KR20230104767A - 모르피난 유도체 - Google Patents

모르피난 유도체 Download PDF

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Publication number
KR20230104767A
KR20230104767A KR1020237022162A KR20237022162A KR20230104767A KR 20230104767 A KR20230104767 A KR 20230104767A KR 1020237022162 A KR1020237022162 A KR 1020237022162A KR 20237022162 A KR20237022162 A KR 20237022162A KR 20230104767 A KR20230104767 A KR 20230104767A
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KR
South Korea
Prior art keywords
carbon atoms
alkyl
moiety
compound
substituted
Prior art date
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KR1020237022162A
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English (en)
Korean (ko)
Inventor
히로시 나가세
히데아키 후지이
아키요시 사이토
에리코 나카타
마사아키 히로세
이사오 오오이
고헤이 하야시다
Original Assignee
닛뽕 케미파 가부시키가이샤
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56919074&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20230104767(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 닛뽕 케미파 가부시키가이샤 filed Critical 닛뽕 케미파 가부시키가이샤
Publication of KR20230104767A publication Critical patent/KR20230104767A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020237022162A 2015-03-17 2016-03-17 모르피난 유도체 KR20230104767A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JPJP-P-2015-054079 2015-03-17
JP2015054079 2015-03-17
KR1020177029778A KR102551969B1 (ko) 2015-03-17 2016-03-17 모르피난 유도체
PCT/JP2016/058475 WO2016148232A1 (ja) 2015-03-17 2016-03-17 モルヒナン誘導体

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020177029778A Division KR102551969B1 (ko) 2015-03-17 2016-03-17 모르피난 유도체

Publications (1)

Publication Number Publication Date
KR20230104767A true KR20230104767A (ko) 2023-07-10

Family

ID=56919074

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020237022162A KR20230104767A (ko) 2015-03-17 2016-03-17 모르피난 유도체
KR1020177029778A KR102551969B1 (ko) 2015-03-17 2016-03-17 모르피난 유도체

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020177029778A KR102551969B1 (ko) 2015-03-17 2016-03-17 모르피난 유도체

Country Status (24)

Country Link
US (4) US10442802B2 (zh)
EP (2) EP3974430A1 (zh)
JP (4) JP6692345B2 (zh)
KR (2) KR20230104767A (zh)
CN (3) CN107614500B (zh)
AU (2) AU2016234222C1 (zh)
BR (1) BR112017019805B1 (zh)
CA (1) CA2979023C (zh)
CY (1) CY1124908T1 (zh)
DK (1) DK3272750T3 (zh)
ES (1) ES2904511T3 (zh)
HK (1) HK1249900A1 (zh)
HU (1) HUE057266T2 (zh)
IL (1) IL254473B (zh)
MA (1) MA41790B1 (zh)
MX (2) MX2021008741A (zh)
MY (1) MY197742A (zh)
PH (1) PH12017501655A1 (zh)
PL (1) PL3272750T3 (zh)
RU (1) RU2762567C2 (zh)
SG (2) SG11201707427TA (zh)
TW (2) TWI775723B (zh)
WO (1) WO2016148232A1 (zh)
ZA (1) ZA201706882B (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018030382A1 (ja) 2016-08-09 2018-02-15 国立大学法人 筑波大学 モルヒナン誘導体
EP3513792B9 (en) * 2016-09-16 2024-07-10 Nippon Chemiphar Co., Ltd. Morphinan derivatives for the treatment of opioid delta receptor agonist-related diseases
JP7283711B2 (ja) * 2016-10-03 2023-05-30 学校法人星薬科大学 モルヒナン誘導体を含む医薬組成物及びその鎮痛剤への使用
CA3146790A1 (en) 2019-07-19 2021-01-28 Nippon Chemiphar Co., Ltd. Method for producing morphinan derivative
KR20220035378A (ko) 2019-07-19 2022-03-22 닛뽕 케미파 가부시키가이샤 페놀 유도체의 제조 방법
EP4206203A1 (en) 2020-08-28 2023-07-05 Nippon Chemiphar Co., Ltd. Method for preparing morphinan derivative having diaryl ether skeleton using novel copper catalyst

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001046192A1 (fr) 1999-12-22 2001-06-28 Meiji Seika Kaisha, Ltd. COMPOSES SPIRO UTILES EN TANT QU'AGONISTES DES RECEPTEURS DES OPIOIDES $g(d)
JP2006522775A (ja) 2003-04-11 2006-10-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 置換された４−フェニル−４−’１ｈ−イミダゾール−２−イル！−ピペリジン誘導体および抗抑鬱および不安緩解活性を有する選択性非ペプチドデルタオピオイドアゴニストとしてのそれらの使用
WO2008001859A1 (fr) 2006-06-30 2008-01-03 School Juridical Person Kitasato Gakuen AGONISTE DES RÉCEPTEURS δ DES OPIOÏDES
WO2013035833A1 (ja) 2011-09-09 2013-03-14 学校法人北里研究所 モルヒナン誘導体
WO2014021273A1 (ja) 2012-07-30 2014-02-06 学校法人北里研究所 モルヒナン誘導体
WO2014136305A1 (ja) 2013-03-08 2014-09-12 学校法人北里研究所 モルヒナン誘導体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10161963A1 (de) 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
WO2006107254A1 (en) 2005-04-04 2006-10-12 Astrazeneca Ab Novel diazaspiroalkanes and their use for treatment of ccr8 mediated diseases
CN101918403A (zh) 2007-09-06 2010-12-15 阵列生物制药公司 作为酪氨酸激酶抑制剂的吡唑并吡啶类化合物
EP2493878B1 (en) 2009-10-30 2016-10-12 Janssen Pharmaceutica NV Pyrazines as delta opioid receptor modulators
WO2011090935A1 (en) 2010-01-19 2011-07-28 Merck Sharp & Dohme Corp. PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS
US8987293B2 (en) 2010-12-23 2015-03-24 Phoenix Pharmalabs, Inc. Morphinans useful as analgesics
JP2014073964A (ja) 2011-01-28 2014-04-24 Kitasato Institute モルヒナン誘導体
ES2623262T3 (es) 2012-12-14 2017-07-10 Purdue Pharma Lp Derivados de morfinano que contienen nitrógeno y el uso de los mismos
EP3513792B9 (en) 2016-09-16 2024-07-10 Nippon Chemiphar Co., Ltd. Morphinan derivatives for the treatment of opioid delta receptor agonist-related diseases

