KR20220163986A - 브루톤 티로신 키나아제의 억제제를 이용한 재발성 다발성 경화증의 치료 방법 - Google Patents

브루톤 티로신 키나아제의 억제제를 이용한 재발성 다발성 경화증의 치료 방법 Download PDF

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KR20220163986A
KR20220163986A KR1020227037384A KR20227037384A KR20220163986A KR 20220163986 A KR20220163986 A KR 20220163986A KR 1020227037384 A KR1020227037384 A KR 1020227037384A KR 20227037384 A KR20227037384 A KR 20227037384A KR 20220163986 A KR20220163986 A KR 20220163986A
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pharmaceutically acceptable
acceptable salt
fenebbrutinib
compound
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히데키 가렌
에드몬드 후아텅 텡
아우렐리엔 비아코쯔
한스-크리스티안 폰 뷔딘겐
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제넨테크, 인크.
에프. 호프만-라 로슈 아게
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Publication of KR20220163986A publication Critical patent/KR20220163986A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020227037384A 2020-04-03 2021-04-01 브루톤 티로신 키나아제의 억제제를 이용한 재발성 다발성 경화증의 치료 방법 Pending KR20220163986A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063005095P 2020-04-03 2020-04-03
US63/005,095 2020-04-03
US202063051767P 2020-07-14 2020-07-14
US63/051,767 2020-07-14
PCT/US2021/025301 WO2021202825A1 (en) 2020-04-03 2021-04-01 Methods of treating relapsing multiple sclerosis using an inhibitor of bruton's tyrosine kinase

Publications (1)

Publication Number Publication Date
KR20220163986A true KR20220163986A (ko) 2022-12-12

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KR1020227037384A Pending KR20220163986A (ko) 2020-04-03 2021-04-01 브루톤 티로신 키나아제의 억제제를 이용한 재발성 다발성 경화증의 치료 방법

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US (1) US12605376B2 (https=)
EP (1) EP4125906A1 (https=)
JP (1) JP2023520469A (https=)
KR (1) KR20220163986A (https=)
CN (1) CN115916205A (https=)
AU (1) AU2021249129A1 (https=)
BR (1) BR112022019846A2 (https=)
CA (1) CA3177390A1 (https=)
CL (1) CL2022002699A1 (https=)
IL (1) IL296990A (https=)
MX (1) MX2022012310A (https=)
TW (1) TWI907406B (https=)
WO (1) WO2021202825A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021173740A1 (en) * 2020-02-28 2021-09-02 Genentech, Inc. Methods of treating primary progressive multiple sclerosis using an inhibitor of bruton's tyrosine kinase
WO2022240920A1 (en) 2021-05-14 2022-11-17 Loxo Oncology, Inc. Cocrystalline forms of a bruton's tyrosine kinase inhibitor
CN114028393B (zh) * 2021-11-07 2023-07-18 天津医科大学 阿帕替尼在制备治疗多发性硬化症药物的用途
TW202508592A (zh) * 2023-05-16 2025-03-01 美商建南德克公司 使用布魯頓酪胺酸激酶之抑制劑來治療復發型多發性硬化症之方法
WO2025264860A2 (en) 2024-06-18 2025-12-26 Yale University Methods of treating post-covid airway disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA111756C2 (uk) 2011-11-03 2016-06-10 Ф. Хоффманн-Ля Рош Аг Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
KR20170033358A (ko) 2014-08-07 2017-03-24 파마싸이클릭스 엘엘씨 브루톤 티로신 키나아제 저해제의 신규한 제제
WO2017148837A1 (en) 2016-02-29 2017-09-08 F. Hoffmann-La Roche Ag Dosage form compositions comprising an inhibitor of bruton's tyrosine kinase
CN107043366B (zh) 2017-04-25 2020-05-26 中国药科大学 4-氨基嘧啶类化合物、其制备方法及医药用途
KR102635949B1 (ko) 2017-05-18 2024-02-14 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 종양 치료용 약물의 제조에 있어서의 ezh2 억제제 및 btk 억제제의 조합물의 용도
WO2019208805A1 (ja) * 2018-04-27 2019-10-31 小野薬品工業株式会社 Ｂｔｋ阻害活性を有する化合物を有効成分として含む自己免疫疾患の予防および／または治療剤
EP3849559A4 (en) * 2018-09-12 2022-06-01 Denovo Biopharma LLC COMBINATION OF ENZASTAURIN AND INHIBITORS OF BTK AND USES THEREOF
TW202042815A (zh) 2019-01-22 2020-12-01 美商建南德克公司 使用布魯頓（bruton）酪胺酸激酶抑制劑治療類風性關節炎、慢性自發性蕁麻疹及全身性紅斑性狼瘡的方法
WO2021173740A1 (en) 2020-02-28 2021-09-02 Genentech, Inc. Methods of treating primary progressive multiple sclerosis using an inhibitor of bruton's tyrosine kinase

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EP4125906A1 (en) 2023-02-08
TW202203925A (zh) 2022-02-01
CA3177390A1 (en) 2021-10-07
US20230149395A1 (en) 2023-05-18
BR112022019846A2 (pt) 2022-11-22
AU2021249129A1 (en) 2022-10-20
CN115916205A (zh) 2023-04-04
WO2021202825A1 (en) 2021-10-07
CL2022002699A1 (es) 2023-03-31
JP2023520469A (ja) 2023-05-17
IL296990A (en) 2022-12-01
TWI907406B (zh) 2025-12-11
MX2022012310A (es) 2022-10-27
US12605376B2 (en) 2026-04-21

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