KR20230028793A - 항-b7-h3 항체를 포함하는 항체-약물 접합체 - Google Patents

항-b7-h3 항체를 포함하는 항체-약물 접합체 Download PDF

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KR20230028793A
KR20230028793A KR1020237002842A KR20237002842A KR20230028793A KR 20230028793 A KR20230028793 A KR 20230028793A KR 1020237002842 A KR1020237002842 A KR 1020237002842A KR 20237002842 A KR20237002842 A KR 20237002842A KR 20230028793 A KR20230028793 A KR 20230028793A
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South Korea
Prior art keywords
seq
amino acid
acid sequence
antibody
cancer
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KR1020237002842A
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Korean (ko)
Inventor
박태교
김선영
박수호
정두환
서동훈
이상광
윤상현
하지현
이향숙
박옥구
서범석
김세나
설민아
송지나
우성호
조종운
이재호
이현미
박재은
송영자
이은진
이현주
심은영
고윤정
이민주
박영우
류요섭
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주식회사 인투셀
주식회사 와이바이오로직스
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Publication of KR20230028793A publication Critical patent/KR20230028793A/ko
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024225837A1 (ko) * 2023-04-28 2024-10-31 주식회사 에이비켐바이오 말레이미드 함유 링커-페이로드 접합체 및 이를 포함하는 신규한 항체-약물 중합체

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020012718A (es) 2018-05-29 2021-02-16 Intocell Inc Derivados de benzodiazepinas novedosos y usos de los mismos.
CN112930350A (zh) 2018-10-31 2021-06-08 尹图赛利有限公司 稠合杂环苯并二氮杂䓬衍生物及其用途
KR20220108783A (ko) * 2019-12-02 2022-08-03 주식회사 인투셀 분자 접합과 관련된 조성물 및 방법
BR112022026401A2 (pt) 2020-06-26 2023-03-14 Intocell Inc Conjugados anticorpo-fármaco compreendendo anticorpos anti-b7-h3
IL313805A (en) * 2021-12-28 2024-08-01 Beigene Switzerland Gmbh Drug antibody conjugates
WO2023173393A1 (zh) * 2022-03-18 2023-09-21 北京天广实生物技术股份有限公司 结合b7-h3的抗体及其用途
JP2026508722A (ja) * 2022-10-28 2026-03-12 イーライ リリー アンド カンパニー バイオコンジュゲーションのための自己加水分解マレイミド
EP4680643A1 (en) * 2023-03-17 2026-01-21 Beone Medicines I GmbH Anti-b7h3 antibodies and methods of use
WO2024235120A1 (zh) * 2023-05-12 2024-11-21 四川科伦博泰生物医药股份有限公司 稠环化合物及其制备方法和用途
CN116949044B (zh) * 2023-09-20 2023-12-12 北京炫景瑞医药科技有限公司 一种双链寡链核苷酸、包含该双链寡核苷酸的缀合物以及它们的用途
CN117777296B (zh) * 2024-02-28 2024-05-28 北京肿瘤医院(北京大学肿瘤医院) B7h3亲和体及其诊疗核素标记物的制备方法与应用
WO2025237246A1 (en) * 2024-05-11 2025-11-20 Westlake Laboratory Of Life Sciences And Biomedicine Novel covalent protein and use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3193933B1 (en) * 2014-09-17 2021-04-28 The U.S.A. as represented by the Secretary, Department of Health and Human Services Anti-cd276 antibodies (b7h3)
GEP20227398B (en) * 2016-04-15 2022-07-25 Macrogenics Inc Novel b7-h3 binding molecules, antibody drug conjugates thereof and usage thereof
AU2017279550A1 (en) 2016-06-08 2019-01-03 Abbvie Inc. Anti-B7-H3 antibodies and antibody drug conjugates
MX2019011117A (es) 2017-03-31 2019-11-05 Jiangsu Hengrui Medicine Co Anticuerpo b7-h3, fragmento de union a antigeno de los mismos y uso medico de los mismos.
CN120682290A (zh) * 2017-07-04 2025-09-23 尹图赛利有限公司 包含可裂解接头的化合物及其用途
MX2020012718A (es) * 2018-05-29 2021-02-16 Intocell Inc Derivados de benzodiazepinas novedosos y usos de los mismos.
CN112930350A (zh) * 2018-10-31 2021-06-08 尹图赛利有限公司 稠合杂环苯并二氮杂䓬衍生物及其用途
KR102732027B1 (ko) * 2019-07-09 2024-11-20 주식회사 와이바이오로직스 B7-h3(cd276)에 특이적으로 결합하는 항체 및 그의 용도
BR112022026401A2 (pt) 2020-06-26 2023-03-14 Intocell Inc Conjugados anticorpo-fármaco compreendendo anticorpos anti-b7-h3

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024225837A1 (ko) * 2023-04-28 2024-10-31 주식회사 에이비켐바이오 말레이미드 함유 링커-페이로드 접합체 및 이를 포함하는 신규한 항체-약물 중합체

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