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001046192A1 (fr) 1999-12-22 2001-06-28 Meiji Seika Kaisha, Ltd. COMPOSES SPIRO UTILES EN TANT QU'AGONISTES DES RECEPTEURS DES OPIOIDES $g(d)
JP2006522775A (ja) 2003-04-11 2006-10-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 置換された４−フェニル−４−’１ｈ−イミダゾール−２−イル！−ピペリジン誘導体および抗抑鬱および不安緩解活性を有する選択性非ペプチドデルタオピオイドアゴニストとしてのそれらの使用
WO2008001859A1 (fr) 2006-06-30 2008-01-03 School Juridical Person Kitasato Gakuen AGONISTE DES RÉCEPTEURS δ DES OPIOÏDES
WO2013035833A1 (ja) 2011-09-09 2013-03-14 学校法人北里研究所 モルヒナン誘導体
WO2014021273A1 (ja) 2012-07-30 2014-02-06 学校法人北里研究所 モルヒナン誘導体
WO2014136305A1 (ja) 2013-03-08 2014-09-12 学校法人北里研究所 モルヒナン誘導体

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Title
Behavioural Brain Research 2011, 223, 271
Current Neuropharmacology, 2012, 10, 231
J.Pharmacol. Exp. Ther. 2011, 338, 195
Nature Genetics 2000, 25, 195
Neuropharmacology, 2013, 67, 485
Neuroscience 2005, 135, 305
Psychopharmacology (Berl) 2013, 228, 1
Tetrahedron, 2011, 67, 6682
The International Narcotics Research Conference 2014, July 13, 2014
Trends in Neurosciences 2013, 36, 195

Also Published As

Publication number Publication date
TWI778933B (zh) 2022-09-21
WO2016148232A1 (ja) 2016-09-22
TW202244044A (zh) 2022-11-16
MA41790A (fr) 2021-06-02
PH12017501655B1 (en) 2018-03-12
US11643411B2 (en) 2023-05-09
CA2979023A1 (en) 2016-09-22
US10995092B2 (en) 2021-05-04
CA2979023C (en) 2023-09-26
CN107614500A (zh) 2018-01-19
AU2020270503A1 (en) 2020-12-17
AU2020270503C1 (en) 2023-08-10
EP3272750A4 (en) 2018-08-08
MY197742A (en) 2023-07-12
US20230159530A1 (en) 2023-05-25
US20200079775A1 (en) 2020-03-12
AU2020270503B2 (en) 2023-02-02
JP2020117533A (ja) 2020-08-06
CY1124908T1 (el) 2023-01-05
MX2017011824A (es) 2018-04-20
US20180057493A1 (en) 2018-03-01
HK1249900A1 (zh) 2018-11-16
US10442802B2 (en) 2019-10-15
RU2762567C2 (ru) 2021-12-21
BR112017019805B1 (pt) 2023-01-31
CN113292559A (zh) 2021-08-24
IL254473B (en) 2022-05-01
JP6692345B2 (ja) 2020-05-13
AU2016234222A1 (en) 2017-10-26
CN113292558A (zh) 2021-08-24
TWI775723B (zh) 2022-09-01
EP3272750B1 (en) 2021-11-03
ES2904511T3 (es) 2022-04-05
PH12017501655A1 (en) 2018-03-12
DK3272750T3 (en) 2022-01-03
SG10201907667RA (en) 2019-09-27
MA41790B1 (fr) 2022-02-28
AU2016234222B2 (en) 2020-08-27
AU2016234222C1 (en) 2021-02-11
EP3272750A1 (en) 2018-01-24
CN113292559B (zh) 2024-04-02
JP2022081656A (ja) 2022-05-31
ZA201706882B (en) 2022-02-23
US20210040094A1 (en) 2021-02-11
CN107614500B (zh) 2021-06-15
IL254473A0 (en) 2017-11-30
BR112017019805A2 (pt) 2018-05-29
PL3272750T3 (pl) 2022-03-07
RU2017134286A3 (zh) 2019-04-19
RU2017134286A (ru) 2019-04-05
TW201638089A (zh) 2016-11-01
KR20180002616A (ko) 2018-01-08
AU2020270503C9 (en) 2024-02-29
KR102551969B1 (ko) 2023-07-05
MX2021008741A (es) 2022-11-01
JP7375076B2 (ja) 2023-11-07
EP3974430A1 (en) 2022-03-30
HUE057266T2 (hu) 2022-05-28
AU2020270503B9 (en) 2023-10-12
SG11201707427TA (en) 2017-10-30
JPWO2016148232A1 (ja) 2018-03-08
JP2024010098A (ja) 2024-01-23

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