KR20220154710A - 소형 유도 및 항법 제어(miniGNC) 항체-유사 단백질 및 이의 제조 및 사용 방법 - Google Patents

소형 유도 및 항법 제어(miniGNC) 항체-유사 단백질 및 이의 제조 및 사용 방법 Download PDF

Info

Publication number
KR20220154710A
KR20220154710A KR1020227033907A KR20227033907A KR20220154710A KR 20220154710 A KR20220154710 A KR 20220154710A KR 1020227033907 A KR1020227033907 A KR 1020227033907A KR 20227033907 A KR20227033907 A KR 20227033907A KR 20220154710 A KR20220154710 A KR 20220154710A
Authority
KR
South Korea
Prior art keywords
ser
gly
val
thr
leu
Prior art date
Application number
KR1020227033907A
Other languages
English (en)
Inventor
이 주
소우밀리 채터지
데니스 알. 고울렛
충-이 차이
블레어 렌쇼
크리스토퍼 지. 빈센트
앤드류 웨이트
응아 제 아만다 막
Original Assignee
시스트이뮨, 인코포레이티드
바이리-바이오 (청두) 파마슈티칼 컴퍼니, 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 시스트이뮨, 인코포레이티드, 바이리-바이오 (청두) 파마슈티칼 컴퍼니, 리미티드 filed Critical 시스트이뮨, 인코포레이티드
Publication of KR20220154710A publication Critical patent/KR20220154710A/ko

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
    • A61K47/6879—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the immunoglobulin having two or more different antigen-binding sites, e.g. bispecific or multispecific immunoglobulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

다중특이적 항체 유사 단백질은 제1 결합 단량체, CH1 도메인, 제1 힌지, 제1 CH2 도메인, 및 제1 CH3 도메인을 포함하는 제1 단량체와, 제2 결합 단량체, CL 도메인, 제2 힌지, 제2 CH2 도메인, 및 제2 CH3 도메인을 포함하는 제2 단량체를 갖고, 여기서 상기 제1 결합 단량체 및 제2 결합 단량체가 이량체를 형성하도록 구성되고, 제1 단량체 및 제2 단량체가 CH1 도메인과 CL 도메인 사이의 적어도 하나의 이황화 결합 및 제1 힌지와 제2 힌지 사이의 적어도 하나의 이황화 결합을 통해 공유적으로 쌍을 이루고, 상기 제1 단량체 및 제2 단량체는 임의로 제1 결합 도메인(D1) 및 제2 결합 도메인(D2), 및 제4 결합 도메인(D4) 및 제5 결합 도메인(D5)을 포함할 수 있고, 여기서 다중특이적 항체 유사 단백질은 적어도 이중특이적이다.

Description

소형 유도 및 항법 제어(miniGNC) 항체-유사 단백질 및 이의 제조 및 사용 방법
관련 출원의 상호 참조
본 출원은 35 U.S.C. 119(e)하에 2020년 3월 17일에 출원된 미국 가출원 제62/991,042호의 출원일의 이익을 주장하며, 이의 전체 개시내용은 본원에 참고로 포함된다.
기술분야
본 출원은 일반적으로 암 면역요법을 위한 다중특이적 항체(multi-specific antibody)의 기술 분야에 관한 것이며, 보다 구체적으로는 면역 세포 및 종양 세포 모두의 표면 분자에 대한 복수의 결합 활성을 갖는 소형 유도 및 항법 제어(miniGNC) 항체의 제조 및 사용에 관한 것이다.
치료 항체는 암, 감염 및 자가면역을 포함하지만 이에 제한되지 않는 여러 질환의 치료에 주류가 되었다. 모노클로날, 단일특이적 항체는, 예를 들어, 특정 신호전달 경로의 억제 또는 활성화를 통해 질환을 치료하기 위한 간단한 메커니즘을 제공하지만, 다중특이적 항체는 보다 복잡한 치료 메커니즘이 탐색될 수 있도록 한다. 단일 항원 내에서 다중 별개의 항원 또는 다중 에피토프(epitope)를 표적화(targeting)함으로써, 세포 공동국재화 및 활성화와 같은 생물학적 반응이 유도될 수 있으며, 이는, 예를 들어, T 세포 및 다른 면역 세포를 특이적 항원 발현 종양 세포의 부위로의 재지시를 가능하게 할 수 있다. 이러한 방식으로, 이중특이적 및 다중특이적 항체는 면역종양학 분야에서 중요한 플랫폼이 되었다.
다중특이적 항체 플랫폼의 장점으로 인해, 많은 이러한 프레임워크(framework)가 개발되었다. 이러한 플랫폼 중 하나는 유도 및 항법 제어(GNC)로서 공지되어 있다. GNC 단백질은 이펙터 세포 및 표적 세포 모두를 함께 가져올 수 있는 단일 독립체에 다수의 기능적으로 독립적인 결합 모이어티를 연결하는 단백질을 포함한다(참조: 출원인의 출원, WO/2019/005641, WO2019191120 및 PCT/US20/59230, 그 전체가 본원에 포함됨). 일반적으로, 이러한 플랫폼은 적어도 두 개의 특이성으로 제한되어 2개 이상의 항원에 대한 결합을 필요로 하는 복잡한 치료 메커니즘의 탐색을 방지한다. 둘 이상의 특이성을 갖는 항체 플랫폼의 경우, 증가된 수의 결합 도메인은 일반적으로 종종 바람직하지 않은 물리적 및 생물학적 특성을 갖는 큰 분자의 형성을 필요로 한다. 분자량의 증가는 더 크고 더 복잡한 분자가 응집 및 용해도에 문제가 있을 가능성이 높기 때문에 개발 가능성을 감소시킬 수 있다. 또한, 고형 종양에 침투하는 큰 거대분자의 능력은 더 작은 크기의 단백질과 비교하여 방해받을 수 있다. 따라서, 모노클로날 IgG 항체보다 유의하게 크지 않은 둘 이상의 특이성을 갖는 다중특이적 항체 플랫폼에 대한 필요성이 존재한다.
다음 요약은 단지 예시일 뿐이며 어떤 식으로든 제한하려는 의도가 아니다. 상기 기재된 예시적인 측면, 구현예 및 특징에 추가하여, 추가의 측면, 구현예 및 특징은 도면 및 이하의 상세한 설명을 참조함으로써 명백해질 것이다.
본 출원은 다중특이적 항체를 포함하는 항체와 같은 다중특이적 단백질과 같은 결합 특이성(binding specificity)을 갖는 단백질, 및 scFv 도메인, Fab 영역, Fc 도메인, VH, VL, 경쇄, 중쇄, 가변 영역 및 상보성(complementary) 결정 영역(CDR)을 제한 없이 포함하는 이러한 결합 단백질의 단편을 제공한다. 본 출원은 본원에 개시된 항체 유사 단백질을 제조하고 사용하는 방법을 추가로 제공한다.
한 측면에서, 본 출원은 다중특이적 항체 유사 단백질(multi-specific antibody-like protein)을 제공한다. 하나의 구현예에서, 다중특이적 항체 유사 단백질은 N-말단 및 C-말단을 갖고, N-말단으로부터 C-말단으로 제1 결합 단량체, CH1 도메인, 제1 힌지(hinge), 제1 CH2 도메인, 및 제1 CH3 도메인을 포함하는 제1 단량체로서, 상기 제1 단량체가 N-말단에 연결된 제1 결합 도메인(D1), C-말단에 연결된 제4 결합 도메인(D4), 또는 둘 다를 임의로 포함할 수 있는, 제1 단량체와, N-말단으로부터 C-말단으로 제2 결합 단량체, CL 도메인, 제2 힌지, 제2 CH2 도메인, 및 제2 CH3 도메인을 포함하는 제2 단량체로서, 상기 제2 단량체가 임의로 N-말단에 연결된 제2 결합 도메인(D2), C-말단에 연결된 제5 결합 도메인(D5), 또는 둘 다를 포함할 수 있는, 제2 단량체를 포함하며, 여기서 제1 결합 단량체 및 제2 결합 단량체는 이량체(dimer)를 형성하도록 구성되며, 여기서 제1 단량체 및 제2 단량체는 CH1 도메인과 CL 도메인 사이의 적어도 하나의 이황화 결합(disulfide bond) 및 제1 힌지와 제2 힌지 사이의 적어도 하나의 이황화 결합을 통해 공유적으로 쌍을 이루고, 상기 다중특이적 항체 유사 단백질은 적어도 이중특이적이다.
하나의 구현예에서, 다중특이적 항체 유사 단백질은 삼중특이적(tri-specific), 사중특이적, 또는 오중특이적일 수 있다. 하나의 구현예에서, 다중특이적 항체 유사 단백질은 모노클로날 항체일 수 있다. 하나의 구현예에서, 다중특이적 항체 유사 단백질은 정제된 모노클로날 항체일 수 있다. 하나의 구현예에서, 다중특이적 항체 유사 단백질은 인간화 항체일 수 있다.
하나의 구현예에서, 다중특이적 항체 유사 단백질은 제1 CH3 도메인과 제2 CH3 도메인 사이에 이황화 결합을 추가로 포함할 수 있다.
하나의 구현예에서, 다중특이적 항체 유사 단백질은 제1 힌지와 제2 힌지 사이에 제2 이황화 결합을 추가로 포함할 수 있다.
하나의 구현예에서, 다양한 도메인 사이에 연결 링커가 사용된다. 하나의 구현예에서, 연결 링커는 (GxSy)n 링커를 포함할 수 있으며, 여기서 n, x 및 y는 각각 독립적으로 1 내지 10의 정수이다. 하나의 구현예에서, D1, D2, D4 또는 D5는 링커를 통해 N-말단 또는 C-말단에 연결된다. 하나의 구현예에서, 링커는 GxSy)n 링커를 포함할 수 있다. n, x 및 y는 각각 독립적으로 1 내지 10의 정수일 수 있다. 하나의 구현예에서, n은 1, 2, 3, 4, 5, 6, 7, 8, 9 및 10이다. 하나의 구현예에서, x는 1, 2, 3, 4, 5, 6, 7, 8, 9 및 10이다. 하나의 구현예에서, y는 1, 2, 3, 4, 5, 6, 7, 8, 9 및 10이다.
하나의 구현예에서, 제1 CH3 도메인은 홀 구조(hole structure)를 형성하도록 구성되고, 여기서 제2 CH3 도메인은 노브 구조(knob structure)를 형성하도록 구성되며, 제1 CH2 및 CH3 도메인과 제2 CH2 및 CH3 도메인은 이종이량체화(heterodimerizing)되어 상보성 Fc 도메인을 형성하도록 구성된다.
하나의 구현예에서, 제1 CH3 도메인은 T366S, L368A 또는 Y407V에 적어도 하나의 "홀" 돌연변이를 포함할 수 있고, 제2 CH3 도메인은 T366W에 "노브" 돌연변이를 포함할 수 있다.
하나의 구현예에서, Fc 도메인은 H435R/Y436F에 돌연변이를 포함할 수 있다.
하나의 구현예에서, Fc 도메인은 ADCC, ADCP, 또는 CDC로부터 선택된 이펙터 세포 기능을 제거하도록 조작된다.
하나의 구현예에서, Fc 도메인은 L234A, L235A, G237A, K322A(Eu 넘버링)에 적어도 하나의 돌연변이를 포함할 수 있다. 하나의 구현예에서, Fc 영역은 L234A/L235A/G237A/K322A에 돌연변이를 포함한다. 하나의 구현예에서, Fc 영역은 L234A/L235A/K322A(Eu 넘버링)에 돌연변이를 포함한다. 하나의 구현예에서, Fc 도메인은 null 돌연변이를 포함한다. 하나의 구현예에서, IgG4 Fc 도메인은 돌연변이 S228P(Eu 넘버링)를 포함한다. 하나의 구현예에서, IgG4 Fc 도메인은 돌연변이 S228P/F234A/L234A(Eu 넘버링)를 포함한다.
하나의 구현예에서, 중쇄 불변 서열은 IgG1 또는 IgG4로부터 유래될 수 있다.
하나의 구현예에서, Fc 도메인은 서열번호 313 또는 314와 적어도 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, 또는 100% 동일성을 갖는 아미노산 서열을 포함할 수 있다.
하나의 구현예에서, 제1 결합 단량체는 VH 도메인을 포함할 수 있고, 제2 결합 단량체는 VL 도메인을 포함할 수 있고, VH, CH1, VL, CL 도메인은 제3 결합 도메인(D3)으로서 Fab 영역을 형성한다. 하나의 구현예에서, Fab 영역은 VH-44C와 VL 100C 사이에 이황화 결합을 포함할 수 있다.
하나의 구현예에서, 제1 결합 단량체 및 제2 결합 단량체는 제3 결합 도메인(D3)으로서 NKG2D 수용체를 형성한다.
하나의 구현예에서, D1, D2, D4 및 D5는 독립적으로 scFv 도메인, VHH 도메인, 수용체 또는 리간드이다.
하나의 구현예에서, scFv 도메인은 VL 도메인에 연결된 VH 도메인을 가질 수 있다. 하나의 구현예에서, scFv 도메인은 VH-VL 배향을 가질 수 있다. 하나의 구현예에서, scFv 도메인은 VL-VH 배향을 갖는다.
하나의 구현예에서, scFv 도메인은 VL과 VH 사이에 이황화 결합을 포함할 수 있다. 하나의 구현예에서, 이황화 결합은 scFv 도메인의 VL100과 VH44 사이에 있다. 하나의 구현예에서, scFv 도메인은 VH에 돌연변이 R19S를 포함할 수 있다.
하나의 구현예에서, VHH 도메인은 VH 또는 VHH에 돌연변이 R19S를 포함할 수 있다.
하나의 구현예에서, D1, D2, D4 및 D5 중 적어도 1개, 2개 또는 3개는 scFv일 수 있다. 하나의 구현예에서, D1, D2, D4 및 D5 모두는 scFv일 수 있다.
하나의 구현예에서, D1, D2, D4 및 D5 중 적어도 1개, 2개 또는 3개는 VHH 도메인일 수 있다. 하나의 구현예에서, D1, D2, D4 및 D5 모두는 VHH 도메인일 수 있다.
하나의 구현예에서, D1, D2, D4 및 D5 중 적어도 1개, 2개 또는 3개는 수용체일 수 있다. 하나의 구현예에서, D1, D2, D4 및 D5 모두는 수용체일 수 있다.
하나의 구현예에서, D1, D2, D4 및 D5 중 적어도 1개, 2개 또는 3개는 리간드일 수 있다. 하나의 구현예에서, D1, D2, D4 및 D5 모두는 리간드일 수 있다.
하나의 구현예에서, D1, D2, D3, D4 및 D5는 각각 독립적으로 T 세포 활성화 수용체, 면역 세포 결합 수용체, 면역 체크포인트 분자, 공자극 인자, 백혈구의 수용체, 종양 항원, 종양 관련 항원(TAA), 조직 세포의 수용체, 암 세포의 수용체, 또는 이의 조합으로부터 선택된 항원에 대해 결합 특이성을 가질 수 있다.
하나의 구현예에서, T 세포 활성화 수용체의 결합 도메인은 종양 관련 항원(TAA)의 결합 도메인에 인접한다.
하나의 구현예에서, T 세포 활성화 수용체는 CD3을 포함할 수 있다.
하나의 구현예에서, 면역 체크포인트 수용체는 PD-L1, PD-1, TIGIT, TIM-3, LAG-3, CTLA4, BTLA, VISTA, PD-L2, CD160, LOX-1, siglec-15, CD47, HVEM SIRPα CSF1R, CD73, Siglec-15, CD47 또는 이의 조합을 포함할 수 있다.
하나의 구현예에서, 공자극 수용체는 4-1BB, CD28, OX40, GITR, CD40L, CD40, ICOS, LIGHT, CD27, CD30, 또는 이의 조합을 포함할 수 있다.
하나의 구현예에서, 종양 관련 항원은 EGFR, HER2, HER3, EGRFVIII, CD19, BCMA, CD20, CD33, CD123, CD22, CD30, ROR1, CEA, LMP1, LMP2A, 메소텔린(Mesothelin), PSMA, EpCAM, 글리피칸-3, gpA33, GD2, TROP2, NKG2D 리간드, CD39, CLDN18.2, DLL3, HLA-G, FcRH5, GPRC5D, LIV-1, MUC1, CD138, CD70, uPAR, CD38 또는 이의 조합을 포함할 수 있다.
하나의 구현예에서, D1, D2, D3, D4 및 D5는 각각 독립적으로, 선택된 항원, EGFR, HER2, HER3, EGFRvIII, ROR1, CD3, CD28, CEA, LMP1, LMP2A, 메소텔린, PSMA, EpCAM, 글리피칸-3, gpA33, GD2, TROP2, NKG2D, NKG2D 리간드, BCMA, CD19, CD20, CD33, CD123, CD22, CD30, PD-L1, PD1, OX40, 4-1BB, GITR, TIGIT, TIM-3, LAG-3, CTLA4, CD40, CD40L, VISTA, ICOS, BTLA, LIGHT, HVEM, CSF1R, CD73, CD39, CLDN18.2, DLL3, HLA-G, FcRH5, GPRC5D, LIV-1, MUC1, CD138, CD70, CD16, uPAR, Siglec-15, CD47, CD38, NKp46, PD-L2, CD160, LOX-1, SIRPα CD27에 대해 결합 특이성을 가질 수 있으며, Fc 도메인은 인간 IgG Fc 도메인을 포함할 수 있다.
하나의 구현예에서, D1은 CD3, CD20, CEA, HER2, EGFR 또는 NKG2D 리간드에 대한 결합 특이성을 가질 수 있다. 하나의 구현예에서, D2는 HER3, EGFR, CD3, 또는 CD19에 대한 결합 특이성을 가질 수 있다. 하나의 구현예에서, D3은 HER3, EGFR, CD3, 또는 NKG2D 리간드에 대한 결합 특이성을 가질 수 있다. 하나의 구현예에서, D4는 4-1BB 또는 EGFR에 대한 결합 특이성을 가질 수 있다. 하나의 구현예에서, D5는 PD-L1 또는 HER3에 대한 결합 특이성을 가질 수 있다.
하나의 구현예에서, D1은 CD3에 대한 결합 특이성을 가질 수 있고, D2는 HER3에 대한 결합 특이성을 가질 수 있고, D3은 EGFR에 대한 결합 특이성을 가질 수 있고, D4는 4-1BB에 대한 결합 특이성을 가질 수 있고, D5는 PD-L1에 대한 결합 특이성을 가질 수 있다.
하나의 구현예에서, D1은 EGFR에 대한 결합 특이성을 가질 수 있고, D2는 HER3에 대한 결합 특이성을 가질 수 있고, D3은 CD3에 대한 결합 특이성을 가질 수 있고, D4는 4-1BB에 대한 결합 특이성을 가질 수 있고, D5는 PD-L1에 대한 결합 특이성을 가질 수 있다.
하나의 구현예에서, D1은 EGFR에 대한 결합 특이성을 가질 수 있고, D2는 CD3에 대한 결합 특이성을 가질 수 있고, D3은 HER3에 대한 결합 특이성을 가질 수 있고, D4는 4-1BB에 대한 결합 특이성을 가질 수 있고, D5는 PD-L1에 대한 결합 특이성을 가질 수 있다.
하나의 구현예에서, D1은 CD3 또는 EGFR에 대한 결합 특이성을 가질 수 있고, D2는 CD19에 대한 결합 특이성을 가질 수 있고, D3은 CD3 또는 EGFR에 대한 결합 특이성을 가질 수 있고, D4는 4-1BB에 대한 결합 특이성을 가질 수 있고, D5는 PD-L1에 대한 결합 특이성을 가질 수 있다.
하나의 구현예에서, D1 및 D4는 각각 EGFR에 대한 결합 특이성을 가질 수 있고, D2 및 D5는 각각 HER3에 대한 결합 특이성을 가질 수 있고, D3은 CD3에 대한 결합 특이성을 가질 수 있다.
하나의 구현예에서, D1은 CD20에 대한 결합 특이성을 가질 수 있고, D2는 CD19에 대한 결합 특이성을 가질 수 있고, D3은 CD3에 대한 결합 특이성을 가질 수 있고, D4는 4-1BB에 대해 결합 특이성을 가질 수 있고, D5는 PD-L1에 대한 결합 특이성을 가질 수 있다.
하나의 구현예에서, D1은 NKG2D 리간드에 대한 결합 특이성을 가질 수 있고, D2는 CD19에 대한 결합 특이성을 가질 수 있고, D3은 CD3에 대한 결합 특이성을 가질 수 있고, D4는 4-1BB에 대한 결합 특이성을 가질 수 있고, D5는 PD-L1에 대한 결합 특이성을 가질 수 있다.
하나의 구현예에서, D1은 CD3에 대한 결합 특이성을 가질 수 있고, D3은 NKG2D 수용체를 포함할 수 있다. 하나의 구현예에서, 단백질은 CD19에 대한 결합 특이성을 갖는 D2를 추가로 포함할 수 있다. 하나의 구현예에서, 단백질은 PD-L1에 대한 결합 특이성을 갖는 D5를 추가로 포함할 수 있다. 하나의 구현예에서, 단백질은 4-1BB에 대한 결합 특이성을 갖는 D4를 추가로 포함할 수 있다.
하나의 구현예에서, 다중특이적 항체 유사 단백질은 이중특이적이다. 하나의 구현예에서, D2는 HER3에 대한 결합 특이성을 가질 수 있고, D3은 CD3에 대한 결합 특이성을 가질 수 있다. 하나의 구현예에서, D1은 HER2에 대한 결합 특이성을 가질 수 있고, D3은 CD3에 대한 결합 특이성을 가질 수 있다. 하나의 구현예에서, D1은 EGFR에 대한 결합 특이성을 가질 수 있고, D3은 CD3에 대한 결합 특이성을 가질 수 있다. 하나의 구현예에서, D3은 CD3에 대한 결합 특이성을 가질 수 있고, D5는 HER3에 대한 결합 특이성을 가질 수 있다. 하나의 구현예에서, D3은 CD3에 대한 결합 특이성을 가질 수 있고, D4는 EGFR에 대한 결합 특이성을 가질 수 있다.
하나의 구현예에서, 이중특이적 항체 유사 단백질은 서열번호 1 및 3; 5 및 7; 9 및 11; 13 및 15; 53 및 55; 57 및 59; 113 및 115; 117 및 119; 121 및 123; 125 및 127; 157 및 159; 297 및 299; 또는 199 및 201과 적어도 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99% 또는 100% 동일성을 갖는 아미노산 서열을 포함할 수 있다.
하나의 구현예에서, 다중특이적 항체 유사 단백질은 삼중특이적이다. 하나의 구현예에서, D1은 EGFR에 대한 결합 특이성을 가질 수 있고, D2는 HER3에 대한 결합 특이성을 가질 수 있고, D3은 CD3에 대한 결합 특이성을 가질 수 있다. 하나의 구현예에서, D1은 CEA에 대한 결합 특이성을 가질 수 있고, D2는 EGFR에 대한 결합 특이성을 가질 수 있고, D3은 CD3에 대한 결합 특이성을 가질 수 있다. 하나의 구현예에서, D3은 CD3에 대한 결합 특이성을 가질 수 있고, D4는 EGFR에 대한 결합 특이성을 가질 수 있고, D5는 HER3에 대한 결합 특이성을 가질 수 있다. 하나의 구현예에서, 항체는 EGFR, HER3 및 CD3에 대한 결합 특이성을 갖는 삼중특이적 항체이다. 하나의 구현예에서, 삼중특이적 항체 유사 단백질은 서열번호 41 및 43; 45 및 47; 49 및 51; 101 및 103; 105 및 107; 109 및 111; 195 및 197; 137 및 139; 또는 161 및 163과 적어도 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99% 또는 100% 동일성을 갖는 아미노산 서열을 포함할 수 있다.
하나의 구현예에서, 다중특이적 항체 유사 단백질은 사중특이적이다. 하나의 구현예에서, D1은 EGFR에 대한 결합 특이성을 가질 수 있고, D2는 HER3에 대한 결합 특이성을 가질 수 있고, D3은 CD3에 대한 결합 특이성을 가질 수 있고, D4는 4-1BB에 대한 결합 특이성을 가질 수 있다. 하나의 구현예에서, D1은 EGFR에 대한 결합 특이성을 가질 수 있고, D2는 HER3에 대한 결합 특이성을 가질 수 있고, D3은 CD3에 대한 결합 특이성을 가질 수 있고, D5는 PD-L1에 대한 결합 특이성을 가질 수 있다. 이 항체는 EGFR, HER3, CD3 및 4-1BB에 대한 결합 특이성을 갖는 사중특이적 항체이다. 이 항체는 EGFR, HER3, CD3 및 PD-L1에 대한 결합 특이성을 갖는 사중특이적 항체이다. 하나의 구현예에서, 사중특이적 항체 유사 단백질은 서열번호 33 및 35; 37 및 39; 141 및 143; 145 및 147; 또는 165 및 167과 적어도 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99% 또는 100% 동일성을 갖는 아미노산 서열을 포함할 수 있다.
하나의 구현예에서, 항체는 오중특이적이다. 하나의 구현예에서, 항체 유사 단백질은 EGFR, HER3, CD3, 4-1BB 및 PD-L1에 대한 결합 특이성을 가질 수 있다. 하나의 구현예에서, 오중특이적 항체 유사 단백질은 서열번호 17 및 19; 21 및 23; 25 및 27; 29 및 31; 69 및 71; 73 및 75; 77 및 79; 81 및 83; 85 및 87; 89 및 91; 93 및 95; 97 및 99; 129 및 131; 133 및 135; 149 및 151; 169 및 171; 173 및 175; 또는 177 및 179와 적어도 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99% 또는 100% 동일성을 갖는 아미노산 서열을 포함할 수 있다.
제2 측면에서, 본 출원은 상보성 결정 영역(CDR)에 대한 신규한 서열을 제공한다. 하나의 구현예에서, 본 출원은 본원에 개시된 CDR을 포함하는 단백질, 항체 유사 단백질 또는 항체를 제공한다.
하나의 구현예에서, CDR은 CEA에 대한 친화성을 가질 수 있다. 하나의 구현예에서, CDR은 CEA에 대한 평형 해리 상수(KD)를 가질 수 있고, 여기서 KD는 0.1nM, 2nM, 5nM, 10nM, 20nM, 30nM 또는 50nM 이하이다. 하나의 구현예에서, CDR은 서열번호 301, 302, 303, 304, 305 또는 306과 적어도 80% 서열 동일성(sequence identity)을 갖는 아미노산 서열을 포함할 수 있다.
하나의 구현예에서, 본 출원은 CEA에 대한 친화성을 갖는 단백질을 제공한다. 하나의 구현예에서, 단백질은 서열번호 301과 적어도 80% 서열 동일성을 갖는 아미노산 서열을 갖는 CDR H1을 가질 수 있다. 하나의 구현예에서, 단백질은 서열번호 302와 적어도 80% 서열 동일성을 갖는 아미노산 서열을 갖는 CDR H2를 가질 수 있다. 하나의 구현예에서, 단백질은 서열번호 303과 적어도 80% 서열 동일성을 갖는 아미노산 서열을 갖는 CDR H3을 가질 수 있다. 하나의 구현예에서, 단백질은 서열번호 314와 적어도 80% 서열 동일성을 갖는 아미노산 서열을 갖는 CDR L1을 가질 수 있다. 하나의 구현예에서, 단백질은 서열번호 305와 적어도 80% 서열 동일성을 갖는 아미노산 서열을 갖는 CDR L2를 가질 수 있다. 하나의 구현예에서, 단백질은 서열번호 306과 적어도 80% 서열 동일성을 갖는 아미노산 서열을 갖는 CDR L3을 가질 수 있다. 하나의 구현예에서, 단백질은 서열번호 279, 280, 281 또는 282로부터 선택된 아미노산 서열과 적어도 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99% 또는 100% 서열 동일성을 갖는 아미노산 서열을 포함할 수 있다. 하나의 구현예에서, 단백질은 서열번호 279, 280, 281 또는 282로부터 선택된 아미노산 서열과 적어도 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99% 또는 100% 서열 동일성을 갖는 아미노산 서열을 포함할 수 있다.
하나의 구현예에서, 본 출원은 가변 영역을 갖는 다중특이적 항체 유사 단백질을 제공하며, 여기서 가변 영역은 서열번호 301, 302, 303, 304, 305 또는 306으로부터 선택된 아미노산 서열을 포함할 수 있다.
하나의 구현예에서, CDR은 CD3에 대한 친화성을 가질 수 있다. 하나의 구현예에서, CDR은 CD3에 대한 평형 해리 상수(KD)를 가질 수 있고, 여기서 KD는 10nM, 20nM, 30nM 또는 50nM, 100nM, 200nM, 300nM, 400nM 또는 500nM 이하이다. 하나의 구현예에서, CDR은 서열번호 307, 308, 309, 310, 311 또는 312와 적어도 80% 서열 동일성을 갖는 아미노산 서열을 포함할 수 있다.
하나의 구현예에서, CD3에 대한 친화성을 갖는 단백질은 서열번호 307과 적어도 80% 서열 동일성을 갖는 아미노산 서열을 갖는 CDR H1을 포함한다. 하나의 구현예에서, CD3에 대한 친화성을 갖는 단백질은 서열번호 308과 적어도 80% 서열 동일성을 갖는 아미노산 서열을 갖는 CDR H2를 포함한다. 하나의 구현예에서, CD3에 대한 친화성을 갖는 단백질은 서열번호 309와 적어도 80% 서열 동일성을 갖는 아미노산 서열을 갖는 CDR H3을 포함한다. 하나의 구현예에서, CD3에 대한 친화성을 갖는 단백질은 서열번호 310과 적어도 80% 서열 동일성을 갖는 아미노산 서열을 갖는 CDR L1을 포함한다. 하나의 구현예에서, CD3에 대한 친화성을 갖는 단백질은 서열번호 311과 적어도 80% 서열 동일성을 갖는 아미노산 서열을 갖는 CDR L2를 포함한다. 하나의 구현예에서, CD3에 대한 친화성을 갖는 단백질은 서열번호 312와 적어도 80% 서열 동일성을 갖는 아미노산 서열을 갖는 CDR L3을 포함한다.
하나의 구현예에서, 단백질은 서열번호 227-230, 231-234, 235-238, 239-242 및 291-294로부터 선택된 아미노산 서열과 적어도 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99% 또는 100% 서열 동일성을 갖는 아미노산 서열을 포함할 수 있다. 하나의 구현예에서, 다중특이적 항체 유사 단백질은 서열번호 227-230, 231-234, 235-238, 239-242 및 291-294로부터 선택된 아미노산 서열과 적어도 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, 또는 100% 서열 동일성을 갖는 아미노산 서열을 포함할 수 있다.
하나의 구현예에서, 다중특이적 항체 유사 단백질은 가변 영역을 가질 수 있고, 여기서 가변 영역은 서열번호 307, 308, 309, 310, 311 또는 312로부터 선택된 아미노산 서열을 포함할 수 있다.
추가의 측면에서, 본 출원은 본원에 개시된 다중특이적 항체 유사 단백질, 단편, 도메인, 영역을 인코딩(encoding)하는 단리된 핵산 서열을 제공한다.
추가의 측면에서, 본 출원은 본원에 개시된 단리된 핵산 서열을 포함하는 발현 벡터(expression vector)를 제공한다.
추가의 측면에서, 본 출원은 본원에 개시된 단리된 핵산 서열을 포함하는 숙주 세포를 제공한다. 하나의 구현예에서, 숙주 세포는 본원에 개시된 발현 벡터를 포함한다. 하나의 구현예에서, 숙주 세포는 원핵 세포 또는 진핵 세포일 수 있다.
추가의 측면에서, 본 출원은 본원에 개시된 다중특이적 항체 유사 단백질을 생산하는 방법을 제공한다. 하나의 구현예에서, 상기 방법은 다중특이적 항체 유사 단백질을 인코딩하는 DNA 서열이 발현되도록 숙주 세포를 배양하는 단계 및 상기 다중특이적 항체를 정제하는 단계를 포함한다. 하나의 구현예에서, 상기 방법은 상기 다중특이적 항체 유사 단백질이 생산되는 조건하에서 숙주 세포를 배양하는 단계 및 상기 항체 유사 단백질을 회수하는 단계를 포함한다.
또 다른 측면에서, 본 출원은 면역접합체(immunoconjugate)를 제공한다. 하나의 구현예에서, 면역접합체는 세포독성제, 영상화제, 또는 둘 다에 연결된 다중특이적 항체 유사 단백질을 포함할 수 있다.
추가의 측면에서, 본 출원은 약제학적 조성물을 제공한다. 하나의 구현예에서, 약제학적 조성물은 다중특이적 항체 유사 단백질 및 약제학적으로 허용되는 담체를 포함할 수 있다. 하나의 구현예에서, 약제학적 조성물은 방사성 동위원소, 방사성 핵종, 독소, 치료제, 화학요법제 또는 이의 조합을 추가로 포함할 수 있다. 하나의 구현예에서, 약제학적 조성물은 이의 개시된 면역접합체 및 약제학적으로 허용되는 담체를 포함할 수 있다.
추가의 측면에서, 본 출원은 대상체(subject)에서 암, 자가면역 질환, 또는 감염성 질환을 치료 또는 예방하는 방법을 제공한다. 하나의 구현예에서, 상기 방법은 본원에 개시된 바와 같은 정제된 다중특이적 항체 유사 단백질, 면역접합체, 또는 약제학적 조성물을 포함하는 약제학적 조성물을 대상체에게 투여하는 단계를 포함할 수 있다. 하나의 구현예에서, 상기 방법은 유효량의 치료제를 공동 투여하는 단계를 추가로 포함할 수 있다. 하나의 구현예에서, 치료제는 항체, 화학요법제, 효소, 또는 이의 조합을 포함할 수 있다.
하나의 구현예에서, 대상체는 인간이다. 하나의 구현예에서, 대상체는 포유동물이다. 하나의 구현예에서, 대상체는 침팬지이다. 하나의 구현예에서, 대상체는 애완 동물이다.
추가의 측면에서, 본 출원은 본원에 개시된 바와 같은 다중특이적 항체 유사 단백질, 면역접합체, 또는 약제학적 조성물의 유효 농도를 포함하는 용액을 제공한다. 하나의 구현예에서, 용액은 대상체의 혈장이다.
본 개시내용의 상기 및 다른 특징은 첨부된 도면과 함께 취해진 이하의 설명 및 첨부된 청구범위로부터 더욱 완전하게 명백해질 것이다. 이러한 도면은 본 개시내용에 따라 배열된 일부 구현예만을 묘사하며, 따라서 이의 범위를 제한하는 것으로 간주되어서는 안된다는 것을 이해하여, 본 개시내용은 첨부 도면을 사용하여 추가의 특이성 및 세부 사항으로 기재될 것이며, 여기서:
도 1은 5개의 결합 도메인(D1-D5)을 갖는 miniGNC 분자의 이종이량체 구성을 묘사하며, 이중 2개의 단량체는 쇄 A(N-D1-D3/VH-CH1-CH2-CH3-D4-C) 및 쇄 B(N-D2-D3/VL-CL-CH2-CH3-D5-C)에 의해 인코딩되고;
도 2는 (2a) 혼합물을 동종이량체(a), 목적하는 이종이량체(b) 및 쇄 B 단량체(c)로 분획하기 위한 단백질-A 정제에 의해; 및 (2b) 단백질-A 분획화 동종단량체(a), 이종이량체(b), 쇄 B 단량체(c) 및 쇄 A 단량체(d)의 SDS-PAGE 분석에 의해 비환원 및 환원 조건하에 예상된 크기로 VH 또는 Fc 상에 녹아웃 돌연변이(KO)를 갖는 조작된 miniGNC 쇄 A와 쇄 B의 이량체화를 도시하고;
도 3은 펜타-miniGNC(SI-75P6), 테트라-miniGNC(SI-75E2), 트리-miniGNC(SI-75X3), 바이-miniGNC(SI-75X2), 및 모노-miniGNC(SI-75O2) 분자를 사용하여 BXPC3 종양 세포에 대한 다중특이적 miniGNC 분자 매개 TDCC의 비교 효능을 도시하고;
도 4는 0.1 내지 5.5pM 범위의 EC50 값을 갖는 BXPC3 종양 세포주에 대한 miniGNC 분자 매개 TDCC의 비교 효능을 도시하고;
도 5는 (a) TDCC 검정에서 췌장암 세포(HPAFII)를 사멸시키기 위한 펜타-miniGNC(SI-68P1), 테트라-miniGNC(SI-68E2 및 SI-68E1) 및 트리-miniGNC(SI-68x2)를 포함하는 스테이플링된 도메인을 갖는 다중특이적 miniGNC 분자, 및 (b) MCF-7 유방암 세포에 대한 SI-68X1의 비교 효능을 측정하는 TDCC 검정의 생존 곡선을 도시하고;
도 6은 TDCC 검정에서 유방암 세포(MDA-MB-231)를 사멸시키기는 데 있어서 삼중특이적(SI-49R25), 사중특이적(SI-49P_X), 오중특이적(SI-49PM1 및 SI-49P8)을 포함하는 이량체 NKG2D 수용체를 포함하는 다중특이적 miniGNC 분자의 기능성을 도시한다.
이하의 상세한 설명에서, 이의 일부를 형성하는 첨부 도면을 참조한다. 도면에서, 유사한 기호는 문맥상 달리 지시되지 않는 한, 전형적으로 유사한 구성 요소를 식별한다. 상세한 설명, 도면 및 청구범위에 기재된 예시적인 구현예는 제한적임을 의미하지 않는다. 다른 구현예들이 이용될 수 있고, 본원에 제시된 주제의 정신 또는 범위를 벗어나지 않고 다른 변화가 이루어질 수 있다. 본 개시내용의 측면은 본원에 일반적으로 기재되고 도면에 도시된 바와 같이 매우 다양한 상이한 구성으로 배열, 치환, 조합, 분리 및 설계될 수 있으며, 이들 모두는 본원에서 명백하게 고려된다는 것이 쉽게 이해될 것이다.
본 개시내용은 특히 단리된 항체, 이러한 항체, 이중특이적 또는 다중특이적 분자, 이러한 항체 또는 항원 결합 단편으로 구성된 항체-약물 접합체 및/또는 면역접합체의 제조 방법, 항체, 이중특이적 또는 다중특이적 분자, 항체-약물 접합체 및/또는 면역접합체를 함유하는 약제학적 조성물, 분자 및 조성물을 제조하는 방법, 및 본원에 개시된 분자 및 조성물을 사용하여 암을 치료하는 방법을 제공한다.
본 출원은 소형 구성의 다중특이적 유도 및 항법 제어(GNC)(miniGNC) 항체를 개시한다. miniGNC 플랫폼 분자는 도 1에 설명된 바와 같이, 1, 2, 3 또는 4개의 추가 결합 도메인(D1 내지 D5로부터)을 갖는 Fab-힌지-Fc 영역 코어 구조의 형성을 특징으로 하는 2개의 폴리펩티드 쇄의 조립된 이종이량체이다. 쇄 A(또는 쇄 1): N-D1-D3(VH)-CH1-힌지-CH2-CH3-D4-C; 및 쇄 B(또는 쇄 2): N-D2-D3(VL)-CL-힌지-CH2-CH3-D5-C에 대해 2개의 폴리펩티드가 구성될 수 있다. 두 쇄의 Fc 도메인은 이종이량체의 형성을 향상시키기 위해, "노브-인투-홀"로도 공지된 상보성 돌연변이를 함유하도록 조작되었다. miniGNC 플랫폼 분자는 가변 구성 요소를 가질 수 있다. 예를 들어, Fab 영역의 VH 및 VL은 결합 특이성을 갖거나 갖지 않는 비-Fab 이량체로 대체될 수 있다. 추가의 결합 도메인은 scFv 또는 VHH와 같은 항체 단편, 또는 리간드 또는 수용체와 같은 비-항체 구조일 수 있다. miniGNC 플랫폼 항체는 최대 5개의 별개의 특이성을 갖는 2가, 3가, 4가 또는 5가일 수 있고, 정상적인 2가 IgG 항체(150kD에서 트리-miniGNC Ab) 또는 약간 더 큰 항체(175kD에서 테트라-miniGNC Ab 및 200kD에서 펜타-miniGNC Ab)의 대략적인 크기를 유지한다.
본 출원은 miniGNC 항체, 특히 오중특이적 miniGNC 항체(펜타-miniGNC Ab)를 제조 및 사용하는 방법에 관한 것이다. 일반적으로, GNC 항체와 같은 GNC 단백질은 종양 세포를 표적화하면서 T 세포를 활성화시키는 것과 같은 면역 세포를 결합시키기 위한 두 모이어티를 포함하는 것을 특징으로 한다. GNC 항체와 유사하게, miniGNC 항체는 면역 세포를 결합하기 위한 다중 항원 결합 도메인, 예를 들어, T 세포 활성화를 위한 항-CD3, 공동 자극을 위한 항-4-1BB, 및 면역 체크포인트를 억제하기 위한 항-PD-L1을 보유한다. 암을 치료하기 위한 항체 요법의 효능을 향상시키기 위해, miniGNC 항체는 GNC 항체의 두 모이어티의 특징적인 특징을 보유하면서 구조적으로 안정하고 컴팩트하도록 설계된다. 이러한 개선은 동일하거나 상이한 종양 세포 상의 제2 종양 관련 항원에 대한 추가적인 결합 특이성을 가능하게 한다. GNC 항체와 비교하여, miniGNC는 FcRn 매개 재활용 및 반감기 연장 및 쉬운 단백질-A 기반 정제를 가능하게 하는 Fc 도메인을 함유한다. 필요한 경우, Fc 수용체 매개 면역이 혼입될 수 있다. Fc 함유 miniGNC 항체는 매우 컴팩트하고, 이는 더 나은 개발 가능성과 종양 침투의 증가를 가능하게 한다. GNC 항체는 일반적으로 증가된 수의 항원 결합 도메인(AgBD)으로 인해 IgG 항체보다 더 크고, 이는 T 세포와 종양 세포 모두에 결합하기 위한 공간적 유연성을 제공한다. 한편, miniGNC 항체는 인간 IgG에 대한 150kD와 비교하여, 이중특이적인 경우 약 110 내지 130kD; 삼중특이적인 경우 120 내지 160kD; 사중특이적인 경우 130 내지 190kD; 오중특이적인 경우 140 내지 220kD에서 계산된 인간 IgG 항체와 동일한 대략적인 크기를 보유한다. 각 쇄에 하나 또는 두 개의 scFv의 통합은 종양 미세환경을 탐색하는 동안 쇄 짝짓기 합병증을 줄이고 안정성을 향상시킬 수 있다. 이러한 특징적인 특징과 함께, GNC 및 miniGNC 항체는 동일한 암을 치료하는 효과적인 항체 요법의 대안일 수 있는데, 이는 EGFR, HER2, HER3, EGRFVIII, CD19, BCMA, CD20, CD33, CD123, CD22, CD30, ROR1, CEA, LMP1, LMP2A, 메소텔린, PSMA, EpCAM, 글리피칸-3, gpA33, GD2, TROP2, NKG2D 리간드, CD39, CLDN18.2, DLL3, HLA-G, FcRH5, GPRC5D, LIV-1, MUC1, CD138, CD70, uPAR, CD38을 포함하지만 이에 제한되지 않는 종양 관련 항원을 표적화하기 위한 모이어티가 동일하게 유지되기 때문이다.
용어 "항체"는 가장 넓은 의미로 사용되며, 그들이 목적하는 생물학적 활성을 나타내는 한, 구체적으로 단일 모노클로날 항체(효능제 및 길항제 항체 포함), 폴리에피토프 특이성을 갖는 항체 조성물 및 항체 단편(예: Fab, F(ab')2, 및 Fv)를 포괄한다. 일부 구현예에서, 항체는 모노클로날, 폴리클로날, 키메라, 단일 쇄, 이중특이적 또는 이중효과적, 인간 및 인간화 항체, 및 이의 활성 단편일 수 있다. 공지된 항원에 결합하는 분자의 활성 단편의 예는 Fab, F(ab')2, scFv 및 Fv 단편을 포함하며, 이는 aFab 면역글로불린 발현 라이브러리의 생성물 및 상기 언급된 임의의 항체 및 단편의 에피토프 결합 단편을 포함한다. 일부 구현예에서, 항체는 면역글로불린 분자 및 면역글로불린 분자의 면역학적 활성 부분, 즉 항원에 면역특이적으로 결합하는 결합 부위를 함유하는 분자를 포함할 수 있다. 면역글로불린은 면역글로불린 분자의 임의의 유형(IgG, IgM, IgD, IgE, IgA 및 IgY) 또는 부류(IgG1, IgG2, IgG3, IgG4, IgA1 및 IgA2) 또는 하위부류일 수 있다. 하나의 구현예에서, 항체는 전체 항체 및 전체 항체로부터 유래된 임의의 항원 결합 단편일 수 있다. 전형적인 항체는 전형적으로 2개의 중(H) 쇄 및 2개의 경(L) 쇄를 포함하는 이종사량체 단백질을 지칭한다. 각 중쇄는 중쇄 가변 도메인(VH로서 약칭됨)과 중쇄 불변 도메인으로 구성된다. 각각의 경쇄는 경쇄 가변 도메인(VL로서 약칭됨) 및 경쇄 불변 도메인으로 구성된다. VH 및 VL 영역은 초가변 상보성 결정 영역(CDR)의 도메인과 프레임워크 영역(FR)이라 지칭되는 더 보존된 영역으로 추가로 세분화될 수 있다. 각각의 가변 도메인(VH 또는 VL)은 전형적으로 아미노 말단에서 카르복시 말단으로 FR1, CDR1, FR2, CDR2, FR3, CDR3, FR4 순서로 배열된 3개의 CDR과 4개의 FR로 구성된다. 경쇄 및 중쇄의 가변 영역 내에는 항원과 상호작용하는 결합 영역이 있다.
본원에 사용된 용어 "모노클로날 항체"는 실질적으로 균일한 항체 집단으로부터 수득된 항체를 지칭하고, 즉, 집단을 포함하는 개별 항체는 소량으로 존재할 수 있는 가능한 천연 돌연변이를 제외하고 동일하다. 모노클로날 항체는 매우 특이적이고, 단일 항원성 부위에 대해 지시된다. 또한, 전형적으로 상이한 결정인자(에피토프)에 대해 지시된 상이한 항체를 포함하는 통상적인 (폴리클로날) 항체 제제와는 대조적으로, 각각의 모노클로날 항체는 항원 상의 단일 결정인자에 대해 지시된다. 이의 특이성 이외에, 모노클로날 항체는 하이브리도마 배양에 의해 합성되고 다른 면역글로불린에 의해 오염되지 않는다는 점에서 유리하다. 변형제 "모노클로날"은 항체의 실질적으로 균일한 집단으로부터 수득되는 것으로서 항체의 특징을 나타내며, 임의의 특정 방법에 의한 항체의 생산을 필요로 하는 것으로 해석되어서는 안 된다. 예를 들어, 본 개시내용에 따라 사용되는 모노클로날 항체는 문헌(참조: Kohler & Milstein, Nature, 256:495 (1975))에 의해 처음 기재된 하이브리도마 방법에 의해 제조될 수 있거나, 재조합 DNA 방법(참조: 예를 들어, 미국 특허 제4,816,567호)에 의해 제조될 수 있다.
모노클로날 항체는 중쇄 및/또는 경쇄의 일부가 특정 종으로부터 유래되거나 특정 항체 부류 또는 하위부류에 속하는 항체의 상응하는 서열과 동일하거나 상동성인 반면, 쇄(들)의 나머지가 다른 종으로부터 유래되거나 다른 항체 부류 또는 하위부류에 속하는 항체의 상응하는 서열과 동일하거나 상동성인 "키메라" 항체(면역글로불린) 및 그들이 목적하는 생물학적 활성을 나타내는 한, 이러한 항체의 단편을 포함할 수 있다(참조: 미국 특허 제4,816,567호; 및 Morrison et al., Proc. Natl. Acad. Sci. USA, 81:6851-6855 [1984]).
모노클로날 항체는 마우스 하이브리도마 또는 파지 디스플레이를 포함한 다양한 방법을 사용하여(검토를 위해, Siegel. Transfus. Clin. Biol. 9:15-22 (2002) 참조), 또는 1차 B 세포로부터 직접 항체의 분자 클로닝으로부터(참조: Tiller. New Biotechnol. 28:453-7 (2011)) 생산될 수 있다. 본 개시내용에서, 항체는 하이브리도마 또는 디스플레이와 같은 후속 전략과 조합하여 토끼, 마우스 또는 라마를 면역화하는 방법에 의해 생성되었다. 토끼는 높은 친화성, 다양성 및 특이성의 항체를 생성하는 것으로 공지되어 있다(Weber et al. Exp. Mol. Med. 49:e305). 토끼의 면역화에 이어 B 세포 배양 이외에, 항체 생성 및 발견을 위한 다른 일반적인 전략은 다른 동물(예: 마우스, 라마)의 면역화에 이어, 파지, 효모, 또는 포유류 세포 상의 하이브리도마 및/또는 디스플레이; 또는 합성 가변 유전자 라이브러리를 사용하는 디스플레이를 포함한다. 이 항체 발견의 일반적인 방법은 문헌(참조: Seeber et al. PLOS One. 9:e86184 (2014))에 기재된 것과 유사하다.
용어 "항원- 또는 에피토프-결합 부분 또는 단편"은 항원에 결합할 수 있는 항체의 단편을 지칭한다. 이러한 단편은 항원 결합 기능 및 무손상 항체의 추가 기능을 할 수 있다. 결합 단편의 예는 합성 링커에 의해 단일 폴리펩티드 쇄에 연결된 항체의 단일 암의 VL 및 VH 도메인으로 이루어진 단일 쇄 Fv 단편(scFv), 또는 VL, 불변 경쇄(CL), VH 및 불변 중쇄 1(CH1) 도메인으로 구성된 1가 단편인 Fab 단편을 포함하지만, 이에 제한되지 않는다. 항체 단편은 심지어 더 작은 하위 단편일 수 있으며, 단일 CDR 도메인, 특히 VL 및/또는 VH 도메인 중 어느 하나로부터의 CDR3 영역만큼 작은 도메인으로 구성될 수 있다(예를 들어, Beiboer et al., J. Mol. Biol. 296:833-49 (2000) 참조). 항체 단편은 당업자에게 공지된 통상적인 방법을 사용하여 생산된다. 항체 단편은 무손상 항체와 함께 사용된 동일한 기술을 사용하여 유용성에 대해 스크리닝될 수 있다.
"항원- 또는 에피토프-결합 단편"은 다수의 당업계 공지된 기술에 의해 본 개시내용의 항체로부터 유래될 수 있다. 예를 들어, 정제된 모노클로날 항체는 펩신과 같은 효소로 절단되고, HPLC 겔 여과에 적용될 수 있다. 이어서, Fab 단편을 함유하는 적절한 분획이 수집되고, 막 여과 등에 의해 농축될 수 있다. 항체의 활성 단편의 단리를 위한 일반적인 기술의 추가 설명을 위해, 예를 들어, 문헌(Khaw, B. A. et al. J. Nucl. Med. 23:1011-1019 (1982); Rousseaux et al. Methods Enzymology, 121:663-69, Academic Press, 1986)을 참조한다.
항체의 파파인 소화는 각각 단일 항원 결합 부위를 갖는 "Fab" 단편으로 칭명되는 2개의 동일한 항원 결합 단편과 나머지 "Fc" 단편을 생성하며, 이의 명칭은 쉽게 결정화되는 이의 능력을 반영한다. 펩신 처리는 2개의 항원 결합 부위를 갖고 여전히 항원을 가교 결합할 수 있는 F(ab')2 단편을 산출한다.
Fab 단편은 경쇄의 불변 도메인 및 중쇄의 제1 불변 도메인(CH1)을 함유할 수 있다. Fab' 단편은 항체 힌지 영역으로부터의 하나 이상의 시스테인을 포함하는 중쇄 CH1 도메인의 카르복시 말단에 몇 개의 잔기의 첨가로 Fab 단편과 상이하다. Fab'-SH는 불변 도메인의 시스테인 잔기(들)가 유리 티올 그룹을 보유하는 Fab'에 대한 본원에서의 명칭이다. F(ab')2 항체 단편은 원래 그들 사이에 힌지 시스테인을 갖는 Fab' 단편의 쌍으로서 생성되었다. 항체 단편의 다른 화학적 결합도 공지되어 있다.
"Fv"는 완전한 항원 인식 및 결합 부위를 함유하는 최소 항체 단편이다. 이 영역은 단단한 비공유 회합으로 하나의 중쇄 가변 도메인과 하나의 경쇄 가변 도메인의 이량체로 구성된다. 각각의 가변 도메인의 3개의 CDR이 상호작용하여 VH-VL 이량체의 표면 상의 항원 결합 부위를 정의하는 것이 이러한 구성에 있다. 집합적으로, 6개의 CDR은 항체에 항원 결합 특이성을 부여한다. 그러나, 단일 가변 도메인(또는 항원에 특이적인 3개의 CDR만을 포함하는 Fv의 절반)조차도 전체 결합 부위보다 낮은 친화성에서이지만 항원을 인식하고 결합하는 능력을 갖는다.
임의의 척추동물 종으로부터의 항체(면역글로불린)의 "경쇄"는 이의 불변 도메인의 아미노산 서열에 기초하여 카파(κ) 및 람다(λ)라고 불리는 2개의 명확하게 뚜렷한 유형 중 하나에 할당될 수 있다.
이의 중쇄의 불변 도메인의 아미노산 서열에 따라, 면역글로불린은 상이한 부류에 할당될 수 있다. 5가지 주요 부류의 면역글로불린: IgA, IgD, IgE, IgG 및 IgM이 존재하고, 이들 중 일부는 하위 부류(아이소타입), 예를 들어, IgG-1, IgG-2, IgG-3 및 IgG-4; IgA-1 및 IgA-2로 추가로 세분될 수 있다. 면역글로불린의 상이한 부류에 상응하는 중쇄 불변 도메인은 각각 α, 델타, 엡실론, γ 및 μ로 지칭된다. 상이한 부류의 면역글로불린의 서브유닛 구조 및 3차원 구성은 익히 공지되어 있다.
"인간화 항체"는 비인간 공여체 면역글로불린으로부터 유래된 이의 CDR을 갖는 조작된 항체의 일종을 지칭하며, 분자의 나머지 면역글로불린 유래 부분은 하나(또는 그 이상)의 인간 면역글로불린(들)으로부터 유래된다. 또한, 프레임워크 지지 잔기는 결합 친화성을 보존하기 위해 변경될 수 있다. "인간화 항체"를 수득하는 방법은 당업자에게 익히 공지되어 있다. (예를 들어, 문헌(Queen et al., Proc. Natl Acad Sci USA, 86:10029-10032 (1989), Hodgson et al., Bio/Technology, 9:421 (1991))을 참조한다).
본원에서 사용된 용어 "폴리펩티드", "펩티드" 및 "단백질"은 상호교환 가능하며, 펩티드 결합에 의해 연결된 아미노산으로 구성된 생체분자를 의미하는 것으로 정의된다.
본원에서 사용되는 용어 "a", "an" 및 "the"는 "하나 이상"을 의미하는 것으로 정의되며, 문맥이 부적절하지 않은 한, 복수를 포함한다.
"단리된"이란 그것이 자연적으로 발생하는 성분들 중 적어도 일부를 함유하지 않는 생물학적 분자를 의미한다. 본원에 개시된 다양한 폴리펩티드를 기재하기 위해 사용될 때, "단리된"은 그것이 발현된 세포 또는 세포 배양물로부터 동정되고 분리되고/되거나 회수된 폴리펩티드를 의미한다. 통상적으로, 단리된 폴리펩티드는 적어도 하나의 정제 단계에 의해 제조될 것이다. "단리된 항체"는 상이한 항원성 결합 특이성을 갖는 다른 항체를 실질적으로 함유하지 않는 항체를 지칭한다.
"재조합"은 외인성 숙주 세포에서 재조합 핵산 기술을 사용하여 항체가 생성됨을 의미한다.
용어 "항원"은 유기체, 특히 동물, 보다 구체적으로 인간을 포함하는 포유동물에서 면역 반응을 유도할 수 있는 독립체 또는 이의 단편을 지칭한다. 상기 용어는 항원성 또는 항원성 결정인자를 담당하는 면역원 및 이의 영역을 포함한다.
또한, 본원에서 사용되는 용어 "면역원성"은 면역원성 제제에 대해 지시된 항체, T-세포 또는 다른 반응성 면역 세포의 생산을 유도하거나 증강시키고, 인간 또는 동물에서 면역 반응에 기여하는 물질을 지칭한다. 면역 반응은 개체가 치료될 장애를 완화 또는 경감시키기 위해 본 개시내용의 투여된 면역원성 조성물에 대해 충분한 항체, T-세포 및 기타 반응성 면역 세포를 생산할 때 발생한다.
특정 항원 또는 에피토프에 "특이적 결합" 또는 "특이적으로 결합한다" 또는 "특이적"은 비특이적 상호작용과는 측정 가능하게 상이한 결합을 의미한다. 특이적 결합은, 예를 들어, 일반적으로 결합 활성을 갖지 않는 유사한 구조의 분자인 대조군 분자의 결합과 비교하여 분자의 결합을 결정함으로써 측정될 수 있다. 예를 들어, 특이적 결합은 표적과 유사한 대조군 분자와의 경쟁에 의해 결정될 수 있다.
용어 "친화성"은 항체/항원, 수용체/리간드 등과 같은 두 폴리펩티드 사이의 인력의 척도를 지칭한다. 두 폴리펩티드 사이의 고유한 인력은 특정 상호작용의 결합 친화성 평형 해리 상수(KD)로서 표현될 수 있다. KD 결합 친화성 상수는, 예를 들어, 생물층 간섭 측정법에 의해 측정될 수 있으며, 여기서 KD는 KD=kdis/kon와 같이 kdis(해리 속도 상수) 대 kon(회합 속도 상수)의 비율이다.
특정 항원 또는 에피토프에 대한 특이적 결합은, 예를 들어, 항원 또는 에피토프에 대해 적어도 약 10-4M, 적어도 약 10-5M, 적어도 약 10-6M, 적어도 약 10-7M, 적어도 약 10-8M, 적어도 약 10-9M, 대안적으로 적어도 약 10-10M, 적어도 약 10-11M, 적어도 약 10-12M, 또는 그 이상의 KD를 갖는 항체에 의해 나타날 수 있고, 여기서 KD는 특정 항체-항원 상호작용의 평형 해리 상수를 지칭한다. 전형적으로, 항원에 특이적으로 결합하는 항체는 항원 또는 에피토프에 비해 대조군 분자에 대해 20배, 50배, 100배, 500배, 1000배, 5,000배, 10,000배 또는 그 이상 배수의 KD를 가질 것이다.
또한, 특정 항원 또는 에피토프에 대한 특이적 결합은, 예를 들어, 대조군에 비해 에피토프에 대해 적어도 20배, 50배, 100배, 500배, 1000배, 5,000배, 10,000배 또는 그 이상 배수 더 큰 항원 또는 에피토프에 대한 KA 또는 Ka를 갖는 항체에 의해 나타날 수 있고, 여기서 KA 또는 Ka는 특정 항체-항원 상호작용의 회합 속도를 지칭한다.
두 서열 사이의 "상동성"은 서열 동일성에 의해 결정된다. 서로 비교되는 두 서열의 길이가 상이한 경우, 서열 동일성은 바람직하게는 더 긴 서열의 뉴클레오티드 잔기와 동일한 더 짧은 서열의 뉴클레오티드 잔기의 백분율에 관한 것이다. 서열 동일성은 컴퓨터 프로그램을 사용하여 통상적으로 결정될 수 있다. 주어진 서열과 본 개시내용의 상기한 서열 사이의 비교에서 나타나는 편차는, 예를 들어, 부가, 결실, 치환, 삽입 또는 재조합에 의해 야기될 수 있다.
본 개시내용은 본원에 포함된 특정 구현예 및 실시예의 이하 상세한 설명을 참조함으로써 보다 용이하게 이해될 수 있다. 본 개시내용은 이의 특정 구현예의 특정 세부사항을 참조하여 기재되었지만, 이러한 세부사항은 본 개시내용의 범위에 대한 제한으로 간주되어야 하는 것으로 의도되지 않는다.
