CY1124908T1 - Παραγωγο μορφινανης - Google Patents
Παραγωγο μορφινανηςInfo
- Publication number
- CY1124908T1 CY1124908T1 CY20221100041T CY221100041T CY1124908T1 CY 1124908 T1 CY1124908 T1 CY 1124908T1 CY 20221100041 T CY20221100041 T CY 20221100041T CY 221100041 T CY221100041 T CY 221100041T CY 1124908 T1 CY1124908 T1 CY 1124908T1
- Authority
- CY
- Cyprus
- Prior art keywords
- represent hydrogen
- heterocycle
- carbon atoms
- carbon atom
- hydrogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Τα παράγωγα μορφινάνης που αντιπροσωπεύονται με το γενικό τύπο (Ι) (όπου R1 αντιπροσωπεύει υδρογόνο, C1-10αλκύλ, κυκλοαλκυλαλκύλ όπου η κυκλοαλκύλ χαρακτηριστική ομάδα έχει 3-6 άτομα άνθρακα και η αλκυλένο χαρακτηριστική ομάδα έχει 1-5 άτομα άνθρακα, ή τα παρόμοια· R2 αντιπροσωπεύει ετερόκυκλο που συμπεριλαμβάνει τουλάχιστον ένα άτομο άνθρακα και 1-4 ετεροάτομα που επιλέγονται μεταξύ Ν, Ο και S ως συστατικό δακτυλιοειδή άτομα, με τουλάχιστον μία ομάδα γειτονικών δακτυλιοειδών ατόμων συστατικών που έχουν διπλό δεσμό, ο εν λόγω δε ετερόκυκλος επίσης συμπεριλαμβάνει τουλάχιστον μία όξο ομάδα ως υποκαταστάτη· Υ συνδέεται προς άτομο άνθρακα που είναι συστατικό δακτυλιοειδές άτομο της R2· R3· R4 και R5 αντιπροσωπεύουν υδρογόνο, υδρόξυ ή τα παρόμοια· R6a και R6b αντιπροσωπεύουν υδρογόνο ή τα παρόμοια· R7 και R8 αντιπροσωπεύουν υδρογόνο ή τα παρόμοια· R9 και R10 είναι οι ίδιες ή διαφορετικές, και αντιπροσωπεύουν υδρογόνο ή τα παρόμοια· Χ αντιπροσωπεύει Ο ή CH2· και Υ αντιπροσωπεύει C(=O)), παραλλαγές και στερεοϊσομερή των παραγώγων, φαρμακευτικώς αποδεκτά άλατα αυτών, και διαλυτώματα αυτών σύμφωνα προς την παρούσα εφεύρεση χρησιμοποιούνται ως αντιαγχωτικά φάρμακα, αντικαταθλιπτικά και τα παρόμοια.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015054079 | 2015-03-17 | ||
| PCT/JP2016/058475 WO2016148232A1 (ja) | 2015-03-17 | 2016-03-17 | モルヒナン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124908T1 true CY1124908T1 (el) | 2023-01-05 |
Family
ID=56919074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20221100041T CY1124908T1 (el) | 2015-03-17 | 2022-01-18 | Παραγωγο μορφινανης |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US10442802B2 (el) |
| EP (2) | EP3974430A1 (el) |
| JP (4) | JP6692345B2 (el) |
| KR (2) | KR20230104767A (el) |
| CN (3) | CN113292558A (el) |
| AU (2) | AU2016234222C1 (el) |
| BR (1) | BR112017019805B1 (el) |
| CA (1) | CA2979023C (el) |
| CY (1) | CY1124908T1 (el) |
| DK (1) | DK3272750T3 (el) |
| ES (1) | ES2904511T3 (el) |
| HK (1) | HK1249900A1 (el) |
| HU (1) | HUE057266T2 (el) |
| IL (1) | IL254473B (el) |
| MA (1) | MA41790B1 (el) |
| MX (2) | MX2021008741A (el) |
| MY (1) | MY197742A (el) |
| PH (1) | PH12017501655A1 (el) |
| PL (1) | PL3272750T3 (el) |
| RU (1) | RU2762567C2 (el) |
| SG (2) | SG10201907667RA (el) |
| TW (2) | TWI775723B (el) |
| WO (1) | WO2016148232A1 (el) |
| ZA (1) | ZA201706882B (el) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018030382A1 (ja) | 2016-08-09 | 2018-02-15 | 国立大学法人 筑波大学 | モルヒナン誘導体 |
| AU2017327304B9 (en) * | 2016-09-16 | 2023-10-12 | Nippon Chemiphar Co., Ltd. | Use of morphinan derivative for therapeutic treatment of opioid δ receptor agonist-related disease |
| JP7283711B2 (ja) * | 2016-10-03 | 2023-05-30 | 学校法人星薬科大学 | モルヒナン誘導体を含む医薬組成物及びその鎮痛剤への使用 |
| AU2020317503A1 (en) * | 2019-07-19 | 2022-02-10 | Nippon Chemiphar Co., Ltd. | Method for producing phenol derivative |
| AU2020318159A1 (en) | 2019-07-19 | 2022-02-10 | Nippon Chemiphar Co., Ltd. | Method for producing morphinan derivative |
| CA3192609A1 (en) | 2020-08-28 | 2022-03-03 | Nippon Chemiphar Co., Ltd. | Method for preparing morphinan derivative having diaryl ether skeleton using novel copper catalyst |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005231995A (ja) | 1999-12-22 | 2005-09-02 | Meiji Seika Kaisha Ltd | オピオイドδ受容体アゴニスト／アンタゴニストとして有用なスピロ化合物 |
| DE10161963A1 (de) | 2001-12-17 | 2003-07-03 | Johannes Schuetz | 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung |
