03-28 2022-12-07 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 암을 치료하기 위한 세포 면역치료
EP4178678A1 (en) 2020-07-07 2023-05-17 Cancure, LLC Mic antibodies and binding agents and methods of using the same
TW202233829A (zh) * 2020-10-26 2022-09-01 美國全美兒童醫院之研究學會 嵌合抗原受體(car) nk細胞及其用途
US11591381B2 (en) 2020-11-30 2023-02-28 Crispr Therapeutics Ag Gene-edited natural killer cells
US11473060B2 (en) 2020-12-30 2022-10-18 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into NK cells
WO2024236557A1 (en) 2023-05-12 2024-11-21 Gilboa Therapeutics LTD Compositions comprising an fc domain for the treatment of medical conditions
WO2025158400A1 (en) * 2024-01-24 2025-07-31 Yale University Compositions and methods of natural killer cell hyperboosts for enhancement of nk cell therapy

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2263205T3 (es) 1997-04-30 2006-12-01 Hans Klingemann Estirpes celulares citoliticas naturales y metodos de uso.
US8034332B2 (en) 1997-04-30 2011-10-11 Conkwest, Inc. Interleukin-secreting natural killer cell lines and methods of use
TR200001253T2 (tr) 1997-11-06 2000-11-21 Roche Diagnostics Gmbh Tümöre özel antijenler
WO2000020460A1 (en) 1998-10-05 2000-04-13 Ludwig Institute For Cancer Research Methods for producing human tumor antigen specific antibodies
US7098008B2 (en) 2000-04-25 2006-08-29 Ic&G Do. Ltd. Selected primers for detection of MAGE or GAGE genes for diagnosis of cancer and methods of use
SE526227C2 (sv) * 2002-05-15 2005-08-02 North China Pharmaceutical Group Metod för rening av rekombinant humant serumalbumin
ATE483472T1 (de) 2002-05-30 2010-10-15 Macrogenics Inc Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten
JP2008505071A (ja) * 2004-07-02 2008-02-21 アヴァリス・アクチエボラーグ 細胞を遺伝学的に活性化する方法、および、該細胞の使用
DK2112162T3 (da) * 2004-07-10 2015-02-23 Fox Chase Cancer Ct Genetisk modificerede humane naturlige dræbercellelinjer
ATE504647T1 (de) * 2007-01-30 2011-04-15 Forerunner Pharma Res Co Ltd Chimärer fc gamma rezeptor und verfahren zur bestimmung von adcc-aktivität unter verwendung des rezeptors
EP2161339A1 (en) * 2008-08-29 2010-03-10 F. Hoffmann-La Roche Ag ADCC with modified NK92 cells
EP2585476A4 (en) 2010-06-22 2014-01-22 Neogenix Oncology Inc ANTIGENS AND ANTIBODIES SPECIFIC TO COLON AND PANCREATIC CANCER
ES2754394T3 (es) * 2010-09-08 2020-04-17 Chemotherapeutisches Forschungsinstitut Georg Speyer Haus Receptores de antígenos quiméricos con una región bisagra optimizada
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
KR101956751B1 (ko) 2011-10-07 2019-03-11 고쿠리츠다이가쿠호진 미에다이가쿠 키메라 항원 수용체
RU2644243C2 (ru) 2011-10-20 2018-02-08 Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез Химерные антигенные рецепторы к cd22
CN103483452B (zh) * 2012-06-12 2021-08-13 上海细胞治疗集团有限公司 双信号独立的嵌合抗原受体及其用途
RU2663725C2 (ru) 2012-09-04 2018-08-08 Селлектис Многоцепочечный химерный антигенный рецептор и его применения
CN104853766A (zh) * 2012-10-02 2015-08-19 纪念斯隆-凯特琳癌症中心 用于免疫疗法的组合物和方法
US20150329640A1 (en) 2012-12-20 2015-11-19 Bluebird Bio, Inc. Chimeric antigen receptors and immune cells targeting b cell malignancies
US20160015749A1 (en) * 2013-03-05 2016-01-21 Baylor College Of Medicine Engager cells for immunotherapy
US9745368B2 (en) * 2013-03-15 2017-08-29 The Trustees Of The University Of Pennsylvania Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
EP2992020B1 (en) * 2013-05-03 2020-01-15 Ohio State Innovation Foundation Cs1-specific chimeric antigen receptor engineered immune effector cells
CN104561069A (zh) * 2013-10-23 2015-04-29 深圳先进技术研究院 含重组嵌合抗原受体基因表达盒的微环dna重组母质粒、含该表达盒的微环dna及应用
CN105848662A (zh) * 2013-11-01 2016-08-10 南克维斯特公司 杀肿瘤和抗微生物组合物和方法
MX373687B (es) * 2013-11-21 2020-07-07 Ucl Business Ltd Célula natural (nk)
EP4424326A3 (en) 2015-06-10 2024-11-13 ImmunityBio, Inc. Modified nk-92 cells for treating cancer
KR20250024868A (ko) * 2018-10-31 2025-02-19 난트퀘스트, 인크. Cd19-car 발현 nk 세포에 의한 cd19-양성 림프성 악성종양의 제거

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