실시예
실시예 1 : 오중특이적 miniGNC 항체의 구성
miniGNC 항체의 설계는 쇄 A와 쇄 B 사이의 이종이량체의 두 폴리펩티드 쇄의 공동 발현 및 조립에 의존한다(도 1). 쇄 A는 천연 중쇄(HC)일 수 있지만, 쇄 B는 HC의 경쇄와 Fc 도메인 사이의 재조합 융합 펩티드이다. 이 항체 구조의 코어에는 Fab 영역(VH-CH1/VL-CL)에 이어, 인간 IgG1의 힌지 및 Fc 영역(CH2-CH3/CH2-CH3)이 존재한다. "노브-인투-홀" 돌연변이 또는 돌연변이의 다른 상보성 세트를 CH3 도메인에 도입하여 동종이량체를 불안정화시키고 이종이량체 형성을 촉진할 수 있다(참조: Ridgway JB, Presta LG, Carter P., Protein Eng 1996;9:617-21). 쇄 A의 CH3 도메인의 "홀" 돌연변이는 T366S, L368A 및 Y470V로 구성되는 반면, 쇄 B의 CH3 도메인의 "노브" 돌연변이는 T366W이다. 쇄 B 상의 T366W 돌연변이에 의해 생성된 "노브"는 쇄 A 상의 3개의 돌연변이에 의해 생성된 "홀"과 우선적으로 상호작용한다. 이 우선적 짝짓기는 이종이량체를 추가로 안정화시킬 수 있는 반면, Fab 도메인 구성 요소(쇄 A 상의 VH-CH1과 쇄 B 상의 VL-Ck 사이)의 비공유 짝짓기는 기능적 Fab 영역을 생성한다. 즉, 기능적 D3 결합 도메인, 예를 들어, 기능적 Fab 영역 또는 비-Fab 수용체 이량체는 쇄 A-쇄 B 이종이량체에서만 생성될 수 있다. GNC 항체와 비교하여, miniGNC 항체는 천연 IgG (Fab, Fc) 및 다른 가변 서열 기반 구조, 예를 들어, scFv 및 VHH로부터의 항체 단편을 함유하지만, 이종이량체의 형성 후 Fab 영역-힌지-Fc 영역 구조를 우선적으로 구성하도록 조작된다. miniGNC 항체의 특징적인 특징은 이 조작된 구조의 소형화이다.
하나 이상의 구조적으로 다양화된 항원 결합 도메인을 D1, D2 D4 또는 D5로서 miniGNC 분자의 2개의 N-말단 및 2개의 C-말단에 첨가하여 최대 5개의 결합 특이성을 생성할 수 있다. 이러한 첨가된 결합 도메인 각각은 가변 서열 기반 구조, 예를 들어, scFv 및 VHH, 또는 비가변 서열 기반 구조, 예를 들어, 리간드 및 수용체일 수 있다. 도 1에서 설명된 바와 같이, D1 및 D2는 각각 쇄 A와 쇄 B의 N-말단에 연결된 결합 도메인을 지칭하는 반면, D4 및 D5는 각각 쇄 A와 쇄 B의 C-말단에 연합된 결합 도메인을 지칭한다. 따라서, 오중특이적 miniGNC(펜타-miniGNC) 항체의 2개의 폴리펩티드는 다음과 같이 구성될 수 있다:
쇄 A: N-D1-D3(VH)-CH1-힌지-CH2-CH3-D4-C; 및
쇄 B: N-D2-D3(VL)-CL-힌지-CH2-CH3-D5-C;
여기서, VL은 도 1에 제시된 바와 같이, Vλ 또는 Vκ 중 하나이고, CL은 Cλ 또는 Cκ 중 하나일 수 있다.
결합 도메인의 수와 이의 결합 특이성에 따라, 도 1의 펜타-miniGNC 항체의 구조적 구성은 하나 이상의 결합 도메인을 감소시키고 테트라-, 트리- 및 바이-miniGNC가 됨으로써 단순화될 수 있다. 발병률에 대해, 표 1은 EGFR 및 HER3을 표적으로 하는 이의 효능을 최적화하기 위한 항-CD3 miniGNC 항체의 패밀리의 생성 및 특성화를 묘사한다. 이 경우, 각 결합 도메인은 하나의 결합 특이성을 발휘한다. 5개의 결합 도메인 중 2개가 항원의 동일한 에피토프, 즉 동일한 결합 특이성을 표적으로 하는 경우, 펜타-miniGNC 항체는 사중특이적 펜타-miniGNC 항체가 된다.
실시예 2 : miniGNC 항체의 조작된 코어 구조
miniGNC의 구성이 안정하고 기능적인 이종이량체 단백질로 번역될 수 있음을 입증하기 위해, miniGNC 분자의 이종이량체 형성에 대한 구성 및 돌연변이의 영향을 평가하기 위한 단순화된 비대칭 포맷이 설계되었다. 간단히 말해서, 단일 scFv(D1)는 쇄 A의 N-말단에 융합되지만, 쇄 B는 임의의 첨가된 결합 도메인을 갖지 않는다. 이러한 방식으로, 쇄 A 동종이량체(관찰되지 않음), 쇄 B 동종이량체 및 쇄 A 및 쇄 B 이종이량체에 대한 예측된 크기가 각각 100kDa, 150kDa 및 125 kDa이기 때문에 쇄 A와 쇄 B 사이의 이량체화의 각 종의 비율은 SDS-PAGE 및 SEC에 의해 구별될 수 있다(도 2).
혼합물로부터 이종이량체성 miniGNC 분자를 선택적으로 정제하기 위한 전략을 조작하기 위해, 쇄 B의 CH3 도메인(H435 및 Y436)의 2개의 아미노산 잔기가 치환된다. 특히, 히스티딘(H435)은 치료 항체의 정제 동안 쇄 B가 단백질-A 수지에 결합하는 데 중요하며(Tustian et al., 2016), 이 아미노산의 치환 또는 ProA 녹아웃 돌연변이(ProAKO)는 단백질-A 결합을 종결시킨다. 이 전략은 단백질 A 컬럼으로부터의 선택적 용출을 통해 이종이량체의 분리를 가능하게 할 수 있다. 단백질-A 컬럼은 이의 부모 중쇄 결합 부위를 통해 이종이량체를 보유하기 때문에, 쇄 B 이종이량체는 쇄 B가 단백질-A 결합이 결여될 때 유동한다. 쇄 B 상의 ProAKO 설계는 IgG3 하위 부류의 상동성 영역에서 취한 잔기에 의한 단백질-A 결합 부위의 아미노산 치환에 의해 면역원성을 변경하는 임의의 가능한 문제를 최소화한다. 대부분의 miniGNC 분자는 주로 IgG1 아형의 구조와 서열을 통합하지만, IgG3은 단백질-A, 단백질-G 및 FcRn (신생아 Fc 수용체)에 결합하는 데 있어서 일부 특이적 구조 섭동을 갖는 다른 IgG 하위 부류와 전반적으로 유사한 구조를 갖는다. 이 차이는 IgG3 중의 R435(다른 아형에서는 H435)의 존재가 단백질-A와 이의 Fc 상호작용을 제거하는 이전에 밝혀진 바와 같은 Fc 서열 차이에 기초한다. 따라서, 대표적인 miniGNC 분자에서, miniGNC 쇄 B 상의 단백질-A 결합에 중요한 아미노산(H435 및 F436)은 IgG3 대응물 서열(R435 및 Y436)로 돌연변이되었다.
쇄 B의 N-말단에 융합된 scFv가 첨가된 다중특이적 miniGNC 항체의 부류에서, scFv가 VH3 패밀리로부터 유래되는 경우, 단백질-A 결합에 대한 상호작용이 여전히 가능하다. VH3 인코딩된 항체는 스타필로코컬 단백질 A(SPA)와 상호작용하는 것으로 공지되어 있으며, FR1, CDR2 및 FR3 중 잔기가 SPA 결합에 관여하는 것으로 확인되었으며(Roben, et al., 1995), 구조 데이터는 단일 관련 영역을 비결합 면역글로불린으로부터 상응하는 영역으로 대체하면 VH3 인코딩된 항체에 의한 단백질-A 결합을 제거한다는 것을 나타냈다. FR1에서 아미노산 R19의 치환은 단백질-A에 대한 결합에 중요한 것으로 확인되었고, VH4 패밀리 내의 등가 영역으로부터의 아미노산 서열(S19)을 사용하여 시작되었다.
ProAKO:H435R/Y436F(Fc) 및 R19S(VH)의 상이한 조합을 포함하는 4개의 상이한 버전의 쇄 B 돌연변이(서열번호 3, 7, 11 및 15)를 포함하는 4세트의 miniGNC 분자(서열번호 1-16)를 정제하고, 분석적 크기 배제 크로마토그래피로 분석했다. 두 세트의 돌연변이를 갖는 쇄 B를 함유하는 단백질만이 쇄 B 오염물질의 완전한 제거를 가능하게 했다(도 2a). 이 VH3 단백질 A 녹아웃 돌연변이(R19S)는 쇄 B 상의 Fc 단백질A 녹아웃 돌연변이(H435R, F436Y)와 함께 대부분의 다중특이적 항체 포맷에 혼입되고, 바이-, 트리-, 테트라- 및 펜타-miniGNC 분자를 생성하는 데 사용되었다.
대안적인 항체 아이소타입을 사용하여 기능적 miniGNC 단백질을 생성할 가능성을 입증하기 위해, IgG4 불변 영역을 함유하는 miniGNC의 예를 생성하였다. SI-75XM9(서열번호 297-300)는 IgG1 CH1, 힌지 및 Fc가 IgG4 CH1, 힌지 및 Fc로 대체된 것을 제외하고는 SI-75X5(서열번호 1-4) 이중특이적 miniGNC와 유사한다. 특히, 두 단백질은 모두 동일한 결합 도메인(D2의 항-HER3 도메인 및 D3의 항-CD3* 도메인)을 가지며, 동일한 코어 구조 및 돌연변이(노브-인투-홀 Fc 돌연변이; 항-HER3 scFv의 R19S; 및 Fc의 H435R/Y436F 돌연변이)를 함유한다. 표 8에 나타낸 바와 같이, SI-75XM9는 SI-77X5에 필적하는 역가를 가졌고, 분석적 SEC에 의해 평가된 바와 같이 단백질 A 정제 후 관심 단백질의 퍼센트가 유의하게 19% 증가하였다( 85.6% POI 대 72.2% POI). 고분자량 종의 감소는 IgG4의 더 짧은 힌지 길이(15개 대신 12개 아미노산)와 관련될 수 있으며, 이는 고차 올리고머의 회합 경향을 감소시킬 수 있다. 따라서, 대안적인 항체 아이소타입을 사용하는 miniGNC 단백질의 생성이 가능할 뿐만 아니라 감소된 응집과 같은 보다 유리한 특성을 초래할 수 있다.
실시예 3 : 다중특이적 miniGNC 항체의 구성
다중특이적 miniGNC 항체의 첫 번째 그룹을 생성하고 특성화하기 위해, 모이어티 1 결합 도메인의 트리오, 즉 αCD3, αPD-L1 및 α4-1BB, 및 각각 EGFR 및 HER3에 대한 2개의 모이어티 2 결합 도메인이 비교용으로 선택되었다. 표 1에 나타낸 바와 같이, 그룹은 펜타-miniGNC, 테트라-miniGNC, 트리-miniGNC 및 바이-miniGNC 그룹으로 세분되었다. 각 하위 그룹에는 D3으로부터의 CD3 결합을 갖는 적어도 하나의 miniGNC 항체가 있었다. 펜타-miniGNC 그룹은 SI-75P6(서열번호 17, 19, D3 위치로부터의 αEGFR 포함), SI-75P4(서열번호 21, 23, D4에 4-1BB 수용체에 대한 리간드인 41BBL 포함), SI-75P3(서열번호 25, 27) 및 SI-75P9(서열번호 29, 31, D3으로부터의 αHER3 포함)를 포함한다. 테트라-miniGNC 그룹은 α4-1BB 또는 αPD-L1 도메인 중 하나의 존재 및 부재하에 효과를 비교하는 2개의 항체, SI-75E1(서열번호 33, 35) 및 SI-75E2(서열번호 37, 39)를 갖는다. 트리-miniGNC 그룹은 이종이량체의 N-말단 또는 C-말단 상에서 2개의 모이어티 2 결합 도메인을 비교하기 위한 3개의 항체, SI-75X3(서열번호 41, 43), SI-75X16(서열번호 45, 47) 및 SI-75X18(서열번호 49, 51)을 갖는다. 바이-miniGNC 그룹은 3개의 항체, SI-75X1(서열번호 53, 55), SI-75X2(서열번호 57, 59) 및 SI-75X5(서열번호 1, 3)를 가지며, 이들 각각은 1개의 모이어티 1 결합 도메인과 1개의 모이어티 2 결합 도메인을 갖는다.
miniGNC 항체의 첫 번째 그룹의 각 구성원을 인코딩하는 DNA를 벡터 pTT5에 클로닝하고, 이를 9일 동안 ExpiCHO 발현 시스템을 사용하여 허용 가능한 역가로 발현시켰다. miniGNC 항체를 5mL MabSelect 단백질-A 컬럼으로 정제한 후, Akta Avant 또는 Purifier 시스템 상의 hiload 16/600 200pg 분취용 SEC 컬럼을 사용하여 크기 배제했다. SEC 응집체는 다각도 광 산란(MALS, Wyatt 시스템)에 연결된 waters HPLC를 사용하여 분석하여 dn/dc 계산 방법으로 정확한 분자량을 확인하였다.
실시예 4 : 결합 친화성의 옥텟 분석
miniGNC 항체의 기능성을 평가하기 위해, 각 도메인의 결합 친화성을 생물층 간섭 측정법(Octet 384 시스템)을 사용하여 결정했다. 옥텟 분석을 사용하여 선택된 miniGNC 항체가 이의 모든 동족 항원에 대한 결합 특이성과 친화성을 유지하고 있음을 확인하였다. 각 miniGNC 항체를 AHC 센서에 10ug/ml로 180초 동안 로딩한 후, 60초 기준선 단계, 100nM의 시판되는 인간 항원과의 180초 회합 단계 및 360초 해리 단계가 이어졌다. 모든 단계의 샘플은 옥텟 완충액(0.1% Tween 20 및 1% BSA를 함유하는 PBS)에 포함되었다. 적합도는 친화성 KD 값을 추출하기 위해 1:1 결합 모델을 사용하여 수행되었다. 표 1에 나타낸 바와 같이, 각 결합 도메인에 대한 결합 친화성은 이의 KD에 의해 측정된 바와 같이 허용 가능한 범위 내에서 변한다. 모이어티 1 결합의 경우, CD3 도메인에 대한 KD는 17.4 내지 36.2nM, αPD-L1의 경우 1 내지 2.72nM, 및 α4-1BB의 경우 7.51 내지 37.3nM에서 변할 수 있고; 모이어티 2 결합의 경우, αEGFR에 대한 KD는 5.56 내지 11.1, aHER3의 경우, 112.8 내지 185nM에서 변한다.
실시예 5 : 다중특이적 miniGNC 항체의 비교 효능
다중특이적 miniGNC 항체의 첫 번째 그룹은 암 세포를 사멸시키는 효능을 측정하기 위한 T-세포 의존적 세포 세포독성(TDCC) 검정에 적용되었다. 모든 분자의 αCD3 결합 도메인과 함께 이 그룹의 miniGNC 항체는 T 세포에 결합하고 T-세포 매개된 세포용해를 재지시하고 궁극적으로 표적 세포를 죽일 수 있도록 장착되었다.
발광 기반 T-세포 의존적 세포 세포독성(TDCC) 검정을 사용하여 루시퍼라제의 구성적 발현을 통한 세포 생존율의 정량화에 의해 항체 유도 세포 세포독성의 정도를 측정했다. 루시퍼화된 BXPC3 인간 췌장암 세포주(ATCC, Manassas, VA)는 10% 열 불활성화 태아 소 혈청(Invitrogen, Waltham, MA)을 갖는 RPMI(ATCC, Manassas, VA) 배지 중에서 37℃, 5% CO2에서 배양하였다. 세포 생존력(cell viability)은 Vi-CELL 자동화 세포 계수기(Beckman Coulter, Pasadena, CA)로 모니터링했다. 표적 세포 표면 발현은 유세포 계측법에 의해 측정되었다. 인간 췌장암 세포인 BXPC3 세포를 이펙터 대 표적(E:T) 비 5:1로 인간 pan T 세포와 공동 배양하고, 항체를 5배 희석 계열(0-30nM)로 첨가했다. Multidrop 벌크 액체 분배기(BIOTEK, Winooski, VT)를 사용하여 500개 세포/웰의 표적 세포(20μL/웰) 및 25,00개 세포/웰의 T 세포(20μL/웰)를 384-웰, 흰색, 평저 폴리스티렌 TC-처리된 마이크로플레이트(Corning, Corning, NY)에 순차적으로 플레이팅했다. 항체 희석물을 첨가하고(10μL/웰), 플레이트를 발광 기반 세포 생존력 정량화 전에 37℃, 5% CO2에서 72시간 동안 배양하였다. 20㎕의 Bright-Glo(Promega)를 웰에 첨가하고, 종양 세포의 생존력에 상응하는 발광을 CLARIOstar 플레이트 판독기를 사용하여 결정하였다.
데이터는 비교를 위해 표 1의 EC50 값을 계산하고 나열하기 위해 S자형 함수에 적합화했다. 도 3은 펜타-miniGNC(SI-75P6), 테트라-miniGNC(SI-75E2), 트리-miniGNC(SI-75X3), 바이-miniGNC(SI-75X2) 및 모노-miniGNC(SI-75O2) 분자로부터 선택된 miniGNC 항체의 투여량 의존적 세포 생존력 곡선을 도시한다. 모든 다중특이적 miniGNC 항체는 BXPC3 세포를 완전히 사멸시킬 수 있었지만, 펜타- 및 테트라-miniGNC 항체는 모두 pM 단위의 EC50 범위에서 꾸준히 높은 효능을 나타냈다. 이와 관련하여, SI-75X1은 매우 강력했다. 상기 데이터는 BXPC3 암 세포를 표적으로 할 때 면역 체크포인트 억제제로서 모이어티 1 결합 도메인, 특히 αPD-L1 도메인의 중요한 역할을 입증한다.
실시예 6 : miniGNC 항체에서 CD3 결합 도메인의 구성
정의에 의해, miniGNC 항체는 각각 이의 모이어티 1 및 2 결합 도메인의 결합을 통해 적어도 하나의 면역 이펙터 세포 및 하나의 표적 암 세포와 접속할 수 있다. miniGNC 항체 구성의 일반적인 반응식(도 1)을 사용하여, 두 개의 모이어티 2 결합 도메인을 D1과 D2에 할당하면 세포 표면 상의 표적의 상대적 위치가 상부 및 하부 또는 양 측면에서 상이하기 때문에 그들을 D1과 D4 또는 D2와 D5에 할당하는 것과는 상이한 효능을 유도할 수 있음이 가능하다. 이러한 맥락에서, 펜타-miniGNC 항체의 두 번째 그룹이 구성되고, 표 2에 나열되었다. 이 그룹의 minGNC 항체는 CD3, CD19, EGFR, 4-1BB 및 PD-L1에 대해 동일한 결합 특이성을 공유하며, D2, D4 및 D5에서 동일한 결합 도메인을 공유한다. SI-68P13(서열번호 69, 71)은 αCD3 D3 도메인을 갖고, 이는 D2의 차이를 제외하고 첫 번째 그룹의 SI-75P3, 즉 αCD19 대 αHER3에 필적하며, αCD3 도메인의 D1으로의 전환을 제외하고 두 번째 그룹의 SI-68P17(서열번호 73, 75)에 필적한다. miniGNC 항체의 두 번째 그룹의 나머지는 D1(αCD3) 및 D3(αEGFR)과 동일한 결합 특이성을 공유한다. SI-68P17(각각 CD19, 4-1BB 및 PD-L1에 대한 결합 특이성을 갖는다.
항-CD3 항체는 T 세포 활성화 기반 면역 요법에서 중심 역할을 한다. 인간화 항체는 치료 항체의 개발에 바람직하다. CD3 도메인은 위치 D1 및 D3에 혼입되어 위치 효과를 시험하기 위한 SI-68P17(서열번호 73, 75) 및 SI-68P13(서열번호 69, 71)을 생성시켰다. 인간화 프레임워크 1(CD3**), 2(CD3***), 3(CD****) 및 4(CD*****) 내의 항-CD3 서열은 SI-68P15(서열번호 77, 79), SI-68P18(서열번호 81, 83), SI-68P19(서열번호 85, 87) 및 SI-68P16(서열번호 89, 91)을 생성하기 위한 발현 카세트로 클로닝하였다(표 2). 각 발현 카세트를 25mL의 ExpiCHO로 형질감염시키고, 8일 동안 발현시킨 후, 각 펜타-miniGNC 항체를 수거 및 정제하기 위한 단백질-A 친화성 크로마토그래피를 수행하였다. 항체는 양호한 역가로 생산되었다(표 2). 옥텟을 사용하여 상이한 CD3 도메인을 함유하는 펜타-miniGNC 항체가 각각 인간 CD3에 결합할 수 있음을 검증했다(표 2). 각 펜타-miniGNC 항체는 AHC 센서를 통해 10μg/ml로 로딩하고, 연속 희석(최대 200nM, 1:2.5 희석) 또는 단일 100nM 농도의 His-태깅된 인간 CD3에 결합시켰다. 1:1 결합 모델에 대한 생성되는 글로벌 적합도는 펜타-GNC 항체가 낮은 나노몰 범위의 친화성으로 CD3에 결합함을 입증하였다(표 2).
암 세포에 대한 CD3 매개 T 세포 지시된 세포독성의 효과를 평가하기 위해, BXPC3 종양 세포주를 표적으로 사용하였다. 항체의 일련의 희석물(0 내지 30nM; 1 내지 5 희석 인자)을 총 용적 50ul로 루시퍼화된 표적 세포 및 활성화 T 세포(약물 직전에 플레이팅됨; 이펙터:표적 = 5:1)를 함유하는 백색 384-웰 플레이트에 첨가했다. 추가 72시간 후, 20ul의 Bright-Glo(Promega)를 웰에 첨가하고, 루시퍼화된 종양 세포의 생존력에 상응하는 발광을 CLARIOstar 플레이트 판독기를 사용하여 결정하였다. 데이터는 EC50 값을 계산하기 위해 S자형 함수에 적합화하였고, 이는 도 4에 도시되고 표 2에 나열된 바와 같이 0.1 내지 5.5pM 범위에 있었다. 상기 데이터는 항-CD3 배치, 구성 및 결합 친화성에 어느 정도의 유연성이 있음을 입증한다.
실시예 7 . 결합 도메인으로서 VHH를 갖는 다중특이적 miniGNC 항체
다중 scFv 도메인을 함유하는 GNC 및 miniGNC 항체와 같은 다중특이적 항체 플랫폼에, 동일한 분자 내의 다중 VH 및 VL 도메인으로 인한 쇄 미스페어링과 관련된 잠재적인 문제가 있다. 상이한 VH 및 VL 도메인은 서로 상호작용하는 상이한 경향을 갖는다. 상이한 특이성의 결합 도메인이 우수한 상호작용 에너지를 갖는 경우, 단백질이 조립될 때 잘못된 짝짓기가 형성될 수 있다. 그 결과, 어떤 결합 도메인도 이의 표적 항원에 결합하지 않을 것이다.
VHH는 단일 도메인 항체(sdAb) 또는 나노바디로도 공지된 단일 Ig 도메인, 즉 "중쇄 단독"을 갖는 "항체"를 지칭한다. 첫 번째 단일 도메인 항체는 VHH 단편(VHH)으로도 공지된 낙타과에서 발견되는 중쇄 항체로부터 조작되었다. VHH 도메인은 몇 가지 유리한 특성으로 인해 항체 기반 요법에 점점 더 혼입되었다. VHH 도메인은 보다 전통적으로 사용되는 scFv 도메인과 비교하여 증가된 안정성 및 용해도를 가질 수 있다. 전통적인 항체 가변 영역의 VH/VL 계면은 소수성이지만, 이러한 표면의 일시적 노출은 상당한 응집 또는 침전을 초래할 수 있다. 한편, VHH 도메인은 자연적으로 더 친수성 표면을 가지며, 따라서 우수한 용해도 및 안정성 특성을 가질 수 있다. Fab 또는 scFv 도메인에 대한 VHH 도메인의 명백한 이점은 이의 작은 크기이다. Fab 도메인이 약 50kDa이고 scFv 도메인이 약 25kDa인 경우, VHH 도메인은 매우 조밀한 12-15kDa이다. 펜타-miniGNC 항체는 5개의 결합 도메인을 함유한다(도 1). scFv 도메인 대신 VHH 도메인의 혼입은 분자 크기를 상당히 감소시키고 종양 침투를 증가시킬 수 있다.
다중특이적 miniGNC 항체의 세 번째 그룹이 생성되었고, EGFR 및 HER3에 대한 VHH 결합 도메인을 갖도록 구성되었다(Gottlin et al., 2009; Eliseev et al., 2018)(표 3). 오중, 삼중 및 이중특이적 단일 도메인 가변 영역(VHH) 혼입된 miniGNC 분자가 작제되고 합리적인 역가로 정제되었다. 다중특이적 miniGNC의 각 도메인: SI-75P5(서열번호 93, 95), SI-75P8(서열번호 97, 99), SI-75X4(서열번호 101, 103), SI-75X17(서열번호 105, 107), SI-75X19(서열번호 109, 111), SI-75X9(서열번호 113-115), SI-75X11(서열번호 117, 119), SI-75X15(서열번호 121, 123) 및 SI-75X13(서열번호 125, 127)의 결합 활성은 옥텟을 사용하여 검증되었다. AHC 센서를 사용하여 GNC 항체를 10ug/ml의 농도로 180초 동안 포획하였다. 60초 기준선 단계 후, 단일 농도의 항원을 180초 회합 단계에 사용했다. 시험된 항원은 200nM 인간 EGFR(인-하우스 정제됨), 100nM 인간 CD3(Acro CDD-H52W1), 20nM 인간 PD-L1(Acro PD1-H5229), 400nM 인간 4-1BB(인-하우스 정제됨), 200nM 인간 HER3(Acro ER3-H5223)을 포함한다. 회합 후, 420초의 해리 단계가 사용되었다. 표로 정리된 KD 값은 ForteBio 데이터 분석 소프트웨어 버전 11에 일대일 결합 모델을 사용하여 계산되었다. 데이터는 모든 도메인이 VHH-통합된 miniGNC 플랫폼에서 높은 친화성을 유지했음을 입증하였다.
암 세포, BXPC3 종양 세포주에 대한 T 세포 지시된 세포독성을 표적으로 사용하였다. 항체의 연속 희석물(0 내지 30nM; 1 내지 5 희석 인자)을 총 용적 50ul로 루시퍼화된 표적 세포 및 활성화 T 세포(약물 직전에 플레이팅됨; 이펙터:표적 = 5:1)를 함유하는 백색 384-웰 플레이트에 첨가하였다. 추가 72시간 후, 20ul의 Bright-Glo(Promega)를 웰에 첨가하고, 루시퍼화된 종양 세포의 생존력에 상응하는 발광을 CLARIOstar 플레이트 판독기를 사용하여 결정하였다. EC50 값은 표 3에 표로 정리되어 있다.
실시예 8 . 개선된 발현 및 단백질 품질을 위한 조작된 Fab (D3) 도메인.
이황화 스테이플을 임의로 fab 영역의 VH-VL 계면에 도입하였다(도 5). 이 조작의 목적은 이종이량체 짝짓기를 개선시키고 코어-팹 계면에서 공유 이황화 결합(Weatherill et al., 2012)의 형성에 의해 전체 구조를 안정화시키는 것이었다. 시스테인 쌍을 임의로 도입하여 쇄 B 상의 VLA100 및 쇄 A fab 영역 상의 이의 상응하는 VHA44에서 이황화 결합을 형성하였다.
동일한 결합 특이성을 갖는 한 쌍의 펜타-miniGNC 항체(SI-38P11 및 SI-76PM1)(서열번호 129 및 131; 133 및 135)를 Fab 내의 스테이플링된 가변 영역의 효과를 분석하기 위해 생성하였다. 두 항체의 쇄 A는 D1에 αCD20 scFv, D3에 αCD3 VH(VH Fab-CH1-Fc), 및 D4에 α4-1BB를 포함하는 반면, 쇄 B는 D2에 αCD19, D3에 αCD3VL(VKappa Fab CL-Fc) 및 도 1의 명명 시스템에 따라 D5에 αPD-L1 scFv (표 4)를 포함한다. SI-76PM1은 D3(VH/VL Fab-CH1/CL-Fc)에 추가의 디설파이드로 작제되었고, SI-38P11은 VH/VL 팹에서 임의의 추가의 디설파이드 짝짓기 없이 작제되었다.
위치 D3에 디설파이드 스테이플을 포함하거나 포함하지 않는 펜타-miniGNC 항체 작제물을 ExpiCHO 시스템에서 발현시켰다. 스테이플링된 D3(SI-76PM1)을 갖는 작제물은 SI-38P11보다 유의하게 더 높은 역가로 생성되었다. 두 단백질 모두 5mL MabSelect 단백질 A 컬럼으로 정제한 후, Akta Avant 또는 Akta Pure Purifier 시스템 상의 hiload 16/600 200pg 분취용 SEC 컬럼을 사용하여 크기 배제하였다. SEC 응집체는 다각도 광 산란(MALS, Wyatt systems)에 연결된 waters HPLC를 사용하여 분석하여 dn/dc 계산된 방법으로 정확한 분자량을 확인하였다. 표 4에 나타낸 바와 같이 수행된 모든 분석으로, 이황화 결합, 즉 "D3 스테이플링된 Fab", 펜타-miniGNC 항체는 5% 더 높은 관심 단백질 생산을 나타냈다. 두 분자 모두 동등한 항원 결합 동역학을 나타냈다(표 4).
실시예 9 . 스테이플링된 scFv 결합 도메인을 갖는 다중특이적 miniGNC 항체
다중특이적 miniGNC 분자의 코어 구조는 Fc 영역의 CH3 도메인에 의한 "노브-인투-홀"의 공유적으로 연결된 힌지와 비공유 및 우선적인 상호작용을 포함하는 이종이량체를 안정화시키기 위해 몇 가지 특징을 획득하도록 조작되었다. 안정성과 소형화가 바람직하지만, D1과 D2 또는 D3과 D4의 더 가까운 근접성이 이의 안정성과 독립적 기능에 영향을 미칠 수 있는지 여부는 불분명하다. 각각의 추가된 결합 도메인의 안정성과 독립성을 유지하기 위해, 한 가지 옵션은 각 scFv 도메인의 VL100 및 VH44에 이황화 결합을 도입하는 것, 즉 각 scFv 도메인을 스테이플링하는 것이다. VL과 VH 사이의 이황화 결합을 모든 scFv 도메인을 위해 사용하여 전체 구조를 안정화시킬 수 있다. 대안적으로, 이황화 결합은 임의의 위치에서 적어도 하나의 선택된 scFv 도메인에 도입될 수 있다.
EGFR 및 HER3을 표적으로 하는 이의 D1 및 D2를 갖는 4개의 miniGNC 항체는 트리-miniGNC(SI-68X2, 서열번호 137, 139), 테트라-miniGNC(SI-68E1, 서열번호 141, 143 및 SI-68E2, 서열번호 145, 147), 및 펜타-miniGNC(SI-68P1, 서열번호 149, 151) 분자를 포함하는 췌장암 세포(HPAF-II)에 대한 TDCC의 비교 효능을 측정하기 위해 그룹화되었다. 4-1BB 및 PD-L1에 대한 모이어티 1 결합 특이성은 가변적이었지만, CD3은 다중특이성과 관련하여 그룹에서 D3으로서 일정했다. 이러한 4개의 miniGNC 항체 각각을 인코딩하는 발현 작제물은 모든 scFv 도메인이 이황화 결합을 운반하도록 변형되었다. 작제물은 ExpiCHO 시스템에서 개별적으로 발현되었고, 각 항체는 합리적인 역가로 정제되었다. 각각의 항원에 대한 결합 동역학은 옥텟을 사용하여 검증되었다. AHC 센서를 사용하여 miniGNC 항체를 10ug/ml의 농도로 180초 동안 포획하였다. 60초 기준선 단계 후, 단일 농도의 항원을 180초 회합 단계에 사용했다. 시험된 항원은 200nM 인간 EGFR(인-하우스 정제됨), 100nM 인간 CD3(Acro CDD-H52W1), 20nM 인간 PD-L1(Acro PD1-H5229), 400nM 인간 4-1BB(인-하우스 정제됨), 200nM 인간 HER3(Acro ER3-H5223)을 포함하였다. 회합 후 420초 해리 단계가 사용되었다. 표로 정리된 KD 값은 ForteBio 데이터 분석 소프트웨어 버전 11에 일대일 결합 모델을 사용하여 계산되었다. 표 5에 나타낸 바와 같이, 모든 스테이플링된 scFv 도메인을 갖는 각 miniGNC 분자의 분석된 KD 값은 표 6에 나타낸 바와 같은 각각의 항원에 대한 모노클로날 항체 대조군의 KD와 비교되었다. 결합 동역학 데이터는 각각 스테이플링된 scFv 도메인과 이의 각각의 mAb 또는 Fc-scFv 대조군 SI-1C3(서열번호 181, 183), SI-1C7(서열번호 185), SI-9C21(서열번호 187, 189), SI-35SF11(서열번호 191), SI-3SF11(서열번호 193), SI-20C14(서열번호 287 및 289)의 필적할만한 결합 친화성을 나타내며(표 6), 하나 이상의 scFv 도메인을 스테이플링하는 것이 결합 친화성에 거의 영향을 미치지 않는 것으로 보인다는 것을 시사한다.
miniGNC 항체의 효능에 대한 스테이플링된 scFv 도메인의 효과를 평가하기 위해, T 세포 지시된 세포독성(TDCC) 검정을 사용하였고, 표적 세포는 HPAF-II, 인간 및 인간 췌장암 세포주(ATCC, Manassas, VA)였다. 표적 세포의 표면 발현은 유세포 계측법에 의해 검증되었다. 항체의 연속 희석물(0 내지 30nM; 1 내지 5 희석 인자)을 총 용적 50ul로 표적 세포와 활성화 T 세포(약물 직전에 플레이팅됨; 이펙터:표적 = 5:1)를 함유하는 백색 384-웰 플레이트에 첨가하였다. 추가 72시간 후, 20ul의 Bright-Glo(Promega)를 웰에 첨가하고, 루시퍼화 종양 세포의 생존력에 상응하는 발광을 CLARIOstar 플레이트 판독기를 사용하여 결정하였다. 데이터를 EC50 값을 계산하기 위해 S자형 함수에 적합화하였다. 도 6과 표 5에 나타낸 바와 같이, 생존 곡선은 4개의 miniGNC 항체 모두의 효능이 pM의 투여량 범위 내에 있었으며 펜타-miniGNC 항체가 테트라-miniGNC 및 트리-miniGNC 항체보다 더 높은 TDCC 효능을 발휘하는 경향을 갖는다는 것을 나타냈다. 이 관찰은 스테이플링된 scFv 도메인을 사용하여 거의 효과를 나타내지 않는다.
실시예 10 . 결합 도메인으로서 NKG2D 수용체 이량체를 갖는 miniGNC
증가된 수의 결합 특이성은 GNC 항체가 T 세포뿐만 아니라 T 세포의 서브세트, 자연 살해 세포, 및 모이어티 1 결합 도메인/특이성으로서 집합적으로 공지된 다른 유형의 면역 세포에 결합할 수 있도록 한다(참조: 출원인의 출원, WO/2019/005641 및 WO2019191120, 전체가 본원에 포함됨). 모이어티 1 결합 특이성의 일부는 표적화 세포에 대한 세포 반응 또는 이의 인식을 대체할 수 있다. 예를 들어, NKG2D는 이의 리간드가, 예를 들어, 암에서와 같이 바이러스 감염 또는 게놈 응력의 결과로서 세포 응력 동안 유도되기 때문에, 형질전환 및 감염된 세포의 검출 및 제거를 위한 주요 인식 수용체이다. 인간에서, NKG2D는 NK 세포, 세포 및 CD8+ T 세포에 의해 발현된다. miniGNC 항체 부류에 대한 결합 도메인/특이성으로 NKG2D의 첨가는 단일 다기능성 치료제로서 항체의 세포독성과 효능을 향상시킬 수 있다.
NK 세포에서, NKG2D는 활성화 수용체 역할을 할 수 있으며, 이는 자체가 세포독성을 유발할 수 있는 반면, CD8+ T 세포 상에서 NKG2D의 기능은 공동자극 신호를 전송하여 그들을 활성화시키는 것이다. NKG2D는 엑토도메인이 리간드 결합을 위해 작용하는 동종이량체를 형성한다. 이 특징은 비가변 서열 기반 결합 도메인으로서 NKG2D를 miniGNC 포맷으로 자격을 부여하고, 다른 결합 도메인을 첨가하여 다중특이적 NKG2D-miniGNC 단백질 부류를 생성할 수 있다. 하나의 miniGNC 포맷에서, 개별 NKG2D 단량체는 Fc 이량체화 상에서 이량체 NKG2D 수용체를 형성한 쇄 A와 쇄 B의 D3 위치에 혼입되었다. 따라서, NKG2D는 다중특이적 miniGNC 분자의 수용체 역할을 하여 이의 리간드에 결합할 수 있다. 다른 miniGNC 포맷에서, NKG2D 탠덤 반복체는 동종이량체화되어 기능적 이량체 수용체를 형성하는 개별 NKG2D 단량체 사이에 (GxSy)n 스페이서/링커를 추가하여 설계되었다. 이 NKG2D 탠덤 이량체 구조는 D1, D2, D4 또는 D5에 배치될 수 있다.
표 7에 나열된 바와 같이, 이 부류는 모노-NKG2D-miniGNC(SI-49R26, 서열번호 153, 155), 바이-miniGNC(SI-49R27, 서열번호 157, 159), 트리-miniGNC(SI-49R25, 서열번호 161, 163), 테트라-miniGNC(SI-49P_X, 서열번호 165, 167), 및 펜타-miniGNC 분자(SI49P8, SI-49P9, 서열번호 169, 171, 177 및 179)를 포함한다. 대조군 펜타-miniGNC인 SI-49PM1(서열번호 173, 175)은 SI-49P8의 D1(αCD3)과 D3의 위치를 교환함으로써 생성되었으며, NKG2D 또는 CD3에 대한 옥텟 결합 친화성은 이 교환으로 영향받지 않았다. 다른 모이어티 1 결합 도메인의 결합 친화성은 이 부류의 NKG2D-miniGNC 분자에서 안정하게 유지되지만, NKG2D의 결합 친화성은 2배 이내였다. 따라서, 펜타-miniGNC 분자는 NKG2D 리간드에 결합하기 위한 NKG2D 수용체의 결합 기능을 보유한다.
NKG2D-miniGNC 분자의 TDCC의 효능을 평가하고 비교하기 위해, 트리-, 테트라- 및 펜타-miniGNC 분자, SI-49R25, SI-49P_X, SI-49P8 및 SI-49PM1을 사용하여 MDA-MB-231 유방암 세포주를 표적화했다. miniGNC 단백질의 연속 희석물(0 내지 30nM; 1 내지 5 희석 인자)을 루시퍼화된 MDA-MB-231 세포를 함유하는 백색 384-웰 플레이트에 24시간 전에 첨가하고, 37℃에서 성장시켰다. 활성화 T 세포를 miniGNC 분자(이펙터:표적 = 15:1) 직전에 총 용적 50μl로 플레이팅하였다. 추가 72시간 동안 배양한 후, 20μl의 Bright-Glo(Promega)를 웰에 첨가하고, 루시퍼화 종양 세포의 생존력에 상응하는 발광을 CLARIOstar 플레이트 판독기를 사용하여 결정하였다. 데이터는 EC50 값을 계산하기 위해 S자형 함수에 적합화했다(도 7). 투여량 생존력 곡선을 기준으로 하여, 두 그룹이 존재하였고, 테트라- 및 펜타-miniGNC 분자는 트리-miniGNC 분자인 SI-49R25보다 더 강력했다. 표 7에 나열된 바와 같이, 차이는 αPD-L1의 첨가로 인해 발생할 수 있다. 그러나, SI-49R25의 EC50 값(59.3nM)은 상대적으로 강력한 것으로 간주되어야 한다. 유방암 세포주 MDA-MB-231에, pan-B 세포 마커인 CD19는 비참여 종양 항원이다. 이와 관련하여, SI-49R25는 CD3 및 NKG2D 리간드에 대한 2개의 결합 특이성을 갖는 것으로 간주될 수 있다. 따라서, 데이터는 NKG2D 수용체의 상이한 miniGNC 항체 포맷에의 혼입이 TDCC의 효능에 기여한다는 것을 나타낸다. 더 광범위한 의미에서, miniGNC 항체 분자는 암과 같은 표적화 세포에 대한 최적화된 면역 반응을 조절, 협력 및 지시하기 위해 다중 결합 특이성을 수용할 수 있다.
표
[표 1]
Figure pct00001
[표 2]
Figure pct00002
[표 3]
Figure pct00003
[표 4]
Figure pct00004
[표 5]
Figure pct00005
[표 6]
Figure pct00006
[표 7]
Figure pct00007
[표 8]
Figure pct00008
[표 9]
Figure pct00009
Figure pct00010
Figure pct00011
Figure pct00012
Figure pct00013
Figure pct00014
Figure pct00015
Figure pct00016
Figure pct00017
Figure pct00018
Figure pct00019
Figure pct00020
Figure pct00021
Figure pct00022
Figure pct00023
Figure pct00024
Figure pct00025
Figure pct00026
Figure pct00027
Figure pct00028
Figure pct00029
Figure pct00030
Figure pct00031
Figure pct00032
Figure pct00033
Figure pct00034
Figure pct00035
Figure pct00036
Figure pct00037
Figure pct00038
Figure pct00039
Figure pct00040
Figure pct00041
Figure pct00042
Figure pct00043
Figure pct00044
Figure pct00045
Figure pct00046
Figure pct00047
Figure pct00048
Figure pct00049
Figure pct00050
Figure pct00051
Figure pct00052
Figure pct00053
Figure pct00054
Figure pct00055
Figure pct00056
Figure pct00057
Figure pct00058
Figure pct00059
Figure pct00060
Figure pct00061
Figure pct00062
Figure pct00063
Figure pct00064
Figure pct00065
Figure pct00066
Figure pct00067
Figure pct00068
Figure pct00069
Figure pct00070
Figure pct00071
Figure pct00072
Figure pct00073
Figure pct00074
Figure pct00075
Figure pct00076
Figure pct00077
Figure pct00078
Figure pct00079
Figure pct00080
Figure pct00081
Figure pct00082
Figure pct00083
Figure pct00084
Figure pct00085
Figure pct00086
Figure pct00087
Figure pct00088
Figure pct00089
Figure pct00090
Figure pct00091
Figure pct00092
Figure pct00093
Figure pct00094
Figure pct00095
Figure pct00096
Figure pct00097
Figure pct00098
Figure pct00099
Figure pct00100
Figure pct00101
Figure pct00102
Figure pct00103
Figure pct00104
Figure pct00105
Figure pct00106
Figure pct00107
Figure pct00108
Figure pct00109
Figure pct00110
Figure pct00111
Figure pct00112
SEQUENCE LISTING <110> SYSTIMMUNE, INC. SICHUAN BAILI PHARMACEUTICAL CO. LTD. <120> MINIATURE GUIDANCE AND NAVIGATION CONTROL (miniGNC) ANTIBODY-LIKE PROTEINS AND METHODS OF MAKING AND USING THEREOF <130> SIBA068PCT <150> 62/991,042 <151> 2020-03-17 <160> 314 <170> PatentIn version 3.5 <210> 1 <211> 442 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 1 Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu 1 5 10 15 Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn 20 25 30 Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met 65 70 75 80 Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly 85 90 95 Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 115 120 125 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 130 135 140 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 145 150 155 160 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 165 170 175 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 180 185 190 Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 195 200 205 Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 210 215 220 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 225 230 235 240 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 245 250 255 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 260 265 270 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 275 280 285 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 290 295 300 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 305 310 315 320 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 325 330 335 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 340 345 350 Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 355 360 365 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 370 375 380 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 385 390 395 400 Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 405 410 415 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 420 425 430 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 <210> 2 <211> 1326 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 2 caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60 acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120 ccaggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180 agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240 aactccctcc ggtccgagga taccgcgata tattactgtg ccagaggggg gtactcctct 300 gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360 gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420 ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480 tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540 gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600 aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660 acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720 cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780 gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840 cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900 gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960 aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020 gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080 ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140 ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200 ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260 tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320 cctgga 1326 <210> 3 <211> 704 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 3 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 260 265 270 Thr Val Gly Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val 275 280 285 Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro 290 295 300 Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro 305 310 315 320 Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile 325 330 335 Thr Arg Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg 340 345 350 Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile 355 360 365 Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 370 375 380 Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 385 390 395 400 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 405 410 415 Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 420 425 430 Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 435 440 445 Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 450 455 460 Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys 465 470 475 480 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 485 490 495 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 500 505 510 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 515 520 525 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 530 535 540 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 545 550 555 560 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 565 570 575 Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 580 585 590 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 595 600 605 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 610 615 620 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 625 630 635 640 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 645 650 655 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 660 665 670 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 675 680 685 Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 690 695 700 <210> 4 <211> 2112 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 4 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt ctcgagtggc ggtggagggt ccggcggtgg tggatcagat 780 cctcaattga cccagtcccc tagtagcctt tctgcaaccg tgggccagag ggtaacaatc 840 aattgccagt caagccagtc cgtagcgaag aataataatt tggcatggtt ccaacaaaaa 900 ccgggtaaac ctcctaaact ccttatctac tcagcttcaa cccttgccgc gggtgtgccc 960 agccggttct caggctcagg ttccgggact caatttacac ttaccatcac tcgcgtccaa 1020 agtgaggatt ttgcaaccta ctattgttct gcacgggatt ccgggaacat acagtccttt 1080 gggggtggaa ctcgggtgga gataaaacgt acggtggctg ccccctctgt gttcatcttc 1140 ccacccagtg atgagcagct gaagagtggc acagcctctg tggtgtgcct gctcaacaac 1200 ttctacccca gagaagccaa ggtgcagtgg aaggtggaca atgccctgca gagtggcaac 1260 agccaggaga gtgtgacaga gcaggacagc aaggacagca cctacagcct gtcctccacc 1320 ctgaccctgt ccaaggctga ctatgagaag cacaaggtgt atgcctgtga ggtgacccac 1380 cagggcctga gcagccctgt gaccaagagc ttcaaccgag gagagtgtgg aggagacaag 1440 acccacacct gccctccctg cccagcccca gaagctgctg gaggcccctc tgtgttcctc 1500 ttccctccca agcccaagga caccctgatg atctccagga ccccagaagt cacctgtgtg 1560 gtggtggatg tgtcccatga agacccagaa gtgaagttca actggtatgt ggatggagtg 1620 gaagtgcaca atgccaagac caagcccaga gaagagcagt acaacagcac ctaccgagtg 1680 gtgtctgtgc tgactgtgct gcaccaggac tggctgaatg ggaaggagta caagtgtgct 1740 gtgtccaaca aggccctgcc tgcccccatt gagaagacca tctccaaggc caagggccag 1800 cccagagagc cccaggtcta caccctgcct ccctccagag atgagctgac caagaaccag 1860 gtgtccctgt ggtgcctggt gaaaggcttc taccccagtg acattgctgt ggagtgggag 1920 agcaatggcc agccagagaa caactacaag accacccctc ctgtgctgga ctctgatggc 1980 tccttcttcc tgtacagcaa gctgactgtg gacaagagcc gctggcagca gggcaatgtg 2040 ttctcctgct ctgtcatgca tgaggccctg cacaaccgct tcacccagaa gagcctgagc 2100 ctgagccctg ga 2112 <210> 5 <211> 442 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 5 Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu 1 5 10 15 Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn 20 25 30 Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met 65 70 75 80 Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly 85 90 95 Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 115 120 125 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 130 135 140 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 145 150 155 160 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 165 170 175 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 180 185 190 Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 195 200 205 Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 210 215 220 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 225 230 235 240 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 245 250 255 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 260 265 270 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 275 280 285 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 290 295 300 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 305 310 315 320 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 325 330 335 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 340 345 350 Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 355 360 365 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 370 375 380 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 385 390 395 400 Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 405 410 415 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 420 425 430 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 <210> 6 <211> 1326 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 6 caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60 acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120 ccaggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180 agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240 aactccctcc ggtccgagga taccgcgata tattactgtg ccagaggggg gtactcctct 300 gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360 gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420 ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480 tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540 gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600 aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660 acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720 cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780 gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840 cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900 gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960 aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020 gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080 ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140 ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200 ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260 tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320 cctgga 1326 <210> 7 <211> 704 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 7 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 260 265 270 Thr Val Gly Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val 275 280 285 Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro 290 295 300 Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro 305 310 315 320 Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile 325 330 335 Thr Arg Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg 340 345 350 Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile 355 360 365 Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 370 375 380 Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 385 390 395 400 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 405 410 415 Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 420 425 430 Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 435 440 445 Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 450 455 460 Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys 465 470 475 480 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 485 490 495 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 500 505 510 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 515 520 525 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 530 535 540 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 545 550 555 560 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 565 570 575 Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 580 585 590 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 595 600 605 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 610 615 620 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 625 630 635 640 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 645 650 655 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 660 665 670 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 675 680 685 Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 690 695 700 <210> 8 <211> 2112 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 8 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt ctcgagtggc ggtggagggt ccggcggtgg tggatcagat 780 cctcaattga cccagtcccc tagtagcctt tctgcaaccg tgggccagag ggtaacaatc 840 aattgccagt caagccagtc cgtagcgaag aataataatt tggcatggtt ccaacaaaaa 900 ccgggtaaac ctcctaaact ccttatctac tcagcttcaa cccttgccgc gggtgtgccc 960 agccggttct caggctcagg ttccgggact caatttacac ttaccatcac tcgcgtccaa 1020 agtgaggatt ttgcaaccta ctattgttct gcacgggatt ccgggaacat acagtccttt 1080 gggggtggaa ctcgggtgga gataaaacgt acggtggctg ccccctctgt gttcatcttc 1140 ccacccagtg atgagcagct gaagagtggc acagcctctg tggtgtgcct gctcaacaac 1200 ttctacccca gagaagccaa ggtgcagtgg aaggtggaca atgccctgca gagtggcaac 1260 agccaggaga gtgtgacaga gcaggacagc aaggacagca cctacagcct gtcctccacc 1320 ctgaccctgt ccaaggctga ctatgagaag cacaaggtgt atgcctgtga ggtgacccac 1380 cagggcctga gcagccctgt gaccaagagc ttcaaccgag gagagtgtgg aggagacaag 1440 acccacacct gccctccctg cccagcccca gaagctgctg gaggcccctc tgtgttcctc 1500 ttccctccca agcccaagga caccctgatg atctccagga ccccagaagt cacctgtgtg 1560 gtggtggatg tgtcccatga agacccagaa gtgaagttca actggtatgt ggatggagtg 1620 gaagtgcaca atgccaagac caagcccaga gaagagcagt acaacagcac ctaccgagtg 1680 gtgtctgtgc tgactgtgct gcaccaggac tggctgaatg ggaaggagta caagtgtgct 1740 gtgtccaaca aggccctgcc tgcccccatt gagaagacca tctccaaggc caagggccag 1800 cccagagagc cccaggtcta caccctgcct ccctccagag atgagctgac caagaaccag 1860 gtgtccctgt ggtgcctggt gaaaggcttc taccccagtg acattgctgt ggagtgggag 1920 agcaatggcc agccagagaa caactacaag accacccctc ctgtgctgga ctctgatggc 1980 tccttcttcc tgtacagcaa gctgactgtg gacaagagcc gctggcagca gggcaatgtg 2040 ttctcctgct ctgtcatgca tgaggccctg cacaaccgct tcacccagaa gagcctgagc 2100 ctgagccctg ga 2112 <210> 9 <211> 442 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 9 Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu 1 5 10 15 Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn 20 25 30 Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met 65 70 75 80 Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly 85 90 95 Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 115 120 125 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 130 135 140 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 145 150 155 160 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 165 170 175 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 180 185 190 Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 195 200 205 Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 210 215 220 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 225 230 235 240 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 245 250 255 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 260 265 270 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 275 280 285 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 290 295 300 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 305 310 315 320 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 325 330 335 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 340 345 350 Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 355 360 365 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 370 375 380 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 385 390 395 400 Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 405 410 415 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 420 425 430 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 <210> 10 <211> 1326 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 10 caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60 acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120 ccaggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180 agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240 aactccctcc ggtccgagga taccgcgata tattactgtg ccagaggggg gtactcctct 300 gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360 gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420 ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480 tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540 gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600 aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660 acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720 cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780 gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840 cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900 gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960 aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020 gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080 ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140 ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200 ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260 tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320 cctgga 1326 <210> 11 <211> 704 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 11 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 260 265 270 Thr Val Gly Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val 275 280 285 Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro 290 295 300 Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro 305 310 315 320 Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile 325 330 335 Thr Arg Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg 340 345 350 Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile 355 360 365 Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 370 375 380 Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 385 390 395 400 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 405 410 415 Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 420 425 430 Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 435 440 445 Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 450 455 460 Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys 465 470 475 480 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 485 490 495 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 500 505 510 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 515 520 525 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 530 535 540 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 545 550 555 560 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 565 570 575 Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 580 585 590 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 595 600 605 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 610 615 620 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 625 630 635 640 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 645 650 655 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 660 665 670 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 675 680 685 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 690 695 700 <210> 12 <211> 2112 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 12 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt ctcgagtggc ggtggagggt ccggcggtgg tggatcagat 780 cctcaattga cccagtcccc tagtagcctt tctgcaaccg tgggccagag ggtaacaatc 840 aattgccagt caagccagtc cgtagcgaag aataataatt tggcatggtt ccaacaaaaa 900 ccgggtaaac ctcctaaact ccttatctac tcagcttcaa cccttgccgc gggtgtgccc 960 agccggttct caggctcagg ttccgggact caatttacac ttaccatcac tcgcgtccaa 1020 agtgaggatt ttgcaaccta ctattgttct gcacgggatt ccgggaacat acagtccttt 1080 gggggtggaa ctcgggtgga gataaaacgt acggtggctg ccccctctgt gttcatcttc 1140 ccacccagtg atgagcagct gaagagtggc acagcctctg tggtgtgcct gctcaacaac 1200 ttctacccca gagaagccaa ggtgcagtgg aaggtggaca atgccctgca gagtggcaac 1260 agccaggaga gtgtgacaga gcaggacagc aaggacagca cctacagcct gtcctccacc 1320 ctgaccctgt ccaaggctga ctatgagaag cacaaggtgt atgcctgtga ggtgacccac 1380 cagggcctga gcagccctgt gaccaagagc ttcaaccgag gagagtgtgg aggagacaag 1440 acccacacct gccctccctg cccagcccca gaagctgctg gaggcccctc tgtgttcctc 1500 ttccctccca agcccaagga caccctgatg atctccagga ccccagaagt cacctgtgtg 1560 gtggtggatg tgtcccatga agacccagaa gtgaagttca actggtatgt ggatggagtg 1620 gaagtgcaca atgccaagac caagcccaga gaagagcagt acaacagcac ctaccgagtg 1680 gtgtctgtgc tgactgtgct gcaccaggac tggctgaatg ggaaggagta caagtgtgct 1740 gtgtccaaca aggccctgcc tgcccccatt gagaagacca tctccaaggc caagggccag 1800 cccagagagc cccaggtcta caccctgcct ccctccagag atgagctgac caagaaccag 1860 gtgtccctgt ggtgcctggt gaaaggcttc taccccagtg acattgctgt ggagtgggag 1920 agcaatggcc agccagagaa caactacaag accacccctc ctgtgctgga ctctgatggc 1980 tccttcttcc tgtacagcaa gctgactgtg gacaagagcc gctggcagca gggcaatgtg 2040 ttctcctgct ctgtcatgca tgaggccctg cacaaccact acacccagaa gagcctgagc 2100 ctgagccctg ga 2112 <210> 13 <211> 442 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 13 Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu 1 5 10 15 Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn 20 25 30 Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met 65 70 75 80 Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly 85 90 95 Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 115 120 125 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 130 135 140 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 145 150 155 160 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 165 170 175 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 180 185 190 Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 195 200 205 Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 210 215 220 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 225 230 235 240 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 245 250 255 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 260 265 270 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 275 280 285 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 290 295 300 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 305 310 315 320 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 325 330 335 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 340 345 350 Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 355 360 365 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 370 375 380 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 385 390 395 400 Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 405 410 415 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 420 425 430 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 <210> 14 <211> 1326 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 14 caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60 acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120 ccaggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180 agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240 aactccctcc ggtccgagga taccgcgata tattactgtg ccagaggggg gtactcctct 300 gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360 gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420 ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480 tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540 gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600 aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660 acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720 cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780 gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840 cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900 gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960 aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020 gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080 ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140 ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200 ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260 tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320 cctgga 1326 <210> 15 <211> 704 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 15 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 260 265 270 Thr Val Gly Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val 275 280 285 Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro 290 295 300 Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro 305 310 315 320 Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile 325 330 335 Thr Arg Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg 340 345 350 Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile 355 360 365 Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 370 375 380 Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 385 390 395 400 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 405 410 415 Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 420 425 430 Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 435 440 445 Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 450 455 460 Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys 465 470 475 480 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 485 490 495 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 500 505 510 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 515 520 525 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 530 535 540 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 545 550 555 560 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 565 570 575 Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 580 585 590 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 595 600 605 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 610 615 620 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 625 630 635 640 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 645 650 655 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 660 665 670 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 675 680 685 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 690 695 700 <210> 16 <211> 2112 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 16 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt ctcgagtggc ggtggagggt ccggcggtgg tggatcagat 780 cctcaattga cccagtcccc tagtagcctt tctgcaaccg tgggccagag ggtaacaatc 840 aattgccagt caagccagtc cgtagcgaag aataataatt tggcatggtt ccaacaaaaa 900 ccgggtaaac ctcctaaact ccttatctac tcagcttcaa cccttgccgc gggtgtgccc 960 agccggttct caggctcagg ttccgggact caatttacac ttaccatcac tcgcgtccaa 1020 agtgaggatt ttgcaaccta ctattgttct gcacgggatt ccgggaacat acagtccttt 1080 gggggtggaa ctcgggtgga gataaaacgt acggtggctg ccccctctgt gttcatcttc 1140 ccacccagtg atgagcagct gaagagtggc acagcctctg tggtgtgcct gctcaacaac 1200 ttctacccca gagaagccaa ggtgcagtgg aaggtggaca atgccctgca gagtggcaac 1260 agccaggaga gtgtgacaga gcaggacagc aaggacagca cctacagcct gtcctccacc 1320 ctgaccctgt ccaaggctga ctatgagaag cacaaggtgt atgcctgtga ggtgacccac 1380 cagggcctga gcagccctgt gaccaagagc ttcaaccgag gagagtgtgg aggagacaag 1440 acccacacct gccctccctg cccagcccca gaagctgctg gaggcccctc tgtgttcctc 1500 ttccctccca agcccaagga caccctgatg atctccagga ccccagaagt cacctgtgtg 1560 gtggtggatg tgtcccatga agacccagaa gtgaagttca actggtatgt ggatggagtg 1620 gaagtgcaca atgccaagac caagcccaga gaagagcagt acaacagcac ctaccgagtg 1680 gtgtctgtgc tgactgtgct gcaccaggac tggctgaatg ggaaggagta caagtgtgct 1740 gtgtccaaca aggccctgcc tgcccccatt gagaagacca tctccaaggc caagggccag 1800 cccagagagc cccaggtcta caccctgcct ccctccagag atgagctgac caagaaccag 1860 gtgtccctgt ggtgcctggt gaaaggcttc taccccagtg acattgctgt ggagtgggag 1920 agcaatggcc agccagagaa caactacaag accacccctc ctgtgctgga ctctgatggc 1980 tccttcttcc tgtacagcaa gctgactgtg gacaagagcc gctggcagca gggcaatgtg 2040 ttctcctgct ctgtcatgca tgaggccctg cacaaccact acacccagaa gagcctgagc 2100 ctgagccctg ga 2112 <210> 17 <211> 967 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 17 Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 130 135 140 Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 145 150 155 160 Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 165 170 175 Leu Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala 180 185 190 Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 195 200 205 Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn 225 230 235 240 Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 245 250 255 Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 260 265 270 Leu Val Lys Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly 275 280 285 Phe Ser Leu Thr Asn Tyr Gly Val His Trp Ile Arg Gln Ala Pro Gly 290 295 300 Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp 305 310 315 320 Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr Ile Thr Lys Asp Asn Ser 325 330 335 Lys Asn Gln Val Tyr Phe Lys Leu Arg Ser Val Arg Ala Asp Asp Thr 340 345 350 Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe 355 360 365 Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 370 375 380 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 385 390 395 400 Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 405 410 415 Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 420 425 430 Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 435 440 445 Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 450 455 460 Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 465 470 475 480 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 485 490 495 Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 500 505 510 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 515 520 525 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 530 535 540 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 545 550 555 560 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 565 570 575 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu 580 585 590 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 595 600 605 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 610 615 620 Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 625 630 635 640 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 645 650 655 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 660 665 670 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 675 680 685 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 690 695 700 Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 705 710 715 720 Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 725 730 735 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr 740 745 750 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 755 760 765 Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 770 775 780 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro 785 790 795 800 Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp 805 810 815 Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 820 825 830 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 835 840 845 Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 850 855 860 Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile 865 870 875 880 Ser Ser Tyr His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 885 890 895 Glu Tyr Ile Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser 900 905 910 Ser Ala Arg Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr 915 920 925 Val Asp Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 930 935 940 Tyr Cys Ala Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly 945 950 955 960 Thr Leu Val Thr Val Ser Ser 965 <210> 18 <211> 2901 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 18 gacgtcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcaattgcc aagccagtga gagcattagc agttggttag cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaaggc tatttttatt ttattagtcg tacttatgta 300 aattctttcg gcggagggac caaggtggag atcaaaggcg gtggcggtag tgggggaggc 360 ggttctggcg gcggagggtc cggcggtgga ggatcagagg tgcagctggt ggagtctggg 420 ggaggcttgg tccagcctgg ggggtccctg agactctcct gtgcagcctc tggattcacc 480 atcagtacca atgcaatgag ctgggtccgc caggctccag ggaaggggct ggagtggatc 540 ggagtcatta ctggtcgtga tatcacatac tacgcgagct gggcgaaagg cagattcacc 600 atctccagag acaattccaa gaacacgctg tatcttcaaa tgaacagcct gagagccgag 660 gacacggctg tgtattactg tgcgagagac ggtggttctt ctgctattac tagtaacaac 720 atttggggcc agggaaccct ggtcaccgtc tcgagtggcg gtggagggtc cggcggtggt 780 ggatcacaag tacagttgca gcaatccggt cccggtctcg tcaaaccgag tgagacgctt 840 agtataacgt gtactgtttc aggctttagc cttacgaact atggagttca ctggattcgg 900 caggcacccg gcaaaggttt ggaatggctg ggtgttattt ggtcaggtgg aaatacagac 960 tataacaccc cctttacaag tcggttcaca attacgaaag ataattccaa aaatcaagtt 1020 tatttcaagt tgagatccgt ccgcgcggac gacactgcga tctactattg tgcgagggca 1080 ctgacctact acgattacga atttgcgtat tgggggcaag ggactcttgt aacagtctcc 1140 agtgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct 1200 gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg 1260 tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc 1320 tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag 1380 acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag 1440 cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga agccgcgggg 1500 ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc 1560 cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac 1620 tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac 1680 aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc 1740 aaggagtaca agtgcgcggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc 1800 tccaaagcca aagggcagcc ccgagaacca caggtgtata ccctgccccc atcccgggat 1860 gagctgacca agaaccaggt cagcctgtcc tgcgccgtca aaggcttcta tcccagcgac 1920 atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc 1980 gtgctggact ccgacggctc cttcttcctc gtgagcaagc tcaccgtgga caagagcagg 2040 tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac 2100 acgcagaaga gcctctccct gtctccgggt ggcggcggcg gttcaggtgg tgggggatcc 2160 gacgttgtga tgacgcagtc tcctagttca gtatcagcgt ctgttgggga tcgagtcacg 2220 attacatgcc aggcgagcca aaatattagg acgtatctgt cttggtatca acaaaagcct 2280 ggtaaggctc caaaactcct catttacgcc gctgccaact tggctagtgg agtaccttca 2340 cgctttagtg ggtcaggttc tggaacagat tttacgttga cgatctccga tttggaacca 2400 ggggacgctg ccacgtatta ttgccagtcc acctacctcg ggactgacta cgttggtggg 2460 gcgtttggcg gaggaacaaa actcactgta cttggtggtg gtggttcagg cggggggggt 2520 tccggcggag gcggttctgg gggtggaggt tccgaggttc agttggttga aagtgggggg 2580 ggactcgttc agcctggagg ctctttgcga ctttcttgta ccgcttctgg gttcactata 2640 agttcatatc atatgcaatg ggtaagacag gcgcctggta agggacttga atacatagga 2700 acaataagct ctggtggtaa cgtctattac gcctcatccg cgcgggggag gtttacaatt 2760 tccaggcctt ctagcaaaaa cacggtagat ctgcaaatga actctcttcg cgctgaagat 2820 acagcagtct actactgcgc cagggattca gggtattctg accccatgtg ggggcagggc 2880 acattggtta ccgtgtcctc t 2901 <210> 19 <211> 963 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 19 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val 260 265 270 Ser Pro Gly Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile 275 280 285 Gly Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg 290 295 300 Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg 305 310 315 320 Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 325 330 335 Val Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn 340 345 350 Trp Pro Thr Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Arg Thr 355 360 365 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 370 375 380 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 385 390 395 400 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 405 410 415 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 420 425 430 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 435 440 445 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 450 455 460 Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr 465 470 475 480 Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 485 490 495 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 500 505 510 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 515 520 525 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 530 535 540 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 545 550 555 560 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 565 570 575 Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 580 585 590 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 595 600 605 Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 610 615 620 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 625 630 635 640 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 645 650 655 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 660 665 670 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 675 680 685 Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly 690 695 700 Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 705 710 715 720 Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala 725 730 735 Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly 740 745 750 Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly 755 760 765 Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 770 775 780 Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 785 790 795 800 Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly Gly Thr 805 810 815 Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 820 825 830 Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser 835 840 845 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala 850 855 860 Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg 865 870 875 880 Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala Ala Gly 885 890 895 Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg Phe Thr 900 905 910 Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 915 920 925 Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Phe 930 935 940 Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr 945 950 955 960 Val Ser Ser <210> 20 <211> 2892 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 20 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt ctcgagtggc ggtggagggt ccggcggtgg tggatcagaa 780 atcgtcctta cacaatctcc tagcacactg agtgtgagcc ccggcgaacg cgcgactttc 840 tcttgcaggg caagtcaatc catagggact aatatacatt ggtatcaaca aaagccaggt 900 aaaccaccca ggcttttgat taagtatgca agtgagtcta tttccggtat ccctgaccgc 960 ttctctggat caggcagtgg cacagagttc acactcacca tatctagtgt gcaatcagag 1020 gacttcgccg tgtattactg ccaacagaat aataactggc cgactacctt cggacccggt 1080 acaaagctga ccgttttacg tacggtggct gcaccatctg tcttcatctt cccgccatct 1140 gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc 1200 agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag 1260 agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg 1320 agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg 1380 agctcgcccg tcacaaagag cttcaacagg ggagagtgtg gaggcgacaa aactcacaca 1440 tgcccaccgt gcccagcacc tgaagccgcg gggggaccgt cagtcttcct cttcccccca 1500 aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac 1560 gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat 1620 aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc 1680 ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcgc ggtctccaac 1740 aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa 1800 ccacaggtgt acaccctgcc cccaagccgg gatgagctga ccaagaacca ggtcagcctg 1860 tggtgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg 1920 cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc 1980 ctctatagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc 2040 tccgtgatgc atgaggctct gcacaacaga ttcacgcaga agagcctctc cctgtctccg 2100 ggtggcggtg gagggtccgg cggtggtgga tccgacattc agatgacaca gtcaccgtct 2160 acgctctcag cctcagtagg cgatagggtg actatcacct gccaagcctc ccaatctata 2220 agttcacacc tcaactggta tcaacagaaa cccggtaaag caccgaagct gctcatctac 2280 aaggcatcaa ctcttgcctc aggtgtgcct agtcgcttct ccgggagcgg ctccggtact 2340 gagtttactt tgacgatatc ttccctccaa cccgacgact tcgccacata ctattgtcag 2400 cagggttata gttggggaaa tgttgacaat gtgtttggag ggggaacgaa agtgactgtg 2460 ttgggagggg gaggaagtgg cggcggcgga agcggaggtg gtggctccgg cgggggtgga 2520 agcgaagtgc aattgctcga aagtggtggc ggacttgtgc aacctggtgg aagcctctca 2580 ctctcttgcg cggcgagtgg ttttagcttc agtagcggct acgatatgtg ctgggtaaga 2640 caggctcctg gtaaaggcct tgagtggatt gcgtgtatcg ccgccgggtc tgctggtata 2700 acatacgatg caaactgggc gaaagggcgc ttcacaatct ccagggacaa ctcaaaaaat 2760 acattgtacc tccagatgaa tagcctgaga gccgaagaca ccgcagtcta ctattgcgca 2820 aggtcagcat ttagcttcga ttatgcaatg gatctttggg gccaggggac gctcgtcacc 2880 gtctcatctt ga 2892 <210> 21 <211> 1277 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 21 Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 20 25 30 Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 85 90 95 Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 115 120 125 Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 130 135 140 Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 145 150 155 160 Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 165 170 175 Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 180 185 190 Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys 195 200 205 Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 210 215 220 Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 260 265 270 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 275 280 285 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 290 295 300 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 305 310 315 320 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 325 330 335 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 340 345 350 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 355 360 365 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 370 375 380 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 385 390 395 400 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 405 410 415 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 420 425 430 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 435 440 445 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 450 455 460 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 465 470 475 480 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 485 490 495 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 500 505 510 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 515 520 525 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 530 535 540 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 545 550 555 560 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 565 570 575 Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 580 585 590 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 595 600 605 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 610 615 620 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 625 630 635 640 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 645 650 655 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 660 665 670 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 675 680 685 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 690 695 700 Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu 705 710 715 720 Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met 725 730 735 Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu 740 745 750 Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly 755 760 765 Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 770 775 780 Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 785 790 795 800 Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg 805 810 815 Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro 820 825 830 Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu 835 840 845 Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu 850 855 860 Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu 865 870 875 880 Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Gly Ser Thr 885 890 895 Gly Ser Gly Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Arg 900 905 910 Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 915 920 925 Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 930 935 940 Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 945 950 955 960 Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 965 970 975 Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 980 985 990 Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 995 1000 1005 Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 1010 1015 1020 Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 1025 1030 1035 Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 1040 1045 1050 Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 1055 1060 1065 Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 1070 1075 1080 Glu Ile Pro Ala Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly 1085 1090 1095 Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 1100 1105 1110 Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn 1115 1120 1125 Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 1130 1135 1140 Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 1145 1150 1155 Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 1160 1165 1170 Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 1175 1180 1185 Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 1190 1195 1200 Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser 1205 1210 1215 Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu 1220 1225 1230 His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu 1235 1240 1245 Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 1250 1255 1260 Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 1265 1270 1275 <210> 22 <211> 3834 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 22 gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60 ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120 ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180 cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240 gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300 ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360 gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420 ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480 gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540 ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600 tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660 tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720 cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780 gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840 tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900 ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960 ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020 ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080 actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaag 1140 ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 1200 ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 1260 gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 1320 ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 1380 gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 1440 aaaactcaca catgcccacc gtgcccagca cctgaagccg cggggggacc gtcagtcttc 1500 ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1560 gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1620 gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt 1680 gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1740 gcggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1800 cagccccgag aaccacaggt gtataccctg cccccatccc gggatgagct gaccaagaac 1860 caggtcagcc tgtcctgcgc cgtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1920 gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1980 ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac 2040 gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 2100 tccctgtctc cgggtggcgg cggcggttca ggtggtgggg gatcccgaga gggccccgag 2160 ctgtctcctg atgacccagc aggcctcttg gacttgcggc agggtatgtt cgctcaactt 2220 gtggctcaga atgttctgct cattgatgga ccactctctt ggtatagtga ccccggtctg 2280 gccggggtga gtctgaccgg cgggctctct tataaagagg atactaagga actggtcgta 2340 gcaaaagcgg gcgtttatta cgtttttttt cagctggagc tcaggcgcgt ggtggccggc 2400 gagggcagtg gctctgtgtc cctggccctg cacttacagc ccttgagaag cgctgcaggt 2460 gctgccgcac tggctttaac tgttgacctc cctccggcct cttctgaagc tagaaacagc 2520 gctttcggct tccaagggcg cctgctgcac ctgagcgcag gccagcgctt aggtgtgcac 2580 cttcatacag aggccagggc ccgacacgct tggcagctca cacagggtgc cacggttctc 2640 ggacttttcc gcgttactcc cgagatcccc gctggcctcg gaagtactgg ttctgggtct 2700 aaacccggtt ccggcgaagg tagtactaaa ggacgagaag ggccagagtt aagtccagat 2760 gaccctgctg ggcttttgga cctgcggcag ggcatgttcg ctcaactggt ggctcagaac 2820 gtgctgctga tcgatggccc cctgagttgg tacagcgatc ccgggctggc aggcgtgtca 2880 cttacagggg gcctctctta caaggaagac accaaggagt tagtggtcgc taaggctggc 2940 gtgtattacg tgttcttcca actggagctg agaagggttg tggcaggaga gggtagcggc 3000 agcgtgtctt tagcccttca cttgcagccc ctgaggtctg ctgcaggtgc agccgctctc 3060 gcgctcaccg tggatctccc cccagcctca tctgaagcta ggaacagtgc atttggcttt 3120 cagggacgct tgctgcacct ctccgctgga cagaggctgg gcgtgcacct tcacacagag 3180 gcccgtgcca ggcatgcatg gcagctcact cagggggcaa cagtgctggg tctcttccgc 3240 gtgactcctg aaataccagc tggacttggc ggtggaggca gcggcggagg aggatctcgt 3300 gaggggccag aactgtcccc cgatgaccca gccggactgc tcgatctcag acagggcatg 3360 ttcgctcagc ttgtagccca aaatgtcctc ctgattgacg gccctttgag ctggtatagt 3420 gatcccggct tggccggggt atctctgacc ggaggcctct cctacaagga agacaccaaa 3480 gagctggtgg tggcaaaagc gggggtgtat tatgtgttct ttcagctcga gctgcggaga 3540 gttgtggccg gggaagggtc tgggagcgta tctcttgcac ttcacctgca gcccctgcgc 3600 agcgccgctg gagccgccgc ccttgctctt actgtggatc tgcctcctgc ttcctcagaa 3660 gcacgcaaca gcgccttcgg ctttcaagga cgtctcctgc acttgtccgc aggacagagg 3720 ttgggcgtcc atttacacac tgaggcacgg gcacggcacg cttggcagct tacccaggga 3780 gccaccgtgc tgggactctt tagagtgaca cccgagatcc ccgctggctt gtga 3834 <210> 23 <211> 968 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 23 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala 260 265 270 Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile 275 280 285 Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 290 295 300 Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 305 310 315 320 Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 325 330 335 Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr 340 345 350 Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val 355 360 365 Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 370 375 380 Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 385 390 395 400 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 405 410 415 Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 420 425 430 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 435 440 445 Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 450 455 460 Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly 465 470 475 480 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 485 490 495 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 500 505 510 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 515 520 525 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 530 535 540 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 545 550 555 560 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 565 570 575 Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 580 585 590 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 595 600 605 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 610 615 620 Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 625 630 635 640 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 645 650 655 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 660 665 670 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 675 680 685 His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 690 695 700 Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 705 710 715 720 Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 725 730 735 Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr 740 745 750 Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser 755 760 765 Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 770 775 780 Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 785 790 795 800 Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val 805 810 815 Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly 820 825 830 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 835 840 845 Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 850 855 860 Ser Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp 865 870 875 880 Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 885 890 895 Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala 900 905 910 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 915 920 925 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 930 935 940 Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln 945 950 955 960 Gly Thr Leu Val Thr Val Ser Ser 965 <210> 24 <211> 2907 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 24 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt ctcgagcggc ggtggagggt ccggcggtgg tggatcagac 780 gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840 aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900 aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960 ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020 gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080 tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 1140 atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 1200 aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 1260 ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 1320 agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 1380 acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggaggc 1440 gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 1680 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740 tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800 gggcagcccc gagaaccaca ggtgtacacc ctgcccccaa gccgggatga gctgaccaag 1860 aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1920 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980 gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg 2040 aacgtcttct catgctccgt gatgcatgag gctctgcaca acagattcac gcagaagagc 2100 ctctccctgt ctccgggtgg cggtggaggg tccggcggtg gtggatccga cattcagatg 2160 acacagtcac cgtctacgct ctcagcctca gtaggcgata gggtgactat cacctgccaa 2220 gcctcccaat ctataagttc acacctcaac tggtatcaac agaaacccgg taaagcaccg 2280 aagctgctca tctacaaggc atcaactctt gcctcaggtg tgcctagtcg cttctccggg 2340 agcggctccg gtactgagtt tactttgacg atatcttccc tccaacccga cgacttcgcc 2400 acatactatt gtcagcaggg ttatagttgg ggaaatgttg acaatgtgtt tggaggggga 2460 acgaaagtga ctgtgttggg agggggagga agtggcggcg gcggaagcgg aggtggtggc 2520 tccggcgggg gtggaagcga agtgcaattg ctcgaaagtg gtggcggact tgtgcaacct 2580 ggtggaagcc tctcactctc ttgcgcggcg agtggtttta gcttcagtag cggctacgat 2640 atgtgctggg taagacaggc tcctggtaaa ggccttgagt ggattgcgtg tatcgccgcc 2700 gggtctgctg gtataacata cgatgcaaac tgggcgaaag ggcgcttcac aatctccagg 2760 gacaactcaa aaaatacatt gtacctccag atgaatagcc tgagagccga agacaccgca 2820 gtctactatt gcgcaaggtc agcatttagc ttcgattatg caatggatct ttggggccag 2880 gggacgctcg tcaccgtctc atcttga 2907 <210> 25 <211> 962 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 25 Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 20 25 30 Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 85 90 95 Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 115 120 125 Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 130 135 140 Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 145 150 155 160 Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 165 170 175 Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 180 185 190 Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys 195 200 205 Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 210 215 220 Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 260 265 270 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 275 280 285 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 290 295 300 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 305 310 315 320 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 325 330 335 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 340 345 350 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 355 360 365 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 370 375 380 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 385 390 395 400 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 405 410 415 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 420 425 430 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 435 440 445 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 450 455 460 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 465 470 475 480 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 485 490 495 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 500 505 510 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 515 520 525 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 530 535 540 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 545 550 555 560 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 565 570 575 Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 580 585 590 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 595 600 605 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 610 615 620 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 625 630 635 640 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 645 650 655 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 660 665 670 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 675 680 685 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 690 695 700 Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr 705 710 715 720 Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile 725 730 735 Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln 740 745 750 Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn 755 760 765 Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 770 775 780 Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr 785 790 795 800 Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala 805 810 815 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly 820 825 830 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 835 840 845 Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 850 855 860 Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His Met 865 870 875 880 Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Thr 885 890 895 Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly Arg 900 905 910 Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln Met 915 920 925 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 930 935 940 Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr Val 945 950 955 960 Ser Ser <210> 26 <211> 2886 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 26 gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60 ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120 ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180 cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240 gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300 ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360 gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420 ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480 gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540 ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600 tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660 tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720 cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780 gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840 tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900 ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960 ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020 ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080 actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaag 1140 ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 1200 ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 1260 gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 1320 ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 1380 gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 1440 aaaactcaca catgcccacc gtgcccagca cctgaagccg cggggggacc gtcagtcttc 1500 ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1560 gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1620 gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt 1680 gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1740 gcggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1800 cagccccgag aaccacaggt gtataccctg cccccatccc gggatgagct gaccaagaac 1860 caggtcagcc tgtcctgcgc cgtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1920 gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1980 ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac 2040 gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 2100 tccctgtctc cgggtggcgg cggcggttca ggtggtgggg gatccgacgt tgtgatgacg 2160 cagtctccta gttcagtatc agcgtctgtt ggggatcgag tcacgattac atgccaggcg 2220 agccaaaata ttaggacgta tctgtcttgg tatcaacaaa agcctggtaa ggctccaaaa 2280 ctcctcattt acgccgctgc caacttggct agtggagtac cttcacgctt tagtgggtca 2340 ggttctggaa cagattttac gttgacgatc tccgatttgg aaccagggga cgctgccacg 2400 tattattgcc agtccaccta cctcgggact gactacgttg gtggggcgtt tggcggagga 2460 acaaaactca ctgtacttgg tggtggtggt tcaggcgggg ggggttccgg cggaggcggt 2520 tctgggggtg gaggttccga ggttcagttg gttgaaagtg gggggggact cgttcagcct 2580 ggaggctctt tgcgactttc ttgtaccgct tctgggttca ctataagttc atatcatatg 2640 caatgggtaa gacaggcgcc tggtaaggga cttgaataca taggaacaat aagctctggt 2700 ggtaacgtct attacgcctc atccgcgcgg gggaggttta caatttccag gccttctagc 2760 aaaaacacgg tagatctgca aatgaactct cttcgcgctg aagatacagc agtctactac 2820 tgcgccaggg attcagggta ttctgacccc atgtgggggc agggcacatt ggttaccgtg 2880 tcctct 2886 <210> 27 <211> 968 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 27 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala 260 265 270 Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile 275 280 285 Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 290 295 300 Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 305 310 315 320 Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 325 330 335 Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr 340 345 350 Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val 355 360 365 Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 370 375 380 Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 385 390 395 400 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 405 410 415 Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 420 425 430 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 435 440 445 Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 450 455 460 Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly 465 470 475 480 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 485 490 495 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 500 505 510 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 515 520 525 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 530 535 540 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 545 550 555 560 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 565 570 575 Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 580 585 590 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 595 600 605 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 610 615 620 Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 625 630 635 640 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 