AU2021297036A1 - Antibody-drug conjugates comprising anti-b7-h3 antibodies - Google Patents

Antibody-drug conjugates comprising anti-b7-h3 antibodies Download PDF

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Publication number
AU2021297036A1
AU2021297036A1 AU2021297036A AU2021297036A AU2021297036A1 AU 2021297036 A1 AU2021297036 A1 AU 2021297036A1 AU 2021297036 A AU2021297036 A AU 2021297036A AU 2021297036 A AU2021297036 A AU 2021297036A AU 2021297036 A1 AU2021297036 A1 AU 2021297036A1
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Australia
Prior art keywords
seq
amino acid
acid sequence
antibody
cancer
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AU2021297036A
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English (en)
Inventor
Jongun CHO
Jihyeon HA
Doohwan JUNG
Sena Kim
Sunyoung Kim
Yunjung KO
Eunjin Lee
Hyang Sook LEE
Hyun Ju Lee
Hyun Mi Lee
Jaeho Lee
Minju Lee
Sangkwang LEE
Jae Eun Park
Okku PARK
Suho Park
Taekyo PARK
Young Woo Park
Yosup Rew
Beomseok Seo
Donghoon SEO
Minah SEOL
Eun-Young Shim
Jina SONG
Youngja SONG
Sung Ho Woo
Sanghyeon YUN
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Y Biologics Inc
Intocell Inc
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Y Biologics Inc
Intocell Inc
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Application filed by Y Biologics Inc, Intocell Inc filed Critical Y Biologics Inc
Publication of AU2021297036A1 publication Critical patent/AU2021297036A1/en
Pending legal-status Critical Current

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    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/6813Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/522CH1 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
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    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/524CH2 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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AU2021297036A 2020-06-26 2021-06-25 Antibody-drug conjugates comprising anti-b7-h3 antibodies Pending AU2021297036A1 (en)

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MX2022016180A (es) 2023-04-20
CA3182602A1 (en) 2021-12-30
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US20250121087A1 (en) 2025-04-17
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