| AR044010A1 (es) | 2003-04-11 | 2005-08-24 | Janssen Pharmaceutica Nv | Uso de derivados de 4-fenil-4- [1h-imidazol-2-il]- piperidina sustituidos como agonistas delta opioideos no peptidos selectivos, con actividad antidepresiva y ansiolitica |
| WO2006107254A1 (en) | 2005-04-04 | 2006-10-12 | Astrazeneca Ab | Novel diazaspiroalkanes and their use for treatment of ccr8 mediated diseases |
| WO2008001859A1 (fr) | 2006-06-30 | 2008-01-03 | School Juridical Person Kitasato Gakuen | AGONISTE DES RÉCEPTEURS δ DES OPIOÏDES |
| WO2009033084A1 (en) | 2007-09-06 | 2009-03-12 | Array Biopharma Inc. | Pyrazolo-pyridines as tyrosine kinase inhibitors |
| EP2493878B1 (en) | 2009-10-30 | 2016-10-12 | Janssen Pharmaceutica NV | Pyrazines as delta opioid receptor modulators |
| US9227971B2 (en) | 2010-01-19 | 2016-01-05 | Merck Sharp & Dohme Corp. | Pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors |
| ES2604931T3 (es) | 2010-12-23 | 2017-03-10 | Phoenix Pharmalabs, Inc. | Nuevos morfinanos útiles como analgésicos |
| JP2014073964A (ja) | 2011-01-28 | 2014-04-24 | Kitasato Institute | モルヒナン誘導体 |
| JP6061857B2 (ja) * | 2011-09-09 | 2017-01-18 | 学校法人北里研究所 | モルヒナン誘導体 |
| WO2014021273A1 (ja) | 2012-07-30 | 2014-02-06 | 学校法人北里研究所 | モルヒナン誘導体 |
| JP6163210B2 (ja) | 2012-12-14 | 2017-07-12 | パーデュー、ファーマ、リミテッド、パートナーシップ | 窒素含有モルフィナン誘導体およびその使用 |
| CA2908805A1 (en) * | 2013-03-08 | 2014-09-12 | The Kitasato Institute | Morphinan derivative |
| AU2017327304B9 (en) | 2016-09-16 | 2023-10-12 | Nippon Chemiphar Co., Ltd. | Use of morphinan derivative for therapeutic treatment of opioid δ receptor agonist-related disease |
-
2016
- 2016-03-17 MY MYPI2017703345A patent/MY197742A/en unknown
- 2016-03-17 SG SG10201907667RA patent/SG10201907667RA/en unknown
- 2016-03-17 SG SG11201707427TA patent/SG11201707427TA/en unknown
- 2016-03-17 US US15/558,026 patent/US10442802B2/en active Active
- 2016-03-17 PL PL16765061T patent/PL3272750T3/pl unknown
- 2016-03-17 MX MX2021008741A patent/MX2021008741A/es unknown
- 2016-03-17 ES ES16765061T patent/ES2904511T3/es active Active
- 2016-03-17 CN CN202110577382.4A patent/CN113292558A/zh active Pending
- 2016-03-17 DK DK16765061.3T patent/DK3272750T3/da active
- 2016-03-17 KR KR1020237022162A patent/KR20230104767A/ko not_active Application Discontinuation
- 2016-03-17 JP JP2017506606A patent/JP6692345B2/ja active Active
- 2016-03-17 MX MX2017011824A patent/MX2017011824A/es unknown
- 2016-03-17 MA MA41790A patent/MA41790B1/fr unknown
- 2016-03-17 CN CN202110578658.0A patent/CN113292559B/zh active Active
- 2016-03-17 WO PCT/JP2016/058475 patent/WO2016148232A1/ja active Application Filing
- 2016-03-17 CN CN201680016083.0A patent/CN107614500B/zh active Active
- 2016-03-17 RU RU2017134286A patent/RU2762567C2/ru active
- 2016-03-17 AU AU2016234222A patent/AU2016234222C1/en active Active
- 2016-03-17 CA CA2979023A patent/CA2979023C/en active Active
- 2016-03-17 EP EP21203556.2A patent/EP3974430A1/en active Pending
- 2016-03-17 KR KR1020177029778A patent/KR102551969B1/ko active IP Right Grant
- 2016-03-17 EP EP16765061.3A patent/EP3272750B1/en active Active
- 2016-03-17 TW TW105108248A patent/TWI775723B/zh active
- 2016-03-17 HU HUE16765061A patent/HUE057266T2/hu unknown
- 2016-03-17 TW TW111126713A patent/TWI778933B/zh active
- 2016-03-17 BR BR112017019805-3A patent/BR112017019805B1/pt active IP Right Grant
-
2017
- 2017-09-11 PH PH12017501655A patent/PH12017501655A1/en unknown
- 2017-09-13 IL IL254473A patent/IL254473B/en unknown
- 2017-10-11 ZA ZA2017/06882A patent/ZA201706882B/en unknown
-
2018
- 2018-07-19 HK HK18109334.6A patent/HK1249900A1/zh unknown
-
2019
- 2019-07-19 US US16/517,081 patent/US10995092B2/en active Active
-
2020
- 2020-04-10 JP JP2020071041A patent/JP2020117533A/ja not_active Ceased
- 2020-10-13 US US17/069,589 patent/US11643411B2/en active Active
- 2020-11-18 AU AU2020270503A patent/AU2020270503C9/en active Active
-
2022
- 2022-01-18 CY CY20221100041T patent/CY1124908T1/el unknown
- 2022-03-18 JP JP2022044083A patent/JP7375076B2/ja active Active
-
2023
- 2023-01-09 US US18/094,687 patent/US20230159530A1/en active Pending
- 2023-10-25 JP JP2023183221A patent/JP2024010098A/ja active Pending
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