645 650 655 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 660 665 670 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 675 680 685 His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 690 695 700 Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 705 710 715 720 Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 725 730 735 Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr 740 745 750 Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser 755 760 765 Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 770 775 780 Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 785 790 795 800 Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val 805 810 815 Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly 820 825 830 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 835 840 845 Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 850 855 860 Ser Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp 865 870 875 880 Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 885 890 895 Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala 900 905 910 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 915 920 925 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 930 935 940 Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln 945 950 955 960 Gly Thr Leu Val Thr Val Ser Ser 965 <210> 28 <211> 2907 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 28 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt ctcgagcggc ggtggagggt ccggcggtgg tggatcagac 780 gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840 aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900 aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960 ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020 gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080 tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 1140 atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 1200 aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 1260 ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 1320 agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 1380 acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggaggc 1440 gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 1680 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740 tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800 gggcagcccc gagaaccaca ggtgtacacc ctgcccccaa gccgggatga gctgaccaag 1860 aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1920 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980 gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg 2040 aacgtcttct catgctccgt gatgcatgag gctctgcaca acagattcac gcagaagagc 2100 ctctccctgt ctccgggtgg cggtggaggg tccggcggtg gtggatccga cattcagatg 2160 acacagtcac cgtctacgct ctcagcctca gtaggcgata gggtgactat cacctgccaa 2220 gcctcccaat ctataagttc acacctcaac tggtatcaac agaaacccgg taaagcaccg 2280 aagctgctca tctacaaggc atcaactctt gcctcaggtg tgcctagtcg cttctccggg 2340 agcggctccg gtactgagtt tactttgacg atatcttccc tccaacccga cgacttcgcc 2400 acatactatt gtcagcaggg ttatagttgg ggaaatgttg acaatgtgtt tggaggggga 2460 acgaaagtga ctgtgttggg agggggagga agtggcggcg gcggaagcgg aggtggtggc 2520 tccggcgggg gtggaagcga agtgcaattg ctcgaaagtg gtggcggact tgtgcaacct 2580 ggtggaagcc tctcactctc ttgcgcggcg agtggtttta gcttcagtag cggctacgat 2640 atgtgctggg taagacaggc tcctggtaaa ggccttgagt ggattgcgtg tatcgccgcc 2700 gggtctgctg gtataacata cgatgcaaac tgggcgaaag ggcgcttcac aatctccagg 2760 gacaactcaa aaaatacatt gtacctccag atgaatagcc tgagagccga agacaccgca 2820 gtctactatt gcgcaaggtc agcatttagc ttcgattatg caatggatct ttggggccag 2880 gggacgctcg tcaccgtctc atcttga 2907 <210> 29 <211> 960 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 29 Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 20 25 30 Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 85 90 95 Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 115 120 125 Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 130 135 140 Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 145 150 155 160 Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 165 170 175 Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 180 185 190 Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys 195 200 205 Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 210 215 220 Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 260 265 270 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 275 280 285 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 290 295 300 Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val 305 310 315 320 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 325 330 335 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 340 345 350 Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr 355 360 365 Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 370 375 380 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 385 390 395 400 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 405 410 415 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 420 425 430 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 435 440 445 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 450 455 460 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 465 470 475 480 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 485 490 495 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 500 505 510 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 515 520 525 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 530 535 540 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 545 550 555 560 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 565 570 575 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 580 585 590 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 595 600 605 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 610 615 620 Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 625 630 635 640 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 645 650 655 Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 660 665 670 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 675 680 685 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 690 695 700 Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser 705 710 715 720 Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 725 730 735 Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln Gln Lys 740 745 750 Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn Leu Ala 755 760 765 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 770 775 780 Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr Tyr Tyr 785 790 795 800 Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala Phe Gly 805 810 815 Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly 820 825 830 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 835 840 845 Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 850 855 860 Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His Met Gln Trp 865 870 875 880 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Thr Ile Ser 885 890 895 Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly Arg Phe Thr 900 905 910 Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln Met Asn Ser 915 920 925 Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Gly 930 935 940 Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 945 950 955 960 <210> 30 <211> 2883 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 30 gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60 ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120 ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180 cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240 gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300 ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360 gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420 ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480 gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540 ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600 tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660 tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720 cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaca ggtgcagctg 780 caggagagtg gaggaggcct ggtgaagcct ggaggcagcc tgcggctgtc ctgtgctgcc 840 tctggcttca ccttctcctc ctactggatg agctgggtgc gccaggcccc aggcaagggc 900 ctggagtggg tggccaacat caacagagat ggctctgcct cctactatgt ggactctgtg 960 aaaggccgct tcaccatctc cagagatgat gccaagaaca gcctgtacct gcagatgaac 1020 agcctgagag ctgaggacac agctgtgtac tactgtgcca gagaccgagg tgtgggctac 1080 tttgacctgt ggggcagagg caccctggtg actgtgtcct ctgctagcac caagggccca 1140 tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc 1200 tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg 1260 accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc 1320 agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat 1380 cacaagccca gcaacaccaa ggtggacaag agagttgagc ccaaatcttg tgacaaaact 1440 cacacatgcc caccgtgccc agcacctgaa gccgcggggg gaccgtcagt cttcctcttc 1500 cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1560 gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1620 gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1680 agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcgcggtc 1740 tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1800 cgagaaccac aggtgtatac cctgccccca tcccgggatg agctgaccaa gaaccaggtc 1860 agcctgtcct gcgccgtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 1920 aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1980 ttcttcctcg tgagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 2040 tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 2100 tctccgggtg gcggcggcgg ttcaggtggt gggggatccg acgttgtgat gacgcagtct 2160 cctagttcag tatcagcgtc tgttggggat cgagtcacga ttacatgcca ggcgagccaa 2220 aatattagga cgtatctgtc ttggtatcaa caaaagcctg gtaaggctcc aaaactcctc 2280 atttacgccg ctgccaactt ggctagtgga gtaccttcac gctttagtgg gtcaggttct 2340 ggaacagatt ttacgttgac gatctccgat ttggaaccag gggacgctgc cacgtattat 2400 tgccagtcca cctacctcgg gactgactac gttggtgggg cgtttggcgg aggaacaaaa 2460 ctcactgtac ttggtggtgg tggttcaggc ggggggggtt ccggcggagg cggttctggg 2520 ggtggaggtt ccgaggttca gttggttgaa agtggggggg gactcgttca gcctggaggc 2580 tctttgcgac tttcttgtac cgcttctggg ttcactataa gttcatatca tatgcaatgg 2640 gtaagacagg cgcctggtaa gggacttgaa tacataggaa caataagctc tggtggtaac 2700 gtctattacg cctcatccgc gcgggggagg tttacaattt ccaggccttc tagcaaaaac 2760 acggtagatc tgcaaatgaa ctctcttcgc gctgaagata cagcagtcta ctactgcgcc 2820 agggattcag ggtattctga ccccatgtgg gggcagggca cattggttac cgtgtcctct 2880 tga 2883 <210> 31 <211> 969 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 31 Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 130 135 140 Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 145 150 155 160 Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 165 170 175 Leu Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala 180 185 190 Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 195 200 205 Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn 225 230 235 240 Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 245 250 255 Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val 260 265 270 Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser 275 280 285 Ser Asp Val Gly Gly Tyr Asn Phe Val Ser Trp Tyr Gln Gln His Pro 290 295 300 Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asp Arg Pro Ser 305 310 315 320 Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 325 330 335 Leu Ile Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys 340 345 350 Ser Ser Tyr Gly Ser Ser Ser Thr His Val Ile Phe Gly Gly Gly Thr 355 360 365 Lys Val Thr Val Leu Arg Thr Pro Lys Ala Asn Pro Thr Val Thr Leu 370 375 380 Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val 385 390 395 400 Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys 405 410 415 Ala Asp Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser 420 425 430 Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr 435 440 445 Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His 450 455 460 Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser Gly 465 470 475 480 Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 485 490 495 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 500 505 510 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 515 520 525 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 530 535 540 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 545 550 555 560 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 565 570 575 Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 580 585 590 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 595 600 605 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 610 615 620 Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 625 630 635 640 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 645 650 655 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 660 665 670 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 675 680 685 Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu 690 695 700 Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 705 710 715 720 Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val 725 730 735 Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp 740 745 750 Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala 755 760 765 Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 770 775 780 Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe 785 790 795 800 Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn 805 810 815 Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser 820 825 830 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 835 840 845 Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 850 855 860 Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr 865 870 875 880 Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 885 890 895 Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp 900 905 910 Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 915 920 925 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 930 935 940 Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly 945 950 955 960 Gln Gly Thr Leu Val Thr Val Ser Ser 965 <210> 32 <211> 2907 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 32 gacgtcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcaattgcc aagccagtga gagcattagc agttggttag cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaaggc tatttttatt ttattagtcg tacttatgta 300 aattctttcg gcggagggac caaggtggag atcaaaggcg gtggcggtag tgggggaggc 360 ggttctggcg gcggagggtc cggcggtgga ggatcagagg tgcagctggt ggagtctggg 420 ggaggcttgg tccagcctgg ggggtccctg agactctcct gtgcagcctc tggattcacc 480 atcagtacca atgcaatgag ctgggtccgc caggctccag ggaaggggct ggagtggatc 540 ggagtcatta ctggtcgtga tatcacatac tacgcgagct gggcgaaagg cagattcacc 600 atctccagag acaattccaa gaacacgctg tatcttcaaa tgaacagcct gagagccgag 660 gacacggctg tgtattactg tgcgagagac ggtggttctt ctgctattac tagtaacaac 720 atttggggcc agggaaccct ggtcaccgtg tcctcaggcg gtggagggtc cggcggtggt 780 ggatcacaga gtgccctgac ccagccagcc tctgtctctg gcagcccagg ccagtccatc 840 accatctcct gcacaggcac ctccagtgat gtgggaggct acaactttgt gtcctggtac 900 cagcagcacc caggcaaggc ccccaagctc atgatctatg atgtgtctga cagaccctct 960 ggagtctctg acagattctc tggctccaag agtggcaaca cagcctccct catcatctct 1020 ggcctgcagg ctgatgatga agctgactac tactgctcct cctatggctc ctcctccacc 1080 catgtcatct ttggaggagg caccaaggtc actgtgctgc gtacgcccaa ggccaacccc 1140 accgtgaccc tgttcccccc aagcagcgag gaactgcagg ccaacaaggc caccctcgtg 1200 tgcctgatca gcgacttcta ccctggcgcc gtgaccgtgg cctggaaggc cgatggatct 1260 cccgtgaagg ccggcgtgga aaccaccaag cccagcaagc agagcaacaa caaatacgcc 1320 gccagctcct acctgagcct gacccccgag cagtggaagt cccaccggtc ctacagctgc 1380 caggtcacac acgaaggcag caccgtggaa aagacagtgg cccccaccga gtgcagcgga 1440 ggcgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg gggaccgtca 1500 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 1560 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 1620 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 1680 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 1740 aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1800 aaagggcagc cccgagaacc acaggtgtac accctgcccc caagccggga tgagctgacc 1860 aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg 1920 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1980 tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 2040 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaacagatt cacgcagaag 2100 agcctctccc tgtctccggg tggcggtgga gggtccggcg gtggtggatc cgacattcag 2160 atgacacagt caccgtctac gctctcagcc tcagtaggcg atagggtgac tatcacctgc 2220 caagcctccc aatctataag ttcacacctc aactggtatc aacagaaacc cggtaaagca 2280 ccgaagctgc tcatctacaa ggcatcaact cttgcctcag gtgtgcctag tcgcttctcc 2340 gggagcggct ccggtactga gtttactttg acgatatctt ccctccaacc cgacgacttc 2400 gccacatact attgtcagca gggttatagt tggggaaatg ttgacaatgt gtttggaggg 2460 ggaacgaaag tgactgtgtt gggaggggga ggaagtggcg gcggcggaag cggaggtggt 2520 ggctccggcg ggggtggaag cgaagtgcaa ttgctcgaaa gtggtggcgg acttgtgcaa 2580 cctggtggaa gcctctcact ctcttgcgcg gcgagtggtt ttagcttcag tagcggctac 2640 gatatgtgct gggtaagaca ggctcctggt aaaggccttg agtggattgc gtgtatcgcc 2700 gccgggtctg ctggtataac atacgatgca aactgggcga aagggcgctt cacaatctcc 2760 agggacaact caaaaaatac attgtacctc cagatgaata gcctgagagc cgaagacacc 2820 gcagtctact attgcgcaag gtcagcattt agcttcgatt atgcaatgga tctttggggc 2880 caggggacgc tcgtcaccgt ctcatct 2907 <210> 33 <211> 962 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 33 Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 20 25 30 Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 85 90 95 Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 115 120 125 Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 130 135 140 Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 145 150 155 160 Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 165 170 175 Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 180 185 190 Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys 195 200 205 Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 210 215 220 Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 260 265 270 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 275 280 285 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 290 295 300 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 305 310 315 320 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 325 330 335 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 340 345 350 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 355 360 365 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 370 375 380 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 385 390 395 400 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 405 410 415 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 420 425 430 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 435 440 445 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 450 455 460 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 465 470 475 480 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 485 490 495 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 500 505 510 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 515 520 525 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 530 535 540 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 545 550 555 560 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 565 570 575 Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 580 585 590 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 595 600 605 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 610 615 620 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 625 630 635 640 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 645 650 655 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 660 665 670 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 675 680 685 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 690 695 700 Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr 705 710 715 720 Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile 725 730 735 Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln 740 745 750 Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn 755 760 765 Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 770 775 780 Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr 785 790 795 800 Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala 805 810 815 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly 820 825 830 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 835 840 845 Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 850 855 860 Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His Met 865 870 875 880 Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Thr 885 890 895 Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly Arg 900 905 910 Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln Met 915 920 925 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 930 935 940 Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr Val 945 950 955 960 Ser Ser <210> 34 <211> 2889 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 34 gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60 ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120 ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180 cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240 gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300 ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360 gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420 ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480 gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540 ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600 tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660 tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720 cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780 gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840 tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900 ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960 ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020 ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080 actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaag 1140 ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 1200 ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 1260 gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 1320 ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 1380 gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 1440 aaaactcaca catgcccacc gtgcccagca cctgaagccg cggggggacc gtcagtcttc 1500 ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1560 gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1620 gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt 1680 gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1740 gcggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1800 cagccccgag aaccacaggt gtataccctg cccccatccc gggatgagct gaccaagaac 1860 caggtcagcc tgtcctgcgc cgtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1920 gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1980 ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac 2040 gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 2100 tccctgtctc cgggtggcgg cggcggttca ggtggtgggg gatccgacgt tgtgatgacg 2160 cagtctccta gttcagtatc agcgtctgtt ggggatcgag tcacgattac atgccaggcg 2220 agccaaaata ttaggacgta tctgtcttgg tatcaacaaa agcctggtaa ggctccaaaa 2280 ctcctcattt acgccgctgc caacttggct agtggagtac cttcacgctt tagtgggtca 2340 ggttctggaa cagattttac gttgacgatc tccgatttgg aaccagggga cgctgccacg 2400 tattattgcc agtccaccta cctcgggact gactacgttg gtggggcgtt tggcggagga 2460 acaaaactca ctgtacttgg tggtggtggt tcaggcgggg ggggttccgg cggaggcggt 2520 tctgggggtg gaggttccga ggttcagttg gttgaaagtg gggggggact cgttcagcct 2580 ggaggctctt tgcgactttc ttgtaccgct tctgggttca ctataagttc atatcatatg 2640 caatgggtaa gacaggcgcc tggtaaggga cttgaataca taggaacaat aagctctggt 2700 ggtaacgtct attacgcctc atccgcgcgg gggaggttta caatttccag gccttctagc 2760 aaaaacacgg tagatctgca aatgaactct cttcgcgctg aagatacagc agtctactac 2820 tgcgccaggg attcagggta ttctgacccc atgtgggggc agggcacatt ggttaccgtg 2880 tcctcttga 2889 <210> 35 <211> 706 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 35 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala 260 265 270 Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile 275 280 285 Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 290 295 300 Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 305 310 315 320 Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 325 330 335 Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr 340 345 350 Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val 355 360 365 Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 370 375 380 Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 385 390 395 400 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 405 410 415 Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 420 425 430 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 435 440 445 Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 450 455 460 Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly 465 470 475 480 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 485 490 495 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 500 505 510 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 515 520 525 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 530 535 540 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 545 550 555 560 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 565 570 575 Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 580 585 590 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 595 600 605 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 610 615 620 Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 625 630 635 640 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 645 650 655 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 660 665 670 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 675 680 685 His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 690 695 700 Pro Gly 705 <210> 36 <211> 2121 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 36 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt ctcgagcggc ggtggagggt ccggcggtgg tggatcagac 780 gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840 aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900 aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960 ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020 gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080 tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcccc ctctgtgttc 1140 atcttcccac ccagtgatga gcagctgaag agtggcacag cctctgtggt gtgcctgctc 1200 aacaacttct accccagaga agccaaggtg cagtggaagg tggacaatgc cctgcagagt 1260 ggcaacagcc aggagagtgt gacagagcag gacagcaagg acagcaccta cagcctgtcc 1320 tccaccctga ccctgtccaa ggctgactat gagaagcaca aggtgtatgc ctgtgaggtg 1380 acccaccagg gcctgagcag ccctgtgacc aagagcttca accgaggaga gtgtggagga 1440 gacaagaccc acacctgccc tccctgccca gccccagaag ctgctggagg cccctctgtg 1500 ttcctcttcc ctcccaagcc caaggacacc ctgatgatct ccaggacccc agaagtcacc 1560 tgtgtggtgg tggatgtgtc ccatgaagac ccagaagtga agttcaactg gtatgtggat 1620 ggagtggaag tgcacaatgc caagaccaag cccagagaag agcagtacaa cagcacctac 1680 cgagtggtgt ctgtgctgac tgtgctgcac caggactggc tgaatgggaa ggagtacaag 1740 tgtgctgtgt ccaacaaggc cctgcctgcc cccattgaga agaccatctc caaggccaag 1800 ggccagccca gagagcccca ggtctacacc ctgcctccct ccagagatga gctgaccaag 1860 aaccaggtgt ccctgtggtg cctggtgaaa ggcttctacc ccagtgacat tgctgtggag 1920 tgggagagca atggccagcc agagaacaac tacaagacca cccctcctgt gctggactct 1980 gatggctcct tcttcctgta cagcaagctg actgtggaca agagccgctg gcagcagggc 2040 aatgtgttct cctgctctgt catgcatgag gccctgcaca accgcttcac ccagaagagc 2100 ctgagcctga gccctggatg a 2121 <210> 37 <211> 705 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 37 Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 20 25 30 Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 85 90 95 Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 115 120 125 Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 130 135 140 Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 145 150 155 160 Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 165 170 175 Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 180 185 190 Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys 195 200 205 Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 210 215 220 Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 260 265 270 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 275 280 285 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 290 295 300 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 305 310 315 320 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 325 330 335 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 340 345 350 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 355 360 365 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 370 375 380 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 385 390 395 400 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 405 410 415 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 420 425 430 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 435 440 445 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 450 455 460 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 465 470 475 480 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 485 490 495 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 500 505 510 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 515 520 525 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 530 535 540 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 545 550 555 560 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 565 570 575 Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 580 585 590 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 595 600 605 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 610 615 620 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 625 630 635 640 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 645 650 655 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 660 665 670 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 675 680 685 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 690 695 700 Gly 705 <210> 38 <211> 2118 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 38 gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60 ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120 ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180 cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240 gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300 ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360 gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420 ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480 gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540 ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600 tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660 tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720 cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780 gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840 tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900 ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960 ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020 ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080 actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaaa 1140 ggcccctctg tgttccctct ggccccctcc tccaagagca cctctggagg cactgctgcc 1200 ctgggctgcc tggtgaagga ctacttccca gagcctgtga ctgtgtcctg gaactctgga 1260 gccctgacct ctggagtgca caccttccct gctgtgctgc agagctctgg cctctacagc 1320 ctgtcctctg tggtcactgt gccctcctcc agcctgggca cccagaccta catctgcaat 1380 gtgaaccaca agccctccaa caccaaggtg gacaagagag tggagcccaa gtcctgtgac 1440 aagacccaca cctgccctcc ctgcccagcc ccagaggctg ctggaggccc ctctgtgttc 1500 ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 1560 gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 1620 gtggaggtgc acaatgccaa gaccaagccc agagaagagc agtacaactc cacctaccga 1680 gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 1740 gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1800 cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1860 caggtgtccc tgtcctgtgc tgtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1920 gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1980 ggctccttct tcctggtctc caagctgact gtggacaaga gccgctggca gcagggcaat 2040 gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc actacaccca gaagagcctg 2100 agcctgagcc ctggatga 2118 <210> 39 <211> 968 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 39 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala 260 265 270 Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile 275 280 285 Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 290 295 300 Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 305 310 315 320 Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 325 330 335 Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr 340 345 350 Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val 355 360 365 Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 370 375 380 Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 385 390 395 400 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 405 410 415 Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 420 425 430 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 435 440 445 Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 450 455 460 Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly 465 470 475 480 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 485 490 495 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 500 505 510 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 515 520 525 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 530 535 540 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 545 550 555 560 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 565 570 575 Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 580 585 590 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 595 600 605 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 610 615 620 Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 625 630 635 640 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 645 650 655 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 660 665 670 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 675 680 685 His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 690 695 700 Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 705 710 715 720 Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 725 730 735 Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr 740 745 750 Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser 755 760 765 Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 770 775 780 Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 785 790 795 800 Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val 805 810 815 Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly 820 825 830 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 835 840 845 Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 850 855 860 Ser Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp 865 870 875 880 Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 885 890 895 Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala 900 905 910 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 915 920 925 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 930 935 940 Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln 945 950 955 960 Gly Thr Leu Val Thr Val Ser Ser 965 <210> 40 <211> 2907 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 40 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt ctcgagcggc ggtggagggt ccggcggtgg tggatcagac 780 gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840 aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900 aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960 ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020 gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080 tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 1140 atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 1200 aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 1260 ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 1320 agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 1380 acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggaggc 1440 gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 1680 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740 tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800 gggcagcccc gagaaccaca ggtgtacacc ctgcccccaa gccgggatga gctgaccaag 1860 aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1920 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980 gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg 2040 aacgtcttct catgctccgt gatgcatgag gctctgcaca acagattcac gcagaagagc 2100 ctctccctgt ctccgggtgg cggtggaggg tccggcggtg gtggatccga cattcagatg 2160 acacagtcac cgtctacgct ctcagcctca gtaggcgata gggtgactat cacctgccaa 2220 gcctcccaat ctataagttc acacctcaac tggtatcaac agaaacccgg taaagcaccg 2280 aagctgctca tctacaaggc atcaactctt gcctcaggtg tgcctagtcg cttctccggg 2340 agcggctccg gtactgagtt tactttgacg atatcttccc tccaacccga cgacttcgcc 2400 acatactatt gtcagcaggg ttatagttgg ggaaatgttg acaatgtgtt tggaggggga 2460 acgaaagtga ctgtgttggg agggggagga agtggcggcg gcggaagcgg aggtggtggc 2520 tccggcgggg gtggaagcga agtgcaattg ctcgaaagtg gtggcggact tgtgcaacct 2580 ggtggaagcc tctcactctc ttgcgcggcg agtggtttta gcttcagtag cggctacgat 2640 atgtgctggg taagacaggc tcctggtaaa ggccttgagt ggattgcgtg tatcgccgcc 2700 gggtctgctg gtataacata cgatgcaaac tgggcgaaag ggcgcttcac aatctccagg 2760 gacaactcaa aaaatacatt gtacctccag atgaatagcc tgagagccga agacaccgca 2820 gtctactatt gcgcaaggtc agcatttagc ttcgattatg caatggatct ttggggccag 2880 gggacgctcg tcaccgtctc atcttga 2907 <210> 41 <211> 705 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 41 Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 20 25 30 Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 85 90 95 Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 115 120 125 Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 130 135 140 Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 145 150 155 160 Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 165 170 175 Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 180 185 190 Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys 195 200 205 Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 210 215 220 Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 260 265 270 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 275 280 285 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 290 295 300 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 305 310 315 320 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 325 330 335 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 340 345 350 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 355 360 365 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 370 375 380 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 385 390 395 400 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 405 410 415 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 420 425 430 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 435 440 445 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 450 455 460 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 465 470 475 480 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 485 490 495 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 500 505 510 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 515 520 525 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 530 535 540 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 545 550 555 560 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 565 570 575 Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 580 585 590 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 595 600 605 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 610 615 620 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 625 630 635 640 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 645 650 655 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 660 665 670 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 675 680 685 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 690 695 700 Gly 705 <210> 42 <211> 2118 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 42 gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60 ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120 ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180 cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240 gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300 ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360 gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420 ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480 gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540 ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600 tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660 tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720 cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780 gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840 tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900 ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960 ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020 ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080 actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaaa 1140 ggcccctctg tgttccctct ggccccctcc tccaagagca cctctggagg cactgctgcc 1200 ctgggctgcc tggtgaagga ctacttccca gagcctgtga ctgtgtcctg gaactctgga 1260 gccctgacct ctggagtgca caccttccct gctgtgctgc agagctctgg cctctacagc 1320 ctgtcctctg tggtcactgt gccctcctcc agcctgggca cccagaccta catctgcaat 1380 gtgaaccaca agccctccaa caccaaggtg gacaagagag tggagcccaa gtcctgtgac 1440 aagacccaca cctgccctcc ctgcccagcc ccagaggctg ctggaggccc ctctgtgttc 1500 ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 1560 gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 1620 gtggaggtgc acaatgccaa gaccaagccc agagaagagc agtacaactc cacctaccga 1680 gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 1740 gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1800 cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1860 caggtgtccc tgtcctgtgc tgtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1920 gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1980 ggctccttct tcctggtctc caagctgact gtggacaaga gccgctggca gcagggcaat 2040 gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc actacaccca gaagagcctg 2100 agcctgagcc ctggatga 2118 <210> 43 <211> 706 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 43 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala 260 265 270 Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile 275 280 285 Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 290 295 300 Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 305 310 315 320 Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 325 330 335 Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr 340 345 350 Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val 355 360 365 Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 370 375 380 Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 385 390 395 400 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 405 410 415 Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 420 425 430 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 435 440 445 Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 450 455 460 Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly 465 470 475 480 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 485 490 495 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 500 505 510 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 515 520 525 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 530 535 540 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 545 550 555 560 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 565 570 575 Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 580 585 590 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 595 600 605 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 610 615 620 Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 625 630 635 640 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 645 650 655 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 660 665 670 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 675 680 685 His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 690 695 700 Pro Gly 705 <210> 44 <211> 2121 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 44 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt ctcgagcggc ggtggagggt ccggcggtgg tggatcagac 780 gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840 aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900 aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960 ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020 gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080 tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcccc ctctgtgttc 1140 atcttcccac ccagtgatga gcagctgaag agtggcacag cctctgtggt gtgcctgctc 1200 aacaacttct accccagaga agccaaggtg cagtggaagg tggacaatgc cctgcagagt 1260 ggcaacagcc aggagagtgt gacagagcag gacagcaagg acagcaccta cagcctgtcc 1320 tccaccctga ccctgtccaa ggctgactat gagaagcaca aggtgtatgc ctgtgaggtg 1380 acccaccagg gcctgagcag ccctgtgacc aagagcttca accgaggaga gtgtggagga 1440 gacaagaccc acacctgccc tccctgccca gccccagaag ctgctggagg cccctctgtg 1500 ttcctcttcc ctcccaagcc caaggacacc ctgatgatct ccaggacccc agaagtcacc 1560 tgtgtggtgg tggatgtgtc ccatgaagac ccagaagtga agttcaactg gtatgtggat 1620 ggagtggaag tgcacaatgc caagaccaag cccagagaag agcagtacaa cagcacctac 1680 cgagtggtgt ctgtgctgac tgtgctgcac caggactggc tgaatgggaa ggagtacaag 1740 tgtgctgtgt ccaacaaggc cctgcctgcc cccattgaga agaccatctc caaggccaag 1800 ggccagccca gagagcccca ggtctacacc ctgcctccct ccagagatga gctgaccaag 1860 aaccaggtgt ccctgtggtg cctggtgaaa ggcttctacc ccagtgacat tgctgtggag 1920 tgggagagca atggccagcc agagaacaac tacaagacca cccctcctgt gctggactct 1980 gatggctcct tcttcctgta cagcaagctg actgtggaca agagccgctg gcagcagggc 2040 aatgtgttct cctgctctgt catgcatgag gccctgcaca accgcttcac ccagaagagc 2100 ctgagcctga gccctggatg a 2121 <210> 45 <211> 698 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 45 Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 20 25 30 Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 85 90 95 Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 115 120 125 Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 130 135 140 Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 145 150 155 160 Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 165 170 175 Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 180 185 190 Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys 195 200 205 Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 210 215 220 Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu 260 265 270 Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn 275 280 285 Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 290 295 300 Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 305 310 315 320 Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met 325 330 335 Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly 340 345 350 Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 355 360 365 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 370 375 380 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 385 390 395 400 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 405 410 415 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 420 425 430 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 435 440 445 Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 450 455 460 Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 465 470 475 480 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 485 490 495 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 500 505 510 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 515 520 525 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 530 535 540 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 545 550 555 560 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 565 570 575 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 580 585 590 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 595 600 605 Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 610 615 620 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 625 630 635 640 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 645 650 655 Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 660 665 670 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 675 680 685 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 690 695 <210> 46 <211> 2097 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 46 gagatcgtgc tgacccagtc tccttccaca ctgtctgtgt ctcccggcga gagagccacc 60 ttcagctgta gagcctctca gtccatcggc accaacatcc actggtatca gcagaagccc 120 ggcaagcctc ctcggctgct gattaagtac gcctccgagt ccatcagcgg catccctgac 180 agattctccg gctctggctc tggcaccgag tttaccctga ccatctcctc cgtgcagtcc 240 gaggatttcg ccgtgtacta ctgccagcag aacaacaact ggcccaccac ctttggaccc 300 ggcaccaagc tgacagttct tggcggcgga ggatctggcg gaggtggaag cggaggcgga 360 ggaagcggtg gcggcggatc tcaagttcag ttgcagcagt ctggccctgg cctggtcaag 420 ccttctgaga cactgtccat cacctgtacc gtgtccggct tctccctgac caattacggc 480 gtgcactgga tcagacaggc ccctggcaaa ggactggaat ggctgggagt gatttggagc 540 ggcggcaaca ccgactacaa cacccctttc accagccggt tcaccatcac caaggacaac 600 tccaagaacc aggtgtactt caagctgcgg agcgtgcggg ctgatgacac cgccatctac 660 tactgtgctc gggccctgac ctactacgac tacgagtttg cttactgggg ccagggcacc 720 ctggtcacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaca agtgcagttg 780 caagaaagtg gtggtagact ggttcagcct ggtgaaccct tgtcactgac gtgtaaaaca 840 agcggcattg atctgtcctc taacgccatc ggatgggtcc gacaggcccc aggaaaaggt 900 ctggagtgga tcggagttat cttcgggagc ggcaatacat actacgcaag ctgggcaaaa 960 gggcgattta cgatatcacg gagcacctct acagtttatt tgaaaatgaa ctccctccgg 1020 tccgaggata ccgcgatata ttactgtgcc agaggggggt actcctctga tatctggggg 1080 cagggtacac tggttacagt ttcatccgct agcaccaaag gcccctctgt gttccctctg 1140 gccccctcct ccaagagcac ctctggaggc actgctgccc tgggctgcct ggtgaaggac 1200 tacttcccag agcctgtgac tgtgtcctgg aactctggag ccctgacctc tggagtgcac 1260 accttccctg ctgtgctgca gagctctggc ctctacagcc tgtcctctgt ggtcactgtg 1320 ccctcctcca gcctgggcac ccagacctac atctgcaatg tgaaccacaa gccctccaac 1380 accaaggtgg acaagagagt ggagcccaag tcctgtgaca agacccacac ctgccctccc 1440 tgcccagccc cagaggctgc tggaggcccc tctgtgttcc tcttccctcc caagcccaag 1500 gacaccctga tgatctccag gaccccagaa gtcacctgtg tggtggtgga tgtgtcccat 1560 gaagacccag aagtgaagtt caactggtat gtggatggag tggaggtgca caatgccaag 1620 accaagccca gagaagagca gtacaactcc acctaccgag tggtgtctgt gctgactgtg 1680 ctgcaccagg actggctgaa tgggaaggag tacaagtgtg ctgtgtccaa caaggccctg 1740 cctgccccca ttgagaagac catctccaag gccaagggcc agcccagaga gccccaggtc 1800 tacaccctgc ctccctccag agatgagctg accaagaacc aggtgtccct gtcctgtgct 1860 gtgaaaggct tctaccccag tgacattgct gtggagtggg agagcaatgg ccagccagag 1920 aacaactaca agaccacccc tcctgtgctg gactctgatg gctccttctt cctggtctcc 1980 aagctgactg tggacaagag ccgctggcag cagggcaatg tgttctcctg ctctgtcatg 2040 catgaggccc tgcacaacca ctacacccag aagagcctga gcctgagccc tggatga 2097 <210> 47 <211> 704 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 47 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 260 265 270 Thr Val Gly Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val 275 280 285 Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro 290 295 300 Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro 305 310 315 320 Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile 325 330 335 Thr Arg Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg 340 345 350 Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile 355 360 365 Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 370 375 380 Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 385 390 395 400 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 405 410 415 Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 420 425 430 Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 435 440 445 Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 450 455 460 Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys 465 470 475 480 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 485 490 495 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 500 505 510 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 515 520 525 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 530 535 540 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 545 550 555 560 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 565 570 575 Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 580 585 590 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 595 600 605 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 610 615 620 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 625 630 635 640 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 645 650 655 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 660 665 670 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 675 680 685 Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 690 695 700 <210> 48 <211> 2112 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 48 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt ctcgagtggc ggtggagggt ccggcggtgg tggatcagat 780 cctcaattga cccagtcccc tagtagcctt tctgcaaccg tgggccagag ggtaacaatc 840 aattgccagt caagccagtc cgtagcgaag aataataatt tggcatggtt ccaacaaaaa 900 ccgggtaaac ctcctaaact ccttatctac tcagcttcaa cccttgccgc gggtgtgccc 960 agccggttct caggctcagg ttccgggact caatttacac ttaccatcac tcgcgtccaa 1020 agtgaggatt ttgcaaccta ctattgttct gcacgggatt ccgggaacat acagtccttt 1080 gggggtggaa ctcgggtgga gataaaacgt acggtggctg ccccctctgt gttcatcttc 1140 ccacccagtg atgagcagct gaagagtggc acagcctctg tggtgtgcct gctcaacaac 1200 ttctacccca gagaagccaa ggtgcagtgg aaggtggaca atgccctgca gagtggcaac 1260 agccaggaga gtgtgacaga gcaggacagc aaggacagca cctacagcct gtcctccacc 1320 ctgaccctgt ccaaggctga ctatgagaag cacaaggtgt atgcctgtga ggtgacccac 1380 cagggcctga gcagccctgt gaccaagagc ttcaaccgag gagagtgtgg aggagacaag 1440 acccacacct gccctccctg cccagcccca gaagctgctg gaggcccctc tgtgttcctc 1500 ttccctccca agcccaagga caccctgatg atctccagga ccccagaagt cacctgtgtg 1560 gtggtggatg tgtcccatga agacccagaa gtgaagttca actggtatgt ggatggagtg 1620 gaagtgcaca atgccaagac caagcccaga gaagagcagt acaacagcac ctaccgagtg 1680 gtgtctgtgc tgactgtgct gcaccaggac tggctgaatg ggaaggagta caagtgtgct 1740 gtgtccaaca aggccctgcc tgcccccatt gagaagacca tctccaaggc caagggccag 1800 cccagagagc cccaggtcta caccctgcct ccctccagag atgagctgac caagaaccag 1860 gtgtccctgt ggtgcctggt gaaaggcttc taccccagtg acattgctgt ggagtgggag 1920 agcaatggcc agccagagaa caactacaag accacccctc ctgtgctgga ctctgatggc 1980 tccttcttcc tgtacagcaa gctgactgtg gacaagagcc gctggcagca gggcaatgtg 2040 ttctcctgct ctgtcatgca tgaggccctg cacaaccgct tcacccagaa gagcctgagc 2100 ctgagccctg ga 2112 <210> 49 <211> 698 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 49 Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu 1 5 10 15 Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn 20 25 30 Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met 65 70 75 80 Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly 85 90 95 Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 115 120 125 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 130 135 140 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 145 150 155 160 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 165 170 175 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 180 185 190 Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 195 200 205 Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 210 215 220 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 225 230 235 240 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 245 250 255 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 260 265 270 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 275 280 285 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 290 295 300 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 305 310 315 320 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 325 330 335 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 340 345 350 Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 355 360 365 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 370 375 380 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 385 390 395 400 Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 405 410 415 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 420 425 430 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 435 440 445 Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 450 455 460 Lys Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser 465 470 475 480 Leu Thr Asn Tyr Gly Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly 485 490 495 Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn 500 505 510 Thr Pro Phe Thr Ser Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn 515 520 525 Gln Val Tyr Phe Lys Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile 530 535 540 Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr 545 550 555 560 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 565 570 575 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 580 585 590 Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly Glu 595 600 605 Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile 610 615 620 His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile Lys 625 630 635 640 Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 645 650 655 Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser Glu 660 665 670 Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr 675 680 685 Phe Gly Pro Gly Thr Lys Leu Thr Val Leu 690 695 <210> 50 <211> 2097 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 50 caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60 acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120 ccaggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180 agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240 aactccctcc ggtccgagga taccgcgata tattactgtg ccagaggggg gtactcctct 300 gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360 gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420 ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480 tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540 gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600 aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660 acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720 cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780 gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840 cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900 gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960 aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020 gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080 ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140 ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200 ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260 tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320 cctggaggag gaggaggctc tggaggagga ggatcccaag ttcagttgca gcagtctggc 1380 cctggcctgg tcaagccttc tgagacactg tccatcacct gtaccgtgtc cggcttctcc 1440 ctgaccaatt acggcgtgca ctggatcaga caggcccctg gcaaaggact ggaatggctg 1500 ggagtgattt ggagcggcgg caacaccgac tacaacaccc ctttcaccag ccggttcacc 1560 atcaccaagg acaactccaa gaaccaggtg tacttcaagc tgcggagcgt gcgggctgat 1620 gacaccgcca tctactactg tgctcgggcc ctgacctact acgactacga gtttgcttac 1680 tggggccagg gcaccctggt cacagtttct tctggtggtg gtggttcagg cggggggggt 1740 tccggcggag gcggttctgg gggtggaggt tccgagatcg tgctgaccca gtctccttcc 1800 acactgtctg tgtctcccgg cgagagagcc accttcagct gtagagcctc tcagtccatc 1860 ggcaccaaca tccactggta tcagcagaag cccggcaagc ctcctcggct gctgattaag 1920 tacgcctccg agtccatcag cggcatccct gacagattct ccggctctgg ctctggcacc 1980 gagtttaccc tgaccatctc ctccgtgcag tccgaggatt tcgccgtgta ctactgccag 2040 cagaacaaca actggcccac cacctttgga cccggcacca agctgaccgt gctgtga 2097 <210> 51 <211> 699 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 51 Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly 1 5 10 15 Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Ala Lys Asn 20 25 30 Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Arg Val 65 70 75 80 Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly 85 90 95 Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr 210 215 220 Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 225 230 235 240 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 245 250 255 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 260 265 270 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 275 280 285 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 290 295 300 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 305 310 315 320 Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 325 330 335 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 340 345 350 Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 355 360 365 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 370 375 380 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 385 390 395 400 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 405 410 415 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 420 425 430 Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly 450 455 460 Gly Leu Val Lys Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser 465 470 475 480 Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro 485 490 495 Gly Lys Gly Leu Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala 500 505 510 Ser Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 515 520 525 Asp Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 530 535 540 Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe 545 550 555 560 Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 565 570 575 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 580 585 590 Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 595 600 605 Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Phe Val Ser 610 615 620 Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp 625 630 635 640 Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 645 650 655 Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu Gln Ala Asp Asp 660 665 670 Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser Ser Thr His Val 675 680 685 Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu 690 695 <210> 52 <211> 2100 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 52 gatcctcaat tgacccagtc ccctagtagc ctttctgcaa ccgtgggcca gagggtaaca 60 atcaattgcc agtcaagcca gtccgtagcg aagaataata atttggcatg gttccaacaa 120 aaaccgggta aacctcctaa actccttatc tactcagctt caacccttgc cgcgggtgtg 180 cccagccggt tctcaggctc aggttccggg actcaattta cacttaccat cactcgcgtc 240 caaagtgagg attttgcaac ctactattgt tctgcacggg attccgggaa catacagtcc 300 tttgggggtg gaactcgggt ggagataaaa cgtacggtgg ctgccccctc tgtgttcatc 360 ttcccaccca gtgatgagca gctgaagagt ggcacagcct ctgtggtgtg cctgctcaac 420 aacttctacc ccagagaagc caaggtgcag tggaaggtgg acaatgccct gcagagtggc 480 aacagccagg agagtgtgac agagcaggac agcaaggaca gcacctacag cctgtcctcc 540 accctgaccc tgtccaaggc tgactatgag aagcacaagg tgtatgcctg tgaggtgacc 600 caccagggcc tgagcagccc tgtgaccaag agcttcaacc gaggagagtg tggaggagac 660 aagacccaca cctgccctcc ctgcccagcc ccagaagctg ctggaggccc ctctgtgttc 720 ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 780 gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 840 gtggaagtgc acaatgccaa gaccaagccc agagaagagc agtacaacag cacctaccga 900 gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 960 gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1020 cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1080 caggtgtccc tgtggtgcct ggtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1140 gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1200 ggctccttct tcctgtacag caagctgact gtggacaaga gccgctggca gcagggcaat 1260 gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc gcttcaccca gaagagcctg 1320 agcctgagcc ctggaggagg aggaggctct ggaggaggag gatcccaggt gcagctgcag 1380 gagtcggggg gaggcctggt caagcctgga gggtccctga gcctctcctg tgcagcctct 1440 ggattcacct ttagtagtta ttggatgagc tgggtccgcc aggctccagg gaaggggctg 1500 gagtgggtgg ccaacataaa ccgcgatgga agtgcgagtt actatgtgga ctctgtgaag 1560 ggccgattca ccatctccag agacgacgcc aagaactcac tgtatctgca aatgaacagc 1620 ctgagagctg aggacacggc tgtgtattac tgtgcgagag atcgtggggt gggctacttc 1680 gatctctggg gccgtggcac cctggtcacc gtgtctagcg gtggaggcgg ttcaggcgga 1740 ggtggttccg gcggtggcgg ctcccagtct gccctgactc agcctgcctc cgtgtctggg 1800 tctcctggac agtcgatcac catctcctgc actggaacca gcagtgacgt tggtggttat 1860 aactttgtct cctggtacca acaacaccca ggcaaagccc ccaaactcat gatctatgat 1920 gtcagtgatc ggccctcagg ggtgtctgat cgcttctccg gctccaagtc tggcaacacg 1980 gcctccctga tcatctctgg cctccaggct gacgacgagg ctgattatta ctgcagctca 2040 tatgggagca gcagcactca tgtgattttc ggcggaggga ccaaggtgac cgtcctataa 2100 <210> 53 <211> 705 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 53 Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 20 25 30 Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 85 90 95 Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 115 120 125 Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 130 135 140 Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 145 150 155 160 Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 165 170 175 Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 180 185 190 Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys 195 200 205 Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 210 215 220 Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 260 265 270 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 275 280 285 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 290 295 300 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 305 310 315 320 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 325 330 335 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 340 345 350 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 355 360 365 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 370 375 380 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 385 390 395 400 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 405 410 415 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 420 425 430 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 435 440 445 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 450 455 460 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 465 470 475 480 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 485 490 495 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 500 505 510 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 515 520 525 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 530 535 540 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 545 550 555 560 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 565 570 575 Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 580 585 590 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 595 600 605 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 610 615 620 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 625 630 635 640 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 645 650 655 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 660 665 670 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 675 680 685 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 690 695 700 Gly 705 <210> 54 <211> 2118 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 54 gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60 ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120 ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180 cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240 gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300 ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360 gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420 ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480 gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540 ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600 tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660 tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720 cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780 gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840 tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900 ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960 ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020 ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080 actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaaa 1140 ggcccctctg tgttccctct ggccccctcc tccaagagca cctctggagg cactgctgcc 1200 ctgggctgcc tggtgaagga ctacttccca gagcctgtga ctgtgtcctg gaactctgga 1260 gccctgacct ctggagtgca caccttccct gctgtgctgc agagctctgg cctctacagc 1320 ctgtcctctg tggtcactgt gccctcctcc agcctgggca cccagaccta catctgcaat 1380 gtgaaccaca agccctccaa caccaaggtg gacaagagag tggagcccaa gtcctgtgac 1440 aagacccaca cctgccctcc ctgcccagcc ccagaggctg ctggaggccc ctctgtgttc 1500 ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 1560 gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 1620 gtggaggtgc acaatgccaa gaccaagccc agagaagagc agtacaactc cacctaccga 1680 gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 1740 gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1800 cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1860 caggtgtccc tgtcctgtgc tgtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1920 gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1980 ggctccttct tcctggtctc caagctgact gtggacaaga gccgctggca gcagggcaat 2040 gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc actacaccca gaagagcctg 2100 agcctgagcc ctggatga 2118 <210> 55 <211> 447 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 55 Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 115 120 125 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 130 135 140 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 145 150 155 160 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 165 170 175 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 180 185 190 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 195 200 205 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 <210> 56 <211> 1344 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 56 gacgtggtca tgacacagag cccttccaca ctgtctgcct ccgtgggcga tagagtgacc 60 atcaactgtc aggcctccga gtccatctcc tcttggctgg cttggtatca gcagaagcct 120 ggcaaggccc ctaagctgct gatctacgag gcttccaagc tggcctctgg cgtgccctct 180 agattttccg gctctggctc tggcaccgag tttaccctga caatctccag cctgcagcct 240 gacgacttcg ccacctacta ctgccaaggc tacttctact tcatctcccg gacctacgtg 300 aactccttcg gcggaggcac caaggtggag atcaagcgta cggtggctgc cccctctgtg 360 ttcatcttcc cacccagtga tgagcagctg aagagtggca cagcctctgt ggtgtgcctg 420 ctcaacaact tctaccccag agaagccaag gtgcagtgga aggtggacaa tgccctgcag 480 agtggcaaca gccaggagag tgtgacagag caggacagca aggacagcac ctacagcctg 540 tcctccaccc tgaccctgtc caaggctgac tatgagaagc acaaggtgta tgcctgtgag 600 gtgacccacc agggcctgag cagccctgtg accaagagct tcaaccgagg agagtgtgga 660 ggagacaaga cccacacctg ccctccctgc ccagccccag aagctgctgg aggcccctct 720 gtgttcctct tccctcccaa gcccaaggac accctgatga tctccaggac cccagaagtc 780 acctgtgtgg tggtggatgt gtcccatgaa gacccagaag tgaagttcaa ctggtatgtg 840 gatggagtgg aagtgcacaa tgccaagacc aagcccagag aagagcagta caacagcacc 900 taccgagtgg tgtctgtgct gactgtgctg caccaggact ggctgaatgg gaaggagtac 960 aagtgtgctg tgtccaacaa ggccctgcct gcccccattg agaagaccat ctccaaggcc 1020 aagggccagc ccagagagcc ccaggtctac accctgcctc cctccagaga tgagctgacc 1080 aagaaccagg tgtccctgtg gtgcctggtg aaaggcttct accccagtga cattgctgtg 1140 gagtgggaga gcaatggcca gccagagaac aactacaaga ccacccctcc tgtgctggac 1200 tctgatggct ccttcttcct gtacagcaag ctgactgtgg acaagagccg ctggcagcag 1260 ggcaatgtgt tctcctgctc tgtcatgcat gaggccctgc acaaccgctt cacccagaag 1320 agcctgagcc tgagccctgg atga 1344 <210> 57 <211> 449 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 57 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 225 230 235 240 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 355 360 365 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly <210> 58 <211> 1350 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 58 gaggtgcagc tggttgaatc tggcggagga ttggttcagc ctggcggctc tctgagactg 60 tcttgtgccg cttctggctt caccatctcc accaacgcca tgtcctgggt ccgacaggct 120 cctggcaaag gcctggaatg gatcggcgtg atcaccggca gagatattac ctactacgcc 180 tcctgggcca agggcagatt caccatcagc cgggacaact ccaagaacac cctgtacctg 240 cagatgaact ccctgagagc cgaggacacc gccgtgtact actgtgctag agatggcggc 300 agcagcgcca tcacctccaa caatatttgg ggccagggca ccctggtcac tgtgtcctct 360 gctagcacca aaggcccctc tgtgttccct ctggccccct cctccaagag cacctctgga 420 ggcactgctg ccctgggctg cctggtgaag gactacttcc cagagcctgt gactgtgtcc 480 tggaactctg gagccctgac ctctggagtg cacaccttcc ctgctgtgct gcagagctct 540 ggcctctaca gcctgtcctc tgtggtcact gtgccctcct ccagcctggg cacccagacc 600 tacatctgca atgtgaacca caagccctcc aacaccaagg tggacaagag agtggagccc 660 aagtcctgtg acaagaccca cacctgccct ccctgcccag ccccagaggc tgctggaggc 720 ccctctgtgt tcctcttccc tcccaagccc aaggacaccc tgatgatctc caggacccca 780 gaagtcacct gtgtggtggt ggatgtgtcc catgaagacc cagaagtgaa gttcaactgg 840 tatgtggatg gagtggaggt gcacaatgcc aagaccaagc ccagagaaga gcagtacaac 900 tccacctacc gagtggtgtc tgtgctgact gtgctgcacc aggactggct gaatgggaag 960 gagtacaagt gtgctgtgtc caacaaggcc ctgcctgccc ccattgagaa gaccatctcc 1020 aaggccaagg gccagcccag agagccccag gtctacaccc tgcctccctc cagagatgag 1080 ctgaccaaga accaggtgtc cctgtcctgt gctgtgaaag gcttctaccc cagtgacatt 1140 gctgtggagt gggagagcaa tggccagcca gagaacaact acaagaccac ccctcctgtg 1200 ctggactctg atggctcctt cttcctggtc tccaagctga ctgtggacaa gagccgctgg 1260 cagcagggca atgtgttctc ctgctctgtc atgcatgagg ccctgcacaa ccactacacc 1320 cagaagagcc tgagcctgag ccctggatga 1350 <210> 59 <211> 706 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 59 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala 260 265 270 Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile 275 280 285 Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 290 295 300 Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 305 310 315 320 Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 325 330 335 Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr 340 345 350 Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val 355 360 365 Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 370 375 380 Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 385 390 395 400 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 405 410 415 Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 420 425 430 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 435 440 445 Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 450 455 460 Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly 465 470 475 480 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 485 490 495 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 500 505 510 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 515 520 525 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 530 535 540 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 545 550 555 560 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 565 570 575 Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 580 585 590 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 595 600 605 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 610 615 620 Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 625 630 635 640 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 645 650 655 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 660 665 670 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 675 680 685 His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 690 695 700 Pro Gly 705 <210> 60 <211> 2121 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 60 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt ctcgagcggc ggtggagggt ccggcggtgg tggatcagac 780 gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840 aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900 aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960 ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020 gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080 tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcccc ctctgtgttc 1140 atcttcccac ccagtgatga gcagctgaag agtggcacag cctctgtggt gtgcctgctc 1200 aacaacttct accccagaga agccaaggtg cagtggaagg tggacaatgc cctgcagagt 1260 ggcaacagcc aggagagtgt gacagagcag gacagcaagg acagcaccta cagcctgtcc 1320 tccaccctga ccctgtccaa ggctgactat gagaagcaca aggtgtatgc ctgtgaggtg 1380 acccaccagg gcctgagcag ccctgtgacc aagagcttca accgaggaga gtgtggagga 1440 gacaagaccc acacctgccc tccctgccca gccccagaag ctgctggagg cccctctgtg 1500 ttcctcttcc ctcccaagcc caaggacacc ctgatgatct ccaggacccc agaagtcacc 1560 tgtgtggtgg tggatgtgtc ccatgaagac ccagaagtga agttcaactg gtatgtggat 1620 ggagtggaag tgcacaatgc caagaccaag cccagagaag agcagtacaa cagcacctac 1680 cgagtggtgt ctgtgctgac tgtgctgcac caggactggc tgaatgggaa ggagtacaag 1740 tgtgctgtgt ccaacaaggc cctgcctgcc cccattgaga agaccatctc caaggccaag 1800 ggccagccca gagagcccca ggtctacacc ctgcctccct ccagagatga gctgaccaag 1860 aaccaggtgt ccctgtggtg cctggtgaaa ggcttctacc ccagtgacat tgctgtggag 1920 tgggagagca atggccagcc agagaacaac tacaagacca cccctcctgt gctggactct 1980 gatggctcct tcttcctgta cagcaagctg actgtggaca agagccgctg gcagcagggc 2040 aatgtgttct cctgctctgt catgcatgag gccctgcaca accgcttcac ccagaagagc 2100 ctgagcctga gccctggatg a 2121 <210> 61 <211> 449 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 61 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 225 230 235 240 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 355 360 365 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly <210> 62 <211> 1350 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 62 gaggtgcagc tggttgaatc tggcggagga ttggttcagc ctggcggctc tctgagactg 60 tcttgtgccg cttctggctt caccatctcc accaacgcca tgtcctgggt ccgacaggct 120 cctggcaaag gcctggaatg gatcggcgtg atcaccggca gagatattac ctactacgcc 180 tcctgggcca agggcagatt caccatcagc cgggacaact ccaagaacac cctgtacctg 240 cagatgaact ccctgagagc cgaggacacc gccgtgtact actgtgctag agatggcggc 300 agcagcgcca tcacctccaa caatatttgg ggccagggca ccctggtcac tgtgtcctct 360 gctagcacca aaggcccctc tgtgttccct ctggccccct cctccaagag cacctctgga 420 ggcactgctg ccctgggctg cctggtgaag gactacttcc cagagcctgt gactgtgtcc 480 tggaactctg gagccctgac ctctggagtg cacaccttcc ctgctgtgct gcagagctct 540 ggcctctaca gcctgtcctc tgtggtcact gtgccctcct ccagcctggg cacccagacc 600 tacatctgca atgtgaacca caagccctcc aacaccaagg tggacaagag agtggagccc 660 aagtcctgtg acaagaccca cacctgccct ccctgcccag ccccagaggc tgctggaggc 720 ccctctgtgt tcctcttccc tcccaagccc aaggacaccc tgatgatctc caggacccca 780 gaagtcacct gtgtggtggt ggatgtgtcc catgaagacc cagaagtgaa gttcaactgg 840 tatgtggatg gagtggaggt gcacaatgcc aagaccaagc ccagagaaga gcagtacaac 900 tccacctacc gagtggtgtc tgtgctgact gtgctgcacc aggactggct gaatgggaag 960 gagtacaagt gtgctgtgtc caacaaggcc ctgcctgccc ccattgagaa gaccatctcc 1020 aaggccaagg gccagcccag agagccccag gtctacaccc tgcctccctc cagagatgag 1080 ctgaccaaga accaggtgtc cctgtcctgt gctgtgaaag gcttctaccc cagtgacatt 1140 gctgtggagt gggagagcaa tggccagcca gagaacaact acaagaccac ccctcctgtg 1200 ctggactctg atggctcctt cttcctggtc tccaagctga ctgtggacaa gagccgctgg 1260 cagcagggca atgtgttctc ctgctctgtc atgcatgagg ccctgcacaa ccactacacc 1320 cagaagagcc tgagcctgag ccctggatga 1350 <210> 63 <211> 447 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 63 Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 115 120 125 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 130 135 140 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 145 150 155 160 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 165 170 175 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 180 185 190 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 195 200 205 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 <210> 64 <211> 1344 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 64 gacgtggtca tgacacagag cccttccaca ctgtctgcct ccgtgggcga tagagtgacc 60 atcaactgtc aggcctccga gtccatctcc tcttggctgg cttggtatca gcagaagcct 120 ggcaaggccc ctaagctgct gatctacgag gcttccaagc tggcctctgg cgtgccctct 180 agattttccg gctctggctc tggcaccgag tttaccctga caatctccag cctgcagcct 240 gacgacttcg ccacctacta ctgccaaggc tacttctact tcatctcccg gacctacgtg 300 aactccttcg gcggaggcac caaggtggag atcaagcgta cggtggctgc cccctctgtg 360 ttcatcttcc cacccagtga tgagcagctg aagagtggca cagcctctgt ggtgtgcctg 420 ctcaacaact tctaccccag agaagccaag gtgcagtgga aggtggacaa tgccctgcag 480 agtggcaaca gccaggagag tgtgacagag caggacagca aggacagcac ctacagcctg 540 tcctccaccc tgaccctgtc caaggctgac tatgagaagc acaaggtgta tgcctgtgag 600 gtgacccacc agggcctgag cagccctgtg accaagagct tcaaccgagg agagtgtgga 660 ggagacaaga cccacacctg ccctccctgc ccagccccag aagctgctgg aggcccctct 720 gtgttcctct tccctcccaa gcccaaggac accctgatga tctccaggac cccagaagtc 780 acctgtgtgg tggtggatgt gtcccatgaa gacccagaag tgaagttcaa ctggtatgtg 840 gatggagtgg aagtgcacaa tgccaagacc aagcccagag aagagcagta caacagcacc 900 taccgagtgg tgtctgtgct gactgtgctg caccaggact ggctgaatgg gaaggagtac 960 aagtgtgctg tgtccaacaa ggccctgcct gcccccattg agaagaccat ctccaaggcc 1020 aagggccagc ccagagagcc ccaggtctac accctgcctc cctccagaga tgagctgacc 1080 aagaaccagg tgtccctgtg gtgcctggtg aaaggcttct accccagtga cattgctgtg 1140 gagtgggaga gcaatggcca gccagagaac aactacaaga ccacccctcc tgtgctggac 1200 tctgatggct ccttcttcct gtacagcaag ctgactgtgg acaagagccg ctggcagcag 1260 ggcaatgtgt tctcctgctc tgtcatgcat gaggccctgc acaaccgctt cacccagaag 1320 agcctgagcc tgagccctgg atga 1344 <210> 65 <211> 442 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 65 Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu 1 5 10 15 Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn 20 25 30 Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met 65 70 75 80 Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly 85 90 95 Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 115 120 125 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 130 135 140 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 145 150 155 160 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 165 170 175 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 180 185 190 Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 195 200 205 Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 210 215 220 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 225 230 235 240 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 245 250 255 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 260 265 270 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 275 280 285 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 290 295 300 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 305 310 315 320 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 325 330 335 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 340 345 350 Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 355 360 365 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 370 375 380 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 385 390 395 400 Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 405 410 415 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 420 425 430 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 <210> 66 <211> 1326 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 66 caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60 acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120 ccaggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180 agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240 aactccctcc ggtccgagga taccgcgata tattactgtg ccagaggggg gtactcctct 300 gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360 gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420 ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480 tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540 gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600 aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660 acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720 cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780 gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840 cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900 gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960 aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020 gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080 ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140 ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200 ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260 tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320 cctgga 1326 <210> 67 <211> 445 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 67 Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly 1 5 10 15 Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Ala Lys Asn 20 25 30 Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Arg Val 65 70 75 80 Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly 85 90 95 Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr 210 215 220 Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 225 230 235 240 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 245 250 255 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 260 265 270 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 275 280 285 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 290 295 300 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 305 310 315 320 Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 325 330 335 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 340 345 350 Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 355 360 365 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 370 375 380 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 385 390 395 400 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 405 410 415 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 420 425 430 Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 <210> 68 <211> 1338 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 68 gatcctcaat tgacccagtc ccctagtagc ctttctgcaa ccgtgggcca gagggtaaca 60 atcaattgcc agtcaagcca gtccgtagcg aagaataata atttggcatg gttccaacaa 120 aaaccgggta aacctcctaa actccttatc tactcagctt caacccttgc cgcgggtgtg 180 cccagccggt tctcaggctc aggttccggg actcaattta cacttaccat cactcgcgtc 240 caaagtgagg attttgcaac ctactattgt tctgcacggg attccgggaa catacagtcc 300 tttgggggtg gaactcgggt ggagataaaa cgtacggtgg ctgccccctc tgtgttcatc 360 ttcccaccca gtgatgagca gctgaagagt ggcacagcct ctgtggtgtg cctgctcaac 420 aacttctacc ccagagaagc caaggtgcag tggaaggtgg acaatgccct gcagagtggc 480 aacagccagg agagtgtgac agagcaggac agcaaggaca gcacctacag cctgtcctcc 540 accctgaccc tgtccaaggc tgactatgag aagcacaagg tgtatgcctg tgaggtgacc 600 caccagggcc tgagcagccc tgtgaccaag agcttcaacc gaggagagtg tggaggagac 660 aagacccaca cctgccctcc ctgcccagcc ccagaagctg ctggaggccc ctctgtgttc 720 ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 780 gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 840 gtggaagtgc acaatgccaa gaccaagccc agagaagagc agtacaacag cacctaccga 900 gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 960 gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1020 cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1080 caggtgtccc tgtggtgcct ggtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1140 gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1200 ggctccttct tcctgtacag caagctgact gtggacaaga gccgctggca gcagggcaat 1260 gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc gcttcaccca gaagagcctg 1320 agcctgagcc ctggatga 1338 <210> 69 <211> 962 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 69 Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 20 25 30 Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 85 90 95 Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 115 120 125 Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 130 135 140 Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 145 150 155 160 Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 165 170 175 Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 180 185 190 Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys 195 200 205 Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 210 215 220 Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 260 265 270 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 275 280 285 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 290 295 300 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 305 310 315 320 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 325 330 335 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 340 345 350 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 355 360 365 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 370 375 380 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 385 390 395 400 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 405 410 415 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 420 425 430 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 435 440 445 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 450 455 460 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 465 470 475 480 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 485 490 495 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 500 505 510 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 515 520 525 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 530 535 540 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 545 550 555 560 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 565 570 575 Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 580 585 590 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 595 600 605 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 610 615 620 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 625 630 635 640 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 645 650 655 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 660 665 670 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 675 680 685 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 690 695 700 Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr 705 710 715 720 Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile 725 730 735 Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln 740 745 750 Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn 755 760 765 Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 770 775 780 Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr 785 790 795 800 Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala 805 810 815 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly 820 825 830 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 835 840 845 Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 850 855 860 Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His Met 865 870 875 880 Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Thr 885 890 895 Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly Arg 900 905 910 Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln Met 915 920 925 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 930 935 940 Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr Val 945 950 955 960 Ser Ser <210> 70 <211> 2889 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 70 gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60 ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120 ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180 cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240 gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300 ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360 gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420 ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480 gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540 ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600 tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660 tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720 cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780 gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840 tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900 ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960 ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020 ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080 actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaag 1140 ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 1200 ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 1260 gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 1320 ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 1380 gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 1440 aaaactcaca catgcccacc gtgcccagca cctgaagccg cggggggacc gtcagtcttc 1500 ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1560 gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1620 gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt 1680 gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1740 gcggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1800 cagccccgag aaccacaggt gtataccctg cccccatccc gggatgagct gaccaagaac 1860 caggtcagcc tgtcctgcgc cgtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1920 gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1980 ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac 2040 gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 2100 tccctgtctc cgggtggcgg cggcggttca ggtggtgggg gatccgacgt tgtgatgacg 2160 cagtctccta gttcagtatc agcgtctgtt ggggatcgag tcacgattac atgccaggcg 2220 agccaaaata ttaggacgta tctgtcttgg tatcaacaaa agcctggtaa ggctccaaaa 2280 ctcctcattt acgccgctgc caacttggct agtggagtac cttcacgctt tagtgggtca 2340 ggttctggaa cagattttac gttgacgatc tccgatttgg aaccagggga cgctgccacg 2400 tattattgcc agtccaccta cctcgggact gactacgttg gtggggcgtt tggcggagga 2460 acaaaactca ctgtacttgg tggtggtggt tcaggcgggg ggggttccgg cggaggcggt 2520 tctgggggtg gaggttccga ggttcagttg gttgaaagtg gggggggact cgttcagcct 2580 ggaggctctt tgcgactttc ttgtaccgct tctgggttca ctataagttc atatcatatg 2640 caatgggtaa gacaggcgcc tggtaaggga cttgaataca taggaacaat aagctctggt 2700 ggtaacgtct attacgcctc atccgcgcgg gggaggttta caatttccag gccttctagc 2760 aaaaacacgg tagatctgca aatgaactct cttcgcgctg aagatacagc agtctactac 2820 tgcgccaggg attcagggta ttctgacccc atgtgggggc agggcacatt ggttaccgtg 2880 tcctcttga 2889 <210> 71 <211> 965 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 71 Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu 130 135 140 Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met 145 150 155 160 Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 165 170 175 Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys 180 185 190 Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu 195 200 205 Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 210 215 220 Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 260 265 270 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 275 280 285 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 290 295 300 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 305 310 315 320 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 325 330 335 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 340 345 350 Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 355 360 365 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 370 375 380 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 385 390 395 400 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 405 410 415 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 420 425 430 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 435 440 445 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 450 455 460 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr 465 470 475 480 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 485 490 495 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 500 505 510 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 515 520 525 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 530 535 540 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 545 550 555 560 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 565 570 575 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 580 585 590 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 595 600 605 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 610 615 620 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 625 630 635 640 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 645 650 655 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 660 665 670 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 675 680 685 Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 690 695 700 Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 705 710 715 720 Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 725 730 735 Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys 740 745 750 Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala 755 760 765 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 770 775 780 Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 785 790 795 800 Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly 805 810 815 Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly 820 825 830 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 835 840 845 Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser 850 855 860 Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp 865 870 875 880 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala 885 890 895 Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg 900 905 910 Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 915 920 925 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser 930 935 940 Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu 945 950 955 960 Val Thr Val Ser Ser 965 <210> 72 <211> 2898 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 72 gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60 atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120 caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180 ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240 gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300 acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360 tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420 ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480 ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540 tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600 acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660 tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720 ctcgtcacgg tctcgagcgg cggtggaggg tccggcggtg gtggatcaga cgtcgtgatg 780 acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat caattgccaa 840 gccagtgaga gcattagcag ttggttagcc tggtatcagc agaaaccagg gaaagcccct 900 aagctcctga tctatgaagc atccaaactg gcatctgggg tcccatcaag gttcagcggc 960 agtggatctg ggacagaatt cactctcacc atcagcagcc tgcagcctga tgattttgca 1020 acttattact gccaaggcta tttttatttt attagtcgta cttatgtaaa ttctttcggc 1080 ggagggacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg 1140 ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc 1200 tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc 1260 caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg 1320 acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag 1380 ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtggagg cgacaaaact 1440 cacacatgcc caccgtgccc agcacctgaa gccgcggggg gaccgtcagt cttcctcttc 1500 cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1560 gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1620 gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1680 agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcgcggtc 1740 tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1800 cgagaaccac aggtgtacac cctgccccca agccgggatg agctgaccaa gaaccaggtc 1860 agcctgtggt gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 1920 aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1980 ttcttcctct atagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 2040 tcatgctccg tgatgcatga ggctctgcac aacagattca cgcagaagag cctctccctg 2100 tctccgggtg gcggtggagg gtccggcggt ggtggatccg acattcagat gacacagtca 2160 ccgtctacgc tctcagcctc agtaggcgat agggtgacta tcacctgcca agcctcccaa 2220 tctataagtt cacacctcaa ctggtatcaa cagaaacccg gtaaagcacc gaagctgctc 2280 atctacaagg catcaactct tgcctcaggt gtgcctagtc gcttctccgg gagcggctcc 2340 ggtactgagt ttactttgac gatatcttcc ctccaacccg acgacttcgc cacatactat 2400 tgtcagcagg gttatagttg gggaaatgtt gacaatgtgt ttggaggggg aacgaaagtg 2460 actgtgttgg gagggggagg aagtggcggc ggcggaagcg gaggtggtgg ctccggcggg 2520 ggtggaagcg aagtgcaatt gctcgaaagt ggtggcggac ttgtgcaacc tggtggaagc 2580 ctctcactct cttgcgcggc gagtggtttt agcttcagta gcggctacga tatgtgctgg 2640 gtaagacagg ctcctggtaa aggccttgag tggattgcgt gtatcgccgc cgggtctgct 2700 ggtataacat acgatgcaaa ctgggcgaaa gggcgcttca caatctccag ggacaactca 2760 aaaaatacat tgtacctcca gatgaatagc ctgagagccg aagacaccgc agtctactat 2820 tgcgcaaggt cagcatttag cttcgattat gcaatggatc tttggggcca ggggacgctc 2880 gtcaccgtct catcttga 2898 <210> 73 <211> 967 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 73 Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 130 135 140 Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 145 150 155 160 Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 165 170 175 Leu Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala 180 185 190 Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 195 200 205 Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn 225 230 235 240 Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 245 250 255 Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 260 265 270 Leu Val Lys Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly 275 280 285 Phe Ser Leu Thr Asn Tyr Gly Val His Trp Ile Arg Gln Ala Pro Gly 290 295 300 Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp 305 310 315 320 Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr Ile Thr Lys Asp Asn Ser 325 330 335 Lys Asn Gln Val Tyr Phe Lys Leu Arg Ser Val Arg Ala Asp Asp Thr 340 345 350 Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe 355 360 365 Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 370 375 380 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 385 390 395 400 Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 405 410 415 Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 420 425 430 Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 435 440 445 Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 450 455 460 Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 465 470 475 480 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 485 490 495 Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 500 505 510 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 515 520 525 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 530 535 540 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 545 550 555 560 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 565 570 575 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu 580 585 590 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 595 600 605 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 610 615 620 Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 625 630 635 640 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 645 650 655 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 660 665 670 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 675 680 685 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 690 695 700 Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 705 710 715 720 Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 725 730 735 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr 740 745 750 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 755 760 765 Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 770 775 780 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro 785 790 795 800 Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp 805 810 815 Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 820 825 830 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 835 840 845 Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 850 855 860 Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile 865 870 875 880 Ser Ser Tyr His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 885 890 895 Glu Tyr Ile Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser 900 905 910 Ser Ala Arg Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr 915 920 925 Val Asp Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 930 935 940 Tyr Cys Ala Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly 945 950 955 960 Thr Leu Val Thr Val Ser Ser 965 <210> 74 <211> 2904 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 74 gacgtcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcaattgcc aagccagtga gagcattagc agttggttag cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaaggc tatttttatt ttattagtcg tacttatgta 300 aattctttcg gcggagggac caaggtggag atcaaaggcg gtggcggtag tgggggaggc 360 ggttctggcg gcggagggtc cggcggtgga ggatcagagg tgcagctggt ggagtctggg 420 ggaggcttgg tccagcctgg ggggtccctg agactctcct gtgcagcctc tggattcacc 480 atcagtacca atgcaatgag ctgggtccgc caggctccag ggaaggggct ggagtggatc 540 ggagtcatta ctggtcgtga tatcacatac tacgcgagct gggcgaaagg cagattcacc 600 atctccagag acaattccaa gaacacgctg tatcttcaaa tgaacagcct gagagccgag 660 gacacggctg tgtattactg tgcgagagac ggtggttctt ctgctattac tagtaacaac 720 atttggggcc agggaaccct ggtcaccgtc tcgagtggcg gtggagggtc cggcggtggt 780 ggatcacaag tacagttgca gcaatccggt cccggtctcg tcaaaccgag tgagacgctt 840 agtataacgt gtactgtttc aggctttagc cttacgaact atggagttca ctggattcgg 900 caggcacccg gcaaaggttt ggaatggctg ggtgttattt ggtcaggtgg aaatacagac 960 tataacaccc cctttacaag tcggttcaca attacgaaag ataattccaa aaatcaagtt 1020 tatttcaagt tgagatccgt ccgcgcggac gacactgcga tctactattg tgcgagggca 1080 ctgacctact acgattacga atttgcgtat tgggggcaag ggactcttgt aacagtctcc 1140 agtgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct 1200 gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg 1260 tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc 1320 tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag 1380 acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag 1440 cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga agccgcgggg 1500 ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc 1560 cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac 1620 tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac 1680 aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc 1740 aaggagtaca agtgcgcggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc 1800 tccaaagcca aagggcagcc ccgagaacca caggtgtata ccctgccccc atcccgggat 1860 gagctgacca agaaccaggt cagcctgtcc tgcgccgtca aaggcttcta tcccagcgac 1920 atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc 1980 gtgctggact ccgacggctc cttcttcctc gtgagcaagc tcaccgtgga caagagcagg 2040 tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac 2100 acgcagaaga gcctctccct gtctccgggt ggcggcggcg gttcaggtgg tgggggatcc 2160 gacgttgtga tgacgcagtc tcctagttca gtatcagcgt ctgttgggga tcgagtcacg 2220 attacatgcc aggcgagcca aaatattagg acgtatctgt cttggtatca acaaaagcct 2280 ggtaaggctc caaaactcct catttacgcc gctgccaact tggctagtgg agtaccttca 2340 cgctttagtg ggtcaggttc tggaacagat tttacgttga cgatctccga tttggaacca 2400 ggggacgctg ccacgtatta ttgccagtcc acctacctcg ggactgacta cgttggtggg 2460 gcgtttggcg gaggaacaaa actcactgta cttggtggtg gtggttcagg cggggggggt 2520 tccggcggag gcggttctgg gggtggaggt tccgaggttc agttggttga aagtgggggg 2580 ggactcgttc agcctggagg ctctttgcga ctttcttgta ccgcttctgg gttcactata 2640 agttcatatc atatgcaatg ggtaagacag gcgcctggta agggacttga atacatagga 2700 acaataagct ctggtggtaa cgtctattac gcctcatccg cgcgggggag gtttacaatt 2760 tccaggcctt ctagcaaaaa cacggtagat ctgcaaatga actctcttcg cgctgaagat 2820 acagcagtct actactgcgc cagggattca gggtattctg accccatgtg ggggcagggc 2880 acattggtta ccgtgtcctc ttga 2904 <210> 75 <211> 960 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 75 Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu 130 135 140 Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met 145 150 155 160 Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 165 170 175 Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys 180 185 190 Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu 195 200 205 Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 210 215 220 Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly 260 265 270 Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 275 280 285 Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 290 295 300 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 305 310 315 320 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 325 330 335 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 340 345 350 Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Arg Thr Val Ala Ala 355 360 365 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 370 375 380 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 385 390 395 400 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 405 410 415 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 420 425 430 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 435 440 445 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 450 455 460 Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro 465 470 475 480 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 485 490 495 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 500 505 510 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 515 520 525 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 530 535 540 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 545 550 555 560 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 565 570 575 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 580 585 590 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 595 600 605 Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 610 615 620 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 625 630 635 640 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 645 650 655 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 660 665 670 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 675 680 685 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 690 695 700 Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 705 710 715 720 Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser 725 730 735 Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 740 745 750 Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser 755 760 765 Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 770 775 780 Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr 785 790 795 800 Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Thr 805 810 815 Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 820 825 830 Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 835 840 845 Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly 850 855 860 Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro 865 870 875 880 Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly 885 890 895 Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg 900 905 910 Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 915 920 925 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp 930 935 940 Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 945 950 955 960 <210> 76 <211> 2883 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 76 gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60 atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120 caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180 ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240 gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300 acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360 tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420 ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480 ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540 tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600 acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660 tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720 ctcgtcacgg tctcgagtgg cggtggaggg tccggcggtg gtggatcaga aatcgtcctt 780 acacaatctc ctagcacact gagtgtgagc cccggcgaac gcgcgacttt ctcttgcagg 840 gcaagtcaat ccatagggac taatatacat tggtatcaac aaaagccagg taaaccaccc 900 aggcttttga ttaagtatgc aagtgagtct atttccggta tccctgaccg cttctctgga 960 tcaggcagtg gcacagagtt cacactcacc atatctagtg tgcaatcaga ggacttcgcc 1020 gtgtattact gccaacagaa taataactgg ccgactacct tcggacccgg tacaaagctg 1080 accgttttac gtacggtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag 1140 ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc 1200 aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca 1260 gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca 1320 gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc 1380 gtcacaaaga gcttcaacag gggagagtgt ggaggcgaca aaactcacac atgcccaccg 1440 tgcccagcac ctgaagccgc ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 1500 gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 1560 gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 1620 acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 1680 ctgcaccagg actggctgaa tggcaaggag tacaagtgcg cggtctccaa caaagccctc 1740 ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 1800 tacaccctgc ccccaagccg ggatgagctg accaagaacc aggtcagcct gtggtgcctg 1860 gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 1920 aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctatagc 1980 aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 2040 catgaggctc tgcacaacag attcacgcag aagagcctct ccctgtctcc gggtggcggt 2100 ggagggtccg gcggtggtgg atccgacatt cagatgacac agtcaccgtc tacgctctca 2160 gcctcagtag gcgatagggt gactatcacc tgccaagcct cccaatctat aagttcacac 2220 ctcaactggt atcaacagaa acccggtaaa gcaccgaagc tgctcatcta caaggcatca 2280 actcttgcct caggtgtgcc tagtcgcttc tccgggagcg gctccggtac tgagtttact 2340 ttgacgatat cttccctcca acccgacgac ttcgccacat actattgtca gcagggttat 2400 agttggggaa atgttgacaa tgtgtttgga gggggaacga aagtgactgt gttgggaggg 2460 ggaggaagtg gcggcggcgg aagcggaggt ggtggctccg gcgggggtgg aagcgaagtg 2520 caattgctcg aaagtggtgg cggacttgtg caacctggtg gaagcctctc actctcttgc 2580 gcggcgagtg gttttagctt cagtagcggc tacgatatgt gctgggtaag acaggctcct 2640 ggtaaaggcc ttgagtggat tgcgtgtatc gccgccgggt ctgctggtat aacatacgat 2700 gcaaactggg cgaaagggcg cttcacaatc tccagggaca actcaaaaaa tacattgtac 2760 ctccagatga atagcctgag agccgaagac accgcagtct actattgcgc aaggtcagca 2820 tttagcttcg attatgcaat ggatctttgg ggccagggga cgctcgtcac cgtctcatct 2880 tga 2883 <210> 77 <211> 967 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 77 Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Gln Gly Thr Lys Leu Thr Val Leu 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 130 135 140 Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 145 150 155 160 Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 165 170 175 Leu Glu Trp Val Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala 180 185 190 Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn 195 200 205 Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn 225 230 235 240 Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 245 250 255 Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly 260 265 270 Leu Val Lys Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly 275 280 285 Phe Ser Leu Thr Asn Tyr Gly Val His Trp Ile Arg Gln Ala Pro Gly 290 295 300 Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp 305 310 315 320 Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr Ile Thr Lys Asp Asn Ser 325 330 335 Lys Asn Gln Val Tyr Phe Lys Leu Arg Ser Val Arg Ala Asp Asp Thr 340 345 350 Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe 355 360 365 Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 370 375 380 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 385 390 395 400 Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 405 410 415 Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 420 425 430 Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 435 440 445 Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 450 455 460 Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 465 470 475 480 Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 485 490 495 Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 500 505 510 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 515 520 525 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 530 535 540 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 545 550 555 560 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 565 570 575 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu 580 585 590 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 595 600 605 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 610 615 620 Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 625 630 635 640 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 645 650 655 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 660 665 670 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 675 680 685 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 690 695 700 Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 705 710 715 720 Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 725 730 735 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr 740 745 750 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 755 760 765 Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 770 775 780 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro 785 790 795 800 Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp 805 810 815 Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 820 825 830 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 835 840 845 Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 850 855 860 Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile 865 870 875 880 Ser Ser Tyr His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 885 890 895 Glu Tyr Ile Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser 900 905 910 Ser Ala Arg Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr 915 920 925 Val Asp Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 930 935 940 Tyr Cys Ala Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly 945 950 955 960 Thr Leu Val Thr Val Ser Ser 965 <210> 78 <211> 2904 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 78 gaaatcgtta tgacgcagag tccctccacg ctctccgcta gtgtcgggga tcgcgtcatt 60 atcacatgcc aggcctccga gtcaatcagc agctggcttg catggtatca acagaagccg 120 ggaaaagctc ctaaattgct gatctatgaa gcgtcaaaat tggcgtctgg tgtcccatct 180 aggttctccg gctctgggtc tggtgcggaa tttactttga caatctccag tcttcaacca 240 gacgatttcg ctacctacta ctgccaaggg tatttctatt ttataagccg gacatatgta 300 aactccttcg gccaaggaac aaagttgact gttcttggtg gcggaggcag tggtggcggg 360 ggcagcggag gtggtggttc agggggtggt gggagcgaag tccaattggt agaaagtggc 420 ggtggtctgg tgcaacctgg tggatctctt cgcctctcat gcgccgctag tggctttact 480 atttcaacta atgcgatgag ctgggttcgc caggcccccg gcaaaggact tgagtgggtc 540 ggcgtcatca ccggcaggga cattacatac tatgcgagtt gggcaaaggg caggttcacg 600 attagccgcg atacttcaaa gaataccgtt taccttcaaa tgaatagctt gagggcggaa 660 gacacagctg tgtattactg cgcgagggat ggaggtagtt ccgccataac ttccaacaac 720 atatggggac aaggcacgct ggttactgtc tcgagtggcg gtggagggtc cggcggtggt 780 ggatcacaag tacagttgca gcaatccggt cccggtctcg tcaaaccgag tgagacgctt 840 agtataacgt gtactgtttc aggctttagc cttacgaact atggagttca ctggattcgg 900 caggcacccg gcaaaggttt ggaatggctg ggtgttattt ggtcaggtgg aaatacagac 960 tataacaccc cctttacaag tcggttcaca attacgaaag ataattccaa aaatcaagtt 1020 tatttcaagt tgagatccgt ccgcgcggac gacactgcga tctactattg tgcgagggca 1080 ctgacctact acgattacga atttgcgtat tgggggcaag ggactcttgt aacagtctcc 1140 agtgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct 1200 gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg 1260 tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc 1320 tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag 1380 acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag 1440 cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga agccgcgggg 1500 ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc 1560 cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac 1620 tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac 1680 aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc 1740 aaggagtaca agtgcgcggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc 1800 tccaaagcca aagggcagcc ccgagaacca caggtgtata ccctgccccc atcccgggat 1860 gagctgacca agaaccaggt cagcctgtcc tgcgccgtca aaggcttcta tcccagcgac 1920 atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc 1980 gtgctggact ccgacggctc cttcttcctc gtgagcaagc tcaccgtgga caagagcagg 2040 tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac 2100 acgcagaaga gcctctccct gtctccgggt ggcggcggcg gttcaggtgg tgggggatcc 2160 gacgttgtga tgacgcagtc tcctagttca gtatcagcgt ctgttgggga tcgagtcacg 2220 attacatgcc aggcgagcca aaatattagg acgtatctgt cttggtatca acaaaagcct 2280 ggtaaggctc caaaactcct catttacgcc gctgccaact tggctagtgg agtaccttca 2340 cgctttagtg ggtcaggttc tggaacagat tttacgttga cgatctccga tttggaacca 2400 ggggacgctg ccacgtatta ttgccagtcc acctacctcg ggactgacta cgttggtggg 2460 gcgtttggcg gaggaacaaa actcactgta cttggtggtg gtggttcagg cggggggggt 2520 tccggcggag gcggttctgg gggtggaggt tccgaggttc agttggttga aagtgggggg 2580 ggactcgttc agcctggagg ctctttgcga ctttcttgta ccgcttctgg gttcactata 2640 agttcatatc atatgcaatg ggtaagacag gcgcctggta agggacttga atacatagga 2700 acaataagct ctggtggtaa cgtctattac gcctcatccg cgcgggggag gtttacaatt 2760 tccaggcctt ctagcaaaaa cacggtagat ctgcaaatga actctcttcg cgctgaagat 2820 acagcagtct actactgcgc cagggattca gggtattctg accccatgtg ggggcagggc 2880 acattggtta ccgtgtcctc ttga 2904 <210> 79 <211> 960 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 79 Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu 130 135 140 Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met 145 150 155 160 Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 165 170 175 Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys 180 185 190 Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu 195 200 205 Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 210 215 220 Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly 260 265 270 Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 275 280 285 Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 290 295 300 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 305 310 315 320 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 325 330 335 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 340 345 350 Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Arg Thr Val Ala Ala 355 360 365 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 370 375 380 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 385 390 395 400 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 405 410 415 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 420 425 430 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 435 440 445 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 450 455 460 Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro 465 470 475 480 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 485 490 495 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 500 505 510 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 515 520 525 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 530 535 540 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 545 550 555 560 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 565 570 575 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 580 585 590 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 595 600 605 Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 610 615 620 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 625 630 635 640 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 645 650 655 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 660 665 670 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 675 680 685 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 690 695 700 Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 705 710 715 720 Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser 725 730 735 Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 740 745 750 Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser 755 760 765 Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 770 775 780 Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr 785 790 795 800 Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Thr 805 810 815 Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 820 825 830 Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 835 840 845 Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly 850 855 860 Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro 865 870 875 880 Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly 885 890 895 Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg 900 905 910 Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 915 920 925 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp 930 935 940 Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 945 950 955 960 <210> 80 <211> 2883 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 80 gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60 atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120 caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180 ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240 gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300 acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360 tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420 ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480 ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540 tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600 acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660 tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720 ctcgtcacgg tctcgagtgg cggtggaggg tccggcggtg gtggatcaga aatcgtcctt 780 acacaatctc ctagcacact gagtgtgagc cccggcgaac gcgcgacttt ctcttgcagg 840 gcaagtcaat ccatagggac taatatacat tggtatcaac aaaagccagg taaaccaccc 900 aggcttttga ttaagtatgc aagtgagtct atttccggta tccctgaccg cttctctgga 960 tcaggcagtg gcacagagtt cacactcacc atatctagtg tgcaatcaga ggacttcgcc 1020 gtgtattact gccaacagaa taataactgg ccgactacct tcggacccgg tacaaagctg 1080 accgttttac gtacggtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag 1140 ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc 1200 aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca 1260 gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca 1320 gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc 1380 gtcacaaaga gcttcaacag gggagagtgt ggaggcgaca aaactcacac atgcccaccg 1440 tgcccagcac ctgaagccgc ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 1500 gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 1560 gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 1620 acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 1680 ctgcaccagg actggctgaa tggcaaggag tacaagtgcg cggtctccaa caaagccctc 1740 ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 1800 tacaccctgc ccccaagccg ggatgagctg accaagaacc aggtcagcct gtggtgcctg 1860 gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 1920 aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctatagc 1980 aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 2040 catgaggctc tgcacaacag attcacgcag aagagcctct ccctgtctcc gggtggcggt 2100 ggagggtccg gcggtggtgg atccgacatt cagatgacac agtcaccgtc tacgctctca 2160 gcctcagtag gcgatagggt gactatcacc tgccaagcct cccaatctat aagttcacac 2220 ctcaactggt atcaacagaa acccggtaaa gcaccgaagc tgctcatcta caaggcatca 2280 actcttgcct caggtgtgcc tagtcgcttc tccgggagcg gctccggtac tgagtttact 2340 ttgacgatat cttccctcca acccgacgac ttcgccacat actattgtca gcagggttat 2400 agttggggaa atgttgacaa tgtgtttgga gggggaacga aagtgactgt gttgggaggg 2460 ggaggaagtg gcggcggcgg aagcggaggt ggtggctccg gcgggggtgg aagcgaagtg 2520 caattgctcg aaagtggtgg cggacttgtg caacctggtg gaagcctctc actctcttgc 2580 gcggcgagtg gttttagctt cagtagcggc tacgatatgt gctgggtaag acaggctcct 2640 ggtaaaggcc ttgagtggat tgcgtgtatc gccgccgggt ctgctggtat aacatacgat 2700 gcaaactggg cgaaagggcg cttcacaatc tccagggaca actcaaaaaa tacattgtac 2760 ctccagatga atagcctgag agccgaagac accgcagtct actattgcgc aaggtcagca 2820 tttagcttcg attatgcaat ggatctttgg ggccagggga cgctcgtcac cgtctcatct 2880 tga 2883 <210> 81 <211> 965 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 81 Asp Val Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Thr Val Gly 1 5 10 15 Gln Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Gln Gln Leu Leu Glu Ser Gly Gly Arg Leu Ile Lys 130 135 140 Pro Gly Ala Thr Leu Arg Leu Thr Cys Lys Thr Ser Gly Phe Thr Ile 145 150 155 160 Ser Thr Asn Ala Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 165 170 175 Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser 180 185 190 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ile Asn Thr Val 195 200 205 Phe Leu Gln Met Arg Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 210 215 220 Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp 225 230 235 240 Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 245 250 255 Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 260 265 270 Lys Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser 275 280 285 Leu Thr Asn Tyr Gly Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly 290 295 300 Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn 305 310 315 320 Thr Pro Phe Thr Ser Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn 325 330 335 Gln Val Tyr Phe Lys Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile 340 345 350 Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr 355 360 365 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 370 375 380 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 385 390 395 400 Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 405 410 415 Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 420 425 430 Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 435 440 445 Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 450 455 460 Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 465 470 475 480 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 485 490 495 Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 500 505 510 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 515 520 525 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 530 535 540 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 545 550 555 560 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 565 570 575 Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala 580 585 590 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 595 600 605 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 610 615 620 Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 625 630 635 640 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 645 650 655 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 660 665 670 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 675 680 685 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 690 695 700 Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val 705 710 715 720 Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg 725 730 735 Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser 740 745 750 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 755 760 765 Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 770 775 780 Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp 785 790 795 800 Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val 805 810 815 Gly Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 820 825 830 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 835 840 845 Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 850 855 860 Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser 865 870 875 880 Tyr His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr 885 890 895 Ile Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala 900 905 910 Arg Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp 915 920 925 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 930 935 940 Ala Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu 945 950 955 960 Val Thr Val Ser Ser 965 <210> 82 <211> 2898 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 82 gatgtgcaga tgacccagag cccgagcacc ctgagcgcga ccgtgggcca gcgcgtgacc 60 attaactgcc aggcgagcga aagcattagc agctggctgg cgtggtatca gcagaaaccg 120 ggccagccgc cgaaactgct gatttatgaa gcgagcaaac tggcgagcgg cgtgccgagc 180 cgctttagcg gcagcggcag cggcaccgaa tttaccctga ccattagcag cctgcagagc 240 gatgattttg cgacctatta ttgccagggc tatttttatt ttattagccg cacctatgtg 300 aacagctttg gcggcggcac ccgcgtggaa attaaaggcg gtggcggtag tgggggaggc 360 ggttctggcg gcggagggtc cggcggtgga ggatcacagc agctgctgga aagcggcggc 420 cgcctgatta aaccgggcgc gaccctgcgc ctgacctgca aaaccagcgg ctttaccatt 480 agcaccaacg cgatgagctg ggtgcgccag ccgccgggca aaggcctgga atggattggc 540 gtgattaccg gccgcgatat tacctattat gcgagctggg cgaaaggccg ctttaccatt 600 agcaaaacca gcattaacac cgtgtttctg cagatgcgca gcctgcgcgc ggaagatacc 660 gcggtgtatt attgcgcgcg cgatggcggc agcagcgcga ttaccagcaa caacatttgg 720 ggccgcggca ccctggtgac cgtgagcagc ggcggtggag ggtccggcgg tggtggatca 780 caagtacagt tgcagcaatc cggtcccggt ctcgtcaaac cgagtgagac gcttagtata 840 acgtgtactg tttcaggctt tagccttacg aactatggag ttcactggat tcggcaggca 900 cccggcaaag gtttggaatg gctgggtgtt atttggtcag gtggaaatac agactataac 960 acccccttta caagtcggtt cacaattacg aaagataatt ccaaaaatca agtttatttc 1020 aagttgagat ccgtccgcgc ggacgacact gcgatctact attgtgcgag ggcactgacc 1080 tactacgatt acgaatttgc gtattggggg caagggactc ttgtaacagt ctccagtgct 1140 agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 1200 acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 1260 aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 1320 ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 1380 atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 1440 tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1500 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1560 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1620 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 1680 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1740 tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1800 gccaaagggc agccccgaga accacaggtg tataccctgc ccccatcccg ggatgagctg 1860 accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1920 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1980 gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 2040 caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2100 aagagcctct ccctgtctcc gggtggcggc ggcggttcag gtggtggggg atccgacgtt 2160 gtgatgacgc agtctcctag ttcagtatca gcgtctgttg gggatcgagt cacgattaca 2220 tgccaggcga gccaaaatat taggacgtat ctgtcttggt atcaacaaaa gcctggtaag 2280 gctccaaaac tcctcattta cgccgctgcc aacttggcta gtggagtacc ttcacgcttt 2340 agtgggtcag gttctggaac agattttacg ttgacgatct ccgatttgga accaggggac 2400 gctgccacgt attattgcca gtccacctac ctcgggactg actacgttgg tggggcgttt 2460 ggcggaggaa caaaactcac tgtacttggt ggtggtggtt caggcggggg gggttccggc 2520 ggaggcggtt ctgggggtgg aggttccgag gttcagttgg ttgaaagtgg ggggggactc 2580 gttcagcctg gaggctcttt gcgactttct tgtaccgctt ctgggttcac tataagttca 2640 tatcatatgc aatgggtaag acaggcgcct ggtaagggac ttgaatacat aggaacaata 2700 agctctggtg gtaacgtcta ttacgcctca tccgcgcggg ggaggtttac aatttccagg 2760 ccttctagca aaaacacggt agatctgcaa atgaactctc ttcgcgctga agatacagca 2820 gtctactact gcgccaggga ttcagggtat tctgacccca tgtgggggca gggcacattg 2880 gttaccgtgt cctcttga 2898 <210> 83 <211> 960 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 83 Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu 130 135 140 Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met 145 150 155 160 Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 165 170 175 Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys 180 185 190 Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu 195 200 205 Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 210 215 220 Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly 260 265 270 Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 275 280 285 Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 290 295 300 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 305 310 315 320 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 325 330 335 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 340 345 350 Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Arg Thr Val Ala Ala 355 360 365 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 370 375 380 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 385 390 395 400 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 405 410 415 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 420 425 430 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 435 440 445 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 450 455 460 Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro 465 470 475 480 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 485 490 495 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 500 505 510 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 515 520 525 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 530 535 540 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 545 550 555 560 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 565 570 575 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 580 585 590 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 595 600 605 Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 610 615 620 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 625 630 635 640 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 645 650 655 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 660 665 670 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 675 680 685 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 690 695 700 Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 705 710 715 720 Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser 725 730 735 Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 740 745 750 Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser 755 760 765 Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 770 775 780 Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr 785 790 795 800 Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Thr 805 810 815 Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 820 825 830 Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 835 840 845 Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly 850 855 860 Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro 865 870 875 880 Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly 885 890 895 Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg 900 905 910 Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 915 920 925 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp 930 935 940 Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 945 950 955 960 <210> 84 <211> 2883 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 84 gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60 atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120 caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180 ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240 gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300 acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360 tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420 ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480 ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540 tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600 acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660 tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720 ctcgtcacgg tctcgagtgg cggtggaggg tccggcggtg gtggatcaga aatcgtcctt 780 acacaatctc ctagcacact gagtgtgagc cccggcgaac gcgcgacttt ctcttgcagg 840 gcaagtcaat ccatagggac taatatacat tggtatcaac aaaagccagg taaaccaccc 900 aggcttttga ttaagtatgc aagtgagtct atttccggta tccctgaccg cttctctgga 960 tcaggcagtg gcacagagtt cacactcacc atatctagtg tgcaatcaga ggacttcgcc 1020 gtgtattact gccaacagaa taataactgg ccgactacct tcggacccgg tacaaagctg 1080 accgttttac gtacggtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag 1140 ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc 1200 aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca 1260 gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca 1320 gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc 1380 gtcacaaaga gcttcaacag gggagagtgt ggaggcgaca aaactcacac atgcccaccg 1440 tgcccagcac ctgaagccgc ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 1500 gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 1560 gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 1620 acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 1680 ctgcaccagg actggctgaa tggcaaggag tacaagtgcg cggtctccaa caaagccctc 1740 ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 1800 tacaccctgc ccccaagccg ggatgagctg accaagaacc aggtcagcct gtggtgcctg 1860 gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 1920 aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctatagc 1980 aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 2040 catgaggctc tgcacaacag attcacgcag aagagcctct ccctgtctcc gggtggcggt 2100 ggagggtccg gcggtggtgg atccgacatt cagatgacac agtcaccgtc tacgctctca 2160 gcctcagtag gcgatagggt gactatcacc tgccaagcct cccaatctat aagttcacac 2220 ctcaactggt atcaacagaa acccggtaaa gcaccgaagc tgctcatcta caaggcatca 2280 actcttgcct caggtgtgcc tagtcgcttc tccgggagcg gctccggtac tgagtttact 2340 ttgacgatat cttccctcca acccgacgac ttcgccacat actattgtca gcagggttat 2400 agttggggaa atgttgacaa tgtgtttgga gggggaacga aagtgactgt gttgggaggg 2460 ggaggaagtg gcggcggcgg aagcggaggt ggtggctccg gcgggggtgg aagcgaagtg 2520 caattgctcg aaagtggtgg cggacttgtg caacctggtg gaagcctctc actctcttgc 2580 gcggcgagtg gttttagctt cagtagcggc tacgatatgt gctgggtaag acaggctcct 2640 ggtaaaggcc ttgagtggat tgcgtgtatc gccgccgggt ctgctggtat aacatacgat 2700 gcaaactggg cgaaagggcg cttcacaatc tccagggaca actcaaaaaa tacattgtac 2760 ctccagatga atagcctgag agccgaagac accgcagtct actattgcgc aaggtcagca 2820 tttagcttcg attatgcaat ggatctttgg ggccagggga cgctcgtcac cgtctcatct 2880 tga 2883 <210> 85 <211> 965 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 85 Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile 145 150 155 160 Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp Val Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser 180 185 190 Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Lys Asn Thr Val 195 200 205 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 210 215 220 Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp 225 230 235 240 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 245 250 255 Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 260 265 270 Lys Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser 275 280 285 Leu Thr Asn Tyr Gly Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly 290 295 300 Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn 305 310 315 320 Thr Pro Phe Thr Ser Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn 325 330 335 Gln Val Tyr Phe Lys Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile 340 345 350 Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr 355 360 365 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 370 375 380 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 385 390 395 400 Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 405 410 415 Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 420 425 430 Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 435 440 445 Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 450 455 460 Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 465 470 475 480 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 485 490 495 Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 500 505 510 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 515 520 525 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 530 535 540 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 545 550 555 560 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 565 570 575 Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala 580 585 590 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 595 600 605 Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 610 615 620 Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 625 630 635 640 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 645 650 655 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 660 665 670 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 675 680 685 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 690 695 700 Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val 705 710 715 720 Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg 725 730 735 Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser 740 745 750 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 755 760 765 Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 770 775 780 Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp 785 790 795 800 Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val 805 810 815 Gly Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 820 825 830 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 835 840 845 Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 850 855 860 Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser 865 870 875 880 Tyr His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr 885 890 895 Ile Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala 900 905 910 Arg Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp 915 920 925 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 930 935 940 Ala Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu 945 950 955 960 Val Thr Val Ser Ser 965 <210> 86 <211> 2898 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 86 gatgtggtga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc 60 attagctgcc aggcgagcga aagcattagc agctggctgg cgtggtatca gcagaaaccg 120 ggccaggcgc cgaaactgct gatttatgaa gcgagcaaac tggcgagcgg cgtgccgagc 180 cgctttagcg gcagcggcag cggcaccgaa tttaccctga ccattagcag cctggaaccg 240 gaagattttg cgacctatta ttgccagggc tatttttatt ttattagccg cacctatgtg 300 aacagctttg gcggcggcac caaagtggaa attaaaggcg gtggcggtag tgggggaggc 360 ggttctggcg gcggagggtc cggcggtgga ggatcacagc agctggtgga aagcggcggc 420 ggcctggtga aaccgggcgg cagcctgcgc ctgagctgcg cggcgagcgg ctttaccatt 480 agcaccaacg cgatgagctg ggtgcgccag gcgccgggca aaggcctgga atgggtgggc 540 gtgattaccg gccgcgatat tacctattat gcgagctggg cgaaaggccg ctttaccatt 600 agcaaaacca gcaaaaacac cgtgtatctg cagatgaaca gcctgcgcgc ggaagatacc 660 gcggtgtatt attgcgcgcg cgatggcggc agcagcgcga ttaccagcaa caacatttgg 720 ggccagggca ccctggtgac cgtgagcagc ggcggtggag ggtccggcgg tggtggatca 780 caagtacagt tgcagcaatc cggtcccggt ctcgtcaaac cgagtgagac gcttagtata 840 acgtgtactg tttcaggctt tagccttacg aactatggag ttcactggat tcggcaggca 900 cccggcaaag gtttggaatg gctgggtgtt atttggtcag gtggaaatac agactataac 960 acccccttta caagtcggtt cacaattacg aaagataatt ccaaaaatca agtttatttc 1020 aagttgagat ccgtccgcgc ggacgacact gcgatctact attgtgcgag ggcactgacc 1080 tactacgatt acgaatttgc gtattggggg caagggactc ttgtaacagt ctccagtgct 1140 agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 1200 acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 1260 aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 1320 ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 1380 atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 1440 tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1500 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1560 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1620 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 1680 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1740 tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1800 gccaaagggc agccccgaga accacaggtg tataccctgc ccccatcccg ggatgagctg 1860 accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1920 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1980 gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 2040 caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2100 aagagcctct ccctgtctcc gggtggcggc ggcggttcag gtggtggggg atccgacgtt 2160 gtgatgacgc agtctcctag ttcagtatca gcgtctgttg gggatcgagt cacgattaca 2220 tgccaggcga gccaaaatat taggacgtat ctgtcttggt atcaacaaaa gcctggtaag 2280 gctccaaaac tcctcattta cgccgctgcc aacttggcta gtggagtacc ttcacgcttt 2340 agtgggtcag gttctggaac agattttacg ttgacgatct ccgatttgga accaggggac 2400 gctgccacgt attattgcca gtccacctac ctcgggactg actacgttgg tggggcgttt 2460 ggcggaggaa caaaactcac tgtacttggt ggtggtggtt caggcggggg gggttccggc 2520 ggaggcggtt ctgggggtgg aggttccgag gttcagttgg ttgaaagtgg ggggggactc 2580 gttcagcctg gaggctcttt gcgactttct tgtaccgctt ctgggttcac tataagttca 2640 tatcatatgc aatgggtaag acaggcgcct ggtaagggac ttgaatacat aggaacaata 2700 agctctggtg gtaacgtcta ttacgcctca tccgcgcggg ggaggtttac aatttccagg 2760 ccttctagca aaaacacggt agatctgcaa atgaactctc ttcgcgctga agatacagca 2820 gtctactact gcgccaggga ttcagggtat tctgacccca tgtgggggca gggcacattg 2880 gttaccgtgt cctcttga 2898 <210> 87 <211> 960 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 87 Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu 130 135 140 Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met 145 150 155 160 Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 165 170 175 Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys 180 185 190 Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu 195 200 205 Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 210 215 220 Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly 260 265 270 Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 275 280 285 Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 290 295 300 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 305 310 315 320 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 325 330 335 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 340 345 350 Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Arg Thr Val Ala Ala 355 360 365 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 370 375 380 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 385 390 395 400 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 405 410 415 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 420 425 430 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 435 440 445 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 450 455 460 Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro 465 470 475 480 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 485 490 495 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 500 505 510 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 515 520 525 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 530 535 540 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 545 550 555 560 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 565 570 575 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 580 585 590 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 595 600 605 Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 610 615 620 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 625 630 635 640 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 645 650 655 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 660 665 670 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 675 680 685 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 690 695 700 Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 705 710 715 720 Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser 725 730 735 Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 740 745 750 Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser 755 760 765 Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 770 775 780 Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr 785 790 795 800 Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Thr 805 810 815 Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 820 825 830 Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 835 840 845 Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly 850 855 860 Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro 865 870 875 880 Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly 885 890 895 Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg 900 905 910 Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 915 920 925 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp 930 935 940 Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 945 950 955 960 <210> 88 <211> 2883 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 88 gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60 atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120 caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180 ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240 gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300 acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360 tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420 ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480 ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540 tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600 acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660 tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720 ctcgtcacgg tctcgagtgg cggtggaggg tccggcggtg gtggatcaga aatcgtcctt 780 acacaatctc ctagcacact gagtgtgagc cccggcgaac gcgcgacttt ctcttgcagg 840 gcaagtcaat ccatagggac taatatacat tggtatcaac aaaagccagg taaaccaccc 900 aggcttttga ttaagtatgc aagtgagtct atttccggta tccctgaccg cttctctgga 960 tcaggcagtg gcacagagtt cacactcacc atatctagtg tgcaatcaga ggacttcgcc 1020 gtgtattact gccaacagaa taataactgg ccgactacct tcggacccgg tacaaagctg 1080 accgttttac gtacggtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag 1140 ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc 1200 aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca 1260 gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca 1320 gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc 1380 gtcacaaaga gcttcaacag gggagagtgt ggaggcgaca aaactcacac atgcccaccg 1440 tgcccagcac ctgaagccgc ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 1500 gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 1560 gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 1620 acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 1680 ctgcaccagg actggctgaa tggcaaggag tacaagtgcg cggtctccaa caaagccctc 1740 ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 1800 tacaccctgc ccccaagccg ggatgagctg accaagaacc aggtcagcct gtggtgcctg 1860 gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 1920 aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctatagc 1980 aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 2040 catgaggctc tgcacaacag attcacgcag aagagcctct ccctgtctcc gggtggcggt 2100 ggagggtccg gcggtggtgg atccgacatt cagatgacac agtcaccgtc tacgctctca 2160 gcctcagtag gcgatagggt gactatcacc tgccaagcct cccaatctat aagttcacac 2220 ctcaactggt atcaacagaa acccggtaaa gcaccgaagc tgctcatcta caaggcatca 2280 actcttgcct caggtgtgcc tagtcgcttc tccgggagcg gctccggtac tgagtttact 2340 ttgacgatat cttccctcca acccgacgac ttcgccacat actattgtca gcagggttat 2400 agttggggaa atgttgacaa tgtgtttgga gggggaacga aagtgactgt gttgggaggg 2460 ggaggaagtg gcggcggcgg aagcggaggt ggtggctccg gcgggggtgg aagcgaagtg 2520 caattgctcg aaagtggtgg cggacttgtg caacctggtg gaagcctctc actctcttgc 2580 gcggcgagtg gttttagctt cagtagcggc tacgatatgt gctgggtaag acaggctcct 2640 ggtaaaggcc ttgagtggat tgcgtgtatc gccgccgggt ctgctggtat aacatacgat 2700 gcaaactggg cgaaagggcg cttcacaatc tccagggaca actcaaaaaa tacattgtac 2760 ctccagatga atagcctgag agccgaagac accgcagtct actattgcgc aaggtcagca 2820 tttagcttcg attatgcaat ggatctttgg ggccagggga cgctcgtcac cgtctcatct 2880 tga 2883 <210> 89 <211> 957 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 89 Asp Pro Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Ala Lys Asn 20 25 30 Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val 65 70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly 85 90 95 Asn Ile Gln Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly 100 105 110 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly 130 135 140 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu Ser Ser 145 150 155 160 Asn Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 165 170 175 Val Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala 180 185 190 Lys Gly Arg Phe Thr Ile Ser Arg Ser Lys Asn Thr Val Tyr Leu Gln 195 200 205 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 210 215 220 Gly Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val 225 230 235 240 Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 245 250 255 Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Ile 260 265 270 Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp 275 280 285 Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 290 295 300 Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr 305 310 315 320 Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys Leu Arg Ser 325 330 335 Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr 340 345 350 Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 355 360 365 Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 370 375 380 Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 385 390 395 400 Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 405 410 415 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 420 425 430 Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 435 440 445 Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 450 455 460 Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 465 470 475 480 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 485 490 495 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 500 505 510 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 515 520 525 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 530 535 540 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 545 550 555 560 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala 565 570 575 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 580 585 590 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 595 600 605 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 610 615 620 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 625 630 635 640 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 645 650 655 Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 660 665 670 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 675 680 685 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 690 695 700 Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser 705 710 715 720 Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 725 730 735 Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys 740 745 750 Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val 755 760 765 Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 770 775 780 Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser 785 790 795 800 Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr 805 810 815 Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 820 825 830 Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 835 840 845 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr 850 855 860 Ala Ser Gly Phe Thr Ile Ser Ser Tyr His Met Gln Trp Val Arg Gln 865 870 875 880 Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Thr Ile Ser Ser Gly Gly 885 890 895 Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly Arg Phe Thr Ile Ser Arg 900 905 910 Pro Ser Ser Lys Asn Thr Val Asp Leu Gln Met Asn Ser Leu Arg Ala 915 920 925 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Gly Tyr Ser Asp 930 935 940 Pro Met Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 945 950 955 <210> 90 <211> 2874 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 90 gatccagttc tgacacaaag tccatccagc ctgtctgcct cagtcggcga cagagtgacc 60 atcagttgcc agagctcaca gtctgtggct aagaacaaca acttggcgtg gttccaacag 120 aaacctggac aggctccgaa attgctgatc tattctgctt ccacgcttgc tgctggtgtt 180 ccttcccgct tttcaggtag tggtagcggg acagacttca ctttgactat aagcagcgtg 240 cagcctgaag attttgcgac ctactattgt tctgctagag acagtggaaa tattcagtcc 300 tttggggggg gaacgaaggt cgaaataaag ggcggcggag ggtctggtgg gggtggcagt 360 ggtggtggag gaagtggtgg cggtggttcc caacagttgg ttgagtctgg tggcggtctc 420 gttaagcctg gagggtccct tcggcttagt tgtgcggcct ctgggatcga cctgtctagc 480 aacgctatag gatgggtacg gcaagctccg ggcaaaggcc ttgagtgggt cggcgttatt 540 tttgggagcg gtaatacgta ctacgccagc tgggcaaaag gtaggttcac tatcagtcga 600 tcaaagaaca cggtatatct tcagatgaac agtctccggg cggaggacac cgcggtttat 660 tattgcgcaa gggggggata ctcctcagac atatggggcc aaggtacttt ggtgacggtc 720 tcgagcggcg gtggagggtc cggcggtggt ggatcacaag tacagttgca gcaatccggt 780 cccggtctcg tcaaaccgag tgagacgctt agtataacgt gtactgtttc aggctttagc 840 cttacgaact atggagttca ctggattcgg caggcacccg gcaaaggttt ggaatggctg 900 ggtgttattt ggtcaggtgg aaatacagac tataacaccc cctttacaag tcggttcaca 960 attacgaaag ataattccaa aaatcaagtt tatttcaagt tgagatccgt ccgcgcggac 1020 gacactgcga tctactattg tgcgagggca ctgacctact acgattacga atttgcgtat 1080 tgggggcaag ggactcttgt aacagtctcc agtgctagca ccaagggccc atcggtcttc 1140 cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc 1200 aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc 1260 gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg 1320 accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc 1380 agcaacacca aggtggacaa gagagttgag cccaaatctt gtgacaaaac tcacacatgc 1440 ccaccgtgcc cagcacctga agccgcgggg ggaccgtcag tcttcctctt ccccccaaaa 1500 cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 1560 agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 1620 gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 1680 accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcgcggt ctccaacaaa 1740 gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 1800 caggtgtata ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgtcc 1860 tgcgccgtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag 1920 ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 1980 gtgagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 2040 gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 2100 ggcggcggcg gttcaggtgg tgggggatcc gacgttgtga tgacgcagtc tcctagttca 2160 gtatcagcgt ctgttgggga tcgagtcacg attacatgcc aggcgagcca aaatattagg 2220 acgtatctgt cttggtatca acaaaagcct ggtaaggctc caaaactcct catttacgcc 2280 gctgccaact tggctagtgg agtaccttca cgctttagtg ggtcaggttc tggaacagat 2340 tttacgttga cgatctccga tttggaacca ggggacgctg ccacgtatta ttgccagtcc 2400 acctacctcg ggactgacta cgttggtggg gcgtttggcg gaggaacaaa actcactgta 2460 cttggtggtg gtggttcagg cggggggggt tccggcggag gcggttctgg gggtggaggt 2520 tccgaggttc agttggttga aagtgggggg ggactcgttc agcctggagg ctctttgcga 2580 ctttcttgta ccgcttctgg gttcactata agttcatatc atatgcaatg ggtaagacag 2640 gcgcctggta agggacttga atacatagga acaataagct ctggtggtaa cgtctattac 2700 gcctcatccg cgcgggggag gtttacaatt tccaggcctt ctagcaaaaa cacggtagat 2760 ctgcaaatga actctcttcg cgctgaagat acagcagtct actactgcgc cagggattca 2820 gggtattctg accccatgtg ggggcagggc acattggtta ccgtgtcctc ttga 2874 <210> 91 <211> 960 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 91 Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu 130 135 140 Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met 145 150 155 160 Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 165 170 175 Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys 180 185 190 Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu 195 200 205 Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 210 215 220 Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly 260 265 270 Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 275 280 285 Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 290 295 300 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 305 310 315 320 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 325 330 335 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 340 345 350 Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Arg Thr Val Ala Ala 355 360 365 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 370 375 380 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 385 390 395 400 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 405 410 415 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 420 425 430 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 435 440 445 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 450 455 460 Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro 465 470 475 480 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 485 490 495 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 500 505 510 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 515 520 525 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 530 535 540 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 545 550 555 560 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 565 570 575 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 