JP2023520469A - ブルトン型チロシンキナーゼの阻害剤を使用する再発性多発性硬化症の治療方法 - Google Patents

ブルトン型チロシンキナーゼの阻害剤を使用する再発性多発性硬化症の治療方法 Download PDF

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JP2023520469A
JP2023520469A JP2022559934A JP2022559934A JP2023520469A JP 2023520469 A JP2023520469 A JP 2023520469A JP 2022559934 A JP2022559934 A JP 2022559934A JP 2022559934 A JP2022559934 A JP 2022559934A JP 2023520469 A JP2023520469 A JP 2023520469A
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fenebrutinib
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pharmaceutically acceptable
acceptable salt
compound
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JP2023520469A5 (https=
JPWO2021202825A5 (https=
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ヒデキ ガレン，
エドモンド ホアトゥン トン，
オーレリアン ヴィアッコス，
ビューディンゲン， ハンス－クリスティアン フォン
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Genentech Inc
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Genentech Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2022559934A 2020-04-03 2021-04-01 ブルトン型チロシンキナーゼの阻害剤を使用する再発性多発性硬化症の治療方法 Pending JP2023520469A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063005095P 2020-04-03 2020-04-03
US63/005,095 2020-04-03
US202063051767P 2020-07-14 2020-07-14
US63/051,767 2020-07-14
PCT/US2021/025301 WO2021202825A1 (en) 2020-04-03 2021-04-01 Methods of treating relapsing multiple sclerosis using an inhibitor of bruton's tyrosine kinase

Publications (3)

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JP2023520469A true JP2023520469A (ja) 2023-05-17
JP2023520469A5 JP2023520469A5 (https=) 2024-04-10
JPWO2021202825A5 JPWO2021202825A5 (https=) 2024-04-10

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JP2022559934A Pending JP2023520469A (ja) 2020-04-03 2021-04-01 ブルトン型チロシンキナーゼの阻害剤を使用する再発性多発性硬化症の治療方法

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Country Link
US (1) US12605376B2 (https=)
EP (1) EP4125906A1 (https=)
JP (1) JP2023520469A (https=)
KR (1) KR20220163986A (https=)
CN (1) CN115916205A (https=)
AU (1) AU2021249129A1 (https=)
BR (1) BR112022019846A2 (https=)
CA (1) CA3177390A1 (https=)
CL (1) CL2022002699A1 (https=)
IL (1) IL296990A (https=)
MX (1) MX2022012310A (https=)
TW (1) TWI907406B (https=)
WO (1) WO2021202825A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022010513A (es) * 2020-02-28 2022-09-21 Genentech Inc Metodos para tratar esclerosis multiple progresiva primaria usando un inhibidor de tirosina quinasa de bruton.
KR102933902B1 (ko) 2021-05-14 2026-03-05 록쏘 온콜로지, 인코포레이티드 브루톤 티로신 키나제 억제제의 공결정질 형태
CN114028393B (zh) * 2021-11-07 2023-07-18 天津医科大学 阿帕替尼在制备治疗多发性硬化症药物的用途
WO2024238524A1 (en) * 2023-05-16 2024-11-21 Genentech, Inc. Methods of treating relapsing multiple sclerosis using an inhibitor of bruton's tyrosine kinase
WO2025264860A2 (en) 2024-06-18 2025-12-26 Yale University Methods of treating post-covid airway disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA111756C2 (uk) 2011-11-03 2016-06-10 Ф. Хоффманн-Ля Рош Аг Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
SG11201700849XA (en) 2014-08-07 2017-03-30 Pharmacyclics Llc Novel formulations of a bruton's tyrosine kinase inhibitor
EP4049660B1 (en) 2016-02-29 2025-02-19 F. Hoffmann-La Roche AG Dosage form compositions comprising an inhibitor of bruton's tyrosine kinase
CN107043366B (zh) 2017-04-25 2020-05-26 中国药科大学 4-氨基嘧啶类化合物、其制备方法及医药用途
MX393601B (es) 2017-05-18 2025-03-21 Jiangsu Hengrui Medicine Co Uso del inhibidor mejorador de homologo zeste 2 (ezh2) combinado con el inhibidor tirosina cinasa de bruton (btk) en la preparacion de farmacos para tratar tumores.
WO2019208805A1 (ja) * 2018-04-27 2019-10-31 小野薬品工業株式会社 Ｂｔｋ阻害活性を有する化合物を有効成分として含む自己免疫疾患の予防および／または治療剤
CN112512527A (zh) * 2018-09-12 2021-03-16 杭州索元生物医药股份有限公司 恩扎妥林和btk抑制剂的组合及其用途
CN113423401A (zh) 2019-01-22 2021-09-21 豪夫迈·罗氏有限公司 使用布鲁顿氏酪氨酸激酶抑制剂来治疗类风湿性关节炎、慢性自发性荨麻疹和系统性红斑狼疮的方法
MX2022010513A (es) 2020-02-28 2022-09-21 Genentech Inc Metodos para tratar esclerosis multiple progresiva primaria usando un inhibidor de tirosina quinasa de bruton.

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANN RHEUM DIS, vol. p.80-81, JPN6025018695, 2019, ISSN: 0005759866 *
F1000RESEARCH, vol. Vol.8:245, JPN6025018694, 2019, pages 1 - 20, ISSN: 0005759865 *
JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, JPN6025018693, 2018, pages 2227 - 2245, ISSN: 0005759864 *
MULTIPLE SCLEROSIS JOURNAL, vol. Vol.25, S2, JPN6025018699, 2019, pages 31 - 32, ISSN: 0005759867 *

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Publication number Publication date
US12605376B2 (en) 2026-04-21
KR20220163986A (ko) 2022-12-12
BR112022019846A2 (pt) 2022-11-22
CA3177390A1 (en) 2021-10-07
WO2021202825A1 (en) 2021-10-07
MX2022012310A (es) 2022-10-27
CN115916205A (zh) 2023-04-04
US20230149395A1 (en) 2023-05-18
TWI907406B (zh) 2025-12-11
IL296990A (en) 2022-12-01
EP4125906A1 (en) 2023-02-08
TW202203925A (zh) 2022-02-01
CL2022002699A1 (es) 2023-03-31
AU2021249129A1 (en) 2022-10-20

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