KR20230095923A - Jak1 억제제를 제조하기 위한 공정 및 중간체 - Google Patents

Jak1 억제제를 제조하기 위한 공정 및 중간체 Download PDF

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KR20230095923A
KR20230095923A KR1020237009250A KR20237009250A KR20230095923A KR 20230095923 A KR20230095923 A KR 20230095923A KR 1020237009250 A KR1020237009250 A KR 1020237009250A KR 20237009250 A KR20237009250 A KR 20237009250A KR 20230095923 A KR20230095923 A KR 20230095923A
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formula
compound
salt
reacting
prepared
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KR1020237009250A
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English (en)
Korean (ko)
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자청 저우
스리 천
핑리 류
데이비드 제이. 멜로니
융춘 판
나이징 수
마이클 샤
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인사이트 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Health & Medical Sciences (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
KR1020237009250A 2020-08-18 2021-08-17 Jak1 억제제를 제조하기 위한 공정 및 중간체 KR20230095923A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063067062P 2020-08-18 2020-08-18
US63/067,062 2020-08-18
PCT/US2021/046286 WO2022040172A1 (en) 2020-08-18 2021-08-17 Process and intermediates for preparing a jak1 inhibitor

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KR20230095923A true KR20230095923A (ko) 2023-06-29

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US (1) US11897889B2 (ja)
EP (1) EP4200278A1 (ja)
JP (1) JP2023538614A (ja)
KR (1) KR20230095923A (ja)
CN (1) CN117043152A (ja)
AR (1) AR123268A1 (ja)
AU (1) AU2021329301A1 (ja)
BR (1) BR112023002939A2 (ja)
CA (1) CA3192055A1 (ja)
CL (1) CL2023000482A1 (ja)
CO (1) CO2023003286A2 (ja)
CR (1) CR20230130A (ja)
EC (1) ECSP23019419A (ja)
IL (1) IL300557A (ja)
MX (1) MX2023002035A (ja)
PE (1) PE20231308A1 (ja)
TW (1) TW202212341A (ja)
WO (1) WO2022040172A1 (ja)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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WO2023288197A1 (en) * 2021-07-12 2023-01-19 Incyte Corporation Process and intermediates for preparing baricitinib

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CR20230130A (es) 2023-07-13
IL300557A (en) 2023-04-01
WO2022040172A1 (en) 2022-02-24
US20220056034A1 (en) 2022-02-24
TW202212341A (zh) 2022-04-01
CL2023000482A1 (es) 2023-09-29
AU2021329301A1 (en) 2023-04-13
AR123268A1 (es) 2022-11-16
CA3192055A1 (en) 2022-02-24
CN117043152A (zh) 2023-11-10
US11897889B2 (en) 2024-02-13
MX2023002035A (es) 2023-06-12
ECSP23019419A (es) 2023-04-28
PE20231308A1 (es) 2023-08-24
CO2023003286A2 (es) 2023-06-09
EP4200278A1 (en) 2023-06-28
JP2023538614A (ja) 2023-09-08
BR112023002939A2 (pt) 2023-04-25

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