580 585 590 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 595 600 605 Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 610 615 620 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 625 630 635 640 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 645 650 655 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 660 665 670 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 675 680 685 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 690 695 700 Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 705 710 715 720 Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser 725 730 735 Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 740 745 750 Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser 755 760 765 Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 770 775 780 Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr 785 790 795 800 Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Thr 805 810 815 Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 820 825 830 Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 835 840 845 Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly 850 855 860 Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro 865 870 875 880 Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly 885 890 895 Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg 900 905 910 Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 915 920 925 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp 930 935 940 Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 945 950 955 960 <210> 92 <211> 2883 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 92 gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60 atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120 caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180 ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240 gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300 acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360 tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420 ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480 ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540 tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600 acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660 tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720 ctcgtcacgg tctcgagtgg cggtggaggg tccggcggtg gtggatcaga aatcgtcctt 780 acacaatctc ctagcacact gagtgtgagc cccggcgaac gcgcgacttt ctcttgcagg 840 gcaagtcaat ccatagggac taatatacat tggtatcaac aaaagccagg taaaccaccc 900 aggcttttga ttaagtatgc aagtgagtct atttccggta tccctgaccg cttctctgga 960 tcaggcagtg gcacagagtt cacactcacc atatctagtg tgcaatcaga ggacttcgcc 1020 gtgtattact gccaacagaa taataactgg ccgactacct tcggacccgg tacaaagctg 1080 accgttttac gtacggtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag 1140 ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc 1200 aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca 1260 gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca 1320 gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc 1380 gtcacaaaga gcttcaacag gggagagtgt ggaggcgaca aaactcacac atgcccaccg 1440 tgcccagcac ctgaagccgc ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 1500 gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 1560 gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 1620 acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 1680 ctgcaccagg actggctgaa tggcaaggag tacaagtgcg cggtctccaa caaagccctc 1740 ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 1800 tacaccctgc ccccaagccg ggatgagctg accaagaacc aggtcagcct gtggtgcctg 1860 gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 1920 aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctatagc 1980 aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 2040 catgaggctc tgcacaacag attcacgcag aagagcctct ccctgtctcc gggtggcggt 2100 ggagggtccg gcggtggtgg atccgacatt cagatgacac agtcaccgtc tacgctctca 2160 gcctcagtag gcgatagggt gactatcacc tgccaagcct cccaatctat aagttcacac 2220 ctcaactggt atcaacagaa acccggtaaa gcaccgaagc tgctcatcta caaggcatca 2280 actcttgcct caggtgtgcc tagtcgcttc tccgggagcg gctccggtac tgagtttact 2340 ttgacgatat cttccctcca acccgacgac ttcgccacat actattgtca gcagggttat 2400 agttggggaa atgttgacaa tgtgtttgga gggggaacga aagtgactgt gttgggaggg 2460 ggaggaagtg gcggcggcgg aagcggaggt ggtggctccg gcgggggtgg aagcgaagtg 2520 caattgctcg aaagtggtgg cggacttgtg caacctggtg gaagcctctc actctcttgc 2580 gcggcgagtg gttttagctt cagtagcggc tacgatatgt gctgggtaag acaggctcct 2640 ggtaaaggcc ttgagtggat tgcgtgtatc gccgccgggt ctgctggtat aacatacgat 2700 gcaaactggg cgaaagggcg cttcacaatc tccagggaca actcaaaaaa tacattgtac 2760 ctccagatga atagcctgag agccgaagac accgcagtct actattgcgc aaggtcagca 2820 tttagcttcg attatgcaat ggatctttgg ggccagggga cgctcgtcac cgtctcatct 2880 tga 2883 <210> 93 <211> 840 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 93 Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 1 5 10 15 Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser Phe Asn Ser Tyr 20 25 30 Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 35 40 45 Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly Asn Val Tyr Ser 100 105 110 Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 130 135 140 Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 145 150 155 160 Phe Thr Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly 165 170 175 Lys Gly Leu Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr 180 185 190 Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 195 200 205 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 210 215 220 Ala Val Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser 225 230 235 240 Asn Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 245 250 255 Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 260 265 270 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 275 280 285 Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 290 295 300 His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 305 310 315 320 Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 325 330 335 Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 340 345 350 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 355 360 365 Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 370 375 380 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 385 390 395 400 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 405 410 415 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 420 425 430 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 435 440 445 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 450 455 460 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 465 470 475 480 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 485 490 495 Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 500 505 510 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 515 520 525 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 530 535 540 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 545 550 555 560 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 565 570 575 Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 580 585 590 Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val 595 600 605 Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr 610 615 620 Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 625 630 635 640 Ile Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 645 650 655 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu 660 665 670 Pro Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr 675 680 685 Asp Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 690 695 700 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 705 710 715 720 Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 725 730 735 Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr 740 745 750 Ile Ser Ser Tyr His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly 755 760 765 Leu Glu Tyr Ile Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala 770 775 780 Ser Ser Ala Arg Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn 785 790 795 800 Thr Val Asp Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 805 810 815 Tyr Tyr Cys Ala Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln 820 825 830 Gly Thr Leu Val Thr Val Ser Ser 835 840 <210> 94 <211> 2523 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 94 gaggtgcagc tgcaggagtc tggcggcggc ctggtgcagg ctggggacag cctgagcctg 60 tcctgcctgg tgtctggccg ctccttcaac tcctacacca tgggctggtt ccgccaggcc 120 cctgggaagg agcgggagtt tgtggctgcc atcctgtgga gtggccccac cacctactat 180 gctgactctg tgaagggccg cttcaccatc tccagagaca atgccaagaa cactgtgtac 240 ctgcagatga acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgccctg 300 ggagtgctgg tgctggcccc tggcaatgtg tacagctact ggggccaggg cacccaggtg 360 actgtctcga gcggcggtgg agggtccggc ggtggtggat cagaggtgca gctggtggag 420 tctgggggag gcttggtcca gcctgggggg tccctgagac tctcctgtgc agcctctgga 480 ttcaccatca gtaccaatgc aatgagctgg gtccgccagg ctccagggaa ggggctggag 540 tggatcggag tcattactgg tcgtgatatc acatactacg cgagctgggc gaaaggcaga 600 ttcaccatct ccagagacaa ttccaagaac acgctgtatc ttcaaatgaa cagcctgaga 660 gccgaggaca cggctgtgta ttactgtgcg agagacggtg gttcttctgc tattactagt 720 aacaacattt ggggccaggg aaccctggtc accgtgtcct cagctagcac caagggccca 780 tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc 840 tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg 900 accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc 960 agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat 1020 cacaagccca gcaacaccaa ggtggacaag agagttgagc ccaaatcttg tgacaaaact 1080 cacacatgcc caccgtgccc agcacctgaa gccgcggggg gaccgtcagt cttcctcttc 1140 cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1200 gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1260 gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1320 agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcgcggtc 1380 tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1440 cgagaaccac aggtgtatac cctgccccca tcccgggatg agctgaccaa gaaccaggtc 1500 agcctgtcct gcgccgtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 1560 aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1620 ttcttcctcg tgagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 1680 tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 1740 tctccgggtg gcggcggcgg ttcaggtggt gggggatccg acgttgtgat gacgcagtct 1800 cctagttcag tatcagcgtc tgttggggat cgagtcacga ttacatgcca ggcgagccaa 1860 aatattagga cgtatctgtc ttggtatcaa caaaagcctg gtaaggctcc aaaactcctc 1920 atttacgccg ctgccaactt ggctagtgga gtaccttcac gctttagtgg gtcaggttct 1980 ggaacagatt ttacgttgac gatctccgat ttggaaccag gggacgctgc cacgtattat 2040 tgccagtcca cctacctcgg gactgactac gttggtgggg cgtttggcgg aggaacaaaa 2100 ctcactgtac ttggtggtgg tggttcaggc ggggggggtt ccggcggagg cggttctggg 2160 ggtggaggtt ccgaggttca gttggttgaa agtggggggg gactcgttca gcctggaggc 2220 tctttgcgac tttcttgtac cgcttctggg ttcactataa gttcatatca tatgcaatgg 2280 gtaagacagg cgcctggtaa gggacttgaa tacataggaa caataagctc tggtggtaac 2340 gtctattacg cctcatccgc gcgggggagg tttacaattt ccaggccttc tagcaaaaac 2400 acggtagatc tgcaaatgaa ctctcttcgc gctgaagata cagcagtcta ctactgcgcc 2460 agggattcag ggtattctga ccccatgtgg gggcagggca cattggttac cgtgtcctct 2520 tga 2523 <210> 95 <211> 846 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 95 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 1 5 10 15 Ser Leu Ser Leu Ser Cys Ala Phe Ser Gly Arg Thr Phe Ser Met Tyr 20 25 30 Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 35 40 45 Ala Ala Asn Arg Gly Arg Gly Leu Ser Pro Asp Ile Ala Asp Ser Val 50 55 60 Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ala Asp Leu Gln Tyr Gly Ser Ser Trp Pro Gln Arg Ser Ser Ala 100 105 110 Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser 130 135 140 Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys 145 150 155 160 Gln Ala Ser Glu Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys 165 170 175 Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala 180 185 190 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 195 200 205 Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 210 215 220 Cys Gln Gly Tyr Phe Tyr Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe 225 230 235 240 Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 245 250 255 Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 260 265 270 Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 275 280 285 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 290 295 300 Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 305 310 315 320 Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 325 330 335 Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 340 345 350 Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 355 360 365 Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 370 375 380 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 385 390 395 400 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 405 410 415 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 420 425 430 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 435 440 445 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 450 455 460 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 465 470 475 480 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 485 490 495 Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 500 505 510 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 515 520 525 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 530 535 540 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 545 550 555 560 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 565 570 575 Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 580 585 590 Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser 595 600 605 Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser 610 615 620 Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 625 630 635 640 Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 645 650 655 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 660 665 670 Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp 675 680 685 Gly Asn Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 690 695 700 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 705 710 715 720 Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 725 730 735 Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Ser 740 745 750 Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys 755 760 765 Gly Leu Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr 770 775 780 Tyr Asp Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 785 790 795 800 Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 805 810 815 Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala 820 825 830 Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 835 840 845 <210> 96 <211> 2541 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 96 caggtgcagc tggtgcagtc tggcggaggc ctggtgcagg ctgggggcag cctgagcctg 60 agctgtgcct tctctggccg caccttctcc atgtacacca tgggctggtt ccgccaggcc 120 ccagggaagg agagagagtt tgtggctgcc aacagaggca gaggcctgag cccagacatt 180 gctgactctg tgaatggccg cttcaccatc tccagagaca atgccaagaa caccctgtac 240 ctgcagatgg acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgacctg 300 cagtatggca gcagctggcc tcagaggagc tctgctgagt atgactactg gggccagggc 360 accactgtga ctgtctcgag cggcggtgga gggtccggcg gtggtggatc agacgtcgtg 420 atgacccagt ctccttccac cctgtctgca tctgtaggag acagagtcac catcaattgc 480 caagccagtg agagcattag cagttggtta gcctggtatc agcagaaacc agggaaagcc 540 cctaagctcc tgatctatga agcatccaaa ctggcatctg gggtcccatc aaggttcagc 600 ggcagtggat ctgggacaga attcactctc accatcagca gcctgcagcc tgatgatttt 660 gcaacttatt actgccaagg ctatttttat tttattagtc gtacttatgt aaattctttc 720 ggcggaggga ccaaggtgga gatcaaacgt acggtggctg caccatctgt cttcatcttc 780 ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac 840 ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac 900 tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc 960 ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat 1020 cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtgg aggcgacaaa 1080 actcacacat gcccaccgtg cccagcacct gaagccgcgg ggggaccgtc agtcttcctc 1140 ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg 1200 gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg 1260 gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg 1320 gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcgcg 1380 gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag 1440 ccccgagaac cacaggtgta caccctgccc ccaagccggg atgagctgac caagaaccag 1500 gtcagcctgt ggtgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag 1560 agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc 1620 tccttcttcc tctatagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc 1680 ttctcatgct ccgtgatgca tgaggctctg cacaacagat tcacgcagaa gagcctctcc 1740 ctgtctccgg gtggcggtgg agggtccggc ggtggtggat ccgacattca gatgacacag 1800 tcaccgtcta cgctctcagc ctcagtaggc gatagggtga ctatcacctg ccaagcctcc 1860 caatctataa gttcacacct caactggtat caacagaaac ccggtaaagc accgaagctg 1920 ctcatctaca aggcatcaac tcttgcctca ggtgtgccta gtcgcttctc cgggagcggc 1980 tccggtactg agtttacttt gacgatatct tccctccaac ccgacgactt cgccacatac 2040 tattgtcagc agggttatag ttggggaaat gttgacaatg tgtttggagg gggaacgaaa 2100 gtgactgtgt tgggaggggg aggaagtggc ggcggcggaa gcggaggtgg tggctccggc 2160 gggggtggaa gcgaagtgca attgctcgaa agtggtggcg gacttgtgca acctggtgga 2220 agcctctcac tctcttgcgc ggcgagtggt tttagcttca gtagcggcta cgatatgtgc 2280 tgggtaagac aggctcctgg taaaggcctt gagtggattg cgtgtatcgc cgccgggtct 2340 gctggtataa catacgatgc aaactgggcg aaagggcgct tcacaatctc cagggacaac 2400 tcaaaaaata cattgtacct ccagatgaat agcctgagag ccgaagacac cgcagtctac 2460 tattgcgcaa ggtcagcatt tagcttcgat tatgcaatgg atctttgggg ccaggggacg 2520 ctcgtcaccg tctcatcttg a 2541 <210> 97 <211> 832 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 97 Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 1 5 10 15 Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser Phe Asn Ser Tyr 20 25 30 Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 35 40 45 Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly Asn Val Tyr Ser 100 105 110 Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Arg 130 135 140 Leu Val Gln Pro Gly Glu Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly 145 150 155 160 Ile Asp Leu Ser Ser Asn Ala Ile Gly Trp Val Arg Gln Ala Pro Gly 165 170 175 Lys Gly Leu Glu Trp Ile Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr 180 185 190 Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser 195 200 205 Thr Val Tyr Leu Lys Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile 210 215 220 Tyr Tyr Cys Ala Arg Gly Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly 225 230 235 240 Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 245 250 255 Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 260 265 270 Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 275 280 285 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 290 295 300 Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 305 310 315 320 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 325 330 335 Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 340 345 350 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 355 360 365 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 370 375 380 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 385 390 395 400 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 405 410 415 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 420 425 430 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 435 440 445 Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 450 455 460 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 465 470 475 480 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser 485 490 495 Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 500 505 510 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 515 520 525 Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 530 535 540 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 545 550 555 560 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 565 570 575 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 580 585 590 Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Ile Thr Cys 595 600 605 Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp Ile Arg 610 615 620 Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly 625 630 635 640 Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr Ile Thr 645 650 655 Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys Leu Arg Ser Val Arg 660 665 670 Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr 675 680 685 Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 690 695 700 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 705 710 715 720 Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu 725 730 735 Ser Val Ser Pro Gly Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln 740 745 750 Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro 755 760 765 Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro 770 775 780 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 785 790 795 800 Ser Ser Val Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn 805 810 815 Asn Asn Trp Pro Thr Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu 820 825 830 <210> 98 <211> 2499 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 98 gaggtgcagc tgcaggagtc tggcggcggc ctggtgcagg ctggggacag cctgagcctg 60 tcctgcctgg tgtctggccg ctccttcaac tcctacacca tgggctggtt ccgccaggcc 120 cctgggaagg agcgggagtt tgtggctgcc atcctgtgga gtggccccac cacctactat 180 gctgactctg tgaagggccg cttcaccatc tccagagaca atgccaagaa cactgtgtac 240 ctgcagatga acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgccctg 300 ggagtgctgg tgctggcccc tggcaatgtg tacagctact ggggccaggg cacccaggtg 360 actgtctcga gcggcggtgg agggtccggc ggtggtggat cacaagtgca gttgcaagaa 420 agtggtggta gactggttca gcctggtgaa cccttgtcac tgacgtgtaa aacaagcggc 480 attgatctgt cctctaacgc catcggatgg gtccgacagg ccccaggaaa aggtctggag 540 tggatcggag ttatcttcgg gagcggcaat acatactacg caagctgggc aaaagggcga 600 tttacgatat cacggagcac ctctacagtt tatttgaaaa tgaactccct ccggtccgag 660 gataccgcga tatattactg tgccagaggg gggtactcct ctgatatctg ggggcagggt 720 acactggtta cagtttcatc cgctagcacc aaaggcccct ctgtgttccc tctggccccc 780 tcctccaaga gcacctctgg aggcactgct gccctgggct gcctggtgaa ggactacttc 840 ccagagcctg tgactgtgtc ctggaactct ggagccctga cctctggagt gcacaccttc 900 cctgctgtgc tgcagagctc tggcctctac agcctgtcct ctgtggtcac tgtgccctcc 960 tccagcctgg gcacccagac ctacatctgc aatgtgaacc acaagccctc caacaccaag 1020 gtggacaaga gagtggagcc caagtcctgt gacaagaccc acacctgccc tccctgccca 1080 gccccagagg ctgctggagg cccctctgtg ttcctcttcc ctcccaagcc caaggacacc 1140 ctgatgatct ccaggacccc agaagtcacc tgtgtggtgg tggatgtgtc ccatgaagac 1200 ccagaagtga agttcaactg gtatgtggat ggagtggagg tgcacaatgc caagaccaag 1260 cccagagaag agcagtacaa ctccacctac cgagtggtgt ctgtgctgac tgtgctgcac 1320 caggactggc tgaatgggaa ggagtacaag tgtgctgtgt ccaacaaggc cctgcctgcc 1380 cccattgaga agaccatctc caaggccaag ggccagccca gagagcccca ggtctacacc 1440 ctgcctccct ccagagatga gctgaccaag aaccaggtgt ccctgtcctg tgctgtgaaa 1500 ggcttctacc ccagtgacat tgctgtggag tgggagagca atggccagcc agagaacaac 1560 tacaagacca cccctcctgt gctggactct gatggctcct tcttcctggt ctccaagctg 1620 actgtggaca agagccgctg gcagcagggc aatgtgttct cctgctctgt catgcatgag 1680 gccctgcaca accactacac ccagaagagc ctgagcctga gccctggagg aggaggaggc 1740 tctggaggag gaggatccca agttcagttg cagcagtctg gccctggcct ggtcaagcct 1800 tctgagacac tgtccatcac ctgtaccgtg tccggcttct ccctgaccaa ttacggcgtg 1860 cactggatca gacaggcccc tggcaaagga ctggaatggc tgggagtgat ttggagcggc 1920 ggcaacaccg actacaacac ccctttcacc agccggttca ccatcaccaa ggacaactcc 1980 aagaaccagg tgtacttcaa gctgcggagc gtgcgggctg atgacaccgc catctactac 2040 tgtgctcggg ccctgaccta ctacgactac gagtttgctt actggggcca gggcaccctg 2100 gtcacagttt cttctggtgg tggtggttca ggcggggggg gttccggcgg aggcggttct 2160 gggggtggag gttccgagat cgtgctgacc cagtctcctt ccacactgtc tgtgtctccc 2220 ggcgagagag ccaccttcag ctgtagagcc tctcagtcca tcggcaccaa catccactgg 2280 tatcagcaga agcccggcaa gcctcctcgg ctgctgatta agtacgcctc cgagtccatc 2340 agcggcatcc ctgacagatt ctccggctct ggctctggca ccgagtttac cctgaccatc 2400 tcctccgtgc agtccgagga tttcgccgtg tactactgcc agcagaacaa caactggccc 2460 accacctttg gacccggcac caagctgacc gtgctgtga 2499 <210> 99 <211> 836 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 99 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 1 5 10 15 Ser Leu Ser Leu Ser Cys Ala Phe Ser Gly Arg Thr Phe Ser Met Tyr 20 25 30 Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 35 40 45 Ala Ala Asn Arg Gly Arg Gly Leu Ser Pro Asp Ile Ala Asp Ser Val 50 55 60 Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ala Asp Leu Gln Tyr Gly Ser Ser Trp Pro Gln Arg Ser Ser Ala 100 105 110 Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser 130 135 140 Pro Ser Ser Leu Ser Ala Thr Val Gly Gln Arg Val Thr Ile Asn Cys 145 150 155 160 Gln Ser Ser Gln Ser Val Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln 165 170 175 Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr 180 185 190 Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Gln Phe Thr Leu Thr Ile Thr Arg Val Gln Ser Glu Asp Phe Ala Thr 210 215 220 Tyr Tyr Cys Ser Ala Arg Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly 225 230 235 240 Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 245 250 255 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 260 265 270 Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 275 280 285 Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 290 295 300 Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 305 310 315 320 Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 325 330 335 Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 340 345 350 Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 355 360 365 Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 370 375 380 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 385 390 395 400 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 405 410 415 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 420 425 430 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 435 440 445 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu 450 455 460 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 465 470 475 480 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 485 490 495 Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 500 505 510 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 515 520 525 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 530 535 540 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 545 550 555 560 Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 565 570 575 Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 580 585 590 Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 595 600 605 Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 610 615 620 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 625 630 635 640 Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val 645 650 655 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 660 665 670 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 675 680 685 Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr 690 695 700 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 705 710 715 720 Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser 725 730 735 Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser 740 745 750 Asp Val Gly Gly Tyr Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly 755 760 765 Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly 770 775 780 Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu 785 790 795 800 Ile Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser 805 810 815 Ser Tyr Gly Ser Ser Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys 820 825 830 Val Thr Val Leu 835 <210> 100 <211> 2511 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 100 caggtgcagc tggtgcagtc tggcggaggc ctggtgcagg ctgggggcag cctgagcctg 60 agctgtgcct tctctggccg caccttctcc atgtacacca tgggctggtt ccgccaggcc 120 ccagggaagg agagagagtt tgtggctgcc aacagaggca gaggcctgag cccagacatt 180 gctgactctg tgaatggccg cttcaccatc tccagagaca atgccaagaa caccctgtac 240 ctgcagatgg acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgacctg 300 cagtatggca gcagctggcc tcagaggagc tctgctgagt atgactactg gggccagggc 360 accactgtga ctgtctcgag tggcggtgga gggtccggcg gtggtggatc agatcctcaa 420 ttgacccagt cccctagtag cctttctgca accgtgggcc agagggtaac aatcaattgc 480 cagtcaagcc agtccgtagc gaagaataat aatttggcat ggttccaaca aaaaccgggt 540 aaacctccta aactccttat ctactcagct tcaacccttg ccgcgggtgt gcccagccgg 600 ttctcaggct caggttccgg gactcaattt acacttacca tcactcgcgt ccaaagtgag 660 gattttgcaa cctactattg ttctgcacgg gattccggga acatacagtc ctttgggggt 720 ggaactcggg tggagataaa acgtacggtg gctgccccct ctgtgttcat cttcccaccc 780 agtgatgagc agctgaagag tggcacagcc tctgtggtgt gcctgctcaa caacttctac 840 cccagagaag ccaaggtgca gtggaaggtg gacaatgccc tgcagagtgg caacagccag 900 gagagtgtga cagagcagga cagcaaggac agcacctaca gcctgtcctc caccctgacc 960 ctgtccaagg ctgactatga gaagcacaag gtgtatgcct gtgaggtgac ccaccagggc 1020 ctgagcagcc ctgtgaccaa gagcttcaac cgaggagagt gtggaggaga caagacccac 1080 acctgccctc cctgcccagc cccagaagct gctggaggcc cctctgtgtt cctcttccct 1140 cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 1200 gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaagtg 1260 cacaatgcca agaccaagcc cagagaagag cagtacaaca gcacctaccg agtggtgtct 1320 gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 1380 aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1440 gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1500 ctgtggtgcc tggtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1560 ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1620 ttcctgtaca gcaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1680 tgctctgtca tgcatgaggc cctgcacaac cgcttcaccc agaagagcct gagcctgagc 1740 cctggaggag gaggaggctc tggaggagga ggatcccagg tgcagctgca ggagtcgggg 1800 ggaggcctgg tcaagcctgg agggtccctg agcctctcct gtgcagcctc tggattcacc 1860 tttagtagtt attggatgag ctgggtccgc caggctccag ggaaggggct ggagtgggtg 1920 gccaacataa accgcgatgg aagtgcgagt tactatgtgg actctgtgaa gggccgattc 1980 accatctcca gagacgacgc caagaactca ctgtatctgc aaatgaacag cctgagagct 2040 gaggacacgg ctgtgtatta ctgtgcgaga gatcgtgggg tgggctactt cgatctctgg 2100 ggccgtggca ccctggtcac cgtgtctagc ggtggaggcg gttcaggcgg aggtggttcc 2160 ggcggtggcg gctcccagtc tgccctgact cagcctgcct ccgtgtctgg gtctcctgga 2220 cagtcgatca ccatctcctg cactggaacc agcagtgacg ttggtggtta taactttgtc 2280 tcctggtacc aacaacaccc aggcaaagcc cccaaactca tgatctatga tgtcagtgat 2340 cggccctcag gggtgtctga tcgcttctcc ggctccaagt ctggcaacac ggcctccctg 2400 atcatctctg gcctccaggc tgacgacgag gctgattatt actgcagctc atatgggagc 2460 agcagcactc atgtgatttt cggcggaggg accaaggtga ccgtcctata a 2511 <210> 101 <211> 583 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 101 Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 1 5 10 15 Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser Phe Asn Ser Tyr 20 25 30 Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 35 40 45 Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly Asn Val Tyr Ser 100 105 110 Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 130 135 140 Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 145 150 155 160 Phe Thr Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly 165 170 175 Lys Gly Leu Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr 180 185 190 Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 195 200 205 Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr 210 215 220 Ala Val Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser 225 230 235 240 Asn Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 245 250 255 Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 260 265 270 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 275 280 285 Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 290 295 300 His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 305 310 315 320 Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 325 330 335 Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 340 345 350 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 355 360 365 Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 370 375 380 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 385 390 395 400 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 405 410 415 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 420 425 430 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 435 440 445 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 450 455 460 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 465 470 475 480 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 485 490 495 Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 500 505 510 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 515 520 525 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 530 535 540 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 545 550 555 560 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 565 570 575 Ser Leu Ser Leu Ser Pro Gly 580 <210> 102 <211> 1752 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 102 gaggtgcagc tgcaggagtc tggcggcggc ctggtgcagg ctggggacag cctgagcctg 60 tcctgcctgg tgtctggccg ctccttcaac tcctacacca tgggctggtt ccgccaggcc 120 cctgggaagg agcgggagtt tgtggctgcc atcctgtgga gtggccccac cacctactat 180 gctgactctg tgaagggccg cttcaccatc tccagagaca atgccaagaa cactgtgtac 240 ctgcagatga acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgccctg 300 ggagtgctgg tgctggcccc tggcaatgtg tacagctact ggggccaggg cacccaggtg 360 actgtctcga gcggaggagg aggctctgga ggaggaggca gtgaggtgca gctggtggag 420 agtggaggag gcctggtgca gcctggaggc agcctgcggc tgtcctgtgc tgcctctggc 480 ttcaccatct ccaccaatgc catgtcctgg gtgcgccagg cccctggcaa gggcctggag 540 tggattggag tcatcactgg cagagacatc acctactatg cctcctgggc caaaggccgc 600 ttcaccatct ccagagacaa cagcaagaac accctgtacc tgcagatgag cagcctgcgc 660 agtgaggaca cagctgtgta ctactgtgcc cgagatggag gcagcagtgc catcacctcc 720 aacaacatct ggggccaggg caccctggtc actgtgtcct ctgctagcac caaaggcccc 780 tctgtgttcc ctctggcccc ctcctccaag agcacctctg gaggcactgc tgccctgggc 840 tgcctggtga aggactactt cccagagcct gtgactgtgt cctggaactc tggagccctg 900 acctctggag tgcacacctt ccctgctgtg ctgcagagct ctggcctcta cagcctgtcc 960 tctgtggtca ctgtgccctc ctccagcctg ggcacccaga cctacatctg caatgtgaac 1020 cacaagccct ccaacaccaa ggtggacaag agagtggagc ccaagtcctg tgacaagacc 1080 cacacctgcc ctccctgccc agccccagag gctgctggag gcccctctgt gttcctcttc 1140 cctcccaagc ccaaggacac cctgatgatc tccaggaccc cagaagtcac ctgtgtggtg 1200 gtggatgtgt cccatgaaga cccagaagtg aagttcaact ggtatgtgga tggagtggag 1260 gtgcacaatg ccaagaccaa gcccagagaa gagcagtaca actccaccta ccgagtggtg 1320 tctgtgctga ctgtgctgca ccaggactgg ctgaatggga aggagtacaa gtgtgctgtg 1380 tccaacaagg ccctgcctgc ccccattgag aagaccatct ccaaggccaa gggccagccc 1440 agagagcccc aggtctacac cctgcctccc tccagagatg agctgaccaa gaaccaggtg 1500 tccctgtcct gtgctgtgaa aggcttctac cccagtgaca ttgctgtgga gtgggagagc 1560 aatggccagc cagagaacaa ctacaagacc acccctcctg tgctggactc tgatggctcc 1620 ttcttcctgg tctccaagct gactgtggac aagagccgct ggcagcaggg caatgtgttc 1680 tcctgctctg tcatgcatga ggccctgcac aaccactaca cccagaagag cctgagcctg 1740 agccctggat ga 1752 <210> 103 <211> 584 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 103 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 1 5 10 15 Ser Leu Ser Leu Ser Cys Ala Phe Ser Gly Arg Thr Phe Ser Met Tyr 20 25 30 Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 35 40 45 Ala Ala Asn Arg Gly Arg Gly Leu Ser Pro Asp Ile Ala Asp Ser Val 50 55 60 Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ala Asp Leu Gln Tyr Gly Ser Ser Trp Pro Gln Arg Ser Ser Ala 100 105 110 Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser 130 135 140 Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys 145 150 155 160 Gln Ala Ser Glu Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys 165 170 175 Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala 180 185 190 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 195 200 205 Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 210 215 220 Cys Gln Gly Tyr Phe Tyr Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe 225 230 235 240 Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 245 250 255 Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 260 265 270 Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 275 280 285 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 290 295 300 Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 305 310 315 320 Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 325 330 335 Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 340 345 350 Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 355 360 365 Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 370 375 380 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 385 390 395 400 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 405 410 415 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 420 425 430 Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 435 440 445 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 450 455 460 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 465 470 475 480 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 485 490 495 Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 500 505 510 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 515 520 525 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 530 535 540 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 545 550 555 560 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 565 570 575 Lys Ser Leu Ser Leu Ser Pro Gly 580 <210> 104 <211> 1755 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 104 caggtgcagc tggtgcagtc tggcggaggc ctggtgcagg ctgggggcag cctgagcctg 60 agctgtgcct tctctggccg caccttctcc atgtacacca tgggctggtt ccgccaggcc 120 ccagggaagg agagagagtt tgtggctgcc aacagaggca gaggcctgag cccagacatt 180 gctgactctg tgaatggccg cttcaccatc tccagagaca atgccaagaa caccctgtac 240 ctgcagatgg acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgacctg 300 cagtatggca gcagctggcc tcagaggagc tctgctgagt atgactactg gggccagggc 360 accactgtga ctgtctcgag cggaggagga ggctctggag gaggaggcag tgatgtggtg 420 atgacccaga gcccctccac cctgtctgcc tctgtgggag acagagtgac catcaactgc 480 caggccagtg agagcatctc ctcctggctg gcctggtacc agcagaagcc aggcaaggcc 540 cccaagctgc tcatctatga agcctccaag ctggcctctg gagtgccctc ccgcttctct 600 ggctctggct ctggcacaga gttcaccctg accatctcca gcctgcagcc agatgacttt 660 gccacctact actgccaggg ctacttctac ttcatctcca ggacctatgt gaacagcttt 720 ggaggaggca ccaaggtgga gatcaagcgt acggtggctg ccccctctgt gttcatcttc 780 ccacccagtg atgagcagct gaagagtggc acagcctctg tggtgtgcct gctcaacaac 840 ttctacccca gagaagccaa ggtgcagtgg aaggtggaca atgccctgca gagtggcaac 900 agccaggaga gtgtgacaga gcaggacagc aaggacagca cctacagcct gtcctccacc 960 ctgaccctgt ccaaggctga ctatgagaag cacaaggtgt atgcctgtga ggtgacccac 1020 cagggcctga gcagccctgt gaccaagagc ttcaaccgag gagagtgtgg aggagacaag 1080 acccacacct gccctccctg cccagcccca gaagctgctg gaggcccctc tgtgttcctc 1140 ttccctccca agcccaagga caccctgatg atctccagga ccccagaagt cacctgtgtg 1200 gtggtggatg tgtcccatga agacccagaa gtgaagttca actggtatgt ggatggagtg 1260 gaagtgcaca atgccaagac caagcccaga gaagagcagt acaacagcac ctaccgagtg 1320 gtgtctgtgc tgactgtgct gcaccaggac tggctgaatg ggaaggagta caagtgtgct 1380 gtgtccaaca aggccctgcc tgcccccatt gagaagacca tctccaaggc caagggccag 1440 cccagagagc cccaggtcta caccctgcct ccctccagag atgagctgac caagaaccag 1500 gtgtccctgt ggtgcctggt gaaaggcttc taccccagtg acattgctgt ggagtgggag 1560 agcaatggcc agccagagaa caactacaag accacccctc ctgtgctgga ctctgatggc 1620 tccttcttcc tgtacagcaa gctgactgtg gacaagagcc gctggcagca gggcaatgtg 1680 ttctcctgct ctgtcatgca tgaggccctg cacaaccgct tcacccagaa gagcctgagc 1740 ctgagccctg gatga 1755 <210> 105 <211> 576 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 105 Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 1 5 10 15 Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser Phe Asn Ser Tyr 20 25 30 Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 35 40 45 Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly Asn Val Tyr Ser 100 105 110 Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Arg 130 135 140 Leu Val Gln Pro Gly Glu Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly 145 150 155 160 Ile Asp Leu Ser Ser Asn Ala Ile Gly Trp Val Arg Gln Ala Pro Gly 165 170 175 Lys Gly Leu Glu Trp Ile Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr 180 185 190 Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser 195 200 205 Thr Val Tyr Leu Lys Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile 210 215 220 Tyr Tyr Cys Ala Arg Gly Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly 225 230 235 240 Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 245 250 255 Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 260 265 270 Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 275 280 285 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 290 295 300 Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 305 310 315 320 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 325 330 335 Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 340 345 350 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 355 360 365 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 370 375 380 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 385 390 395 400 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 405 410 415 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 420 425 430 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 435 440 445 Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 450 455 460 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 465 470 475 480 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser 485 490 495 Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 500 505 510 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 515 520 525 Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 530 535 540 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 545 550 555 560 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 565 570 575 <210> 106 <211> 1731 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 106 gaggtgcagc tgcaggagtc tggcggcggc ctggtgcagg ctggggacag cctgagcctg 60 tcctgcctgg tgtctggccg ctccttcaac tcctacacca tgggctggtt ccgccaggcc 120 cctgggaagg agcgggagtt tgtggctgcc atcctgtgga gtggccccac cacctactat 180 gctgactctg tgaagggccg cttcaccatc tccagagaca atgccaagaa cactgtgtac 240 ctgcagatga acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgccctg 300 ggagtgctgg tgctggcccc tggcaatgtg tacagctact ggggccaggg cacccaggtg 360 actgtctcga gcggcggtgg agggtccggc ggtggtggat cacaagtgca gttgcaagaa 420 agtggtggta gactggttca gcctggtgaa cccttgtcac tgacgtgtaa aacaagcggc 480 attgatctgt cctctaacgc catcggatgg gtccgacagg ccccaggaaa aggtctggag 540 tggatcggag ttatcttcgg gagcggcaat acatactacg caagctgggc aaaagggcga 600 tttacgatat cacggagcac ctctacagtt tatttgaaaa tgaactccct ccggtccgag 660 gataccgcga tatattactg tgccagaggg gggtactcct ctgatatctg ggggcagggt 720 acactggtta cagtttcatc cgctagcacc aaaggcccct ctgtgttccc tctggccccc 780 tcctccaaga gcacctctgg aggcactgct gccctgggct gcctggtgaa ggactacttc 840 ccagagcctg tgactgtgtc ctggaactct ggagccctga cctctggagt gcacaccttc 900 cctgctgtgc tgcagagctc tggcctctac agcctgtcct ctgtggtcac tgtgccctcc 960 tccagcctgg gcacccagac ctacatctgc aatgtgaacc acaagccctc caacaccaag 1020 gtggacaaga gagtggagcc caagtcctgt gacaagaccc acacctgccc tccctgccca 1080 gccccagagg ctgctggagg cccctctgtg ttcctcttcc ctcccaagcc caaggacacc 1140 ctgatgatct ccaggacccc agaagtcacc tgtgtggtgg tggatgtgtc ccatgaagac 1200 ccagaagtga agttcaactg gtatgtggat ggagtggagg tgcacaatgc caagaccaag 1260 cccagagaag agcagtacaa ctccacctac cgagtggtgt ctgtgctgac tgtgctgcac 1320 caggactggc tgaatgggaa ggagtacaag tgtgctgtgt ccaacaaggc cctgcctgcc 1380 cccattgaga agaccatctc caaggccaag ggccagccca gagagcccca ggtctacacc 1440 ctgcctccct ccagagatga gctgaccaag aaccaggtgt ccctgtcctg tgctgtgaaa 1500 ggcttctacc ccagtgacat tgctgtggag tgggagagca atggccagcc agagaacaac 1560 tacaagacca cccctcctgt gctggactct gatggctcct tcttcctggt ctccaagctg 1620 actgtggaca agagccgctg gcagcagggc aatgtgttct cctgctctgt catgcatgag 1680 gccctgcaca accactacac ccagaagagc ctgagcctga gccctggatg a 1731 <210> 107 <211> 582 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 107 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 1 5 10 15 Ser Leu Ser Leu Ser Cys Ala Phe Ser Gly Arg Thr Phe Ser Met Tyr 20 25 30 Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 35 40 45 Ala Ala Asn Arg Gly Arg Gly Leu Ser Pro Asp Ile Ala Asp Ser Val 50 55 60 Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ala Asp Leu Gln Tyr Gly Ser Ser Trp Pro Gln Arg Ser Ser Ala 100 105 110 Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser 130 135 140 Pro Ser Ser Leu Ser Ala Thr Val Gly Gln Arg Val Thr Ile Asn Cys 145 150 155 160 Gln Ser Ser Gln Ser Val Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln 165 170 175 Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr 180 185 190 Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Gln Phe Thr Leu Thr Ile Thr Arg Val Gln Ser Glu Asp Phe Ala Thr 210 215 220 Tyr Tyr Cys Ser Ala Arg Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly 225 230 235 240 Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 245 250 255 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 260 265 270 Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 275 280 285 Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 290 295 300 Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 305 310 315 320 Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 325 330 335 Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 340 345 350 Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 355 360 365 Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 370 375 380 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 385 390 395 400 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 405 410 415 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 420 425 430 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 435 440 445 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu 450 455 460 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 465 470 475 480 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 485 490 495 Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 500 505 510 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 515 520 525 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 530 535 540 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 545 550 555 560 Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 565 570 575 Leu Ser Leu Ser Pro Gly 580 <210> 108 <211> 1749 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 108 caggtgcagc tggtgcagtc tggcggaggc ctggtgcagg ctgggggcag cctgagcctg 60 agctgtgcct tctctggccg caccttctcc atgtacacca tgggctggtt ccgccaggcc 120 ccagggaagg agagagagtt tgtggctgcc aacagaggca gaggcctgag cccagacatt 180 gctgactctg tgaatggccg cttcaccatc tccagagaca atgccaagaa caccctgtac 240 ctgcagatgg acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgacctg 300 cagtatggca gcagctggcc tcagaggagc tctgctgagt atgactactg gggccagggc 360 accactgtga ctgtctcgag tggcggtgga gggtccggcg gtggtggatc agatcctcaa 420 ttgacccagt cccctagtag cctttctgca accgtgggcc agagggtaac aatcaattgc 480 cagtcaagcc agtccgtagc gaagaataat aatttggcat ggttccaaca aaaaccgggt 540 aaacctccta aactccttat ctactcagct tcaacccttg ccgcgggtgt gcccagccgg 600 ttctcaggct caggttccgg gactcaattt acacttacca tcactcgcgt ccaaagtgag 660 gattttgcaa cctactattg ttctgcacgg gattccggga acatacagtc ctttgggggt 720 ggaactcggg tggagataaa acgtacggtg gctgccccct ctgtgttcat cttcccaccc 780 agtgatgagc agctgaagag tggcacagcc tctgtggtgt gcctgctcaa caacttctac 840 cccagagaag ccaaggtgca gtggaaggtg gacaatgccc tgcagagtgg caacagccag 900 gagagtgtga cagagcagga cagcaaggac agcacctaca gcctgtcctc caccctgacc 960 ctgtccaagg ctgactatga gaagcacaag gtgtatgcct gtgaggtgac ccaccagggc 1020 ctgagcagcc ctgtgaccaa gagcttcaac cgaggagagt gtggaggaga caagacccac 1080 acctgccctc cctgcccagc cccagaagct gctggaggcc cctctgtgtt cctcttccct 1140 cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 1200 gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaagtg 1260 cacaatgcca agaccaagcc cagagaagag cagtacaaca gcacctaccg agtggtgtct 1320 gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 1380 aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1440 gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1500 ctgtggtgcc tggtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1560 ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1620 ttcctgtaca gcaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1680 tgctctgtca tgcatgaggc cctgcacaac cgcttcaccc agaagagcct gagcctgagc 1740 cctggatga 1749 <210> 109 <211> 576 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 109 Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu 1 5 10 15 Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn 20 25 30 Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met 65 70 75 80 Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly 85 90 95 Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 115 120 125 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 130 135 140 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 145 150 155 160 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 165 170 175 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 180 185 190 Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 195 200 205 Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 210 215 220 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 225 230 235 240 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 245 250 255 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 260 265 270 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 275 280 285 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 290 295 300 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 305 310 315 320 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 325 330 335 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 340 345 350 Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 355 360 365 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 370 375 380 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 385 390 395 400 Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 405 410 415 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 420 425 430 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 435 440 445 Gly Gly Gly Ser Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val 450 455 460 Gln Ala Gly Asp Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser 465 470 475 480 Phe Asn Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 485 490 495 Arg Glu Phe Val Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr 500 505 510 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 515 520 525 Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 530 535 540 Val Tyr Tyr Cys Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly 545 550 555 560 Asn Val Tyr Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 565 570 575 <210> 110 <211> 1731 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 110 caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60 acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120 ccaggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180 agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240 aactccctcc ggtccgagga taccgcgata tattactgtg ccagaggggg gtactcctct 300 gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360 gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420 ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480 tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540 gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600 aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660 acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720 cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780 gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840 cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900 gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960 aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020 gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080 ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140 ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200 ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260 tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320 cctggaggag gaggaggctc tggaggagga ggatccgagg tgcagctgca ggagtctggc 1380 ggcggcctgg tgcaggctgg ggacagcctg agcctgtcct gcctggtgtc tggccgctcc 1440 ttcaactcct acaccatggg ctggttccgc caggcccctg ggaaggagcg ggagtttgtg 1500 gctgccatcc tgtggagtgg ccccaccacc tactatgctg actctgtgaa gggccgcttc 1560 accatctcca gagacaatgc caagaacact gtgtacctgc agatgaacag cctgaagcca 1620 gaggacacag ctgtgtacta ctgtgctgct gccctgggag tgctggtgct ggcccctggc 1680 aatgtgtaca gctactgggg ccagggcacc caggtgactg tgtctagctg a 1731 <210> 111 <211> 582 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 111 Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly 1 5 10 15 Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Ala Lys Asn 20 25 30 Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Arg Val 65 70 75 80 Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly 85 90 95 Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr 210 215 220 Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 225 230 235 240 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 245 250 255 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 260 265 270 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 275 280 285 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 290 295 300 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 305 310 315 320 Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 325 330 335 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 340 345 350 Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 355 360 365 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 370 375 380 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 385 390 395 400 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 405 410 415 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 420 425 430 Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly 450 455 460 Gly Leu Val Gln Ala Gly Gly Ser Leu Ser Leu Ser Cys Ala Phe Ser 465 470 475 480 Gly Arg Thr Phe Ser Met Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro 485 490 495 Gly Lys Glu Arg Glu Phe Val Ala Ala Asn Arg Gly Arg Gly Leu Ser 500 505 510 Pro Asp Ile Ala Asp Ser Val Asn Gly Arg Phe Thr Ile Ser Arg Asp 515 520 525 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu 530 535 540 Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Leu Gln Tyr Gly Ser Ser 545 550 555 560 Trp Pro Gln Arg Ser Ser Ala Glu Tyr Asp Tyr Trp Gly Gln Gly Thr 565 570 575 Thr Val Thr Val Ser Ser 580 <210> 112 <211> 1749 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 112 gatcctcaat tgacccagtc ccctagtagc ctttctgcaa ccgtgggcca gagggtaaca 60 atcaattgcc agtcaagcca gtccgtagcg aagaataata atttggcatg gttccaacaa 120 aaaccgggta aacctcctaa actccttatc tactcagctt caacccttgc cgcgggtgtg 180 cccagccggt tctcaggctc aggttccggg actcaattta cacttaccat cactcgcgtc 240 caaagtgagg attttgcaac ctactattgt tctgcacggg attccgggaa catacagtcc 300 tttgggggtg gaactcgggt ggagataaaa cgtacggtgg ctgccccctc tgtgttcatc 360 ttcccaccca gtgatgagca gctgaagagt ggcacagcct ctgtggtgtg cctgctcaac 420 aacttctacc ccagagaagc caaggtgcag tggaaggtgg acaatgccct gcagagtggc 480 aacagccagg agagtgtgac agagcaggac agcaaggaca gcacctacag cctgtcctcc 540 accctgaccc tgtccaaggc tgactatgag aagcacaagg tgtatgcctg tgaggtgacc 600 caccagggcc tgagcagccc tgtgaccaag agcttcaacc gaggagagtg tggaggagac 660 aagacccaca cctgccctcc ctgcccagcc ccagaagctg ctggaggccc ctctgtgttc 720 ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 780 gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 840 gtggaagtgc acaatgccaa gaccaagccc agagaagagc agtacaacag cacctaccga 900 gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 960 gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1020 cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1080 caggtgtccc tgtggtgcct ggtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1140 gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1200 ggctccttct tcctgtacag caagctgact gtggacaaga gccgctggca gcagggcaat 1260 gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc gcttcaccca gaagagcctg 1320 agcctgagcc ctggaggagg aggaggctct ggaggaggag gatcccaggt gcagctggtg 1380 cagtctggcg gaggcctggt gcaggctggg ggcagcctga gcctgagctg tgccttctct 1440 ggccgcacct tctccatgta caccatgggc tggttccgcc aggccccagg gaaggagaga 1500 gagtttgtgg ctgccaacag aggcagaggc ctgagcccag acattgctga ctctgtgaat 1560 ggccgcttca ccatctccag agacaatgcc aagaacaccc tgtacctgca gatggacagc 1620 ctgaagccag aggacacagc tgtgtactac tgtgctgctg acctgcagta tggcagcagc 1680 tggcctcaga ggagctctgc tgagtatgac tactggggcc agggcaccac tgtgactgtg 1740 tctagctga 1749 <210> 113 <211> 442 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 113 Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu 1 5 10 15 Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn 20 25 30 Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met 65 70 75 80 Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly 85 90 95 Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 115 120 125 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 130 135 140 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 145 150 155 160 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 165 170 175 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 180 185 190 Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 195 200 205 Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 210 215 220 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 225 230 235 240 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 245 250 255 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 260 265 270 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 275 280 285 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 290 295 300 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 305 310 315 320 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 325 330 335 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 340 345 350 Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 355 360 365 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 370 375 380 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 385 390 395 400 Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 405 410 415 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 420 425 430 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 <210> 114 <211> 1329 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 114 caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60 acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120 ccaggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180 agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240 aactccctcc ggtccgagga taccgcgata tattactgtg ccagaggggg gtactcctct 300 gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360 gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420 ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480 tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540 gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600 aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660 acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720 cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780 gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840 cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900 gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960 aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020 gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080 ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140 ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200 ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260 tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320 cctggatga 1329 <210> 115 <211> 582 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 115 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 1 5 10 15 Ser Leu Ser Leu Ser Cys Ala Phe Ser Gly Arg Thr Phe Ser Met Tyr 20 25 30 Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 35 40 45 Ala Ala Asn Arg Gly Arg Gly Leu Ser Pro Asp Ile Ala Asp Ser Val 50 55 60 Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ala Asp Leu Gln Tyr Gly Ser Ser Trp Pro Gln Arg Ser Ser Ala 100 105 110 Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser 130 135 140 Pro Ser Ser Leu Ser Ala Thr Val Gly Gln Arg Val Thr Ile Asn Cys 145 150 155 160 Gln Ser Ser Gln Ser Val Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln 165 170 175 Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr 180 185 190 Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Gln Phe Thr Leu Thr Ile Thr Arg Val Gln Ser Glu Asp Phe Ala Thr 210 215 220 Tyr Tyr Cys Ser Ala Arg Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly 225 230 235 240 Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 245 250 255 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 260 265 270 Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 275 280 285 Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 290 295 300 Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 305 310 315 320 Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 325 330 335 Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 340 345 350 Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 355 360 365 Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 370 375 380 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 385 390 395 400 Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 405 410 415 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 420 425 430 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 435 440 445 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu 450 455 460 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 465 470 475 480 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 485 490 495 Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 500 505 510 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 515 520 525 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 530 535 540 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 545 550 555 560 Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 565 570 575 Leu Ser Leu Ser Pro Gly 580 <210> 116 <211> 1749 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 116 caggtgcagc tggtgcagtc tggcggaggc ctggtgcagg ctgggggcag cctgagcctg 60 agctgtgcct tctctggccg caccttctcc atgtacacca tgggctggtt ccgccaggcc 120 ccagggaagg agagagagtt tgtggctgcc aacagaggca gaggcctgag cccagacatt 180 gctgactctg tgaatggccg cttcaccatc tccagagaca atgccaagaa caccctgtac 240 ctgcagatgg acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgacctg 300 cagtatggca gcagctggcc tcagaggagc tctgctgagt atgactactg gggccagggc 360 accactgtga ctgtctcgag tggcggtgga gggtccggcg gtggtggatc agatcctcaa 420 ttgacccagt cccctagtag cctttctgca accgtgggcc agagggtaac aatcaattgc 480 cagtcaagcc agtccgtagc gaagaataat aatttggcat ggttccaaca aaaaccgggt 540 aaacctccta aactccttat ctactcagct tcaacccttg ccgcgggtgt gcccagccgg 600 ttctcaggct caggttccgg gactcaattt acacttacca tcactcgcgt ccaaagtgag 660 gattttgcaa cctactattg ttctgcacgg gattccggga acatacagtc ctttgggggt 720 ggaactcggg tggagataaa acgtacggtg gctgccccct ctgtgttcat cttcccaccc 780 agtgatgagc agctgaagag tggcacagcc tctgtggtgt gcctgctcaa caacttctac 840 cccagagaag ccaaggtgca gtggaaggtg gacaatgccc tgcagagtgg caacagccag 900 gagagtgtga cagagcagga cagcaaggac agcacctaca gcctgtcctc caccctgacc 960 ctgtccaagg ctgactatga gaagcacaag gtgtatgcct gtgaggtgac ccaccagggc 1020 ctgagcagcc ctgtgaccaa gagcttcaac cgaggagagt gtggaggaga caagacccac 1080 acctgccctc cctgcccagc cccagaagct gctggaggcc cctctgtgtt cctcttccct 1140 cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 1200 gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaagtg 1260 cacaatgcca agaccaagcc cagagaagag cagtacaaca gcacctaccg agtggtgtct 1320 gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 1380 aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1440 gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1500 ctgtggtgcc tggtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1560 ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1620 ttcctgtaca gcaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1680 tgctctgtca tgcatgaggc cctgcacaac cgcttcaccc agaagagcct gagcctgagc 1740 cctggatga 1749 <210> 117 <211> 576 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 117 Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 1 5 10 15 Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser Phe Asn Ser Tyr 20 25 30 Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 35 40 45 Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly Asn Val Tyr Ser 100 105 110 Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Arg 130 135 140 Leu Val Gln Pro Gly Glu Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly 145 150 155 160 Ile Asp Leu Ser Ser Asn Ala Ile Gly Trp Val Arg Gln Ala Pro Gly 165 170 175 Lys Gly Leu Glu Trp Ile Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr 180 185 190 Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser 195 200 205 Thr Val Tyr Leu Lys Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile 210 215 220 Tyr Tyr Cys Ala Arg Gly Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly 225 230 235 240 Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 245 250 255 Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 260 265 270 Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 275 280 285 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 290 295 300 Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 305 310 315 320 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 325 330 335 Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 340 345 350 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 355 360 365 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 370 375 380 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 385 390 395 400 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 405 410 415 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 420 425 430 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 435 440 445 Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 450 455 460 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 465 470 475 480 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser 485 490 495 Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 500 505 510 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 515 520 525 Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys 530 535 540 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 545 550 555 560 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 565 570 575 <210> 118 <211> 1731 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 118 gaggtgcagc tgcaggagtc tggcggcggc ctggtgcagg ctggggacag cctgagcctg 60 tcctgcctgg tgtctggccg ctccttcaac tcctacacca tgggctggtt ccgccaggcc 120 cctgggaagg agcgggagtt tgtggctgcc atcctgtgga gtggccccac cacctactat 180 gctgactctg tgaagggccg cttcaccatc tccagagaca atgccaagaa cactgtgtac 240 ctgcagatga acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgccctg 300 ggagtgctgg tgctggcccc tggcaatgtg tacagctact ggggccaggg cacccaggtg 360 actgtctcga gcggcggtgg agggtccggc ggtggtggat cacaagtgca gttgcaagaa 420 agtggtggta gactggttca gcctggtgaa cccttgtcac tgacgtgtaa aacaagcggc 480 attgatctgt cctctaacgc catcggatgg gtccgacagg ccccaggaaa aggtctggag 540 tggatcggag ttatcttcgg gagcggcaat acatactacg caagctgggc aaaagggcga 600 tttacgatat cacggagcac ctctacagtt tatttgaaaa tgaactccct ccggtccgag 660 gataccgcga tatattactg tgccagaggg gggtactcct ctgatatctg ggggcagggt 720 acactggtta cagtttcatc cgctagcacc aaaggcccct ctgtgttccc tctggccccc 780 tcctccaaga gcacctctgg aggcactgct gccctgggct gcctggtgaa ggactacttc 840 ccagagcctg tgactgtgtc ctggaactct ggagccctga cctctggagt gcacaccttc 900 cctgctgtgc tgcagagctc tggcctctac agcctgtcct ctgtggtcac tgtgccctcc 960 tccagcctgg gcacccagac ctacatctgc aatgtgaacc acaagccctc caacaccaag 1020 gtggacaaga gagtggagcc caagtcctgt gacaagaccc acacctgccc tccctgccca 1080 gccccagagg ctgctggagg cccctctgtg ttcctcttcc ctcccaagcc caaggacacc 1140 ctgatgatct ccaggacccc agaagtcacc tgtgtggtgg tggatgtgtc ccatgaagac 1200 ccagaagtga agttcaactg gtatgtggat ggagtggagg tgcacaatgc caagaccaag 1260 cccagagaag agcagtacaa ctccacctac cgagtggtgt ctgtgctgac tgtgctgcac 1320 caggactggc tgaatgggaa ggagtacaag tgtgctgtgt ccaacaaggc cctgcctgcc 1380 cccattgaga agaccatctc caaggccaag ggccagccca gagagcccca ggtctacacc 1440 ctgcctccct ccagagatga gctgaccaag aaccaggtgt ccctgtcctg tgctgtgaaa 1500 ggcttctacc ccagtgacat tgctgtggag tgggagagca atggccagcc agagaacaac 1560 tacaagacca cccctcctgt gctggactct gatggctcct tcttcctggt ctccaagctg 1620 actgtggaca agagccgctg gcagcagggc aatgtgttct cctgctctgt catgcatgag 1680 gccctgcaca accactacac ccagaagagc ctgagcctga gccctggatg a 1731 <210> 119 <211> 445 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 119 Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly 1 5 10 15 Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Ala Lys Asn 20 25 30 Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Arg Val 65 70 75 80 Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly 85 90 95 Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr 210 215 220 Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 225 230 235 240 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 245 250 255 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 260 265 270 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 275 280 285 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 290 295 300 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 305 310 315 320 Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 325 330 335 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 340 345 350 Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 355 360 365 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 370 375 380 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 385 390 395 400 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 405 410 415 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 420 425 430 Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 <210> 120 <211> 1338 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 120 gatcctcaat tgacccagtc ccctagtagc ctttctgcaa ccgtgggcca gagggtaaca 60 atcaattgcc agtcaagcca gtccgtagcg aagaataata atttggcatg gttccaacaa 120 aaaccgggta aacctcctaa actccttatc tactcagctt caacccttgc cgcgggtgtg 180 cccagccggt tctcaggctc aggttccggg actcaattta cacttaccat cactcgcgtc 240 caaagtgagg attttgcaac ctactattgt tctgcacggg attccgggaa catacagtcc 300 tttgggggtg gaactcgggt ggagataaaa cgtacggtgg ctgccccctc tgtgttcatc 360 ttcccaccca gtgatgagca gctgaagagt ggcacagcct ctgtggtgtg cctgctcaac 420 aacttctacc ccagagaagc caaggtgcag tggaaggtgg acaatgccct gcagagtggc 480 aacagccagg agagtgtgac agagcaggac agcaaggaca gcacctacag cctgtcctcc 540 accctgaccc tgtccaaggc tgactatgag aagcacaagg tgtatgcctg tgaggtgacc 600 caccagggcc tgagcagccc tgtgaccaag agcttcaacc gaggagagtg tggaggagac 660 aagacccaca cctgccctcc ctgcccagcc ccagaagctg ctggaggccc ctctgtgttc 720 ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 780 gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 840 gtggaagtgc acaatgccaa gaccaagccc agagaagagc agtacaacag cacctaccga 900 gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 960 gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1020 cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1080 caggtgtccc tgtggtgcct ggtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1140 gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1200 ggctccttct tcctgtacag caagctgact gtggacaaga gccgctggca gcagggcaat 1260 gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc gcttcaccca gaagagcctg 1320 agcctgagcc ctggatga 1338 <210> 121 <211> 442 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 121 Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu 1 5 10 15 Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn 20 25 30 Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met 65 70 75 80 Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly 85 90 95 Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 115 120 125 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 130 135 140 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 145 150 155 160 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 165 170 175 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 180 185 190 Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 195 200 205 Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 210 215 220 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 225 230 235 240 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 245 250 255 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 260 265 270 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 275 280 285 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 290 295 300 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 305 310 315 320 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 325 330 335 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 340 345 350 Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 355 360 365 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 370 375 380 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 385 390 395 400 Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 405 410 415 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 420 425 430 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 <210> 122 <211> 1329 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 122 caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60 acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120 ccaggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180 agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240 aactccctcc ggtccgagga taccgcgata tattactgtg ccagaggggg gtactcctct 300 gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360 gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420 ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480 tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540 gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600 aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660 acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720 cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780 gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840 cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900 gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960 aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020 gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080 ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140 ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200 ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260 tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320 cctggatga 1329 <210> 123 <211> 582 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 123 Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly 1 5 10 15 Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Ala Lys Asn 20 25 30 Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Arg Val 65 70 75 80 Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly 85 90 95 Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr 210 215 220 Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 225 230 235 240 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 245 250 255 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 260 265 270 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 275 280 285 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 290 295 300 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 305 310 315 320 Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 325 330 335 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 340 345 350 Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 355 360 365 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 370 375 380 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 385 390 395 400 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 405 410 415 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 420 425 430 Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly 450 455 460 Gly Leu Val Gln Ala Gly Gly Ser Leu Ser Leu Ser Cys Ala Phe Ser 465 470 475 480 Gly Arg Thr Phe Ser Met Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro 485 490 495 Gly Lys Glu Arg Glu Phe Val Ala Ala Asn Arg Gly Arg Gly Leu Ser 500 505 510 Pro Asp Ile Ala Asp Ser Val Asn Gly Arg Phe Thr Ile Ser Arg Asp 515 520 525 Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu 530 535 540 Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Leu Gln Tyr Gly Ser Ser 545 550 555 560 Trp Pro Gln Arg Ser Ser Ala Glu Tyr Asp Tyr Trp Gly Gln Gly Thr 565 570 575 Thr Val Thr Val Ser Ser 580 <210> 124 <211> 1749 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 124 gatcctcaat tgacccagtc ccctagtagc ctttctgcaa ccgtgggcca gagggtaaca 60 atcaattgcc agtcaagcca gtccgtagcg aagaataata atttggcatg gttccaacaa 120 aaaccgggta aacctcctaa actccttatc tactcagctt caacccttgc cgcgggtgtg 180 cccagccggt tctcaggctc aggttccggg actcaattta cacttaccat cactcgcgtc 240 caaagtgagg attttgcaac ctactattgt tctgcacggg attccgggaa catacagtcc 300 tttgggggtg gaactcgggt ggagataaaa cgtacggtgg ctgccccctc tgtgttcatc 360 ttcccaccca gtgatgagca gctgaagagt ggcacagcct ctgtggtgtg cctgctcaac 420 aacttctacc ccagagaagc caaggtgcag tggaaggtgg acaatgccct gcagagtggc 480 aacagccagg agagtgtgac agagcaggac agcaaggaca gcacctacag cctgtcctcc 540 accctgaccc tgtccaaggc tgactatgag aagcacaagg tgtatgcctg tgaggtgacc 600 caccagggcc tgagcagccc tgtgaccaag agcttcaacc gaggagagtg tggaggagac 660 aagacccaca cctgccctcc ctgcccagcc ccagaagctg ctggaggccc ctctgtgttc 720 ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 780 gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 840 gtggaagtgc acaatgccaa gaccaagccc agagaagagc agtacaacag cacctaccga 900 gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 960 gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1020 cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1080 caggtgtccc tgtggtgcct ggtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1140 gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1200 ggctccttct tcctgtacag caagctgact gtggacaaga gccgctggca gcagggcaat 1260 gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc gcttcaccca gaagagcctg 1320 agcctgagcc ctggaggagg aggaggctct ggaggaggag gatcccaggt gcagctggtg 1380 cagtctggcg gaggcctggt gcaggctggg ggcagcctga gcctgagctg tgccttctct 1440 ggccgcacct tctccatgta caccatgggc tggttccgcc aggccccagg gaaggagaga 1500 gagtttgtgg ctgccaacag aggcagaggc ctgagcccag acattgctga ctctgtgaat 1560 ggccgcttca ccatctccag agacaatgcc aagaacaccc tgtacctgca gatggacagc 1620 ctgaagccag aggacacagc tgtgtactac tgtgctgctg acctgcagta tggcagcagc 1680 tggcctcaga ggagctctgc tgagtatgac tactggggcc agggcaccac tgtgactgtg 1740 tctagctga 1749 <210> 125 <211> 576 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 125 Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu 1 5 10 15 Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn 20 25 30 Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met 65 70 75 80 Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly 85 90 95 Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 115 120 125 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 130 135 140 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 145 150 155 160 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 165 170 175 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 180 185 190 Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 195 200 205 Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 210 215 220 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 225 230 235 240 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 245 250 255 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 260 265 270 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 275 280 285 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 290 295 300 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 305 310 315 320 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 325 330 335 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 340 345 350 Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 355 360 365 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 370 375 380 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 385 390 395 400 Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 405 410 415 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 420 425 430 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 435 440 445 Gly Gly Gly Ser Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val 450 455 460 Gln Ala Gly Asp Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser 465 470 475 480 Phe Asn Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 485 490 495 Arg Glu Phe Val Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr 500 505 510 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 515 520 525 Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 530 535 540 Val Tyr Tyr Cys Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly 545 550 555 560 Asn Val Tyr Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 565 570 575 <210> 126 <211> 1731 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 126 caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60 acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120 ccaggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180 agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240 aactccctcc ggtccgagga taccgcgata tattactgtg ccagaggggg gtactcctct 300 gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360 gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420 ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480 tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540 gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600 aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660 acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720 cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780 gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840 cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900 gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960 aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020 gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080 ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140 ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200 ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260 tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320 cctggaggag gaggaggctc tggaggagga ggatccgagg tgcagctgca ggagtctggc 1380 ggcggcctgg tgcaggctgg ggacagcctg agcctgtcct gcctggtgtc tggccgctcc 1440 ttcaactcct acaccatggg ctggttccgc caggcccctg ggaaggagcg ggagtttgtg 1500 gctgccatcc tgtggagtgg ccccaccacc tactatgctg actctgtgaa gggccgcttc 1560 accatctcca gagacaatgc caagaacact gtgtacctgc agatgaacag cctgaagcca 1620 gaggacacag ctgtgtacta ctgtgctgct gccctgggag tgctggtgct ggcccctggc 1680 aatgtgtaca gctactgggg ccagggcacc caggtgactg tgtctagctg a 1731 <210> 127 <211> 445 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 127 Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly 1 5 10 15 Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Ala Lys Asn 20 25 30 Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Arg Val 65 70 75 80 Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly 85 90 95 Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr 210 215 220 Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 225 230 235 240 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 245 250 255 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 260 265 270 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 275 280 285 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 290 295 300 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 305 310 315 320 Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 325 330 335 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 340 345 350 Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 355 360 365 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 370 375 380 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 385 390 395 400 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 405 410 415 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 420 425 430 Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 <210> 128 <211> 1338 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 128 gatcctcaat tgacccagtc ccctagtagc ctttctgcaa ccgtgggcca gagggtaaca 60 atcaattgcc agtcaagcca gtccgtagcg aagaataata atttggcatg gttccaacaa 120 aaaccgggta aacctcctaa actccttatc tactcagctt caacccttgc cgcgggtgtg 180 cccagccggt tctcaggctc aggttccggg actcaattta cacttaccat cactcgcgtc 240 caaagtgagg attttgcaac ctactattgt tctgcacggg attccgggaa catacagtcc 300 tttgggggtg gaactcgggt ggagataaaa cgtacggtgg ctgccccctc tgtgttcatc 360 ttcccaccca gtgatgagca gctgaagagt ggcacagcct ctgtggtgtg cctgctcaac 420 aacttctacc ccagagaagc caaggtgcag tggaaggtgg acaatgccct gcagagtggc 480 aacagccagg agagtgtgac agagcaggac agcaaggaca gcacctacag cctgtcctcc 540 accctgaccc tgtccaaggc tgactatgag aagcacaagg tgtatgcctg tgaggtgacc 600 caccagggcc tgagcagccc tgtgaccaag agcttcaacc gaggagagtg tggaggagac 660 aagacccaca cctgccctcc ctgcccagcc ccagaagctg ctggaggccc ctctgtgttc 720 ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 780 gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 840 gtggaagtgc acaatgccaa gaccaagccc agagaagagc agtacaacag cacctaccga 900 gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 960 gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1020 cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1080 caggtgtccc tgtggtgcct ggtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1140 gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1200 ggctccttct tcctgtacag caagctgact gtggacaaga gccgctggca gcagggcaat 1260 gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc gcttcaccca gaagagcctg 1320 agcctgagcc ctggatga 1338 <210> 129 <211> 963 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 129 Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 20 25 30 His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 35 40 45 Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val 130 135 140 Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 145 150 155 160 His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala 165 170 175 Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 180 185 190 Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 195 200 205 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 210 215 220 Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly 225 230 235 240 Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 245 250 255 Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 260 265 270 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr 275 280 285 Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 290 295 300 Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala 305 310 315 320 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 325 330 335 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 340 345 350 Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 370 375 380 Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 385 390 395 400 Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 405 410 415 Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 420 425 430 Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 435 440 445 Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 450 455 460 Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 465 470 475 480 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 485 490 495 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 500 505 510 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 515 520 525 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 530 535 540 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 545 550 555 560 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 565 570 575 Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 580 585 590 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 595 600 605 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 610 615 620 Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 625 630 635 640 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 645 650 655 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 660 665 670 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 675 680 685 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 690 695 700 Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met 705 710 715 720 Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr 725 730 735 Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr 740 745 750 Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala 755 760 765 Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 770 775 780 Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala 785 790 795 800 Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly 805 810 815 Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 820 825 830 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 835 840 845 Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 850 855 860 Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His 865 870 875 880 Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 885 890 895 Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly 900 905 910 Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln 915 920 925 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 930 935 940 Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr 945 950 955 960 Val Ser Ser <210> 130 <211> 2892 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 130 cagatcgtgc tgagccagag ccccgccatc ctgagcgcca gccccggcga gaaggtgacc 60 atgacctgcc gggccagcag cagcgtgagc tacatccact ggttccagca gaagcccggc 120 agcagcccca agccctggat ctacgccacc agcaacctgg ccagcggcgt gcccgtgcgg 180 ttcagcggca gcggcagcgg caccagctac agcctgacca tcagccgggt ggaggccgag 240 gacgccgcca cctactactg ccagcagtgg accagcaacc cccccacctt cggcggcggc 300 accaagctga ccgtgctggg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360 tccggcggtg gaggatcaca ggtgcagctg cagcagcccg gcgccgagct ggtgaagccc 420 ggcgccagcg tgaagatgag ctgcaaggcc agcggctaca ccttcaccag ctacaacatg 480 cactgggtga agcagacccc cggccggggc ctggagtgga tcggcgccat ctaccccggc 540 aacggcgaca ccagctacaa ccagaagttc aagggcaagg ccaccctgac cgccgacaag 600 agcagcagca ccgcctacat gcagctgagc agcctgacca gcgaggacag cgccgtgtac 660 tactgcgccc ggagcaccta ctacggcggc gactggtact tcaacgtgtg gggcgccggc 720 accaccgtga ccgtctcgag cggcggtgga gggtccggcg gtggtggatc agaggtgcag 780 ctggtggagt ctgggggagg cttggtccag cctggggggt ccctgagact ctcctgtgca 840 gcctctggat tcaccatcag taccaatgca atgagctggg tccgccaggc tccagggaag 900 gggctggagt ggatcggagt cattactggt cgtgatatca catactacgc gagctgggcg 960 aaaggcagat tcaccatctc cagagacaat tccaagaaca cgctgtatct tcaaatgaac 1020 agcctgagag ccgaggacac ggctgtgtat tactgtgcga gagacggtgg ttcttctgct 1080 attactagta acaacatttg gggccaggga accctggtca ccgtgtcctc agctagcacc 1140 aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg 1200 gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca 1260 ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac 1320 tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc 1380 aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt 1440 gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 1680 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740 tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800 gggcagcccc gagaaccaca ggtgtatacc ctgcccccat cccgggatga gctgaccaag 1860 aaccaggtca gcctgtcctg cgccgtcaaa ggcttctatc ccagcgacat cgccgtggag 1920 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980 gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg 2040 aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 2100 ctctccctgt ctccgggtgg cggcggcggt tcaggtggtg ggggatccga cgttgtgatg 2160 acgcagtctc ctagttcagt atcagcgtct gttggggatc gagtcacgat tacatgccag 2220 gcgagccaaa atattaggac gtatctgtct tggtatcaac aaaagcctgg taaggctcca 2280 aaactcctca tttacgccgc tgccaacttg gctagtggag taccttcacg ctttagtggg 2340 tcaggttctg gaacagattt tacgttgacg atctccgatt tggaaccagg ggacgctgcc 2400 acgtattatt gccagtccac ctacctcggg actgactacg ttggtggggc gtttggcgga 2460 ggaacaaaac tcactgtact tggtggtggt ggttcaggcg gggggggttc cggcggaggc 2520 ggttctgggg gtggaggttc cgaggttcag ttggttgaaa gtgggggggg actcgttcag 2580 cctggaggct ctttgcgact ttcttgtacc gcttctgggt tcactataag ttcatatcat 2640 atgcaatggg taagacaggc gcctggtaag ggacttgaat acataggaac aataagctct 2700 ggtggtaacg tctattacgc ctcatccgcg cgggggaggt ttacaatttc caggccttct 2760 agcaaaaaca cggtagatct gcaaatgaac tctcttcgcg ctgaagatac agcagtctac 2820 tactgcgcca gggattcagg gtattctgac cccatgtggg ggcagggcac attggttacc 2880 gtgtcctctt ga 2892 <210> 131 <211> 965 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 131 Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu 130 135 140 Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met 145 150 155 160 Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 165 170 175 Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys 180 185 190 Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu 195 200 205 Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 210 215 220 Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 260 265 270 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 275 280 285 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 290 295 300 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 305 310 315 320 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 325 330 335 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 340 345 350 Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 355 360 365 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 370 375 380 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 385 390 395 400 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 405 410 415 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 420 425 430 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 435 440 445 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 450 455 460 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr 465 470 475 480 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 485 490 495 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 500 505 510 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 515 520 525 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 530 535 540 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 545 550 555 560 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 565 570 575 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 580 585 590 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 595 600 605 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 610 615 620 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 625 630 635 640 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 645 650 655 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 660 665 670 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 675 680 685 Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 690 695 700 Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 705 710 715 720 Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 725 730 735 Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys 740 745 750 Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala 755 760 765 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 770 775 780 Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 785 790 795 800 Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly 805 810 815 Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly 820 825 830 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 835 840 845 Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser 850 855 860 Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp 865 870 875 880 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala 885 890 895 Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg 900 905 910 Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 915 920 925 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser 930 935 940 Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu 945 950 955 960 Val Thr Val Ser Ser 965 <210> 132 <211> 2898 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 132 gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60 atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120 caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180 ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240 gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300 acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360 tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420 ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480 ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540 tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600 acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660 tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720 ctcgtcacgg tctcgagcgg cggtggaggg tccggcggtg gtggatcaga cgtcgtgatg 780 acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat caattgccaa 840 gccagtgaga gcattagcag ttggttagcc tggtatcagc agaaaccagg gaaagcccct 900 aagctcctga tctatgaagc atccaaactg gcatctgggg tcccatcaag gttcagcggc 960 agtggatctg ggacagaatt cactctcacc atcagcagcc tgcagcctga tgattttgca 1020 acttattact gccaaggcta tttttatttt attagtcgta cttatgtaaa ttctttcggc 1080 ggagggacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg 1140 ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc 1200 tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc 1260 caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg 1320 acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag 1380 ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtggagg cgacaaaact 1440 cacacatgcc caccgtgccc agcacctgaa gccgcggggg gaccgtcagt cttcctcttc 1500 cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1560 gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1620 gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1680 agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcgcggtc 1740 tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1800 cgagaaccac aggtgtacac cctgccccca agccgggatg agctgaccaa gaaccaggtc 1860 agcctgtggt gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 1920 aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1980 ttcttcctct atagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 2040 tcatgctccg tgatgcatga ggctctgcac aacagattca cgcagaagag cctctccctg 2100 tctccgggtg gcggtggagg gtccggcggt ggtggatccg acattcagat gacacagtca 2160 ccgtctacgc tctcagcctc agtaggcgat agggtgacta tcacctgcca agcctcccaa 2220 tctataagtt cacacctcaa ctggtatcaa cagaaacccg gtaaagcacc gaagctgctc 2280 atctacaagg catcaactct tgcctcaggt gtgcctagtc gcttctccgg gagcggctcc 2340 ggtactgagt ttactttgac gatatcttcc ctccaacccg acgacttcgc cacatactat 2400 tgtcagcagg gttatagttg gggaaatgtt gacaatgtgt ttggaggggg aacgaaagtg 2460 actgtgttgg gagggggagg aagtggcggc ggcggaagcg gaggtggtgg ctccggcggg 2520 ggtggaagcg aagtgcaatt gctcgaaagt ggtggcggac ttgtgcaacc tggtggaagc 2580 ctctcactct cttgcgcggc gagtggtttt agcttcagta gcggctacga tatgtgctgg 2640 gtaagacagg ctcctggtaa aggccttgag tggattgcgt gtatcgccgc cgggtctgct 2700 ggtataacat acgatgcaaa ctgggcgaaa gggcgcttca caatctccag ggacaactca 2760 aaaaatacat tgtacctcca gatgaatagc ctgagagccg aagacaccgc agtctactat 2820 tgcgcaaggt cagcatttag cttcgattat gcaatggatc tttggggcca ggggacgctc 2880 gtcaccgtct catcttga 2898 <210> 133 <211> 963 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 133 Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 20 25 30 His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 35 40 45 Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val 130 135 140 Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met 145 150 155 160 His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala 165 170 175 Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly 180 185 190 Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 195 200 205 Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 210 215 220 Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly 225 230 235 240 Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 245 250 255 Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 260 265 270 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr 275 280 285 Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp 290 295 300 Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala 305 310 315 320 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 325 330 335 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 340 345 350 Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 370 375 380 Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 385 390 395 400 Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 405 410 415 Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 420 425 430 Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 435 440 445 Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 450 455 460 Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 465 470 475 480 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 485 490 495 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 500 505 510 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 515 520 525 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 530 535 540 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 545 550 555 560 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 565 570 575 Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 580 585 590 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 595 600 605 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 610 615 620 Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 625 630 635 640 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 645 650 655 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 660 665 670 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 675 680 685 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 690 695 700 Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met 705 710 715 720 Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr 725 730 735 Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr 740 745 750 Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala 755 760 765 Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 770 775 780 Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala 785 790 795 800 Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly 805 810 815 Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 820 825 830 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 835 840 845 Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 850 855 860 Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His 865 870 875 880 Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 885 890 895 Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly 900 905 910 Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln 915 920 925 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 930 935 940 Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr 945 950 955 960 Val Ser Ser <210> 134 <211> 2892 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 134 cagatcgtgc tgagccagag ccccgccatc ctgagcgcca gccccggcga gaaggtgacc 60 atgacctgcc gggccagcag cagcgtgagc tacatccact ggttccagca gaagcccggc 120 agcagcccca agccctggat ctacgccacc agcaacctgg ccagcggcgt gcccgtgcgg 180 ttcagcggca gcggcagcgg caccagctac agcctgacca tcagccgggt ggaggccgag 240 gacgccgcca cctactactg ccagcagtgg accagcaacc cccccacctt cggcggcggc 300 accaagctga ccgtgctggg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360 tccggcggtg gaggatcaca ggtgcagctg cagcagcccg gcgccgagct ggtgaagccc 420 ggcgccagcg tgaagatgag ctgcaaggcc agcggctaca ccttcaccag ctacaacatg 480 cactgggtga agcagacccc cggccggggc ctggagtgga tcggcgccat ctaccccggc 540 aacggcgaca ccagctacaa ccagaagttc aagggcaagg ccaccctgac cgccgacaag 600 agcagcagca ccgcctacat gcagctgagc agcctgacca gcgaggacag cgccgtgtac 660 tactgcgccc ggagcaccta ctacggcggc gactggtact tcaacgtgtg gggcgccggc 720 accaccgtga ccgtctcgag cggcggtgga gggtccggcg gtggtggatc agaggtgcag 780 ctggtggagt ctgggggagg cttggtccag cctggggggt ccctgagact ctcctgtgca 840 gcctctggat tcaccatcag taccaatgca atgagctggg tccgccaggc tccagggaag 900 tgtctggagt ggatcggagt cattactggt cgtgatatca catactacgc gagctgggcg 960 aaaggcagat tcaccatctc cagagacaat tccaagaaca cgctgtatct tcaaatgaac 1020 agcctgagag ccgaggacac ggctgtgtat tactgtgcga gagacggtgg ttcttctgct 1080 attactagta acaacatttg gggccaggga accctggtca ccgtgtcctc agctagcacc 1140 aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg 1200 gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca 1260 ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac 1320 tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc 1380 aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt 1440 gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 1680 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740 tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800 gggcagcccc gagaaccaca ggtgtatacc ctgcccccat cccgggatga gctgaccaag 1860 aaccaggtca gcctgtcctg cgccgtcaaa ggcttctatc ccagcgacat cgccgtggag 1920 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980 gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg 2040 aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 2100 ctctccctgt ctccgggtgg cggcggcggt tcaggtggtg ggggatccga cgttgtgatg 2160 acgcagtctc ctagttcagt atcagcgtct gttggggatc gagtcacgat tacatgccag 2220 gcgagccaaa atattaggac gtatctgtct tggtatcaac aaaagcctgg taaggctcca 2280 aaactcctca tttacgccgc tgccaacttg gctagtggag taccttcacg ctttagtggg 2340 tcaggttctg gaacagattt tacgttgacg atctccgatt tggaaccagg ggacgctgcc 2400 acgtattatt gccagtccac ctacctcggg actgactacg ttggtggggc gtttggcgga 2460 ggaacaaaac tcactgtact tggtggtggt ggttcaggcg gggggggttc cggcggaggc 2520 ggttctgggg gtggaggttc cgaggttcag ttggttgaaa gtgggggggg actcgttcag 2580 cctggaggct ctttgcgact ttcttgtacc gcttctgggt tcactataag ttcatatcat 2640 atgcaatggg taagacaggc gcctggtaag ggacttgaat acataggaac aataagctct 2700 ggtggtaacg tctattacgc ctcatccgcg cgggggaggt ttacaatttc caggccttct 2760 agcaaaaaca cggtagatct gcaaatgaac tctcttcgcg ctgaagatac agcagtctac 2820 tactgcgcca gggattcagg gtattctgac cccatgtggg ggcagggcac attggttacc 2880 gtgtcctctt ga 2892 <210> 135 <211> 965 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 135 Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu 130 135 140 Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met 145 150 155 160 Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 165 170 175 Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys 180 185 190 Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu 195 200 205 Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 210 215 220 Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 260 265 270 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 275 280 285 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 290 295 300 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 305 310 315 320 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 325 330 335 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 340 345 350 Arg Thr Tyr Val Asn Ser Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 355 360 365 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 370 375 380 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 385 390 395 400 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 405 410 415 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 420 425 430 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 435 440 445 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 450 455 460 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr 465 470 475 480 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 485 490 495 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 500 505 510 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 515 520 525 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 530 535 540 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 545 550 555 560 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 565 570 575 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 580 585 590 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 595 600 605 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 610 615 620 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 625 630 635 640 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 645 650 655 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 660 665 670 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 675 680 685 Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 690 695 700 Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 705 710 715 720 Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 725 730 735 Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys 740 745 750 Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala 755 760 765 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 770 775 780 Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 785 790 795 800 Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly 805 810 815 Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly 820 825 830 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 835 840 845 Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser 850 855 860 Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp 865 870 875 880 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala 885 890 895 Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg 900 905 910 Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 915 920 925 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser 930 935 940 Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu 945 950 955 960 Val Thr Val Ser Ser 965 <210> 136 <211> 2898 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 136 gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60 atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120 caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180 ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240 gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300 acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360 tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420 ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480 ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540 tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600 acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660 tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720 ctcgtcacgg tctcgagcgg cggtggaggg tccggcggtg gtggatcaga cgtcgtgatg 780 acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat caattgccaa 840 gccagtgaga gcattagcag ttggttagcc tggtatcagc agaaaccagg gaaagcccct 900 aagctcctga tctatgaagc atccaaactg gcatctgggg tcccatcaag gttcagcggc 960 agtggatctg ggacagaatt cactctcacc atcagcagcc tgcagcctga tgattttgca 1020 acttattact gccaaggcta tttttatttt attagtcgta cttatgtaaa ttctttcggc 1080 tgtgggacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg 1140 ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc 1200 tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc 1260 caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg 1320 acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag 1380 ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtggagg cgacaaaact 1440 cacacatgcc caccgtgccc agcacctgaa gccgcggggg gaccgtcagt cttcctcttc 1500 cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1560 gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1620 gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1680 agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcgcggtc 1740 tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1800 cgagaaccac aggtgtacac cctgccccca agccgggatg agctgaccaa gaaccaggtc 1860 agcctgtggt gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 1920 aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1980 ttcttcctct atagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 2040 tcatgctccg tgatgcatga ggctctgcac aacagattca cgcagaagag cctctccctg 2100 tctccgggtg gcggtggagg gtccggcggt ggtggatccg acattcagat gacacagtca 2160 ccgtctacgc tctcagcctc agtaggcgat agggtgacta tcacctgcca agcctcccaa 2220 tctataagtt cacacctcaa ctggtatcaa cagaaacccg gtaaagcacc gaagctgctc 2280 atctacaagg catcaactct tgcctcaggt gtgcctagtc gcttctccgg gagcggctcc 2340 ggtactgagt ttactttgac gatatcttcc ctccaacccg acgacttcgc cacatactat 2400 tgtcagcagg gttatagttg gggaaatgtt gacaatgtgt ttggaggggg aacgaaagtg 2460 actgtgttgg gagggggagg aagtggcggc ggcggaagcg gaggtggtgg ctccggcggg 2520 ggtggaagcg aagtgcaatt gctcgaaagt ggtggcggac ttgtgcaacc tggtggaagc 2580 ctctcactct cttgcgcggc gagtggtttt agcttcagta gcggctacga tatgtgctgg 2640 gtaagacagg ctcctggtaa aggccttgag tggattgcgt gtatcgccgc cgggtctgct 2700 ggtataacat acgatgcaaa ctgggcgaaa gggcgcttca caatctccag ggacaactca 2760 aaaaatacat tgtacctcca gatgaatagc ctgagagccg aagacaccgc agtctactat 2820 tgcgcaaggt cagcatttag cttcgattat gcaatggatc tttggggcca ggggacgctc 2880 gtcaccgtct catcttga 2898 <210> 137 <211> 706 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 137 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 85 90 95 Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 115 120 125 Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 130 135 140 Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp 145 150 155 160 Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Cys Leu Glu Trp 165 170 175 Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 180 185 190 Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser 195 200 205 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 210 215 220 Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr 225 230 235 240 Met Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 260 265 270 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 275 280 285 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 290 295 300 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 305 310 315 320 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 325 330 335 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 340 345 350 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 355 360 365 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 370 375 380 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 385 390 395 400 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 405 410 415 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 420 425 430 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 435 440 445 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 450 455 460 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 465 470 475 480 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 485 490 495 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 500 505 510 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 515 520 525 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 530 535 540 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 545 550 555 560 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 565 570 575 Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 580 585 590 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 595 600 605 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 610 615 620 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 625 630 635 640 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 645 650 655 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 660 665 670 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 675 680 685 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 690 695 700 Gly Lys 705 <210> 138 <211> 2121 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 138 Gly Ala Cys Ala Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys Cys Cys 1 5 10 15 Ala Gly Thr Cys Thr Cys Cys Ala Thr Cys Cys Thr Cys Cys Cys Thr 20 25 30 Gly Thr Cys Thr Gly Cys Ala Thr Cys Thr Gly Thr Ala Gly Gly Ala 35 40 45 Gly Ala Cys Ala Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Cys Ala 50 55 60 Cys Thr Thr Gly Cys Cys Ala Gly Gly Cys Gly Ala Gly Thr Cys Ala 65 70 75 80 Gly Gly Ala Cys Ala Thr Cys Ala Gly Cys Ala Ala Cys Thr Ala Thr 85 90 95 Thr Thr Ala Ala Ala Thr Thr Gly Gly Thr Ala Thr Cys Ala Gly Cys 100 105 110 Ala Gly Ala Ala Ala Cys Cys Ala Gly Gly Gly Ala Ala Ala Gly Cys 115 120 125 Cys Cys Cys Thr Ala Ala Ala Cys Thr Cys Cys Thr Gly Ala Thr Cys 130 135 140 Thr Ala Cys Gly Ala Thr Gly Cys Ala Thr Cys Cys Ala Ala Thr Thr 145 150 155 160 Thr Gly Gly Ala Ala Ala Cys Ala Gly Gly Gly Gly Thr Cys Cys Cys 165 170 175 Ala Thr Cys Ala Ala Gly Gly Thr Thr Cys Ala Gly Thr Gly Gly Ala 180 185 190 Ala Gly Thr Gly Gly Ala Thr Cys Thr Gly Gly Gly Ala Cys Ala Gly 195 200 205 Ala Thr Thr Thr Thr Ala Cys Thr Thr Thr Cys Ala Cys Cys Ala Thr 210 215 220 Cys Ala Gly Cys Ala Gly Cys Cys Thr Gly Cys Ala Gly Cys Cys Thr 225 230 235 240 Gly Ala Ala Gly Ala Thr Ala Thr Thr Gly Cys Ala Ala Cys Ala Thr 245 250 255 Ala Thr Thr Thr Cys Thr Gly Thr Cys Ala Ala Cys Ala Cys Thr Thr 260 265 270 Thr Gly Ala Thr Cys Ala Thr Cys Thr Cys Cys Cys Gly Cys Thr Cys 275 280 285 Gly Cys Thr Thr Thr Cys Gly Gly Cys Thr Gly Thr Gly Gly Gly Ala 290 295 300 Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala Ala Ala Thr Thr Ala Ala 305 310 315 320 Ala Gly Gly Cys Gly Gly Thr Gly Gly Cys Gly Gly Thr Ala Gly Thr 325 330 335 Gly Gly Gly Gly Gly Ala Gly Gly Cys Gly Gly Thr Thr Cys Thr Gly 340 345 350 Gly Cys Gly Gly Cys Gly Gly Ala Gly Gly Gly Thr Cys Cys Gly Gly 355 360 365 Cys Gly Gly Thr Gly Gly Ala Gly Gly Ala Thr Cys Ala Cys Ala Gly 370 375 380 Gly Thr Gly Cys Ala Gly Cys Thr Gly Cys Ala Gly Gly Ala Gly Thr 385 390 395 400 Cys Gly Gly Gly Cys Cys Cys Ala Gly Gly Ala Cys Thr Gly Gly Thr 405 410 415 Gly Ala Ala Gly Cys Cys Thr Thr Cys Gly Gly Ala Gly Ala Cys Cys 420 425 430 Cys Thr Gly Thr Cys Cys Cys Thr Cys Ala Cys Cys Thr Gly Cys Ala 435 440 445 Cys Thr Gly Thr Cys Thr Cys Thr Gly Gly Thr Gly Gly Cys Thr Cys 450 455 460 Cys Gly Thr Cys Ala Gly Cys Ala Gly Thr Gly Gly Thr Gly Ala Thr 465 470 475 480 Thr Ala Cys Thr Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala 485 490 495 Thr Cys Cys Gly Gly Cys Ala Gly Thr Cys Cys Cys Cys Ala Gly Gly 500 505 510 Gly Ala Ala Gly Thr Gly Cys Cys Thr Gly Gly Ala Gly Thr Gly Gly 515 520 525 Ala Thr Thr Gly Gly Ala Cys Ala Cys Ala Thr Cys Thr Ala Thr Thr 530 535 540 Ala Cys Ala Gly Thr Gly Gly Gly Ala Ala Cys Ala Cys Cys Ala Ala 545 550 555 560 Thr Thr Ala Thr Ala Ala Cys Cys Cys Cys Thr Cys Cys Cys Thr Cys 565 570 575 Ala Ala Gly Ala Gly Cys Cys Gly Ala Cys Thr Cys Ala Cys Cys Ala 580 585 590 Thr Ala Thr Cys Ala Ala Thr Thr Gly Ala Cys Ala Cys Gly Thr Cys 595 600 605 Cys Ala Ala Gly Ala Cys Thr Cys Ala Gly Thr Thr Cys Thr Cys Cys 610 615 620 Cys Thr Gly Ala Ala Gly Cys Thr Gly Ala Gly Thr Thr Cys Thr Gly 625 630 635 640 Thr Gly Ala Cys Cys Gly Cys Thr Gly Cys Gly Gly Ala Cys Ala Cys 645 650 655 Gly Gly Cys Cys Ala Thr Thr Thr Ala Thr Thr Ala Cys Thr Gly Thr 660 665 670 Gly Thr Gly Cys Gly Ala Gly Ala Thr Cys Gly Ala Gly Thr Gly Ala 675 680 685 Cys Thr Gly Gly Thr Gly Cys Thr Thr Thr Thr Gly Ala Thr Ala Thr 690 695 700 Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala Gly Gly Gly Ala Cys Ala 705 710 715 720 Ala Thr Gly Gly Thr Cys Ala Cys Cys Gly Thr Gly Thr Cys Gly Ala 725 730 735 Cys Ala Gly Gly Cys Gly Gly Thr Gly Gly Ala Gly Gly Gly Thr Cys 740 745 750 Cys Gly Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Ala Thr Cys Ala 755 760 765 Gly Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Gly 770 775 780 Ala Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr 785 790 795 800 Gly Gly Thr Cys Cys Ala Gly Cys Cys Thr Gly Gly Gly Gly Gly Gly 805 810 815 Thr Cys Cys Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr 820 825 830 Gly Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Thr Thr 835 840 845 Cys Ala Cys Cys Ala Thr Cys Ala Gly Thr Ala Cys Cys Ala Ala Thr 850 855 860 Gly Cys Ala Ala Thr Gly Ala Gly Cys Thr Gly Gly Gly Thr Cys Cys 865 870 875 880 Gly Cys Cys Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala 885 890 895 Gly Gly Gly Gly Cys Thr Gly Gly Ala Gly Thr Gly Gly Ala Thr Cys 900 905 910 Gly Gly Ala Gly Thr Cys Ala Thr Thr Ala Cys Thr Gly Gly Thr Cys 915 920 925 Gly Thr Gly Ala Thr Ala Thr Cys Ala Cys Ala Thr Ala Cys Thr Ala 930 935 940 Cys Gly Cys Gly Ala Gly Cys Thr Gly Gly Gly Cys Gly Ala Ala Ala 945 950 955 960 Gly Gly Cys Ala Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr 965 970 975 Cys Cys Ala Gly Ala Gly Ala Cys Ala Ala Thr Thr Cys Cys Ala Ala 980 985 990 Gly Ala Ala Cys Ala Cys Gly Cys Thr Gly Thr Ala Thr Cys Thr Thr 995 1000 1005 Cys Ala Ala Ala Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly 1010 1015 1020 Ala Gly Ala Gly Cys Cys Gly Ala Gly Gly Ala Cys Ala Cys Gly 1025 1030 1035 Gly Cys Thr Gly Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr 1040 1045 1050 Gly Cys Gly Ala Gly Ala Gly Ala Cys Gly Gly Thr Gly Gly Thr 1055 1060 1065 Thr Cys Thr Thr Cys Thr Gly Cys Thr Ala Thr Thr Ala Cys Thr 1070 1075 1080 Ala Gly Thr Ala Ala Cys Ala Ala Cys Ala Thr Thr Thr Gly Gly 1085 1090 1095 Gly Gly Cys Cys Ala Gly Gly Gly Ala Ala Cys Cys Cys Thr Gly 1100 1105 1110 Gly Thr Cys Ala Cys Cys Gly Thr Gly Thr Cys Cys Thr Cys Ala 1115 1120 1125 Gly Cys Thr Ala Gly Cys Ala Cys Cys Ala Ala Gly Gly Gly Cys 1130 1135 1140 Cys Cys Ala Thr Cys Gly Gly Thr Cys Thr Thr Cys Cys Cys Cys 1145 1150 1155 Cys Thr Gly Gly Cys Ala Cys Cys Cys Thr Cys Cys Thr Cys Cys 1160 1165 1170 Ala Ala Gly Ala Gly Cys Ala Cys Cys Thr Cys Thr Gly Gly Gly 1175 1180 1185 Gly Gly Cys Ala Cys Ala Gly Cys Gly Gly Cys Cys Cys Thr Gly 1190 1195 1200 Gly Gly Cys Thr Gly Cys Cys Thr Gly Gly Thr Cys Ala Ala Gly 1205 1210 1215 Gly Ala Cys Thr Ala Cys Thr Thr Cys Cys Cys Cys Gly Ala Ala 1220 1225 1230 Cys Cys Gly Gly Thr Gly Ala Cys Gly Gly Thr Gly Thr Cys Gly 1235 1240 1245 Thr Gly Gly Ala Ala Cys Thr Cys Ala Gly Gly Cys Gly Cys Cys 1250 1255 1260 Cys Thr Gly Ala Cys Cys Ala Gly Cys Gly Gly Cys Gly Thr Gly 1265 1270 1275 Cys Ala Cys Ala Cys Cys Thr Thr Cys Cys Cys Gly Gly Cys Thr 1280 1285 1290 Gly Thr Cys Cys Thr Ala Cys Ala Gly Thr Cys Cys Thr Cys Ala 1295 1300 1305 Gly Gly Ala Cys Thr Cys Thr Ala Cys Thr Cys Cys Cys Thr Cys 1310 1315 1320 Ala Gly Cys Ala Gly Cys Gly Thr Gly Gly Thr Gly Ala Cys Cys 1325 1330 1335 Gly Thr Gly Cys Cys Cys Thr Cys Cys Ala Gly Cys Ala Gly Cys 1340 1345 1350 Thr Thr Gly Gly Gly Cys Ala Cys Cys Cys Ala Gly Ala Cys Cys 1355 1360 1365 Thr Ala Cys Ala Thr Cys Thr Gly Cys Ala Ala Cys Gly Thr Gly 1370 1375 1380 Ala Ala Thr Cys Ala Cys Ala Ala Gly Cys Cys Cys Ala Gly Cys 1385 1390 1395 Ala Ala Cys Ala Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala Cys 1400 1405 1410 Ala Ala Gly Ala Gly Ala Gly Thr Thr Gly Ala Gly Cys Cys Cys 1415 1420 1425 Ala Ala Ala Thr Cys Thr Thr Gly Thr Gly Ala Cys Ala Ala Ala 1430 1435 1440 Ala Cys Thr Cys Ala Cys Ala Cys Ala Thr Gly Cys Cys Cys Ala 1445 1450 1455 Cys Cys Gly Thr Gly Cys Cys Cys Ala Gly Cys Ala Cys Cys Thr 1460 1465 1470 Gly Ala Ala Gly Cys Cys Gly Cys Gly Gly Gly Gly Gly Gly Ala 1475 1480 1485 Cys Cys Gly Thr Cys Ala Gly Thr Cys Thr Thr Cys Cys Thr Cys 1490 1495 1500 Thr Thr Cys Cys Cys Cys Cys Cys Ala Ala Ala Ala Cys Cys Cys 1505 1510 1515 Ala Ala Gly Gly Ala Cys Ala Cys Cys Cys Thr Cys Ala Thr Gly 1520 1525 1530 Ala Thr Cys Thr Cys Cys Cys Gly Gly Ala Cys Cys Cys Cys Thr 1535 1540 1545 Gly Ala Gly Gly Thr Cys Ala Cys Ala Thr Gly Cys Gly Thr Gly 1550 1555 1560 Gly Thr Gly Gly Thr Gly Gly Ala Cys Gly Thr Gly Ala Gly Cys 1565 1570 1575 Cys Ala Cys Gly Ala Ala Gly Ala Cys Cys Cys Thr Gly Ala Gly 1580 1585 1590 Gly Thr Cys Ala Ala Gly Thr Thr Cys Ala Ala Cys Thr Gly Gly 1595 1600 1605 Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys Gly Thr Gly 1610 1615 1620 Gly Ala Gly Gly Thr Gly Cys Ala Thr Ala Ala Thr Gly Cys Cys 1625 1630 1635 Ala Ala Gly Ala Cys Ala Ala Ala Gly Cys Cys Gly Cys Gly Gly 1640 1645 1650 Gly Ala Gly Gly Ala Gly Cys Ala Gly Thr Ala Cys Gly Cys Cys 1655 1660 1665 Ala Gly Cys Ala Cys Gly Thr Ala Cys Cys Gly Thr Gly Thr Gly 1670 1675 1680 Gly Thr Cys Ala Gly Cys Gly Thr Cys Cys Thr Cys Ala Cys Cys 1685 1690 1695 Gly Thr Cys Cys Thr Gly Cys Ala Cys Cys Ala Gly Gly Ala Cys 1700 1705 1710 Thr Gly Gly Cys Thr Gly Ala Ala Thr Gly Gly Cys Ala Ala Gly 1715 1720 1725 Gly Ala Gly Thr Ala Cys Ala Ala Gly Thr Gly Cys Gly Cys Gly 1730 1735 1740 Gly Thr Cys Thr Cys Cys Ala Ala Cys Ala Ala Ala Gly Cys Cys 1745 1750 1755 Cys Thr Cys Cys Cys Ala Gly Cys Cys Cys Cys Cys Ala Thr Cys 1760 1765 1770 Gly Ala Gly Ala Ala Ala Ala Cys Cys Ala Thr Cys Thr Cys Cys 1775 1780 1785 Ala Ala Ala Gly Cys Cys Ala Ala Ala Gly Gly Gly Cys Ala Gly 1790 1795 1800 Cys Cys Cys Cys Gly Ala Gly Ala Ala Cys Cys Ala Cys Ala Gly 1805 1810 1815 Gly Thr Gly Thr Gly Thr Ala Cys Cys Cys Thr Gly Cys Cys Cys 1820 1825 1830 Cys Cys Ala Thr Cys Cys Cys Gly Gly Gly Ala Thr Gly Ala Gly 1835 1840 1845 Cys Thr Gly Ala Cys Cys Ala Ala Gly Ala Ala Cys Cys Ala Gly 1850 1855 1860 Gly Thr Cys Ala Gly Cys Cys Thr Gly Thr Cys Cys Thr Gly Cys 1865 1870 1875 Gly Cys Cys Gly Thr Cys Ala Ala Ala Gly Gly Cys Thr Thr Cys 1880 1885 1890 Thr Ala Thr Cys Cys Cys Ala Gly Cys Gly Ala Cys Ala Thr Cys 1895 1900 1905 Gly Cys Cys Gly Thr Gly Gly Ala Gly Thr Gly Gly Gly Ala Gly 1910 1915 1920 Ala Gly Cys Ala Ala Thr Gly Gly Gly Cys Ala Gly Cys Cys Gly 1925 1930 1935 Gly Ala Gly Ala Ala Cys Ala Ala Cys Thr Ala Cys Ala Ala Gly 1940 1945 1950 Ala Cys Cys Ala Cys Gly Cys Cys Thr Cys Cys Cys Gly Thr Gly 1955 1960 1965 Cys Thr Gly Gly Ala Cys Thr Cys Cys Gly Ala Cys Gly Gly Cys 1970 1975 1980 Thr Cys Cys Thr Thr Cys Thr Thr Cys Cys Thr Cys Gly Thr Gly 1985 1990 1995 Ala Gly Cys Ala Ala Gly Cys Thr Cys Ala Cys Cys Gly Thr Gly 2000 2005 2010 Gly Ala Cys Ala Ala Gly Ala Gly Cys Ala Gly Gly Thr Gly Gly 2015 2020 2025 Cys Ala Gly Cys Ala Gly Gly Gly Gly Ala Ala Cys Gly Thr Cys 2030 2035 2040 Thr Thr Cys Thr Cys Ala Thr Gly Cys Thr Cys Cys Gly Thr Gly 2045 2050 2055 Ala Thr Gly Cys Ala Thr Gly Ala Gly Gly Cys Thr Cys Thr Gly 2060 2065 2070 Cys Ala Cys Ala Ala Cys Cys Ala Cys Thr Ala Cys Ala Cys Gly 2075 2080 2085 Cys Ala Gly Ala Ala Gly Ala Gly Cys Cys Thr Cys Thr Cys Cys 2090 2095 2100 Cys Thr Gly Thr Cys Thr Cys Cys Gly Gly Gly Thr Ala Ala Ala 2105 2110 2115 Thr Ala Gly 2120 <210> 139 <211> 707 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 139 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala 260 265 270 Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile 275 280 285 Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 290 295 300 Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 305 310 315 320 Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 325 330 335 Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr 340 345 350 Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val 355 360 365 Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 370 375 380 Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 385 390 395 400 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 405 410 415 Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 420 425 430 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 435 440 445 Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 450 455 460 Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly 465 470 475 480 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 485 490 495 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 500 505 510 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 515 520 525 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 530 535 540 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 545 550 555 560 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 565 570 575 Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 580 585 590 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 595 600 605 Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 610 615 620 Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 625 630 635 640 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 645 650 655 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 660 665 670 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 675 680 685 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 690 695 700 Pro Gly Lys 705 <210> 140 <211> 2124 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 140 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggct gtgggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga agtgcctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt gtcgacaggc ggtggagggt ccggcggtgg tggatcagac 780 gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840 aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900 aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960 ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020 gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080 tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 1140 atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 1200 aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 1260 ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 1320 agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 1380 acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggaggc 1440 gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac 1680 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740 tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat gtcgggatga gctgaccaag 1860 aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1920 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980 gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg 2040 aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 2100 ctctccctgt ctccgggtaa atag 2124 <210> 141 <211> 961 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 141 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 85 90 95 Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 115 120 125 Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 130 135 140 Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp 145 150 155 160 Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Cys Leu Glu Trp 165 170 175 Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 180 185 190 Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser 195 200 205 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 210 215 220 Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr 225 230 235 240 Met Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 260 265 270 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 275 280 285 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 290 295 300 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 305 310 315 320 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 325 330 335 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 340 345 350 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 355 360 365 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 370 375 380 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 385 390 395 400 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 405 410 415 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 420 425 430 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 435 440 445 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 450 455 460 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 465 470 475 480 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 485 490 495 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 500 505 510 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 515 520 525 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 530 535 540 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 545 550 555 560 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 565 570 575 Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 580 585 590 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 595 600 605 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 610 615 620 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 625 630 635 640 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 645 650 655 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 660 665 670 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 675 680 685 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 690 695 700 Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Ser Leu Val Glu 705 710 715 720 Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 725 730 735 Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His Met Gln Trp Val Arg 740 745 750 Gln Ala Pro Gly Lys Cys Leu Glu Tyr Ile Gly Thr Ile Ser Ser Gly 755 760 765 Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly Arg Phe Thr Ile Ser 770 775 780 Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln Met Asn Ser Leu Arg 785 790 795 800 Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Gly Tyr Ser 805 810 815 Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 820 825 830 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 835 840 845 Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser 850 855 860 Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg 865 870 875 880 Thr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 885 890 895 Leu Ile Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 900 905 910 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu 915 920 925 Glu Pro Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly 930 935 940 Thr Asp Tyr Val Gly Gly Ala Phe Gly Cys Gly Thr Lys Val Glu Ile 945 950 955 960 Lys <210> 142 <211> 2886 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 142 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacatcagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatattt ctgtcaacac tttgatcatc tcccgctcgc tttcggctgt 300 gggaccaagg tggaaattaa aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360 gggtccggcg gtggaggatc acaggtgcag ctgcaggagt cgggcccagg actggtgaag 420 ccttcggaga ccctgtccct cacctgcact gtctctggtg gctccgtcag cagtggtgat 480 tactactgga cctggatccg gcagtcccca gggaagtgcc tggagtggat tggacacatc 540 tattacagtg ggaacaccaa ttataacccc tccctcaaga gccgactcac catatcaatt 600 gacacgtcca agactcagtt ctccctgaag ctgagttctg tgaccgctgc ggacacggcc 660 atttattact gtgtgcgaga tcgagtgact ggtgcttttg atatctgggg ccaagggaca 720 atggtcaccg tgtcgacagg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780 gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840 tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900 ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960 ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020 ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080 actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaag 1140 ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 1200 ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 1260 gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 1320 ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 1380 gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 1440 aaaactcaca catgcccacc gtgcccagca cctgaagccg cggggggacc gtcagtcttc 1500 ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1560 gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1620 gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacgccag cacgtaccgt 1680 gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1740 gcggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1800 cagccccgag aaccacaggt gtgtaccctg cccccatccc gggatgagct gaccaagaac 1860 caggtcagcc tgtcctgcgc cgtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1920 gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1980 ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac 2040 gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 2100 tccctgtctc cgggtggcgg tggagggtcc ggcggtggtg gatcccggtc gctggtggag 2160 tctgggggag gcttggtcca gcctgggggg tccctgagac tctcctgtac tgcctctgga 2220 ttcaccatca gtagctacca catgcagtgg gtccggcagg cacctgggaa gtgcctggag 2280 tacatcggaa ccattagtag tggtggtaat gtatactacg caagctccgc tagaggcaga 2340 ttcaccatct ccagaccctc gtccaagaac acggtggatc ttcaaatgaa cagcctgaga 2400 gccgaggaca cggctgtgta ttactgtgcg agagactctg gttatagtga tcctatgtgg 2460 ggccagggaa ccctggtcac cgtctcttca ggcggtggcg gtagtggggg aggcggttct 2520 ggcggcggag ggtccggcgg tggaggatca gacgttgtga tgacccagtc tccatcttcc 2580 gtgtctgcat ctgtaggaga cagagtcacc atcacctgtc aggccagtca gaacattagg 2640 acttacttat cctggtatca gcagaaacca gggaaagccc ctaagctcct gatctatgct 2700 gcagccaatc tggcatctgg ggtcccatca aggttcagcg gcagtggatc tgggacagat 2760 ttcactctca ccatcagcga cttggaacct ggcgatgctg caacttacta ttgtcagtct 2820 acctatcttg gtactgatta tgttggcggt gctttcggct gtgggaccaa ggtggagatc 2880 aaatga 2886 <210> 143 <211> 707 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 143 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala 260 265 270 Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile 275 280 285 Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 290 295 300 Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 305 310 315 320 Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 325 330 335 Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr 340 345 350 Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val 355 360 365 Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 370 375 380 Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 385 390 395 400 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 405 410 415 Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 420 425 430 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 435 440 445 Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 450 455 460 Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly 465 470 475 480 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 485 490 495 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 500 505 510 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 515 520 525 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 530 535 540 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 545 550 555 560 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 565 570 575 Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 580 585 590 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 595 600 605 Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 610 615 620 Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 625 630 635 640 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 645 650 655 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 660 665 670 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 675 680 685 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 690 695 700 Pro Gly Lys 705 <210> 144 <211> 2124 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 144 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggct gtgggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga agtgcctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt gtcgacaggc ggtggagggt ccggcggtgg tggatcagac 780 gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840 aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900 aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960 ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020 gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080 tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 1140 atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 1200 aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 1260 ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 1320 agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 1380 acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggaggc 1440 gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac 1680 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740 tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat gtcgggatga gctgaccaag 1860 aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1920 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980 gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg 2040 aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 2100 ctctccctgt ctccgggtaa atag 2124 <210> 145 <211> 706 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 145 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 85 90 95 Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 115 120 125 Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 130 135 140 Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp 145 150 155 160 Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Cys Leu Glu Trp 165 170 175 Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 180 185 190 Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser 195 200 205 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 210 215 220 Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr 225 230 235 240 Met Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 260 265 270 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 275 280 285 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 290 295 300 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 305 310 315 320 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 325 330 335 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 340 345 350 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 355 360 365 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 370 375 380 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 385 390 395 400 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 405 410 415 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 420 425 430 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 435 440 445 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 450 455 460 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 465 470 475 480 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 485 490 495 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 500 505 510 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 515 520 525 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 530 535 540 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 545 550 555 560 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 565 570 575 Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 580 585 590 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 595 600 605 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 610 615 620 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 625 630 635 640 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 645 650 655 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 660 665 670 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 675 680 685 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 690 695 700 Gly Lys 705 <210> 146 <211> 2121 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 146 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacatcagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatattt ctgtcaacac tttgatcatc tcccgctcgc tttcggctgt 300 gggaccaagg tggaaattaa aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360 gggtccggcg gtggaggatc acaggtgcag ctgcaggagt cgggcccagg actggtgaag 420 ccttcggaga ccctgtccct cacctgcact gtctctggtg gctccgtcag cagtggtgat 480 tactactgga cctggatccg gcagtcccca gggaagtgcc tggagtggat tggacacatc 540 tattacagtg ggaacaccaa ttataacccc tccctcaaga gccgactcac catatcaatt 600 gacacgtcca agactcagtt ctccctgaag ctgagttctg tgaccgctgc ggacacggcc 660 atttattact gtgtgcgaga tcgagtgact ggtgcttttg atatctgggg ccaagggaca 720 atggtcaccg tgtcgacagg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780 gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840 tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900 ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960 ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020 ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080 actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaag 1140 ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 1200 ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 1260 gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 1320 ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 1380 gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 1440 aaaactcaca catgcccacc gtgcccagca cctgaagccg cggggggacc gtcagtcttc 1500 ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1560 gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1620 gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacgccag cacgtaccgt 1680 gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1740 gcggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1800 cagccccgag aaccacaggt gtgtaccctg cccccatccc gggatgagct gaccaagaac 1860 caggtcagcc tgtcctgcgc cgtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1920 gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1980 ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac 2040 gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 2100 tccctgtctc cgggtaaata g 2121 <210> 147 <211> 968 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 147 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala 260 265 270 Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile 275 280 285 Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 290 295 300 Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 305 310 315 320 Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 325 330 335 Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr 340 345 350 Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val 355 360 365 Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 370 375 380 Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 385 390 395 400 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 405 410 415 Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 420 425 430 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 435 440 445 Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 450 455 460 Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly 465 470 475 480 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 485 490 495 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 500 505 510 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 515 520 525 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 530 535 540 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 545 550 555 560 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 565 570 575 Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 580 585 590 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 595 600 605 Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 610 615 620 Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 625 630 635 640 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 645 650 655 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 660 665 670 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 675 680 685 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 690 695 700 Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 705 710 715 720 Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 725 730 735 Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys 740 745 750 Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Ala Cys Ile 755 760 765 Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly 770 775 780 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 785 790 795 800 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 805 810 815 Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr 820 825 830 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 835 840 845 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 850 855 860 Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 865 870 875 880 Cys Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln 885 890 895 Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu 900 905 910 Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 915 920 925 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr 930 935 940 Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val Phe Gly 945 950 955 960 Cys Gly Thr Lys Val Glu Ile Lys 965 <210> 148 <211> 2907 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 148 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggct gtgggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga agtgcctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt gtcgacaggc ggtggagggt ccggcggtgg tggatcagac 780 gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840 aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900 aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960 ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020 gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080 tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 1140 atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 1200 aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 1260 ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 1320 agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 1380 acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggaggc 1440 gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac 1680 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740 tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat gtcgggatga gctgaccaag 1860 aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1920 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980 gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg 2040 aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 2100 ctctccctgt ctccgggtgg cggtggaggg tccggcggtg gtggatccga ggtgcagctg 2160 ttggagtctg ggggaggctt ggtacagcct ggggggtccc tgagactctc ctgtgcagcc 2220 tctggattct ccttcagtag cgggtacgac atgtgctggg tccgccaggc tccagggaag 2280 tgcctggagt ggatcgcatg cattgctgct ggtagtgctg gtatcactta cgacgcgaac 2340 tgggcgaaag gccggttcac catctccaga gacaattcca agaacacgct gtatctgcaa 2400 atgaacagcc tgagagccga ggacacggcc gtatattact gtgcgagatc ggcgttttcg 2460 ttcgactacg ccatggacct ctggggccag ggaaccctgg tcaccgtctc gtctggtgga 2520 ggcggttcag gcggaggtgg aagtggtggt ggcggctctg gaggcggcgg atctgacatc 2580 cagatgaccc agtctccttc caccctgtct gcatctgtag gagacagagt caccatcact 2640 tgccaggcca gtcagagcat tagttcccac ttaaactggt atcagcagaa accagggaaa 2700 gcccctaagc tcctgatcta taaggcatcc actctggcat ctggggtccc atcaaggttc 2760 agcggcagtg gatctgggac agaatttact ctcaccatca gcagcctgca gcctgatgat 2820 tttgcaactt attactgcca acagggttat agttggggta atgttgataa tgttttcggc 2880 tgcgggacca aggtggagat caaatag 2907 <210> 149 <211> 961 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 149 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 85 90 95 Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 115 120 125 Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 130 135 140 Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp 145 150 155 160 Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Cys Leu Glu Trp 165 170 175 Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 180 185 190 Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser 195 200 205 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 210 215 220 Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr 225 230 235 240 Met Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 260 265 270 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 275 280 285 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 290 295 300 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 305 310 315 320 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 325 330 335 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 340 345 350 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 355 360 365 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 370 375 380 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 385 390 395 400 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 405 410 415 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 420 425 430 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 435 440 445 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 450 455 460 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 465 470 475 480 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 485 490 495 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 500 505 510 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 515 520 525 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 530 535 540 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 545 550 555 560 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 565 570 575 Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 580 585 590 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 595 600 605 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 610 615 620 Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 625 630 635 640 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 645 650 655 Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 660 665 670 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 675 680 685 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 690 695 700 Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Ser Leu Val Glu 705 710 715 720 Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 725 730 735 Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His Met Gln Trp Val Arg 740 745 750 Gln Ala Pro Gly Lys Cys Leu Glu Tyr Ile Gly Thr Ile Ser Ser Gly 755 760 765 Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly Arg Phe Thr Ile Ser 770 775 780 Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln Met Asn Ser Leu Arg 785 790 795 800 Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Gly Tyr Ser 805 810 815 Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 820 825 830 Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 835 840 845 Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser 850 855 860 Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg 865 870 875 880 Thr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 885 890 895 Leu Ile Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe 900 905 910 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu 915 920 925 Glu Pro Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly 930 935 940 Thr Asp Tyr Val Gly Gly Ala Phe Gly Cys Gly Thr Lys Val Glu Ile 945 950 955 960 Lys <210> 150 <211> 2886 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 150 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacatcagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatattt ctgtcaacac tttgatcatc tcccgctcgc tttcggctgt 300 gggaccaagg tggaaattaa aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360 gggtccggcg gtggaggatc acaggtgcag ctgcaggagt cgggcccagg actggtgaag 420 ccttcggaga ccctgtccct cacctgcact gtctctggtg gctccgtcag cagtggtgat 480 tactactgga cctggatccg gcagtcccca gggaagtgcc tggagtggat tggacacatc 540 tattacagtg ggaacaccaa ttataacccc tccctcaaga gccgactcac catatcaatt 600 gacacgtcca agactcagtt ctccctgaag ctgagttctg tgaccgctgc ggacacggcc 660 atttattact gtgtgcgaga tcgagtgact ggtgcttttg atatctgggg ccaagggaca 720 atggtcaccg tgtcgacagg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780 gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840 tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900 ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960 ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020 ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080 actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaag 1140 ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 1200 ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 1260 gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 1320 ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 1380 gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 1440 aaaactcaca catgcccacc gtgcccagca cctgaagccg cggggggacc gtcagtcttc 1500 ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1560 gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1620 gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacgccag cacgtaccgt 1680 gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1740 gcggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1800 cagccccgag aaccacaggt gtgtaccctg cccccatccc gggatgagct gaccaagaac 1860 caggtcagcc tgtcctgcgc cgtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1920 gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1980 ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac 2040 gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 2100 tccctgtctc cgggtggcgg tggagggtcc ggcggtggtg gatcccggtc gctggtggag 2160 tctgggggag gcttggtcca gcctgggggg tccctgagac tctcctgtac tgcctctgga 2220 ttcaccatca gtagctacca catgcagtgg gtccggcagg cacctgggaa gtgcctggag 2280 tacatcggaa ccattagtag tggtggtaat gtatactacg caagctccgc tagaggcaga 2340 ttcaccatct ccagaccctc gtccaagaac acggtggatc ttcaaatgaa cagcctgaga 2400 gccgaggaca cggctgtgta ttactgtgcg agagactctg gttatagtga tcctatgtgg 2460 ggccagggaa ccctggtcac cgtctcttca ggcggtggcg gtagtggggg aggcggttct 2520 ggcggcggag ggtccggcgg tggaggatca gacgttgtga tgacccagtc tccatcttcc 2580 gtgtctgcat ctgtaggaga cagagtcacc atcacctgtc aggccagtca gaacattagg 2640 acttacttat cctggtatca gcagaaacca gggaaagccc ctaagctcct gatctatgct 2700 gcagccaatc tggcatctgg ggtcccatca aggttcagcg gcagtggatc tgggacagat 2760 ttcactctca ccatcagcga cttggaacct ggcgatgctg caacttacta ttgtcagtct 2820 acctatcttg gtactgatta tgttggcggt gctttcggct gtgggaccaa ggtggagatc 2880 aaatga 2886 <210> 151 <211> 968 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 151 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala 260 265 270 Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile 275 280 285 Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 290 295 300 Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg 305 310 315 320 Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 325 330 335 Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr 340 345 350 Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val 355 360 365 Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 370 375 380 Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 385 390 395 400 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 405 410 415 Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 420 425 430 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 435 440 445 Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 450 455 460 Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly 465 470 475 480 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 485 490 495 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 500 505 510 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 515 520 525 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 530 535 540 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 545 550 555 560 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 565 570 575 Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 580 585 590 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 595 600 605 Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 610 615 620 Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 625 630 635 640 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 645 650 655 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 660 665 670 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 675 680 685 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 690 695 700 Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 705 710 715 720 Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 725 730 735 Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys 740 745 750 Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Ala Cys Ile 755 760 765 Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly 770 775 780 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 785 790 795 800 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 805 810 815 Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr 820 825 830 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 835 840 845 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 850 855 860 Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 865 870 875 880 Cys Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln 885 890 895 Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu 900 905 910 Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 915 920 925 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr 930 935 940 Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val Phe Gly 945 950 955 960 Cys Gly Thr Lys Val Glu Ile Lys 965 <210> 152 <211> 2907 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 152 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggct gtgggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga agtgcctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt gtcgacaggc ggtggagggt ccggcggtgg tggatcagac 780 gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840 aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900 aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960 ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020 gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080 tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 1140 atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 1200 aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 1260 ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 1320 agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 1380 acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggaggc 1440 gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac 1680 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740 tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat gtcgggatga gctgaccaag 1860 aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1920 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980 gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg 2040 aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 2100 ctctccctgt ctccgggtgg cggtggaggg tccggcggtg gtggatccga ggtgcagctg 2160 ttggagtctg ggggaggctt ggtacagcct ggggggtccc tgagactctc ctgtgcagcc 2220 tctggattct ccttcagtag cgggtacgac atgtgctggg tccgccaggc tccagggaag 2280 tgcctggagt ggatcgcatg cattgctgct ggtagtgctg gtatcactta cgacgcgaac 2340 tgggcgaaag gccggttcac catctccaga gacaattcca agaacacgct gtatctgcaa 2400 atgaacagcc tgagagccga ggacacggcc gtatattact gtgcgagatc ggcgttttcg 2460 ttcgactacg ccatggacct ctggggccag ggaaccctgg tcaccgtctc gtctggtgga 2520 ggcggttcag gcggaggtgg aagtggtggt ggcggctctg gaggcggcgg atctgacatc 2580 cagatgaccc agtctccttc caccctgtct gcatctgtag gagacagagt caccatcact 2640 tgccaggcca gtcagagcat tagttcccac ttaaactggt atcagcagaa accagggaaa 2700 gcccctaagc tcctgatcta taaggcatcc actctggcat ctggggtccc atcaaggttc 2760 agcggcagtg gatctgggac agaatttact ctcaccatca gcagcctgca gcctgatgat 2820 tttgcaactt attactgcca acagggttat agttggggta atgttgataa tgttttcggc 2880 tgcgggacca aggtggagat caaatag 2907 <210> 153 <211> 468 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 153 Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 1 5 10 15 Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 20 25 30 Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 35 40 45 Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 50 55 60 Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 65 70 75 80 Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 85 90 95 Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 100 105 110 Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 115 120 125 Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Ala Ser Thr Lys Gly 130 135 140 Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 145 150 155 160 Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 165 170 175 Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 180 185 190 Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 195 200 205 Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 210 215 220 Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 225 230 235 240 Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 245 250 255 Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 260 265 270 Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 275 280 285 Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 290 295 300 Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser 305 310 315 320 Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 325 330 335 Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala 340 345 350 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 355 360 365 Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 370 375 380 Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 385 390 395 400 Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 405 410 415 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 420 425 430 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 435 440 445 Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 450 455 460 Leu Ser Pro Gly 465 <210> 154 <211> 1407 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 154 tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 60 ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 120 aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 180 tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 240 gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 300 ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 360 gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgct 420 agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 480 acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 540 aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 600 ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 660 atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 720 tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 780 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 840 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 900 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 960 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1020 tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1080 gccaaagggc agccccgaga accacaggtg tgtaccctgc ccccatcccg ggatgagctg 1140 accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1200 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1260 gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 1320 caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1380 aagagcctct ccctgtctcc gggttaa 1407 <210> 155 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 155 Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 1 5 10 15 Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 20 25 30 Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 35 40 45 Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 50 55 60 Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 65 70 75 80 Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 85 90 95 Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 100 105 110 Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 115 120 125 Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Thr Val Ala Ala 130 135 140 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 145 150 155 160 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 165 170 175 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 180 185 190 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 195 200 205 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 210 215 220 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 225 230 235 240 Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro 245 250 255 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 260 265 270 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 275 280 285 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 290 295 300 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 305 310 315 320 Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 325 330 335 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 340 345 350 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 355 360 365 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 370 375 380 Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 385 390 395 400 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 405 410 415 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 420 425 430 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 435 440 445 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 450 455 460 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 465 470 <210> 156 <211> 1425 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 156 ttcctaaact cattattcaa ccaagaagtt caaattccct tgaccgaaag ttactgtggc 60 ccatgtccta aaaactggat atgttacaaa aataactgct accaattttt tgatgagagt 120 aaaaactggt atgagagcca ggcttcttgt atgtctcaaa atgccagcct tctgaaagta 180 tacagcaaag aggaccagga tttacttaaa ctggtgaagt catatcattg gatgggacta 240 gtacacattc caacaaatgg atcttggcag tgggaagatg gctccattct ctcacccaac 300 ctactaacaa taattgaaat gcagaaggga gactgtgcac tctatgcctc gagctttaaa 360 ggctatatag aaaactgttc aactccaaat acgtacatct gcatgcaaag gactgtgcgt 420 acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 480 actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg 540 aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc 600 aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa 660 cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 720 ttcaacaggg gagagtgtgg aggcgacaaa actcacacat gcccaccgtg cccagcacct 780 gaagccgcgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg 840 atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag 900 gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg 960 gaggagcagt acgccagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac 1020 tggctgaatg gcaaggagta caagtgcgcg gtctccaaca aagccctccc agcccccatc 1080 gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc 1140 ccatgtcggg atgagctgac caagaaccag gtcagcctgt ggtgcctggt caaaggcttc 1200 tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag 1260 accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg 1320 gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg 1380 cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttaa 1425 <210> 157 <211> 728 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 157 Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 100 105 110 Gly Ser Thr Gly Ser Gly Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr 115 120 125 Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 130 135 140 Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser 145 150 155 160 Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu 165 170 175 Trp Val Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp 180 185 190 Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val 195 200 205 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 210 215 220 Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp 225 230 235 240 Gly Gln Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly 245 250 255 Gly Gly Gly Ser Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile 260 265 270 Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys 275 280 285 Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr 290 295 300 Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val 305 310 315 320 Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His 325 330 335 Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu 340 345 350 Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln 355 360 365 Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu 370 375 380 Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Ala 385 390 395 400 Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 405 410 415 Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 420 425 430 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 435 440 445 Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 450 455 460 Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 465 470 475 480 Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 485 490 495 Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 500 505 510 Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 515 520 525 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 530 535 540 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 545 550 555 560 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 565 570 575 Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 580 585 590 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 595 600 605 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 610 615 620 Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 625 630 635 640 Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 645 650 655 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 660 665 670 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 675 680 685 Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 690 695 700 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 705 710 715 720 Lys Ser Leu Ser Leu Ser Pro Gly 725 <210> 158 <211> 2187 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 158 gagatcgtga tgacacaatc tccatctacg ctctccgcct cagtgggcga tagagtaatt 60 attacttgtc aagcctcaga gagcatttca tcatggctcg cctggtatca gcaaaagcct 120 gggaaggccc ccaaacttct catctatgaa gcatcaaagc tggcctctgg ggttccgtct 180 cgcttctccg ggtccggcag tggtgcagag tttacgttga ctatatcttc tttgcaacct 240 gacgatttcg caacatatta ttgccaggga tacttttatt ttatttcccg aacatatgtt 300 aactcttttg ggtgcgggac caaactcact gtgctggggt ctaccggtag tggttctaag 360 cctggttcag gcgaaggcag tacgaaaggg gaagtgcaac tggtcgaaag cggtggaggg 420 cttgttcaac ctggaggaag cctccgcttg tcctgcacgg ctagcggctt tacaataagt 480 acgaacgcca tgagctgggt ccggcaggct ccaggtaagt gtctcgaatg ggtgggggtc 540 ataacaggca gggacattac ctactacgcc agttgggcca agggtcgatt taccatttct 600 agagatacat ccaagaacac ggtgtacctc cagatgaatt ctcttagggc ggaagacaca 660 gcagtatact actgcgcgcg agatggcggg agcagtgcga tcacatccaa caacatctgg 720 ggtcagggca ctcttgtcac ggtgtcgact ggcggtggag ggtccggcgg tggtggatca 780 tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 840 ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 900 aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 960 tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 1020 gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 1080 ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 1140 gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgct 1200 agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 1260 acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 1320 aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 1380 ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 1440 atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 1500 tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800 tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860 gccaaagggc agccccgaga accacaggtg tgtaccctgc ccccatcccg ggatgagctg 1920 accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1980 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040 gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 2100 caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160 aagagcctct ccctgtctcc gggttaa 2187 <210> 159 <211> 474 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 159 Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 1 5 10 15 Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 20 25 30 Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 35 40 45 Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 50 55 60 Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 65 70 75 80 Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 85 90 95 Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 100 105 110 Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 115 120 125 Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Thr Val Ala Ala 130 135 140 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 145 150 155 160 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 165 170 175 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 180 185 190 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 195 200 205 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 210 215 220 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 225 230 235 240 Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro 245 250 255 Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 260 265 270 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 275 280 285 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 290 295 300 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 305 310 315 320 Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 325 330 335 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 340 345 350 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 355 360 365 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp 370 375 380 Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 385 390 395 400 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 405 410 415 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 420 425 430 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 435 440 445 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 450 455 460 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 465 470 <210> 160 <211> 1425 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 160 ttcctaaact cattattcaa ccaagaagtt caaattccct tgaccgaaag ttactgtggc 60 ccatgtccta aaaactggat atgttacaaa aataactgct accaattttt tgatgagagt 120 aaaaactggt atgagagcca ggcttcttgt atgtctcaaa atgccagcct tctgaaagta 180 tacagcaaag aggaccagga tttacttaaa ctggtgaagt catatcattg gatgggacta 240 gtacacattc caacaaatgg atcttggcag tgggaagatg gctccattct ctcacccaac 300 ctactaacaa taattgaaat gcagaaggga gactgtgcac tctatgcctc gagctttaaa 360 ggctatatag aaaactgttc aactccaaat acgtacatct gcatgcaaag gactgtgcgt 420 acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 480 actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg 540 aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc 600 aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa 660 cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 720 ttcaacaggg gagagtgtgg aggcgacaaa actcacacat gcccaccgtg cccagcacct 780 gaagccgcgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg 840 atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag 900 gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg 960 gaggagcagt acgccagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac 1020 tggctgaatg gcaaggagta caagtgcgcg gtctccaaca aagccctccc agcccccatc 1080 gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc 1140 ccatgtcggg atgagctgac caagaaccag gtcagcctgt ggtgcctggt caaaggcttc 1200 tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag 1260 accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg 1320 gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg 1380 cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttaa 1425 <210> 161 <211> 728 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 161 Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 100 105 110 Gly Ser Thr Gly Ser Gly Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr 115 120 125 Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 130 135 140 Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser 145 150 155 160 Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu 165 170 175 Trp Val Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp 180 185 190 Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val 195 200 205 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 210 215 220 Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp 225 230 235 240 Gly Gln Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly 245 250 255 Gly Gly Gly Ser Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile 260 265 270 Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys 275 280 285 Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr 290 295 300 Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val 305 310 315 320 Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His 325 330 335 Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu 340 345 350 Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln 355 360 365 Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu 370 375 380 Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Ala 385 390 395 400 Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 405 410 415 Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 420 425 430 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 435 440 445 Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 450 455 460 Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 465 470 475 480 Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 485 490 495 Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 500 505 510 Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 515 520 525 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 530 535 540 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 545 550 555 560 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 565 570 575 Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 580 585 590 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 595 600 605 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 610 615 620 Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 625 630 635 640 Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 645 650 655 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 660 665 670 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 675 680 685 Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 690 695 700 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 705 710 715 720 Lys Ser Leu Ser Leu Ser Pro Gly 725 <210> 162 <211> 2187 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 162 gagatcgtga tgacacaatc tccatctacg ctctccgcct cagtgggcga tagagtaatt 60 attacttgtc aagcctcaga gagcatttca tcatggctcg cctggtatca gcaaaagcct 120 gggaaggccc ccaaacttct catctatgaa gcatcaaagc tggcctctgg ggttccgtct 180 cgcttctccg ggtccggcag tggtgcagag tttacgttga ctatatcttc tttgcaacct 240 gacgatttcg caacatatta ttgccaggga tacttttatt ttatttcccg aacatatgtt 300 aactcttttg ggtgcgggac caaactcact gtgctggggt ctaccggtag tggttctaag 360 cctggttcag gcgaaggcag tacgaaaggg gaagtgcaac tggtcgaaag cggtggaggg 420 cttgttcaac ctggaggaag cctccgcttg tcctgcacgg ctagcggctt tacaataagt 480 acgaacgcca tgagctgggt ccggcaggct ccaggtaagt gtctcgaatg ggtgggggtc 540 ataacaggca gggacattac ctactacgcc agttgggcca agggtcgatt taccatttct 600 agagatacat ccaagaacac ggtgtacctc cagatgaatt ctcttagggc ggaagacaca 660 gcagtatact actgcgcgcg agatggcggg agcagtgcga tcacatccaa caacatctgg 720 ggtcagggca ctcttgtcac ggtgtcgact ggcggtggag ggtccggcgg tggtggatca 780 tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 840 ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 900 aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 960 tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 1020 gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 1080 ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 1140 gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgct 1200 agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 1260 acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 1320 aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 1380 ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 1440 atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 1500 tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800 tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860 gccaaagggc agccccgaga accacaggtg tgtaccctgc ccccatcccg ggatgagctg 1920 accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1980 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040 gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 2100 caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160 aagagcctct ccctgtctcc gggttaa 2187 <210> 163 <211> 728 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 163 Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 85 90 95 Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Gly Ser Gly 100 105 110 Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Thr Leu 115 120 125 Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu Arg Leu 130 135 140 Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val 145 150 155 160 Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Ala His 165 170 175 Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys Ser Arg 180 185 190 Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu Gln Met 195 200 205 Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Met 210 215 220 Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 225 230 235 240 Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Leu 245 250 255 Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 260 265 270 Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr 275 280 285 Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys 290 295 300 Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln 305 310 315 320 Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His 325 330 335 Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser 340 345 350 Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu 355 360 365 Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn 370 375 380 Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Thr Val Ala Ala Pro Ser 385 390 395 400 Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 405 410 415 Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 420 425 430 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 435 440 445 Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 450 455 460 Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 465 470 475 480 Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 485 490 495 Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 500 505 510 Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 515 520 525 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 530 535 540 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 545 550 555 560 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 565 570 575 Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 580 585 590 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 595 600 605 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 610 615 620 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 625 630 635 640 Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 645 650 655 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 660 665 670 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 675 680 685 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 690 695 700 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 705 710 715 720 Lys Ser Leu Ser Leu Ser Pro Gly 725 <210> 164 <211> 2187 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 164 gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60 atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120 caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180 ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240 gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300 acaaaattgg agataaaggg aagtactggt tctgggtcta aacccggttc cggcgaaggt 360 agtactaaag gacaggtcac attgaaggaa tctggccccg gccttgttca gccaggacag 420 acccttaggc tcacctgtgc cttcagtggt ttttctctta gcactagcgg tatgggggtc 480 ggctggattc ggcagcctcc cggcaaaggt cttgagtggt tggctcacat ttggtgggac 540 gacgacaaac ggtataatcc tgccttgaaa agtcggctga ccattagtaa ggatacctca 600 aaaaatcaag tgtacttgca aatgaatagc cttgacgccg aggatacggc tgtatattat 660 tgcgcgcgga tggaactctg gtcttactac tttgattatt gggggcaggg gactctcgtc 720 acggtgtcga ctggcggtgg agggtccggc ggtggtggat cattcctaaa ctcattattc 780 aaccaagaag ttcaaattcc cttgaccgaa agttactgtg gcccatgtcc taaaaactgg 840 atatgttaca aaaataactg ctaccaattt tttgatgaga gtaaaaactg gtatgagagc 900 caggcttctt gtatgtctca aaatgccagc cttctgaaag tatacagcaa agaggaccag 960 gatttactta aactggtgaa gtcatatcat tggatgggac tagtacacat tccaacaaat 1020 ggatcttggc agtgggaaga tggctccatt ctctcaccca acctactaac aataattgaa 1080 atgcagaagg gagactgtgc actctatgcc tcgagcttta aaggctatat agaaaactgt 1140 tcaactccaa atacgtacat ctgcatgcaa aggactgtgc gtacggtggc tgcaccatct 1200 gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc 1260 ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc 1320 caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc 1380 ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc 1440 gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt 1500 ggaggcgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800 tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860 gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatgtcg ggatgagctg 1920 accaagaacc aggtcagcct gtggtgcctg gtcaaaggct tctatcccag cgacatcgcc 1980 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040 gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag 2100 caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160 aagagcctct ccctgtctcc gggttaa 2187 <210> 165 <211> 728 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 165 Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 100 105 110 Gly Ser Thr Gly Ser Gly Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr 115 120 125 Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 130 135 140 Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser 145 150 155 160 Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu 165 170 175 Trp Val Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp 180 185 190 Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val 195 200 205 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 210 215 220 Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp 225 230 235 240 Gly Gln Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly 245 250 255 Gly Gly Gly Ser Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile 260 265 270 Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys 275 280 285 Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr 290 295 300 Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val 305 310 315 320 Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His 325 330 335 Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu 340 345 350 Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln 355 360 365 Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu 370 375 380 Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Ala 385 390 395 400 Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 405 410 415 Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 420 425 430 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 435 440 445 Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 450 455 460 Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 465 470 475 480 Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 485 490 495 Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 500 505 510 Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 515 520 525 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 530 535 540 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 545 550 555 560 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 565 570 575 Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 580 585 590 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 595 600 605 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 610 615 620 Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 625 630 635 640 Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 645 650 655 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 660 665 670 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 675 680 685 Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 690 695 700 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 705 710 715 720 Lys Ser Leu Ser Leu Ser Pro Gly 725 <210> 166 <211> 2187 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 166 gagatcgtga tgacacaatc tccatctacg ctctccgcct cagtgggcga tagagtaatt 60 attacttgtc aagcctcaga gagcatttca tcatggctcg cctggtatca gcaaaagcct 120 gggaaggccc ccaaacttct catctatgaa gcatcaaagc tggcctctgg ggttccgtct 180 cgcttctccg ggtccggcag tggtgcagag tttacgttga ctatatcttc tttgcaacct 240 gacgatttcg caacatatta ttgccaggga tacttttatt ttatttcccg aacatatgtt 300 aactcttttg ggtgcgggac caaactcact gtgctggggt ctaccggtag tggttctaag 360 cctggttcag gcgaaggcag tacgaaaggg gaagtgcaac tggtcgaaag cggtggaggg 420 cttgttcaac ctggaggaag cctccgcttg tcctgcacgg ctagcggctt tacaataagt 480 acgaacgcca tgagctgggt ccggcaggct ccaggtaagt gtctcgaatg ggtgggggtc 540 ataacaggca gggacattac ctactacgcc agttgggcca agggtcgatt taccatttct 600 agagatacat ccaagaacac ggtgtacctc cagatgaatt ctcttagggc ggaagacaca 660 gcagtatact actgcgcgcg agatggcggg agcagtgcga tcacatccaa caacatctgg 720 ggtcagggca ctcttgtcac ggtgtcgact ggcggtggag ggtccggcgg tggtggatca 780 tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 840 ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 900 aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 960 tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 1020 gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 1080 ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 1140 gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgct 1200 agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 1260 acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 1320 aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 1380 ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 1440 atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 1500 tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800 tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860 gccaaagggc agccccgaga accacaggtg tgtaccctgc ccccatcccg ggatgagctg 1920 accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1980 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040 gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 2100 caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160 aagagcctct ccctgtctcc gggttaa 2187 <210> 167 <211> 990 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 167 Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 85 90 95 Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Gly Ser Gly 100 105 110 Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Thr Leu 115 120 125 Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu Arg Leu 130 135 140 Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val 145 150 155 160 Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Ala His 165 170 175 Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys Ser Arg 180 185 190 Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu Gln Met 195 200 205 Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Met 210 215 220 Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 225 230 235 240 Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Leu 245 250 255 Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 260 265 270 Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr 275 280 285 Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys 290 295 300 Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln 305 310 315 320 Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His 325 330 335 Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser 340 345 350 Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu 355 360 365 Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn 370 375 380 Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Thr Val Ala Ala Pro Ser 385 390 395 400 Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 405 410 415 Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 420 425 430 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 435 440 445 Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 450 455 460 Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 465 470 475 480 Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 485 490 495 Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 500 505 510 Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 515 520 525 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 530 535 540 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 545 550 555 560 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 565 570 575 Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 580 585 590 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 595 600 605 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 610 615 620 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 625 630 635 640 Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 645 650 655 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 660 665 670 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 675 680 685 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 690 695 700 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 705 710 715 720 Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 725 730 735 Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 740 745 750 Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 755 760 765 Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 770 775 780 Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp 785 790 795 800 Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 805 810 815 Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 820 825 830 Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp 835 840 845 Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 850 855 860 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 865 870 875 880 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 885 890 895 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His 900 905 910 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 915 920 925 Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 930 935 940 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 945 950 955 960 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn 965 970 975 Val Asp Asn Val Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 980 985 990 <210> 168 <211> 2973 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 168 gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60 atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120 caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180 ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240 gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300 acaaaattgg agataaaggg aagtactggt tctgggtcta aacccggttc cggcgaaggt 360 agtactaaag gacaggtcac attgaaggaa tctggccccg gccttgttca gccaggacag 420 acccttaggc tcacctgtgc cttcagtggt ttttctctta gcactagcgg tatgggggtc 480 ggctggattc ggcagcctcc cggcaaaggt cttgagtggt tggctcacat ttggtgggac 540 gacgacaaac ggtataatcc tgccttgaaa agtcggctga ccattagtaa ggatacctca 600 aaaaatcaag tgtacttgca aatgaatagc cttgacgccg aggatacggc tgtatattat 660 tgcgcgcgga tggaactctg gtcttactac tttgattatt gggggcaggg gactctcgtc 720 acggtgtcga ctggcggtgg agggtccggc ggtggtggat cattcctaaa ctcattattc 780 aaccaagaag ttcaaattcc cttgaccgaa agttactgtg gcccatgtcc taaaaactgg 840 atatgttaca aaaataactg ctaccaattt tttgatgaga gtaaaaactg gtatgagagc 900 caggcttctt gtatgtctca aaatgccagc cttctgaaag tatacagcaa agaggaccag 960 gatttactta aactggtgaa gtcatatcat tggatgggac tagtacacat tccaacaaat 1020 ggatcttggc agtgggaaga tggctccatt ctctcaccca acctactaac aataattgaa 1080 atgcagaagg gagactgtgc actctatgcc tcgagcttta aaggctatat agaaaactgt 1140 tcaactccaa atacgtacat ctgcatgcaa aggactgtgc gtacggtggc tgcaccatct 1200 gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc 1260 ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc 1320 caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc 1380 ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc 1440 gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt 1500 ggaggcgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800 tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860 gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatgtcg ggatgagctg 1920 accaagaacc aggtcagcct gtggtgcctg gtcaaaggct tctatcccag cgacatcgcc 1980 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040 gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag 2100 caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160 aagagcctct ccctgtctcc gggtggcggt ggagggtccg gcggtggtgg atccgaggtg 2220 cagctgttgg agtctggggg aggcttggta cagcctgggg ggtccctgag actctcctgt 2280 gcagcctctg gattctcctt cagtagcggg tacgacatgt gctgggtccg ccaggctcca 2340 gggaagtgcc tggagtggat cgcatgcatt gctgctggta gtgctggtat cacttacgac 2400 gcgaactggg cgaaaggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 2460 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gagatcggcg 2520 ttttcgttcg actacgccat ggacctctgg ggccagggaa ccctggtcac cgtctcgtct 2580 ggtggaggcg gttcaggcgg aggtggaagt ggtggtggcg gctctggagg cggcggatct 2640 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 2700 atcacttgcc aggccagtca gagcattagt tcccacttaa actggtatca gcagaaacca 2760 gggaaagccc ctaagctcct gatctataag gcatccactc tggcatctgg ggtcccatca 2820 aggttcagcg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct 2880 gatgattttg caacttatta ctgccaacag ggttatagtt ggggtaatgt tgataatgtt 2940 ttcggctgcg ggaccaaggt ggagatcaaa tag 2973 <210> 169 <211> 984 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 169 Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 100 105 110 Gly Ser Thr Gly Ser Gly Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr 115 120 125 Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 130 135 140 Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser 145 150 155 160 Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu 165 170 175 Trp Val Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp 180 185 190 Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val 195 200 205 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 210 215 220 Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp 225 230 235 240 Gly Gln Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly 245 250 255 Gly Gly Gly Ser Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile 260 265 270 Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys 275 280 285 Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr 290 295 300 Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val 305 310 315 320 Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His 325 330 335 Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu 340 345 350 Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln 355 360 365 Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu 370 375 380 Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Ala 385 390 395 400 Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 405 410 415 Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 420 425 430 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 435 440 445 Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 450 455 460 Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 465 470 475 480 Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 485 490 495 Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 500 505 510 Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 515 520 525 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 530 535 540 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 545 550 555 560 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 565 570 575 Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 580 585 590 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 595 600 605 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 610 615 620 Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 625 630 635 640 Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 645 650 655 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 660 665 670 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 675 680 685 Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 690 695 700 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 705 710 715 720 Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 725 730 735 Gly Ser Arg Ser Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 740 745 750 Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser 755 760 765 Tyr His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Tyr 770 775 780 Ile Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala 785 790 795 800 Arg Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp 805 810 815 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 820 825 830 Ala Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu 835 840 845 Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 850 855 860 Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser 865 870 875 880 Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 885 890 895 Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln Gln Lys 900 905 910 Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn Leu Ala 915 920 925 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 930 935 940 Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr Tyr Tyr 945 950 955 960 Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala Phe Gly 965 970 975 Cys Gly Thr Lys Val Glu Ile Lys 980 <210> 170 <211> 2955 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 170 gagatcgtga tgacacaatc tccatctacg ctctccgcct cagtgggcga tagagtaatt 60 attacttgtc aagcctcaga gagcatttca tcatggctcg cctggtatca gcaaaagcct 120 gggaaggccc ccaaacttct catctatgaa gcatcaaagc tggcctctgg ggttccgtct 180 cgcttctccg ggtccggcag tggtgcagag tttacgttga ctatatcttc tttgcaacct 240 gacgatttcg caacatatta ttgccaggga tacttttatt ttatttcccg aacatatgtt 300 aactcttttg ggtgcgggac caaactcact gtgctggggt ctaccggtag tggttctaag 360 cctggttcag gcgaaggcag tacgaaaggg gaagtgcaac tggtcgaaag cggtggaggg 420 cttgttcaac ctggaggaag cctccgcttg tcctgcacgg ctagcggctt tacaataagt 480 acgaacgcca tgagctgggt ccggcaggct ccaggtaagt gtctcgaatg ggtgggggtc 540 ataacaggca gggacattac ctactacgcc agttgggcca agggtcgatt taccatttct 600 agagatacat ccaagaacac ggtgtacctc cagatgaatt ctcttagggc ggaagacaca 660 gcagtatact actgcgcgcg agatggcggg agcagtgcga tcacatccaa caacatctgg 720 ggtcagggca ctcttgtcac ggtgtcgact ggcggtggag ggtccggcgg tggtggatca 780 tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 840 ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 900 aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 960 tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 1020 gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 1080 ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 1140 gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgct 1200 agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 1260 acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 1320 aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 1380 ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 1440 atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 1500 tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800 tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860 gccaaagggc agccccgaga accacaggtg tgtaccctgc ccccatcccg ggatgagctg 1920 accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1980 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040 gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 2100 caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160 aagagcctct ccctgtctcc gggtggcggt ggagggtccg gcggtggtgg atcccggtcg 2220 ctggtggagt ctgggggagg cttggtccag cctggggggt ccctgagact ctcctgtact 2280 gcctctggat tcaccatcag tagctaccac atgcagtggg tccggcaggc acctgggaag 2340 tgcctggagt acatcggaac cattagtagt ggtggtaatg tatactacgc aagctccgct 2400 agaggcagat tcaccatctc cagaccctcg tccaagaaca cggtggatct tcaaatgaac 2460 agcctgagag ccgaggacac ggctgtgtat tactgtgcga gagactctgg ttatagtgat 2520 cctatgtggg gccagggaac cctggtcacc gtctcttcag gcggtggcgg tagtggggga 2580 ggcggttctg gcggcggagg gtccggcggt ggaggatcag acgttgtgat gacccagtct 2640 ccatcttccg tgtctgcatc tgtaggagac agagtcacca tcacctgtca ggccagtcag 2700 aacattagga cttacttatc ctggtatcag cagaaaccag ggaaagcccc taagctcctg 2760 atctatgctg cagccaatct ggcatctggg gtcccatcaa ggttcagcgg cagtggatct 2820 gggacagatt tcactctcac catcagcgac ttggaacctg gcgatgctgc aacttactat 2880 tgtcagtcta cctatcttgg tactgattat gttggcggtg ctttcggctg tgggaccaag 2940 gtggagatca aatga 2955 <210> 171 <211> 990 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 171 Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 85 90 95 Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Gly Ser Gly 100 105 110 Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Thr Leu 115 120 125 Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu Arg Leu 130 135 140 Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val 145 150 155 160 Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Ala His 165 170 175 Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys Ser Arg 180 185 190 Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu Gln Met 195 200 205 Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Met 210 215 220 Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 225 230 235 240 Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Leu 245 250 255 Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 260 265 270 Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr 275 280 285 Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys 290 295 300 Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln 305 310 315 320 Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His 325 330 335 Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser 340 345 350 Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu 355 360 365 Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn 370 375 380 Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Thr Val Ala Ala Pro Ser 385 390 395 400 Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 405 410 415 Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 420 425 430 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 435 440 445 Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 450 455 460 Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 465 470 475 480 Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 485 490 495 Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 500 505 510 Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 515 520 525 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 530 535 540 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 545 550 555 560 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 565 570 575 Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 580 585 590 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 595 600 605 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 610 615 620 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 625 630 635 640 Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 645 650 655 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 660 665 670 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 675 680 685 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 690 695 700 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 705 710 715 720 Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 725 730 735 Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 740 745 750 Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 755 760 765 Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 770 775 780 Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp 785 790 795 800 Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 805 810 815 Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 820 825 830 Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp 835 840 845 Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 850 855 860 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 865 870 875 880 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 885 890 895 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His 900 905 910 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 915 920 925 Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 930 935 940 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 945 950 955 960 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn 965 970 975 Val Asp Asn Val Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 980 985 990 <210> 172 <211> 2973 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 172 gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60 atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120 caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180 ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240 gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300 acaaaattgg agataaaggg aagtactggt tctgggtcta aacccggttc cggcgaaggt 360 agtactaaag gacaggtcac attgaaggaa tctggccccg gccttgttca gccaggacag 420 acccttaggc tcacctgtgc cttcagtggt ttttctctta gcactagcgg tatgggggtc 480 ggctggattc ggcagcctcc cggcaaaggt cttgagtggt tggctcacat ttggtgggac 540 gacgacaaac ggtataatcc tgccttgaaa agtcggctga ccattagtaa ggatacctca 600 aaaaatcaag tgtacttgca aatgaatagc cttgacgccg aggatacggc tgtatattat 660 tgcgcgcgga tggaactctg gtcttactac tttgattatt gggggcaggg gactctcgtc 720 acggtgtcga ctggcggtgg agggtccggc ggtggtggat cattcctaaa ctcattattc 780 aaccaagaag ttcaaattcc cttgaccgaa agttactgtg gcccatgtcc taaaaactgg 840 atatgttaca aaaataactg ctaccaattt tttgatgaga gtaaaaactg gtatgagagc 900 caggcttctt gtatgtctca aaatgccagc cttctgaaag tatacagcaa agaggaccag 960 gatttactta aactggtgaa gtcatatcat tggatgggac tagtacacat tccaacaaat 1020 ggatcttggc agtgggaaga tggctccatt ctctcaccca acctactaac aataattgaa 1080 atgcagaagg gagactgtgc actctatgcc tcgagcttta aaggctatat agaaaactgt 1140 tcaactccaa atacgtacat ctgcatgcaa aggactgtgc gtacggtggc tgcaccatct 1200 gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc 1260 ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc 1320 caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc 1380 ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc 1440 gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt 1500 ggaggcgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800 tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860 gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatgtcg ggatgagctg 1920 accaagaacc aggtcagcct gtggtgcctg gtcaaaggct tctatcccag cgacatcgcc 1980 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040 gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag 2100 caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160 aagagcctct ccctgtctcc gggtggcggt ggagggtccg gcggtggtgg atccgaggtg 2220 cagctgttgg agtctggggg aggcttggta cagcctgggg ggtccctgag actctcctgt 2280 gcagcctctg gattctcctt cagtagcggg tacgacatgt gctgggtccg ccaggctcca 2340 gggaagtgcc tggagtggat cgcatgcatt gctgctggta gtgctggtat cacttacgac 2400 gcgaactggg cgaaaggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 2460 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gagatcggcg 2520 ttttcgttcg actacgccat ggacctctgg ggccagggaa ccctggtcac cgtctcgtct 2580 ggtggaggcg gttcaggcgg aggtggaagt ggtggtggcg gctctggagg cggcggatct 2640 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 2700 atcacttgcc aggccagtca gagcattagt tcccacttaa actggtatca gcagaaacca 2760 gggaaagccc ctaagctcct gatctataag gcatccactc tggcatctgg ggtcccatca 2820 aggttcagcg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct 2880 gatgattttg caacttatta ctgccaacag ggttatagtt ggggtaatgt tgataatgtt 2940 ttcggctgcg ggaccaaggt ggagatcaaa tag 2973 <210> 173 <211> 1015 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 173 Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 1 5 10 15 Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 20 25 30 Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 35 40 45 Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 50 55 60 Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 65 70 75 80 Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 85 90 95 Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 100 105 110 Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 115 120 125 Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Gly Gly Gly Gly Ser 130 135 140 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe 145 150 155 160 Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser 165 170 175 Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys 180 185 190 Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser 195 200 205 Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp 210 215 220 Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val 225 230 235 240 His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu 245 250 255 Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala 260 265 270 Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro 275 280 285 Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Val Asp Gly Gly Gly Gly 290 295 300 Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 305 310 315 320 Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 325 330 335 Phe Thr Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly 340 345 350 Lys Gly Leu Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr 355 360 365 Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 370 375 380 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 385 390 395 400 Ala Val Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser 405 410 415 Asn Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 420 425 430 Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 435 440 445 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 450 455 460 Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 465 470 475 480 His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 485 490 495 Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 500 505 510 Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 515 520 525 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 530 535 540 Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 545 550 555 560 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 565 570 575 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 580 585 590 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 595 600 605 Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 610 615 620 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 625 630 635 640 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 645 650 655 Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 660 665 670 Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 675 680 685 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 690 695 700 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 705 710 715 720 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 725 730 735 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 740 745 750 Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 755 760 765 Ser Arg Ser Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 770 775 780 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr 785 790 795 800 His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Tyr Ile 805 810 815 Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg 820 825 830 Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu 835 840 845 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 850 855 860 Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val 865 870 875 880 Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 885 890 895 Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro 900 905 910 Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 915 920 925 Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro 930 935 940 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn Leu Ala Ser 945 950 955 960 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 965 970 975 Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr Tyr Tyr Cys 980 985 990 Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala Phe Gly Cys 995 1000 1005 Gly Thr Lys Val Glu Ile Lys 1010 1015 <210> 174 <211> 3048 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 174 tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 60 ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 120 aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 180 tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 240 gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 300 ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 360 gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgga 420 ggcggtggct caggcggagg cggctcagga ggtggcggtt caggaggcgg cggatctttc 480 ctaaactcat tattcaacca agaagttcaa attcccttga ccgaaagtta ctgtggccca 540 tgtcctaaaa actggatatg ttacaaaaat aactgctacc aattttttga tgagagtaaa 600 aactggtatg agagccaggc ttcttgtatg tctcaaaatg ccagccttct gaaagtatac 660 agcaaagagg accaggattt acttaaactg gtgaagtcat atcattggat gggactagta 720 cacattccaa caaatggatc ttggcagtgg gaagatggct ccattctctc acccaaccta 780 ctaacaataa ttgaaatgca gaagggagac tgtgcactct atgcctcgag ctttaaaggc 840 tatatagaaa actgttcaac tccaaatacg tacatctgca tgcaaaggac tgtggtcgac 900 ggcggtggag ggtccggcgg tggtggatca gaggtgcagc tggtggagtc tgggggaggc 960 ttggtccagc ctggggggtc cctgagactc tcctgtgcag cctctggatt caccatcagt 1020 accaatgcaa tgagctgggt ccgccaggct ccagggaagg ggctggagtg gatcggagtc 1080 attactggtc gtgatatcac atactacgcg agctgggcga aaggcagatt caccatctcc 1140 agagacaatt ccaagaacac gctgtatctt caaatgaaca gcctgagagc cgaggacacg 1200 gctgtgtatt actgtgcgag agacggtggt tcttctgcta ttactagtaa caacatttgg 1260 ggccagggaa ccctggtcac cgtgtcctca gctagcacca agggcccatc ggtcttcccc 1320 ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag 1380 gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg 1440 cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc 1500 gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc 1560 aacaccaagg tggacaagag agttgagccc aaatcttgtg acaaaactca cacatgccca 1620 ccgtgcccag cacctgaagc cgcgggggga ccgtcagtct tcctcttccc cccaaaaccc 1680 aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 1740 cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 1800 aagacaaagc cgcgggagga gcagtacgcc agcacgtacc gtgtggtcag cgtcctcacc 1860 gtcctgcacc aggactggct gaatggcaag gagtacaagt gcgcggtctc caacaaagcc 1920 ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag 1980 gtgtgtaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgtcctgc 2040 gccgtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg 2100 gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctcgtg 2160 agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg 2220 atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtggc 2280 ggtggagggt ccggcggtgg tggatcccgg tcgctggtgg agtctggggg aggcttggtc 2340 cagcctgggg ggtccctgag actctcctgt actgcctctg gattcaccat cagtagctac 2400 cacatgcagt gggtccggca ggcacctggg aagtgcctgg agtacatcgg aaccattagt 2460 agtggtggta atgtatacta cgcaagctcc gctagaggca gattcaccat ctccagaccc 2520 tcgtccaaga acacggtgga tcttcaaatg aacagcctga gagccgagga cacggctgtg 2580 tattactgtg cgagagactc tggttatagt gatcctatgt ggggccaggg aaccctggtc 2640 accgtctctt caggcggtgg cggtagtggg ggaggcggtt ctggcggcgg agggtccggc 2700 ggtggaggat cagacgttgt gatgacccag tctccatctt ccgtgtctgc atctgtagga 2760 gacagagtca ccatcacctg tcaggccagt cagaacatta ggacttactt atcctggtat 2820 cagcagaaac cagggaaagc ccctaagctc ctgatctatg ctgcagccaa tctggcatct 2880 ggggtcccat caaggttcag cggcagtgga tctgggacag atttcactct caccatcagc 2940 gacttggaac ctggcgatgc tgcaacttac tattgtcagt ctacctatct tggtactgat 3000 tatgttggcg gtgctttcgg ctgtgggacc aaggtggaga tcaaatga 3048 <210> 175 <211> 965 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 175 Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 115 120 125 Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu 130 135 140 Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met 145 150 155 160 Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 165 170 175 Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys 180 185 190 Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu 195 200 205 Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 210 215 220 Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 225 230 235 240 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 260 265 270 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 275 280 285 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 290 295 300 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 305 310 315 320 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 325 330 335 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 340 345 350 Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 355 360 365 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 370 375 380 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 385 390 395 400 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 405 410 415 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 420 425 430 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 435 440 445 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 450 455 460 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr 465 470 475 480 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 485 490 495 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 500 505 510 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 515 520 525 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 530 535 540 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 545 550 555 560 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 565 570 575 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 580 585 590 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 595 600 605 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 610 615 620 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 625 630 635 640 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 645 650 655 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 660 665 670 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 675 680 685 Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 690 695 700 Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 705 710 715 720 Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 725 730 735 Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys 740 745 750 Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala 755 760 765 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 770 775 780 Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 785 790 795 800 Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly 805 810 815 Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly 820 825 830 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 835 840 845 Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser 850 855 860 Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp 865 870 875 880 Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala 885 890 895 Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg 900 905 910 Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 915 920 925 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser 930 935 940 Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu 945 950 955 960 Val Thr Val Ser Ser 965 <210> 176 <211> 2898 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 176 gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60 atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120 caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180 ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240 gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300 acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360 tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420 ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480 ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540 tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600 acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660 tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720 ctcgtcacgg tctcgagcgg cggtggaggg tccggcggtg gtggatcaga cgtcgtgatg 780 acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat caattgccaa 840 gccagtgaga gcattagcag ttggttagcc tggtatcagc agaaaccagg gaaagcccct 900 aagctcctga tctatgaagc atccaaactg gcatctgggg tcccatcaag gttcagcggc 960 agtggatctg ggacagaatt cactctcacc atcagcagcc tgcagcctga tgattttgca 1020 acttattact gccaaggcta tttttatttt attagtcgta cttatgtaaa ttctttcggc 1080 ggagggacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg 1140 ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc 1200 tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc 1260 caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg 1320 acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag 1380 ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtggagg cgacaaaact 1440 cacacatgcc caccgtgccc agcacctgaa gccgcggggg gaccgtcagt cttcctcttc 1500 cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1560 gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1620 gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1680 agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcgcggtc 1740 tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1800 cgagaaccac aggtgtacac cctgccccca agccgggatg agctgaccaa gaaccaggtc 1860 agcctgtggt gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 1920 aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1980 ttcttcctct atagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 2040 tcatgctccg tgatgcatga ggctctgcac aacagattca cgcagaagag cctctccctg 2100 tctccgggtg gcggtggagg gtccggcggt ggtggatccg acattcagat gacacagtca 2160 ccgtctacgc tctcagcctc agtaggcgat agggtgacta tcacctgcca agcctcccaa 2220 tctataagtt cacacctcaa ctggtatcaa cagaaacccg gtaaagcacc gaagctgctc 2280 atctacaagg catcaactct tgcctcaggt gtgcctagtc gcttctccgg gagcggctcc 2340 ggtactgagt ttactttgac gatatcttcc ctccaacccg acgacttcgc cacatactat 2400 tgtcagcagg gttatagttg gggaaatgtt gacaatgtgt ttggaggggg aacgaaagtg 2460 actgtgttgg gagggggagg aagtggcggc ggcggaagcg gaggtggtgg ctccggcggg 2520 ggtggaagcg aagtgcaatt gctcgaaagt ggtggcggac ttgtgcaacc tggtggaagc 2580 ctctcactct cttgcgcggc gagtggtttt agcttcagta gcggctacga tatgtgctgg 2640 gtaagacagg ctcctggtaa aggccttgag tggattgcgt gtatcgccgc cgggtctgct 2700 ggtataacat acgatgcaaa ctgggcgaaa gggcgcttca caatctccag ggacaactca 2760 aaaaatacat tgtacctcca gatgaatagc ctgagagccg aagacaccgc agtctactat 2820 tgcgcaaggt cagcatttag cttcgattat gcaatggatc tttggggcca ggggacgctc 2880 gtcaccgtct catcttga 2898 <210> 177 <211> 1300 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 177 Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Cys Gly Thr Lys Leu Thr Val Leu 100 105 110 Gly Ser Thr Gly Ser Gly Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr 115 120 125 Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 130 135 140 Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser 145 150 155 160 Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu 165 170 175 Trp Val Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp 180 185 190 Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val 195 200 205 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 210 215 220 Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp 225 230 235 240 Gly Gln Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly 245 250 255 Gly Gly Gly Ser Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile 260 265 270 Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys 275 280 285 Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr 290 295 300 Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val 305 310 315 320 Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His 325 330 335 Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu 340 345 350 Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln 355 360 365 Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu 370 375 380 Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Ala 385 390 395 400 Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 405 410 415 Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 420 425 430 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 435 440 445 Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 450 455 460 Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 465 470 475 480 Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 485 490 495 Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 500 505 510 Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 515 520 525 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 530 535 540 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 545 550 555 560 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 565 570 575 Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 580 585 590 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 595 600 605 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 610 615 620 Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 625 630 635 640 Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 645 650 655 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 660 665 670 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 675 680 685 Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 690 695 700 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 705 710 715 720 Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 725 730 735 Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 740 745 750 Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 755 760 765 Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 770 775 780 Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 785 790 795 800 Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 805 810 815 Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 820 825 830 Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 835 840 845 Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 850 855 860 Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 865 870 875 880 Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 885 890 895 Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 900 905 910 Pro Ala Gly Leu Gly Ser Thr Gly Ser Gly Ser Lys Pro Gly Ser Gly 915 920 925 Glu Gly Ser Thr Lys Gly Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 930 935 940 Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 945 950 955 960 Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 965 970 975 Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 980 985 990 Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 995 1000 1005 Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 1010 1015 1020 Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 1025 1030 1035 Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser 1040 1045 1050 Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu 1055 1060 1065 His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu 1070 1075 1080 Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 1085 1090 1095 Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Gly 1100 1105 1110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu 1115 1120 1125 Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met 1130 1135 1140 Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 1145 1150 1155 Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 1160 1165 1170 Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 1175 1180 1185 Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 1190 1195 1200 Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 1205 1210 1215 Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 1220 1225 1230 Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 1235 1240 1245 Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 1250 1255 1260 Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 1265 1270 1275 Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 1280 1285 1290 Pro Glu Ile Pro Ala Gly Leu 1295 1300 <210> 178 <211> 3903 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 178 gagatcgtga tgacacaatc tccatctacg ctctccgcct cagtgggcga tagagtaatt 60 attacttgtc aagcctcaga gagcatttca tcatggctcg cctggtatca gcaaaagcct 120 gggaaggccc ccaaacttct catctatgaa gcatcaaagc tggcctctgg ggttccgtct 180 cgcttctccg ggtccggcag tggtgcagag tttacgttga ctatatcttc tttgcaacct 240 gacgatttcg caacatatta ttgccaggga tacttttatt ttatttcccg aacatatgtt 300 aactcttttg ggtgcgggac caaactcact gtgctggggt ctaccggtag tggttctaag 360 cctggttcag gcgaaggcag tacgaaaggg gaagtgcaac tggtcgaaag cggtggaggg 420 cttgttcaac ctggaggaag cctccgcttg tcctgcacgg ctagcggctt tacaataagt 480 acgaacgcca tgagctgggt ccggcaggct ccaggtaagt gtctcgaatg ggtgggggtc 540 ataacaggca gggacattac ctactacgcc agttgggcca agggtcgatt taccatttct 600 agagatacat ccaagaacac ggtgtacctc cagatgaatt ctcttagggc ggaagacaca 660 gcagtatact actgcgcgcg agatggcggg agcagtgcga tcacatccaa caacatctgg 720 ggtcagggca ctcttgtcac ggtgtcgact ggcggtggag ggtccggcgg tggtggatca 780 tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 840 ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 900 aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 960 tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 1020 gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 1080 ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 1140 gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgct 1200 agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 1260 acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 1320 aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 1380 ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 1440 atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 1500 tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800 tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860 gccaaagggc agccccgaga accacaggtg tgtaccctgc ccccatcccg ggatgagctg 1920 accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1980 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040 gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 2100 caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160 aagagcctct ccctgtctcc gggtggcggt ggagggtccg gcggtggtgg atcccgagag 2220 ggccccgagc tgtctcctga tgacccagca ggcctcttgg acttgcggca gggtatgttc 2280 gctcaacttg tggctcagaa tgttctgctc attgatggac cactctcttg gtatagtgac 2340 cccggtctgg ccggggtgag tctgaccggc gggctctctt ataaagagga tactaaggaa 2400 ctggtcgtag caaaagcggg cgtttattac gttttttttc agctggagct caggcgcgtg 2460 gtggccggcg agggcagtgg ctctgtgtcc ctggccctgc acttacagcc cttgagaagc 2520 gctgcaggtg ctgccgcact ggctttaact gttgacctcc ctccggcctc ttctgaagct 2580 agaaacagcg ctttcggctt ccaagggcgc ctgctgcacc tgagcgcagg ccagcgctta 2640 ggtgtgcacc ttcatacaga ggccagggcc cgacacgctt ggcagctcac acagggtgcc 2700 acggttctcg gacttttccg cgttactccc gagatccccg ctggcctcgg aagtactggt 2760 tctgggtcta aacccggttc cggcgaaggt agtactaaag gacgagaagg gccagagtta 2820 agtccagatg accctgctgg gcttttggac ctgcggcagg gcatgttcgc tcaactggtg 2880 gctcagaacg tgctgctgat cgatggcccc ctgagttggt acagcgatcc cgggctggca 2940 ggcgtgtcac ttacaggggg cctctcttac aaggaagaca ccaaggagtt agtggtcgct 3000 aaggctggcg tgtattacgt gttcttccaa ctggagctga gaagggttgt ggcaggagag 3060 ggtagcggca gcgtgtcttt agcccttcac ttgcagcccc tgaggtctgc tgcaggtgca 3120 gccgctctcg cgctcaccgt ggatctcccc ccagcctcat ctgaagctag gaacagtgca 3180 tttggctttc agggacgctt gctgcacctc tccgctggac agaggctggg cgtgcacctt 3240 cacacagagg cccgtgccag gcatgcatgg cagctcactc agggggcaac agtgctgggt 3300 ctcttccgcg tgactcctga aataccagct ggacttggcg gtggaggcag cggcggagga 3360 ggatctcgtg aggggccaga actgtccccc gatgacccag ccggactgct cgatctcaga 3420 cagggcatgt tcgctcagct tgtagcccaa aatgtcctcc tgattgacgg ccctttgagc 3480 tggtatagtg atcccggctt ggccggggta tctctgaccg gaggcctctc ctacaaggaa 3540 gacaccaaag agctggtggt ggcaaaagcg ggggtgtatt atgtgttctt tcagctcgag 3600 ctgcggagag ttgtggccgg ggaagggtct gggagcgtat ctcttgcact tcacctgcag 3660 cccctgcgca gcgccgctgg agccgccgcc cttgctctta ctgtggatct gcctcctgct 3720 tcctcagaag cacgcaacag cgccttcggc tttcaaggac gtctcctgca cttgtccgca 3780 ggacagaggt tgggcgtcca tttacacact gaggcacggg cacggcacgc ttggcagctt 3840 acccagggag ccaccgtgct gggactcttt agagtgacac ccgagatccc cgctggcttg 3900 taa 3903 <210> 179 <211> 990 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 179 Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 85 90 95 Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Gly Ser Gly 100 105 110 Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Thr Leu 115 120 125 Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu Arg Leu 130 135 140 Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val 145 150 155 160 Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Ala His 165 170 175 Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys Ser Arg 180 185 190 Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu Gln Met 195 200 205 Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Met 210 215 220 Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 225 230 235 240 Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Leu 245 250 255 Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 260 265 270 Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr 275 280 285 Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys 290 295 300 Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln 305 310 315 320 Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His 325 330 335 Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser 340 345 350 Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu 355 360 365 Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn 370 375 380 Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Thr Val Ala Ala Pro Ser 385 390 395 400 Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 405 410 415 Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 420 425 430 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 435 440 445 Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 450 455 460 Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 465 470 475 480 Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 485 490 495 Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 500 505 510 Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 515 520 525 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 530 535 540 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 545 550 555 560 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 565 570 575 Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 580 585 590 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 595 600 605 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 610 615 620 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 625 630 635 640 Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 645 650 655 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 660 665 670 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 675 680 685 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 690 695 700 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 705 710 715 720 Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 725 730 735 Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 740 745 750 Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 755 760 765 Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu 770 775 780 Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp 785 790 795 800 Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 805 810 815 Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 820 825 830 Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp 835 840 845 Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 850 855 860 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 865 870 875 880 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 885 890 895 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His 900 905 910 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 915 920 925 Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 930 935 940 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 945 950 955 960 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn 965 970 975 Val Asp Asn Val Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 980 985 990 <210> 180 <211> 2973 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 180 gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60 atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120 caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180 ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240 gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300 acaaaattgg agataaaggg aagtactggt tctgggtcta aacccggttc cggcgaaggt 360 agtactaaag gacaggtcac attgaaggaa tctggccccg gccttgttca gccaggacag 420 acccttaggc tcacctgtgc cttcagtggt ttttctctta gcactagcgg tatgggggtc 480 ggctggattc ggcagcctcc cggcaaaggt cttgagtggt tggctcacat ttggtgggac 540 gacgacaaac ggtataatcc tgccttgaaa agtcggctga ccattagtaa ggatacctca 600 aaaaatcaag tgtacttgca aatgaatagc cttgacgccg aggatacggc tgtatattat 660 tgcgcgcgga tggaactctg gtcttactac tttgattatt gggggcaggg gactctcgtc 720 acggtgtcga ctggcggtgg agggtccggc ggtggtggat cattcctaaa ctcattattc 780 aaccaagaag ttcaaattcc cttgaccgaa agttactgtg gcccatgtcc taaaaactgg 840 atatgttaca aaaataactg ctaccaattt tttgatgaga gtaaaaactg gtatgagagc 900 caggcttctt gtatgtctca aaatgccagc cttctgaaag tatacagcaa agaggaccag 960 gatttactta aactggtgaa gtcatatcat tggatgggac tagtacacat tccaacaaat 1020 ggatcttggc agtgggaaga tggctccatt ctctcaccca acctactaac aataattgaa 1080 atgcagaagg gagactgtgc actctatgcc tcgagcttta aaggctatat agaaaactgt 1140 tcaactccaa atacgtacat ctgcatgcaa aggactgtgc gtacggtggc tgcaccatct 1200 gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc 1260 ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc 1320 caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc 1380 ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc 1440 gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt 1500 ggaggcgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800 tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860 gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatgtcg ggatgagctg 1920 accaagaacc aggtcagcct gtggtgcctg gtcaaaggct tctatcccag cgacatcgcc 1980 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040 gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag 2100 caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160 aagagcctct ccctgtctcc gggtggcggt ggagggtccg gcggtggtgg atccgaggtg 2220 cagctgttgg agtctggggg aggcttggta cagcctgggg ggtccctgag actctcctgt 2280 gcagcctctg gattctcctt cagtagcggg tacgacatgt gctgggtccg ccaggctcca 2340 gggaagtgcc tggagtggat cgcatgcatt gctgctggta gtgctggtat cacttacgac 2400 gcgaactggg cgaaaggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 2460 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gagatcggcg 2520 ttttcgttcg actacgccat ggacctctgg ggccagggaa ccctggtcac cgtctcgtct 2580 ggtggaggcg gttcaggcgg aggtggaagt ggtggtggcg gctctggagg cggcggatct 2640 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 2700 atcacttgcc aggccagtca gagcattagt tcccacttaa actggtatca gcagaaacca 2760 gggaaagccc ctaagctcct gatctataag gcatccactc tggcatctgg ggtcccatca 2820 aggttcagcg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct 2880 gatgattttg caacttatta ctgccaacag ggttatagtt ggggtaatgt tgataatgtt 2940 ttcggctgcg ggaccaaggt ggagatcaaa tag 2973 <210> 181 <211> 449 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 181 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 20 25 30 Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 85 90 95 Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 115 120 125 Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 130 135 140 Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 145 150 155 160 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 165 170 175 Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 180 185 190 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 195 200 205 Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 210 215 220 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 225 230 235 240 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 245 250 255 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 260 265 270 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 275 280 285 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 290 295 300 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 305 310 315 320 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 325 330 335 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 340 345 350 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 355 360 365 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 370 375 380 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 385 390 395 400 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 405 410 415 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 420 425 430 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 Lys <210> 182 <211> 1350 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 182 caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccgtcagc agtggtgatt actactggac ctggatccgg 120 cagtccccag ggaagggact ggagtggatt ggacacatct attacagtgg gaacaccaat 180 tataacccct ccctcaagag ccgactcacc atatcaattg acacgtccaa gactcagttc 240 tccctgaagc tgagttctgt gaccgctgcg gacacggcca tttattactg tgtgcgagat 300 cgagtgactg gtgcttttga tatctggggc caagggacaa tggtcaccgt ctcgagcgct 360 agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420 acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480 aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540 ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600 atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 660 tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960 tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020 gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg 1080 accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200 gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag 1260 caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320 aagagcctct ccctgtctcc gggtaaatga 1350 <210> 183 <211> 214 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 183 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 85 90 95 Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 <210> 184 <211> 645 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 184 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacatcagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatattt ctgtcaacac tttgatcatc tcccgctcgc tttcggcgga 300 gggaccaagg tggaaattaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360 tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420 cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480 gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540 ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600 ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag 645 <210> 185 <211> 485 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 185 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 1 5 10 15 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 35 40 45 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 50 55 60 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 65 70 75 80 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 85 90 95 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 100 105 110 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 115 120 125 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 130 135 140 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 145 150 155 160 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 195 200 205 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 210 215 220 Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 225 230 235 240 Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly 245 250 255 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 260 265 270 Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 275 280 285 Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser 290 295 300 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu 305 310 315 320 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 325 330 335 Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly 340 345 350 Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 355 360 365 Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val 370 375 380 Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser 385 390 395 400 Ser Asp Val Gly Gly Tyr Asn Phe Val Ser Trp Tyr Gln Gln His Pro 405 410 415 Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asp Arg Pro Ser 420 425 430 Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 435 440 445 Leu Ile Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys 450 455 460 Ser Ser Tyr Gly Ser Ser Ser Thr His Val Ile Phe Gly Gly Gly Thr 465 470 475 480 Lys Val Thr Val Leu 485 <210> 186 <211> 1458 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 186 gagcccaaat cttccgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg 60 gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 120 acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc 180 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 240 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 300 ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc 360 atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 420 gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 480 gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 540 cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc 600 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 660 tacacgcaga agagcctctc cctgtctccg ggtggcggtg gagggtccgg cggtggtgga 720 tcccaggtgc agctgcagga gtcgggggga ggcctggtca agcctggagg gtccctgaga 780 ctctcctgtg cagcctctgg attcaccttt agtagttatt ggatgagctg ggtccgccag 840 gctccaggga aggggctgga gtgggtggcc aacataaacc gcgatggaag tgcgagttac 900 tatgtggact ctgtgaaggg ccgattcacc atctccagag acgacgccaa gaactcactg 960 tatctgcaaa tgaacagcct gagagctgag gacacggctg tgtattactg tgcgagagat 1020 cgtggggtgg gctacttcga tctctggggc cgtggcaccc tggtcaccgt ctcgagcggt 1080 ggaggcggtt caggcggagg tggttccggc ggtggcggct cccagtctgc cctgactcag 1140 cctgcctccg tgtctgggtc tcctggacag tcgatcacca tctcctgcac tggaaccagc 1200 agtgacgttg gtggttataa ctttgtctcc tggtaccaac aacacccagg caaagccccc 1260 aaactcatga tctatgatgt cagtgatcgg ccctcagggg tgtctgatcg cttctccggc 1320 tccaagtctg gcaacacggc ctccctgatc atctctggcc tccaggctga cgacgaggct 1380 gattattact gcagctcata tgggagcagc agcactcatg tgattttcgg cggagggacc 1440 aaggtgaccg tcctataa 1458 <210> 187 <211> 449 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 187 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Thr Asn 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala 225 230 235 240 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 355 360 365 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Leu Leu Tyr Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly <210> 188 <211> 1350 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 188 gaagtccaat tggtagaaag tggcggtggt ctggtgcaac ctggtggatc tcttcgcctc 60 tcatgcacgg ctagtggctt tactatttca actaatgcga tgagctgggt tcgccaggcc 120 cccggcaaag gacttgagtg ggtcggcgtc atcaccggca gggacattac atactatgcg 180 agttgggcaa agggcaggtt cacgattagc cgcgatactt caaagaatac cgtttacctt 240 caaatgaata gcttgcgcgc ggaagacaca gctgtgtatt actgcgcgcg ggatggaggt 300 agttccgcca taacttccaa caacatatgg ggacaaggca cgctggttac tgtgtcgtca 360 gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 420 ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 480 tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 540 ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 600 tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc 660 aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaagc cgcgggggca 720 ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 780 gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 840 tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 900 agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 960 gagtacaagt gcgcggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 1020 aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 1080 ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 1140 gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 1200 ctggactccg acggctcctt cctgctctat agcaagctca ccgtggacaa gagcaggtgg 1260 cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 1320 cagaagagcc tctccctgtc tccgggttga 1350 <210> 189 <211> 219 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 189 Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Gln Gly Thr Lys Leu Thr Val Leu 100 105 110 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 115 120 125 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 130 135 140 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 145 150 155 160 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 165 170 175 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 180 185 190 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 195 200 205 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 190 <211> 660 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 190 gaaatcgtta tgacgcagag tccctccacg ctctccgcta gtgtcgggga tcgcgtcatt 60 atcacatgcc aggcctccga gtcaatcagc agctggcttg catggtatca acagaagccg 120 ggaaaagctc ctaaattgct gatctatgaa gcgtcaaaat tggcgtctgg tgtcccatct 180 aggttctccg gctctgggtc tggtgcggaa tttactttga caatctccag tcttcaacca 240 gacgatttcg ctacctacta ctgccaaggg tatttctatt ttataagccg gacatatgta 300 aactccttcg gccaaggaac aaagttgact gttcttcgta cggtggctgc accatctgtc 360 ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg 420 ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa 480 tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc 540 agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa 600 gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag 660 <210> 191 <211> 487 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 191 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 1 5 10 15 Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 35 40 45 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 50 55 60 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 65 70 75 80 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 85 90 95 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 100 105 110 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 115 120 125 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 130 135 140 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 145 150 155 160 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 195 200 205 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 210 215 220 Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 225 230 235 240 Ser Arg Ser Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 245 250 255 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr 260 265 270 His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 275 280 285 Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg 290 295 300 Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu 305 310 315 320 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 325 330 335 Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val 340 345 350 Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 355 360 365 Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro 370 375 380 Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 385 390 395 400 Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro 405 410 415 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn Leu Ala Ser 420 425 430 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 435 440 445 Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr Tyr Tyr Cys 450 455 460 Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala Phe Gly Gly 465 470 475 480 Gly Thr Lys Val Glu Ile Lys 485 <210> 192 <211> 1464 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 192 gagcccaaat cttccgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg 60 ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 120 acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc 180 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 240 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 300 ggcaaggagt acaagtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc 360 atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 420 gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 480 gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 540 cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc 600 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 660 tacacgcaga agagcctctc cctgtctccg ggtggcggtg gagggtccgg cggtggtgga 720 tcccggtcgc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 780 tcctgtactg cctctggatt caccatcagt agctaccaca tgcagtgggt ccgccaggct 840 ccagggaagg ggctggagta catcggaacc attagtagtg gtggtaatgt atactacgcg 900 agctccgcga gaggcagatt caccatctcc agaccctcgt ccaagaacac ggtggatctt 960 caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agactctggt 1020 tatagtgatc ctatgtgggg ccagggaacc ctggtcaccg tctcttcagg cggtggcggt 1080 agtgggggag gcggttctgg cggcggaggg tccggcggtg gaggatcaga cgttgtgatg 1140 acccagtctc catcttccgt gtctgcatct gtaggagaca gagtcaccat cacctgtcag 1200 gccagtcaga acattaggac ttacttatcc tggtatcagc agaaaccagg gaaagcccct 1260 aagctcctga tctatgctgc agccaatctg gcatctgggg tcccatcaag gttcagcggc 1320 agtggatctg ggacagattt cactctcacc atcagcgacc tggagcctgg cgatgctgca 1380 acttactatt gtcagtctac ctatcttggt actgattatg ttggcggtgc tttcggcgga 1440 gggaccaagg tggagatcaa atga 1464 <210> 193 <211> 493 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 193 Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 1 5 10 15 Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 20 25 30 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 35 40 45 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 50 55 60 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 65 70 75 80 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 85 90 95 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala 100 105 110 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 115 120 125 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 130 135 140 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 145 150 155 160 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 165 170 175 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 180 185 190 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 195 200 205 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 210 215 220 Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 225 230 235 240 Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 245 250 255 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser 260 265 270 Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 275 280 285 Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala 290 295 300 Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 305 310 315 320 Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 325 330 335 Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu 340 345 350 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 355 360 365 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 370 375 380 Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp 385 390 395 400 Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His Leu 405 410 415 Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 420 425 430 Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 435 440 445 Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 450 455 460 Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val 465 470 475 480 Asp Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 485 490 <210> 194 <211> 1482 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 194 gagcccaaat cttccgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg 60 ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 120 acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc 180 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 240 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 300 ggcaaggagt acaagtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc 360 atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 420 gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 480 gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 540 cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc 600 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 660 tacacgcaga agagcctctc cctgtctccg ggtggcggtg gagggtccgg cggtggtgga 720 tccgaggtgc agctgttgga gtctggggga ggcttggtac agcctggggg gtccctgaga 780 ctctcctgtg cagcctctgg attctccttc agtagcgggt acgacatgtg ctgggtccgc 840 caggctccag ggaaggggct ggagtggatc gcatgcattg ctgctggtag tgctggtatc 900 acttacgacg cgaactgggc gaaaggccgg ttcaccatct ccagagacaa ttccaagaac 960 acgctgtatc tgcaaatgaa cagcctgaga gccgaggaca cggccgtata ttactgtgcg 1020 agatcggcgt tttcgttcga ctacgccatg gacctctggg gccagggaac cctggtcacc 1080 gtctcgagcg gtggaggcgg atctggcgga ggtggttccg gcggtggcgg ctccggtgga 1140 ggcggctctg acatccagat gacccagtct ccttccaccc tgtctgcatc tgtaggagac 1200 agagtcacca tcacttgcca ggccagtcag agcattagtt cccacttaaa ctggtatcag 1260 cagaaaccag ggaaagcccc taagctcctg atctataagg catccactct ggcatctggg 1320 gtcccatcaa ggttcagcgg cagtggatct gggacagaat ttactctcac catcagcagc 1380 ctgcagcctg atgattttgc aacttattac tgccaacagg gttatagttg gggtaatgtt 1440 gataatgttt tcggcggagg gaccaaggtg gagatcaaat aa 1482 <210> 195 <211> 713 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 195 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Asn Asn Ile 85 90 95 Ile Tyr Gly Ala Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 130 135 140 Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe 145 150 155 160 Ser Gly Thr Gln Tyr Val Cys Trp Val Arg Gln Ala Pro Gly Lys Cys 165 170 175 Leu Glu Trp Ile Gly Cys Ile Tyr Val Asp Val Ala Asn Thr Tyr Tyr 180 185 190 Ala Thr Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 195 200 205 Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 210 215 220 Val Tyr Tyr Cys Ala Ser His Asp Thr Val Cys Ala Gly Cys Gly Leu 225 230 235 240 Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly 245 250 255 Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 260 265 270 Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 275 280 285 Gly Phe Thr Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro 290 295 300 Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr 305 310 315 320 Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 325 330 335 Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 340 345 350 Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr 355 360 365 Ser Asn Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 370 375 380 Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 385 390 395 400 Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 405 410 415 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 420 425 430 Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 435 440 445 Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 450 455 460 Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 465 470 475 480 Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 485 490 495 Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 500 505 510 Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 515 520 525 Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 530 535 540 Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 545 550 555 560 Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 565 570 575 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 580 585 590 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 595 600 605 Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 610 615 620 Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 625 630 635 640 Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 645 650 655 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 660 665 670 Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 675 680 685 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 690 695 700 Lys Ser Leu Ser Leu Ser Pro Gly Lys 705 710 <210> 196 <211> 2139 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 196 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtga gaacatttac agcaatttag cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat gcttccactc tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaatct acttattata ataatatcat ttatggggct 300 gctttcggct gtgggaccaa ggtggagatc aaaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcagaggtgc agctggtgga gtctggggga 420 ggcttggtcc agcctggggg gtccctgaga ctctcctgtg cagcctctgg attctccttc 480 agtggcaccc agtacgtgtg ctgggtccgc caggctccag ggaagtgcct ggagtggatc 540 ggatgcattt atgtggatgt ggctaacact tactacgcga cctccgtgaa gggcagattc 600 accatctcca gagacaattc caagaacacg ctgtatcttc aaatgaacag cctgagagcc 660 gaggacacgg ctgtgtatta ctgtgcgagt catgatactg tttgtgctgg ttgtggtttg 720 gacttgtggg gccagggaac cctggtcacc gtgtcgacag gcggtggagg gtccggcggt 780 ggtggatcag aggtgcagct ggtggagtct gggggaggct tggtccagcc tggggggtcc 840 ctgagactct cctgtgcagc ctctggattc accatcagta ccaatgcaat gagctgggtc 900 cgccaggctc cagggaaggg gctggagtgg atcggagtca ttactggtcg tgatatcaca 960 tactacgcga gctgggcgaa aggcagattc accatctcca gagacaattc caagaacacg 1020 ctgtatcttc aaatgaacag cctgagagcc gaggacacgg ctgtgtatta ctgtgcgaga 1080 gacggtggtt cttctgctat tactagtaac aacatttggg gccagggaac cctggtcacc 1140 gtgtcctcag ctagcaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc 1200 acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg 1260 acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta 1320 cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc 1380 acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaga 1440 gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaagcc 1500 gcggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc 1560 cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag 1620 ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag 1680 cagtacgcca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg 1740 aatggcaagg agtacaagtg cgcggtctcc aacaaagccc tcccagcccc catcgagaaa 1800 accatctcca aagccaaagg gcagccccga gaaccacagg tgtgtaccct gcccccatcc 1860 cgggatgagc tgaccaagaa ccaggtcagc ctgtcctgcg ccgtcaaagg cttctatccc 1920 agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg 1980 cctcccgtgc tggactccga cggctccttc ttcctcgtga gcaagctcac cgtggacaag 2040 agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac 2100 cactacacgc agaagagcct ctccctgtct ccgggtaaa 2139 <210> 197 <211> 704 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 197 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 85 90 95 Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 115 120 125 Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 130 135 140 Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp 145 150 155 160 Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Cys Leu Glu Trp 165 170 175 Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu 180 185 190 Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser 195 200 205 Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 210 215 220 Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr 225 230 235 240 Met Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 245 250 255 Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 260 265 270 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 275 280 285 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 290 295 300 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 305 310 315 320 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 325 330 335 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 340 345 350 Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 355 360 365 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 370 375 380 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 385 390 395 400 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 405 410 415 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 420 425 430 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 435 440 445 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 450 455 460 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr 465 470 475 480 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 485 490 495 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 500 505 510 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 515 520 525 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 530 535 540 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 545 550 555 560 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 565 570 575 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 580 585 590 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 595 600 605 Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 610 615 620 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 625 630 635 640 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 645 650 655 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 660 665 670 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 675 680 685 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 690 695 700 <210> 198 <211> 2112 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 198 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacatcagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatattt ctgtcaacac tttgatcatc tcccgctcgc tttcggctgt 300 gggaccaagg tggaaattaa aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360 gggtccggcg gtggaggatc acaggtgcag ctgcaggagt cgggcccagg actggtgaag 420 ccttcggaga ccctgtccct cacctgcact gtctctggtg gctccgtcag cagtggtgat 480 tactactgga cctggatccg gcagtcccca gggaagtgcc tggagtggat tggacacatc 540 tattacagtg ggaacaccaa ttataacccc tccctcaaga gccgactcac catatcaatt 600 gacacgtcca agactcagtt ctccctgaag ctgagttctg tgaccgctgc ggacacggcc 660 atttattact gtgtgcgaga tcgagtgact ggtgcttttg atatctgggg ccaagggaca 720 atggtcaccg tgtcgacagg cggtggaggg tccggcggtg gtggatcaga cgtcgtgatg 780 acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat caattgccaa 840 gccagtgaga gcattagcag ttggttagcc tggtatcagc agaaaccagg gaaagcccct 900 aagctcctga tctatgaagc atccaaactg gcatctgggg tcccatcaag gttcagcggc 960 agtggatctg ggacagaatt cactctcacc atcagcagcc tgcagcctga tgattttgca 1020 acttattact gccaaggcta tttttatttt attagtcgta cttatgtaaa ttctttcggc 1080 ggagggacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg 1140 ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc 1200 tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc 1260 caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg 1320 acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag 1380 ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgtggagg cgacaaaact 1440 cacacatgcc caccgtgccc agcacctgaa gccgcggggg gaccgtcagt cttcctcttc 1500 cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1560 gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1620 gtgcataatg ccaagacaaa gccgcgggag gagcagtacg ccagcacgta ccgtgtggtc 1680 agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcgcggtc 1740 tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1800 cgagaaccac aggtgtacac cctgccccca tgtcgggatg agctgaccaa gaaccaggtc 1860 agcctgtggt gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 1920 aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1980 ttcttcctct atagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 2040 tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 2100 tctccgggta aa 2112 <210> 199 <211> 707 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 199 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 100 105 110 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 115 120 125 Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 130 135 140 Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 145 150 155 160 Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 165 170 175 Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 180 185 190 Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 195 200 205 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 210 215 220 Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 225 230 235 240 Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly 245 250 255 Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 260 265 270 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr 275 280 285 Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 290 295 300 Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala 305 310 315 320 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 325 330 335 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 340 345 350 Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly 355 360 365 Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 370 375 380 Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 385 390 395 400 Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 405 410 415 Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 420 425 430 Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 435 440 445 Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 450 455 460 Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 465 470 475 480 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 485 490 495 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 500 505 510 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 515 520 525 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 530 535 540 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 545 550 555 560 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 565 570 575 Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 580 585 590 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 595 600 605 Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 610 615 620 Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 625 630 635 640 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 645 650 655 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 660 665 670 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 675 680 685 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 690 695 700 Pro Gly Lys 705 <210> 200 <211> 2121 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 200 gacatccaaa tgacgcagtc tccctccagt ttgagtgcaa gtgtgggaga cagagttacg 60 atcacatgta gggcaagtca ggacgtcaat acagccgtcg catggtacca gcagaagcct 120 ggaaaggccc cgaaacttct gatttactct gcaagtttcc tctacagtgg tgttcctagt 180 cgcttcagtg ggtctcggtc aggcaccgat tttaccctga caattagcag cttgcaaccg 240 gaagattttg cgacctatta ttgccagcaa cattatacca cccctcccac atttggacaa 300 ggcacgaagg tagagattaa aggcggtgga gggagcggtg gaggcggttc cggtggaggt 360 ggttctggtg gaggtggcag tgaagtacag cttgttgaga gtggtggtgg acttgtccaa 420 ccagggggaa gtctgcggct gtcatgcgca gcctctggct tcaacattaa ggacacctac 480 attcactggg ttcggcaagc gccggggaag gggctggaat gggtcgccag gatataccct 540 accaacgggt acaccaggta tgcagatagc gttaagggta gattcactat ttcagctgac 600 actagcaaga acaccgcgta tctccagatg aactcccttc gcgccgagga tacggctgtg 660 tactactgct ctaggtgggg aggagatggg ttttacgcaa tggattactg gggacaggga 720 acactcgtta cggtgtcgac aggcggtgga gggtccggcg gtggtggatc agaggtgcag 780 ctggtggagt ctgggggagg cttggtccag cctggggggt ccctgagact ctcctgtgca 840 gcctctggat tcaccatcag taccaatgca atgagctggg tccgccaggc tccagggaag 900 gggctggagt ggatcggagt cattactggt cgtgatatca catactacgc gagctgggcg 960 aaaggcagat tcaccatctc cagagacaat tccaagaaca cgctgtatct tcaaatgaac 1020 agcctgagag ccgaggacac ggctgtgtat tactgtgcga gagacggtgg ttcttctgct 1080 attactagta acaacatttg gggccaggga accctggtca ccgtgtcctc agctagcacc 1140 aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg 1200 gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca 1260 ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac 1320 tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc 1380 aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt 1440 gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560 tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620 ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac 1680 cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740 tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800 gggcagcccc gagaaccaca ggtgtgtacc ctgcccccat cccgggatga gctgaccaag 1860 aaccaggtca gcctgtcctg cgccgtcaaa ggcttctatc ccagcgacat cgccgtggag 1920 tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980 gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg 2040 aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 2100 ctctccctgt ctccgggtaa a 2121 <210> 201 <211> 448 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 201 Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 115 120 125 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 130 135 140 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 145 150 155 160 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 165 170 175 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 180 185 190 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 195 200 205 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 445 <210> 202 <211> 1344 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 202 gacgtcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcaattgcc aagccagtga gagcattagc agttggttag cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaaggc tatttttatt ttattagtcg tacttatgta 300 aattctttcg gcggagggac caaggtggag atcaaacgta cggtggctgc accatctgtc 360 ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg 420 ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa 480 tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc 540 agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa 600 gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgtgga 660 ggcgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg gggaccgtca 720 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 780 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 840 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta cgccagcacg 900 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 960 aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1020 aaagggcagc cccgagaacc acaggtgtac accctgcccc catgtcggga tgagctgacc 1080 aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg 1140 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1200 tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 1260 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1320 agcctctccc tgtctccggg taaa 1344 <210> 203 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 203 Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 20 25 30 Gly Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 35 40 45 Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 50 55 60 Ser Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe 65 70 75 80 Lys Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 85 90 95 Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 204 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 204 caagtacagt tgcagcaatc cggtcccggt ctcgtcaaac cgagtgagac gcttagtata 60 acgtgtactg tttcaggctt tagccttacg aactatggag ttcactggat tcggcaggca 120 cccggcaaag gtttggaatg gctgggtgtt atttggtcag gtggaaatac agactataac 180 acccccttta caagtcggtt cacaattacg aaagataatt ccaaaaatca agtttatttc 240 aagttgagat ccgtccgcgc ggacgacact gcgatctact attgtgcgag ggcactgacc 300 tactacgatt acgaatttgc gtattggggg caagggactc ttgtaacagt ctcgagc 357 <210> 205 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 205 Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 20 25 30 Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 35 40 45 Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 85 90 95 Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu 100 105 <210> 206 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 206 gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60 ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120 ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180 cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240 gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300 ggtacaaagc tgaccgtttt a 321 <210> 207 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 207 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 20 25 30 Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 85 90 95 Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Ser 115 <210> 208 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 208 caagtgcaac tccaggagag tgggccggga ttggttaaac cgagcgagac cctgagtctc 60 acgtgtacag tttcaggcgg gagcgtgagc tcaggcgact attactggac atggataaga 120 cagagtcctg gaaagggcct ggagtggatc ggtcatattt attattcagg gaacactaac 180 tataatccat ctttgaaatc ccgattgaca atctctatcg ataccagtaa aacccagttt 240 agcctcaagc tgtccagcgt tactgctgca gacacagcca tatactattg cgtacgcgat 300 cgcgtgactg gagccttcga catatggggg cagggaacga tggtaacagt ctcgagc 357 <210> 209 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 209 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 85 90 95 Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 210 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 210 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacatcagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatattt ctgtcaacac tttgatcatc tcccgctcgc tttcggcgga 300 gggaccaagg tggaaattaa a 321 <210> 211 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 211 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 20 25 30 Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Cys Leu Glu 35 40 45 Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 85 90 95 Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 100 105 110 Thr Met Val Thr Val Ser Thr 115 <210> 212 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 212 caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccgtcagc agtggtgatt actactggac ctggatccgg 120 cagtccccag ggaagtgcct ggagtggatt ggacacatct attacagtgg gaacaccaat 180 tataacccct ccctcaagag ccgactcacc atatcaattg acacgtccaa gactcagttc 240 tccctgaagc tgagttctgt gaccgctgcg gacacggcca tttattactg tgtgcgagat 300 cgagtgactg gtgcttttga tatctggggc caagggacaa tggtcaccgt gtcgaca 357 <210> 213 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 213 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 85 90 95 Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 100 105 <210> 214 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 214 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggcgagtca ggacatcagc aactatttaa attggtatca gcagaaacca 120 gggaaagccc ctaaactcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240 gaagatattg caacatattt ctgtcaacac tttgatcatc tcccgctcgc tttcggctgt 300 gggaccaagg tggaaattaa a 321 <210> 215 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 215 Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln 1 5 10 15 Thr Leu Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser 20 25 30 Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala 50 55 60 Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 216 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 216 caggtcacat tgaaggaatc tggccccggc cttgttcagc caggacagac ccttagcctc 60 acctgtgcct tcagtggttt ttctcttagc actagcggta tgggggtcgg ctggattcgg 120 cagcctcccg gcaaaggtct tgagtggttg gctcacattt ggtgggacga cgacaaacgg 180 tataatcctg ccttgaaaag tcggctgacc attagtaagg atacctcaaa aaatcaagtg 240 tacttgcaaa tgaatagcct tgacgccgag gatacggctg tatattattg cgcgcggatg 300 gaactctggt cttactactt tgattattgg gggcagggga ctctcgtcac ggtctcgagc 360 <210> 217 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 217 Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr 35 40 45 Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Thr Val Leu 100 105 <210> 218 <211> 318 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 218 gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60 atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120 caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180 ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240 gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300 acaaaagtga ccgtccta 318 <210> 219 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 219 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 220 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 220 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt caccatcagt accaatgcaa tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg gatcggagtc attactggtc gtgatatcac atactacgcg 180 agctgggcga aaggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240 caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agacggtggt 300 tcttctgcta ttactagtaa caacatttgg ggccagggaa ccctggtcac cgtgtcctca 360 <210> 221 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 221 Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 222 <211> 336 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 222 gacgtcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcaattgcc aagccagtga gagcattagc agttggttag cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaaggc tatttttatt ttattagtcg tacttatgta 300 aattctttcg gcggagggac caaggtggag atcaaa 336 <210> 223 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 223 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile 35 40 45 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 224 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 224 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt caccatcagt accaatgcaa tgagctgggt ccgccaggct 120 ccagggaagt gtctggagtg gatcggagtc attactggtc gtgatatcac atactacgcg 180 agctgggcga aaggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240 caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agacggtggt 300 tcttctgcta ttactagtaa caacatttgg ggccagggaa ccctggtcac cgtgtcctca 360 <210> 225 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 225 Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 226 <211> 336 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 226 gacgtcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcaattgcc aagccagtga gagcattagc agttggttag cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaaggc tatttttatt ttattagtcg tacttatgta 300 aattctttcg gctgtgggac caaggtggag atcaaa 336 <210> 227 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 227 Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu 1 5 10 15 Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn 20 25 30 Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met 65 70 75 80 Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly 85 90 95 Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser <210> 228 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 228 caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60 acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120 ccaggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180 agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240 aactccctcc ggtccgagga taccgcgata tattactgtg ccagaggggg gtactcctct 300 gatatctggg ggcagggtac actggttaca gtttcatcc 339 <210> 229 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 229 Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly 1 5 10 15 Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Ala Lys Asn 20 25 30 Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Arg Val 65 70 75 80 Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly 85 90 95 Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys 100 105 110 <210> 230 <211> 330 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 230 gatcctcaat tgacccagtc ccctagtagc ctttctgcaa ccgtgggcca gagggtaaca 60 atcaattgcc agtcaagcca gtccgtagcg aagaataata atttggcatg gttccaacaa 120 aaaccgggta aacctcctaa actccttatc tactcagctt caacccttgc cgcgggtgtg 180 cccagccggt tctcaggctc aggttccggg actcaattta cacttaccat cactcgcgtc 240 caaagtgagg attttgcaac ctactattgt tctgcacggg attccgggaa catacagtcc 300 tttgggggtg gaactcgggt ggagataaaa 330 <210> 231 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 231 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 232 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 232 gaagtccaat tggtagaaag tggcggtggt ctggtgcaac ctggtggatc tcttcgcctc 60 tcatgcgccg ctagtggctt tactatttca actaatgcga tgagctgggt tcgccaggcc 120 cccggcaaag gacttgagtg ggtcggcgtc atcaccggca gggacattac atactatgcg 180 agttgggcaa agggcaggtt cacgattagc cgcgatactt caaagaatac cgtttacctt 240 caaatgaata gcttgagggc ggaagacaca gctgtgtatt actgcgcgag ggatggaggt 300 agttccgcca taacttccaa caacatatgg ggacaaggca cgctggttac tgtctcgagt 360 <210> 233 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 233 Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Gln Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 234 <211> 336 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 234 gaaatcgtta tgacgcagag tccctccacg ctctccgcta gtgtcgggga tcgcgtcatt 60 atcacatgcc aggcctccga gtcaatcagc agctggcttg catggtatca acagaagccg 120 ggaaaagctc ctaaattgct gatctatgaa gcgtcaaaat tggcgtctgg tgtcccatct 180 aggttctccg gctctgggtc tggtgcggaa tttactttga caatctccag tcttcaacca 240 gacgatttcg ctacctacta ctgccaaggg tatttctatt ttataagccg gacatatgta 300 aactccttcg gccaaggaac aaagttgact gttctt 336 <210> 235 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 235 Gln Gln Leu Leu Glu Ser Gly Gly Arg Leu Ile Lys Pro Gly Ala Thr 1 5 10 15 Leu Arg Leu Thr Cys Lys Thr Ser Gly Phe Thr Ile Ser Thr Asn Ala 20 25 30 Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 35 40 45 Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Ile Asn Thr Val Phe Leu Gln Met 65 70 75 80 Arg Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 85 90 95 Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Arg Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 236 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 236 cagcagctgc tggaaagcgg cggccgcctg attaaaccgg gcgcgaccct gcgcctgacc 60 tgcaaaacca gcggctttac cattagcacc aacgcgatga gctgggtgcg ccagccgccg 120 ggcaaaggcc tggaatggat tggcgtgatt accggccgcg atattaccta ttatgcgagc 180 tgggcgaaag gccgctttac cattagcaaa accagcatta acaccgtgtt tctgcagatg 240 cgcagcctgc gcgcggaaga taccgcggtg tattattgcg cgcgcgatgg cggcagcagc 300 gcgattacca gcaacaacat ttggggccgc ggcaccctgg tgaccgtgag cagc 354 <210> 237 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 237 Asp Val Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Thr Val Gly 1 5 10 15 Gln Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys 100 105 110 <210> 238 <211> 336 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 238 gatgtgcaga tgacccagag cccgagcacc ctgagcgcga ccgtgggcca gcgcgtgacc 60 attaactgcc aggcgagcga aagcattagc agctggctgg cgtggtatca gcagaaaccg 120 ggccagccgc cgaaactgct gatttatgaa gcgagcaaac tggcgagcgg cgtgccgagc 180 cgctttagcg gcagcggcag cggcaccgaa tttaccctga ccattagcag cctgcagagc 240 gatgattttg cgacctatta ttgccagggc tatttttatt ttattagccg cacctatgtg 300 aacagctttg gcggcggcac ccgcgtggaa attaaa 336 <210> 239 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 239 Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser 1 5 10 15 Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn Ala 20 25 30 Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 35 40 45 Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Thr Ser Lys Asn Thr Val Tyr Leu Gln Met 65 70 75 80 Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 85 90 95 Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 240 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 240 cagcagctgg tggaaagcgg cggcggcctg gtgaaaccgg gcggcagcct gcgcctgagc 60 tgcgcggcga gcggctttac cattagcacc aacgcgatga gctgggtgcg ccaggcgccg 120 ggcaaaggcc tggaatgggt gggcgtgatt accggccgcg atattaccta ttatgcgagc 180 tgggcgaaag gccgctttac cattagcaaa accagcaaaa acaccgtgta tctgcagatg 240 aacagcctgc gcgcggaaga taccgcggtg tattattgcg cgcgcgatgg cggcagcagc 300 gcgattacca gcaacaacat ttggggccag ggcaccctgg tgaccgtgag cagc 354 <210> 241 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 241 Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser 85 90 95 Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 242 <211> 336 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 242 gatgtggtga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc 60 attagctgcc aggcgagcga aagcattagc agctggctgg cgtggtatca gcagaaaccg 120 ggccaggcgc cgaaactgct gatttatgaa gcgagcaaac tggcgagcgg cgtgccgagc 180 cgctttagcg gcagcggcag cggcaccgaa tttaccctga ccattagcag cctggaaccg 240 gaagattttg cgacctatta ttgccagggc tatttttatt ttattagccg cacctatgtg 300 aacagctttg gcggcggcac caaagtggaa attaaa 336 <210> 243 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 243 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly 20 25 30 Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 244 <211> 369 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 244 gaagtgcaat tgctcgaaag tggtggcgga cttgtgcaac ctggtggaag cctctcactc 60 tcttgcgcgg cgagtggttt tagcttcagt agcggctacg atatgtgctg ggtaagacag 120 gctcctggta aaggccttga gtggattgcg tgtatcgccg ccgggtctgc tggtataaca 180 tacgatgcaa actgggcgaa agggcgcttc acaatctcca gggacaactc aaaaaataca 240 ttgtacctcc agatgaatag cctgagagcc gaagacaccg cagtctacta ttgcgcaagg 300 tcagcattta gcttcgatta tgcaatggat ctttggggcc aggggacgct cgtcaccgtc 360 tcatcttga 369 <210> 245 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 245 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn 85 90 95 Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 246 <211> 330 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 246 gacattcaga tgacacagtc accgtctacg ctctcagcct cagtaggcga tagggtgact 60 atcacctgcc aagcctccca atctataagt tcacacctca actggtatca acagaaaccc 120 ggtaaagcac cgaagctgct catctacaag gcatcaactc ttgcctcagg tgtgcctagt 180 cgcttctccg ggagcggctc cggtactgag tttactttga cgatatcttc cctccaaccc 240 gacgacttcg ccacatacta ttgtcagcag ggttatagtt ggggaaatgt tgacaatgtg 300 tttggagggg gaacgaaagt gactgtgttg 330 <210> 247 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 247 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr 20 25 30 His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 35 40 45 Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg 50 55 60 Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 248 <211> 348 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 248 gaggttcagt tggttgaaag tgggggggga ctcgttcagc ctggaggctc tttgcgactt 60 tcttgtaccg cttctgggtt cactataagt tcatatcata tgcaatgggt aagacaggcg 120 cctggtaagg gacttgaata cataggaaca ataagctctg gtggtaacgt ctattacgcc 180 tcatccgcgc gggggaggtt tacaatttcc aggccttcta gcaaaaacac ggtagatctg 240 caaatgaact ctcttcgcgc tgaagataca gcagtctact actgcgccag ggattcaggg 300 tattctgacc ccatgtgggg gcagggcaca ttggttaccg tgtcctct 348 <210> 249 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 249 Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro 65 70 75 80 Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp 85 90 95 Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 <210> 250 <211> 333 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 250 gacgttgtga tgacgcagtc tcctagttca gtatcagcgt ctgttgggga tcgagtcacg 60 attacatgcc aggcgagcca aaatattagg acgtatctgt cttggtatca acaaaagcct 120 ggtaaggctc caaaactcct catttacgcc gctgccaact tggctagtgg agtaccttca 180 cgctttagtg ggtcaggttc tggaacagat tttacgttga cgatctccga tttggaacca 240 ggggacgctg ccacgtatta ttgccagtcc acctacctcg ggactgacta cgttggtggg 300 gcgtttggcg gaggaacaaa actcactgta ctt 333 <210> 251 <211> 562 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 251 Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 1 5 10 15 Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 20 25 30 Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 35 40 45 Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 50 55 60 Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 65 70 75 80 Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 85 90 95 Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 100 105 110 Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 115 120 125 Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 130 135 140 His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 145 150 155 160 Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 165 170 175 Gly Leu Gly Ser Thr Gly Ser Gly Ser Lys Pro Gly Ser Gly Glu Gly 180 185 190 Ser Thr Lys Gly Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala 195 200 205 Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 210 215 220 Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 225 230 235 240 Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 245 250 255 Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 260 265 270 Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 275 280 285 Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 290 295 300 Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 305 310 315 320 Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 325 330 335 Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 340 345 350 Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 355 360 365 Glu Ile Pro Ala Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 370 375 380 Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 385 390 395 400 Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 405 410 415 Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 420 425 430 Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 435 440 445 Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 450 455 460 Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 465 470 475 480 Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 485 490 495 Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 500 505 510 Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 515 520 525 His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 530 535 540 Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 545 550 555 560 Gly Leu <210> 252 <211> 1689 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 252 cgagagggcc ccgagctgtc tcctgatgac ccagcaggcc tcttggactt gcggcagggt 60 atgttcgctc aacttgtggc tcagaatgtt ctgctcattg atggaccact ctcttggtat 120 agtgaccccg gtctggccgg ggtgagtctg accggcgggc tctcttataa agaggatact 180 aaggaactgg tcgtagcaaa agcgggcgtt tattacgttt tttttcagct ggagctcagg 240 cgcgtggtgg ccggcgaggg cagtggctct gtgtccctgg ccctgcactt acagcccttg 300 agaagcgctg caggtgctgc cgcactggct ttaactgttg acctccctcc ggcctcttct 360 gaagctagaa acagcgcttt cggcttccaa gggcgcctgc tgcacctgag cgcaggccag 420 cgcttaggtg tgcaccttca tacagaggcc agggcccgac acgcttggca gctcacacag 480 ggtgccacgg ttctcggact tttccgcgtt actcccgaga tccccgctgg cctcggaagt 540 actggttctg ggtctaaacc cggttccggc gaaggtagta ctaaaggacg agaagggcca 600 gagttaagtc cagatgaccc tgctgggctt ttggacctgc ggcagggcat gttcgctcaa 660 ctggtggctc agaacgtgct gctgatcgat ggccccctga gttggtacag cgatcccggg 720 ctggcaggcg tgtcacttac agggggcctc tcttacaagg aagacaccaa ggagttagtg 780 gtcgctaagg ctggcgtgta ttacgtgttc ttccaactgg agctgagaag ggttgtggca 840 ggagagggta gcggcagcgt gtctttagcc cttcacttgc agcccctgag gtctgctgca 900 ggtgcagccg ctctcgcgct caccgtggat ctccccccag cctcatctga agctaggaac 960 agtgcatttg gctttcaggg acgcttgctg cacctctccg ctggacagag gctgggcgtg 1020 caccttcaca cagaggcccg tgccaggcat gcatggcagc tcactcaggg ggcaacagtg 1080 ctgggtctct tccgcgtgac tcctgaaata ccagctggac ttggcggtgg aggcagcggc 1140 ggaggaggat ctcgtgaggg gccagaactg tcccccgatg acccagccgg actgctcgat 1200 ctcagacagg gcatgttcgc tcagcttgta gcccaaaatg tcctcctgat tgacggccct 1260 ttgagctggt atagtgatcc cggcttggcc ggggtatctc tgaccggagg cctctcctac 1320 aaggaagaca ccaaagagct ggtggtggca aaagcggggg tgtattatgt gttctttcag 1380 ctcgagctgc ggagagttgt ggccggggaa gggtctggga gcgtatctct tgcacttcac 1440 ctgcagcccc tgcgcagcgc cgctggagcc gccgcccttg ctcttactgt ggatctgcct 1500 cctgcttcct cagaagcacg caacagcgcc ttcggctttc aaggacgtct cctgcacttg 1560 tccgcaggac agaggttggg cgtccattta cacactgagg cacgggcacg gcacgcttgg 1620 cagcttaccc agggagccac cgtgctggga ctctttagag tgacacccga gatccccgct 1680 ggcttgtga 1689 <210> 253 <211> 298 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 253 Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 1 5 10 15 Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 20 25 30 Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 35 40 45 Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 50 55 60 Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 65 70 75 80 Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 85 90 95 Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 100 105 110 Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 115 120 125 Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Gly Gly Gly Gly Ser 130 135 140 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe 145 150 155 160 Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser 165 170 175 Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys 180 185 190 Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser 195 200 205 Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp 210 215 220 Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val 225 230 235 240 His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu 245 250 255 Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala 260 265 270 Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro 275 280 285 Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 290 295 <210> 254 <211> 894 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 254 tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 60 ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 120 aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 180 tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 240 gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 300 ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 360 gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgga 420 ggcggtggct caggcggagg cggctcagga ggtggcggtt caggaggcgg cggatctttc 480 ctaaactcat tattcaacca agaagttcaa attcccttga ccgaaagtta ctgtggccca 540 tgtcctaaaa actggatatg ttacaaaaat aactgctacc aattttttga tgagagtaaa 600 aactggtatg agagccaggc ttcttgtatg tctcaaaatg ccagccttct gaaagtatac 660 agcaaagagg accaggattt acttaaactg gtgaagtcat atcattggat gggactagta 720 cacattccaa caaatggatc ttggcagtgg gaagatggct ccattctctc acccaaccta 780 ctaacaataa ttgaaatgca gaagggagac tgtgcactct atgcctcgag ctttaaaggc 840 tatatagaaa actgttcaac tccaaatacg tacatctgca tgcaaaggac tgtg 894 <210> 255 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 255 Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 256 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 256 caggtgcaat tgcaggagtc ggggggaggc ctggtcaagc ctggagggtc cctgagcctc 60 tcctgtgcag cctctggatt cacctttagt agttattgga tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtggccaac ataaaccgcg atggaagtgc gagttactat 180 gtggactctg tgaagggccg attcaccatc tccagagacg acgccaagaa ctcactgtat 240 ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatcgt 300 ggggtgggct acttcgatct ctggggccgt ggcaccctgg tcaccgtctc gagt 354 <210> 257 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 257 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 258 <211> 333 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 258 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggcg gagggaccaa ggtgaccgtc cta 333 <210> 259 <211> 121 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 259 Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 20 25 30 Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 35 40 45 Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 50 55 60 Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 65 70 75 80 Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 100 105 110 Ala Gly Thr Thr Val Thr Val Ser Ser 115 120 <210> 260 <211> 363 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 260 caggtgcagc tgcagcagcc cggcgccgag ctggtgaagc ccggcgccag cgtgaagatg 60 agctgcaagg ccagcggcta caccttcacc agctacaaca tgcactgggt gaagcagacc 120 cccggccggg gcctggagtg gatcggcgcc atctaccccg gcaacggcga caccagctac 180 aaccagaagt tcaagggcaa ggccaccctg accgccgaca agagcagcag caccgcctac 240 atgcagctga gcagcctgac cagcgaggac agcgccgtgt actactgcgc ccggagcacc 300 tactacggcg gcgactggta cttcaacgtg tggggcgccg gcaccaccgt gaccgtctcg 360 agc 363 <210> 261 <211> 106 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 261 Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 1 5 10 15 Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 20 25 30 His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 35 40 45 Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 85 90 95 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 <210> 262 <211> 318 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 262 cagatcgtgc tgagccagag ccccgccatc ctgagcgcca gccccggcga gaaggtgacc 60 atgacctgcc gggccagcag cagcgtgagc tacatccact ggttccagca gaagcccggc 120 agcagcccca agccctggat ctacgccacc agcaacctgg ccagcggcgt gcccgtgcgg 180 ttcagcggca gcggcagcgg caccagctac agcctgacca tcagccgggt ggaggccgag 240 gacgccgcca cctactactg ccagcagtgg accagcaacc cccccacctt cggcggcggc 300 accaagctga ccgtgctg 318 <210> 263 <211> 124 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 263 Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 1 5 10 15 Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser Phe Asn Ser Tyr 20 25 30 Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 35 40 45 Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly Asn Val Tyr Ser 100 105 110 Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 115 120 <210> 264 <211> 372 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 264 gaggtgcagc tgcaggagtc tggcggcggc ctggtgcagg ctggggacag cctgagcctg 60 tcctgcctgg tgtctggccg ctccttcaac tcctacacca tgggctggtt ccgccaggcc 120 cctgggaagg agcgggagtt tgtggctgcc atcctgtgga gtggccccac cacctactat 180 gctgactctg tgaagggccg cttcaccatc tccagagaca atgccaagaa cactgtgtac 240 ctgcagatga acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgccctg 300 ggagtgctgg tgctggcccc tggcaatgtg tacagctact ggggccaggg cacccaggtg 360 actgtctcga gc 372 <210> 265 <211> 127 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 265 Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 1 5 10 15 Ser Leu Ser Leu Ser Cys Ala Phe Ser Gly Arg Thr Phe Ser Met Tyr 20 25 30 Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 35 40 45 Ala Ala Asn Arg Gly Arg Gly Leu Ser Pro Asp Ile Ala Asp Ser Val 50 55 60 Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ala Asp Leu Gln Tyr Gly Ser Ser Trp Pro Gln Arg Ser Ser Ala 100 105 110 Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 125 <210> 266 <211> 381 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 266 caggtgcagc tggtgcagtc tggcggaggc ctggtgcagg ctgggggcag cctgagcctg 60 agctgtgcct tctctggccg caccttctcc atgtacacca tgggctggtt ccgccaggcc 120 ccagggaagg agagagagtt tgtggctgcc aacagaggca gaggcctgag cccagacatt 180 gctgactctg tgaatggccg cttcaccatc tccagagaca atgccaagaa caccctgtac 240 ctgcagatgg acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgacctg 300 cagtatggca gcagctggcc tcagaggagc tctgctgagt atgactactg gggccagggc 360 accactgtga ctgtctcgag c 381 <210> 267 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 267 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly 20 25 30 Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp 35 40 45 Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 268 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 268 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt ctccttcagt agcgggtacg acatgtgctg ggtccgccag 120 gctccaggga agtgcctgga gtggatcgca tgcattgctg ctggtagtgc tggtatcact 180 tacgacgcga actgggcgaa aggccggttc accatctcca gagacaattc caagaacacg 240 ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaga 300 tcggcgtttt cgttcgacta cgccatggac ctctggggcc agggaaccct ggtcaccgtc 360 tcgtct 366 <210> 269 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 269 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn 85 90 95 Val Asp Asn Val Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 270 <211> 333 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 270 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtca gagcattagt tcccacttaa actggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctataag gcatccactc tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacag ggttatagtt ggggtaatgt tgataatgtt 300 ttcggctgcg ggaccaaggt ggagatcaaa tag 333 <210> 271 <211> 115 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 271 Arg Ser Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 1 5 10 15 Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His 20 25 30 Met Gln Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Tyr Ile Gly 35 40 45 Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly 50 55 60 Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln 65 70 75 80 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 85 90 95 Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> 272 <211> 345 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 272 cggtcgctgg tggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc 60 tgtactgcct ctggattcac catcagtagc taccacatgc agtgggtccg gcaggcacct 120 gggaagtgcc tggagtacat cggaaccatt agtagtggtg gtaatgtata ctacgcaagc 180 tccgctagag gcagattcac catctccaga ccctcgtcca agaacacggt ggatcttcaa 240 atgaacagcc tgagagccga ggacacggct gtgtattact gtgcgagaga ctctggttat 300 agtgatccta tgtggggcca gggaaccctg gtcaccgtct cttca 345 <210> 273 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 273 Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro 65 70 75 80 Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp 85 90 95 Tyr Val Gly Gly Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 274 <211> 336 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 274 gacgttgtga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60 atcacctgtc aggccagtca gaacattagg acttacttat cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcagccaatc tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcga cttggaacct 240 ggcgatgctg caacttacta ttgtcagtct acctatcttg gtactgatta tgttggcggt 300 gctttcggct gtgggaccaa ggtggagatc aaatga 336 <210> 275 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 275 Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 35 40 45 Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr 100 105 110 Leu Val Thr Val Ser Thr 115 <210> 276 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 276 caggtgcaat tgcaggagtc ggggggaggc ctggtcaagc ctggagggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagt agttattgga tgagctgggt ccgccaggct 120 ccagggaagt gcctggagtg ggtggccaac ataaaccgcg atggaagtgc gagttactat 180 gtggactctg tgaagggccg attcaccatc tccagagacg acgccaagaa ctcactgtat 240 ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatcgt 300 ggggtgggct acttcgatct ctggggccgt ggcaccctgg tcaccgtgtc gaca 354 <210> 277 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 277 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Cys Gly Thr Lys Val Thr Val Leu 100 105 110 <210> 278 <211> 333 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 278 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggct gtgggaccaa ggtgaccgtc cta 333 <210> 279 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 279 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Thr 20 25 30 Gln Tyr Val Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly Cys Ile Tyr Val Asp Val Ala Asn Thr Tyr Tyr Ala Thr Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Ser His Asp Thr Val Cys Ala Gly Cys Gly Leu Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 280 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 280 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt ctccttcagt ggcacccagt acgtgtgctg ggtccgccag 120 gctccaggga aggggctgga gtggatcgga tgcatttatg tggatgtggc taacacttac 180 tacgcgacct ccgtgaaggg cagattcacc atctccagag acaattccaa gaacacgctg 240 tatcttcaaa tgaacagcct gagagccgag gacacggctg tgtattactg tgcgagtcat 300 gatactgttt gtgctggttg tggtttggac ttgtggggcc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 281 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 281 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Asn Asn Ile 85 90 95 Ile Tyr Gly Ala Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 282 <211> 333 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 282 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtga gaacatttac agcaatttag cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat gcttccactc tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaatct acttattata ataatatcat ttatggggct 300 gctttcggcg gagggaccaa ggtggagatc aaa 333 <210> 283 <211> 120 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 283 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Thr 115 120 <210> 284 <211> 360 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 284 gaagtacagc ttgttgagag tggtggtgga cttgtccaac cagggggaag tctgcggctg 60 tcatgcgcag cctctggctt caacattaag gacacctaca ttcactgggt tcggcaagcg 120 ccggggaagg ggctggaatg ggtcgccagg atatacccta ccaacgggta caccaggtat 180 gcagatagcg ttaagggtag attcactatt tcagctgaca ctagcaagaa caccgcgtat 240 ctccagatga actcccttcg cgccgaggat acggctgtgt actactgctc taggtgggga 300 ggagatgggt tttacgcaat ggattactgg ggacagggaa cactcgttac ggtgtcgaca 360 <210> 285 <211> 107 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 285 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 20 25 30 Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 286 <211> 321 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 286 gacatccaaa tgacgcagtc tccctccagt ttgagtgcaa gtgtgggaga cagagttacg 60 atcacatgta gggcaagtca ggacgtcaat acagccgtcg catggtacca gcagaagcct 120 ggaaaggccc cgaaacttct gatttactct gcaagtttcc tctacagtgg tgttcctagt 180 cgcttcagtg ggtctcggtc aggcaccgat tttaccctga caattagcag cttgcaaccg 240 gaagattttg cgacctatta ttgccagcaa cattatacca cccctcccac atttggacaa 300 ggcacgaagg tagagattaa a 321 <210> 287 <211> 451 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 287 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Thr 20 25 30 Gln Tyr Val Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Gly Cys Ile Tyr Val Asp Val Ala Asn Thr Tyr Tyr Ala Thr Ser 50 55 60 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 65 70 75 80 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Ser His Asp Thr Val Cys Ala Gly Cys Gly Leu Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 210 215 220 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 225 230 235 240 Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 260 265 270 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 290 295 300 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 305 310 315 320 Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 325 330 335 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 355 360 365 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 385 390 395 400 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445 Ser Pro Gly 450 <210> 288 <211> 1356 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 288 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt ctccttcagt ggcacccagt acgtgtgctg ggtccgccag 120 gctccaggga aggggctgga gtggatcgga tgcatttatg tggatgtggc taacacttac 180 tacgcgacct ccgtgaaggg cagattcacc atctccagag acaattccaa gaacacgctg 240 tatcttcaaa tgaacagcct gagagccgag gacacggctg tgtattactg tgcgagtcat 300 gatactgttt gtgctggttg tggtttggac ttgtggggcc agggaaccct ggtcaccgtc 360 tcgagcgcta gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc 420 tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg 480 gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag 540 tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc 600 cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt 660 gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg 720 ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 780 acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc 840 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 900 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 960 ggcaaggagt acaagtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc 1020 atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1080 gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 1140 gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 1200 cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc 1260 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 1320 tacacgcaga agagcctctc cctgtctccg ggttaa 1356 <210> 289 <211> 218 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 289 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Asn Asn Ile 85 90 95 Ile Tyr Gly Ala Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 290 <211> 657 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 290 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtga gaacatttac agcaatttag cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat gcttccactc tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaatct acttattata ataatatcat ttatggggct 300 gctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 360 atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 420 aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 480 ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 540 agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 600 acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttag 657 <210> 291 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 291 Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser 1 5 10 15 Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu Ser Ser Asn Ala 20 25 30 Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 35 40 45 Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Arg Ser Lys Asn Thr Val Tyr Leu Gln Met Asn 65 70 75 80 Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly 85 90 95 Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 100 105 110 <210> 292 <211> 336 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 292 caacagttgg ttgagtctgg tggcggtctc gttaagcctg gagggtccct tcggcttagt 60 tgtgcggcct ctgggatcga cctgtctagc aacgctatag gatgggtacg gcaagctccg 120 ggcaaaggcc ttgagtgggt cggcgttatt tttgggagcg gtaatacgta ctacgccagc 180 tgggcaaaag gtaggttcac tatcagtcga tcaaagaaca cggtatatct tcagatgaac 240 agtctccggg cggaggacac cgcggtttat tattgcgcaa gggggggata ctcctcagac 300 atatggggcc aaggtacttt ggtgacggtc tcgagc 336 <210> 293 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 293 Asp Pro Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Ala Lys Asn 20 25 30 Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val 65 70 75 80 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly 85 90 95 Asn Ile Gln Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 294 <211> 330 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 294 gatccagttc tgacacaaag tccatccagc ctgtctgcct cagtcggcga cagagtgacc 60 atcagttgcc agagctcaca gtctgtggct aagaacaaca acttggcgtg gttccaacag 120 aaacctggac aggctccgaa attgctgatc tattctgctt ccacgcttgc tgctggtgtt 180 ccttcccgct tttcaggtag tggtagcggg acagacttca ctttgactat aagcagcgtg 240 cagcctgaag attttgcgac ctactattgt tctgctagag acagtggaaa tattcagtcc 300 tttggggggg gaacgaaggt cgaaataaag 330 <210> 295 <211> 139 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 295 Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 1 5 10 15 Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 20 25 30 Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 35 40 45 Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 50 55 60 Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 65 70 75 80 Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 85 90 95 Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 100 105 110 Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 115 120 125 Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 130 135 <210> 296 <211> 417 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 296 tttctgaata gcctgttcaa ccaggaggtg cagatcccac tgaccgagag ctattgtgga 60 ccttgtccta agaactggat ctgttacaag aacaactgct accagttctt cgacgagagc 120 aagaattggt atgaaagcca ggccagctgc atgagccaaa acgcctctct gctgaaggtg 180 tactccaaag aagatcagga cctgctgaag ctggtgaagt cctaccactg gatgggcctg 240 gtgcacatcc caaccaacgg cagctggcag tgggaagacg gcagcatcct gagccctaac 300 ctgctgacaa tcattgagat gcagaaaggc gactgcgccc tgtacgccag ttcttttaag 360 ggctacatcg aaaactgtag cacccctaac acctacatct gcatgcagag aacagtg 417 <210> 297 <211> 439 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 297 Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu 1 5 10 15 Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn 20 25 30 Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met 65 70 75 80 Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly 85 90 95 Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 115 120 125 Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 130 135 140 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 145 150 155 160 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 165 170 175 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 180 185 190 Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 195 200 205 Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 210 215 220 Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 225 230 235 240 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 245 250 255 Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 260 265 270 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 275 280 285 Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 290 295 300 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 305 310 315 320 Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 325 330 335 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 340 345 350 Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 355 360 365 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 370 375 380 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 385 390 395 400 Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 405 410 415 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 420 425 430 Ser Leu Ser Leu Ser Leu Gly 435 <210> 298 <211> 1320 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 298 caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60 acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120 ccaggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180 agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240 aactccctcc ggtccgagga taccgcgata tattactgtg ccagaggggg gtactcctct 300 gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa gggaccctct 360 gtgtttcctc tggctccttg ctccagatcc acctccgagt ctacagctgc tctgggctgc 420 ctggtcaagg actactttcc tgagcctgtg accgtgtcct ggaactctgg cgctctgaca 480 tctggcgtgc acacctttcc agctgtgctg cagtcctccg gcctgtactc tctgtcctct 540 gtcgtgaccg tgccttcctc tagcctgggc accaagacct acacctgtaa tgtggaccac 600 aagccttcca acaccaaggt ggacaagcgc gtggaatcta agtacggccc tccttgtcct 660 ccatgtcctg ctccagaagc tgctggcggc ccatccgtgt ttctgttccc tccaaagcct 720 aaggacaccc tgatgatctc tcggacccct gaagtgacct gcgtggtggt ggatgtgtcc 780 caagaggatc ccgaggtgca gttcaattgg tacgtggacg gcgtggaagt gcacaacgcc 840 aagaccaagc ctagagagga acagttcaac tccacctaca gagtggtgtc cgtgctgacc 900 gtgctgcacc aggattggct gaacggcaaa gagtacaagt gcaaggtgtc caacaagggc 960 ctgccttcca gcatcgaaaa gaccatctcc aaggccaagg gccagcctag ggaaccccag 1020 gtttacaccc tgcctccaag ccaagaggaa atgaccaaga accaggtgtc cctgtcctgc 1080 gccgtgaagg gcttctaccc ttccgatatc gccgtggaat gggagagcaa tggccagcct 1140 gagaacaact acaagacaac ccctcctgtg ctggactccg acggctcctt cttcctggtg 1200 tcccgcctga ccgtggacaa gtccagatgg caagagggca acgtgttctc ctgctccgtg 1260 atgcacgagg ccctgcacaa tcactacacc cagaagtccc tgtctctgtc cctgggatga 1320 <210> 299 <211> 702 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 299 Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe 50 55 60 Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu 65 70 75 80 Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser 85 90 95 Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 100 105 110 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 130 135 140 Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 145 150 155 160 Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 165 170 175 Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val 180 185 190 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 195 200 205 Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 210 215 220 Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly 225 230 235 240 Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 245 250 255 Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 260 265 270 Thr Val Gly Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val 275 280 285 Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro 290 295 300 Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro 305 310 315 320 Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile 325 330 335 Thr Arg Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg 340 345 350 Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile 355 360 365 Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 370 375 380 Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 385 390 395 400 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 405 410 415 Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 420 425 430 Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 435 440 445 Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 450 455 460 Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Pro 465 470 475 480 Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 485 490 495 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 500 505 510 Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 515 520 525 Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 530 535 540 Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 545 550 555 560 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 565 570 575 Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 580 585 590 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 595 600 605 Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 610 615 620 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 625 630 635 640 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 645 650 655 Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 660 665 670 Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 675 680 685 His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 690 695 700 <210> 300 <211> 2109 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 300 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120 cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180 tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240 caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300 attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360 tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420 ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480 agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540 aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600 atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660 gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720 cgtggcaccc tggtcaccgt ctcgagtggc ggtggagggt ccggcggtgg tggatcagat 780 cctcaattga cccagtcccc tagtagcctt tctgcaaccg tgggccagag ggtaacaatc 840 aattgccagt caagccagtc cgtagcgaag aataataatt tggcatggtt ccaacaaaaa 900 ccgggtaaac ctcctaaact ccttatctac tcagcttcaa cccttgccgc gggtgtgccc 960 agccggttct caggctcagg ttccgggact caatttacac ttaccatcac tcgcgtccaa 1020 agtgaggatt ttgcaaccta ctattgttct gcacgggatt ccgggaacat acagtccttt 1080 gggggtggaa ctcgggtgga gataaaacgt acggtggctg caccatctgt cttcatcttc 1140 ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac 1200 ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac 1260 tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc 1320 ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat 1380 cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtgg cggcggacct 1440 ccttgtcctc catgtcctgc tccagaagct gctggcggcc catccgtgtt tctgttccct 1500 ccaaagccta aggacaccct gatgatctct cggacccctg aagtgacctg cgtggtggtg 1560 gatgtgtccc aagaggatcc cgaggtgcag ttcaattggt acgtggacgg cgtggaagtg 1620 cacaacgcca agaccaagcc tagagaggaa cagttcaact ccacctacag agtggtgtcc 1680 gtgctgaccg tgctgcacca ggattggctg aacggcaaag agtacaagtg caaggtgtcc 1740 aacaagggcc tgccttccag catcgaaaag accatctcca aggccaaggg ccagcctagg 1800 gaaccccagg tttacaccct gcctccaagc caagaggaaa tgaccaagaa ccaggtgtcc 1860 ctgtggtgcc tcgtgaaggg cttctaccct tccgatatcg ccgtggaatg ggagagcaat 1920 ggccagcctg agaacaacta caagacaacc cctcctgtgc tggactccga cggctccttc 1980 ttcctgtatt cccgcctgac cgtggacaag tccagatggc aagagggcaa cgtgttctcc 2040 tgctccgtga tgcacgaggc cctgcacaat cgcttcaccc agaagtccct gtctctgtcc 2100 ctgggatga 2109 <210> 301 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 301 Gly Thr Gln Tyr Val Cys 1 5 <210> 302 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 302 Cys Ile Tyr Val Asp Val Ala Asn Thr Tyr Tyr Ala Thr Ser Val Lys 1 5 10 15 Gly <210> 303 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 303 His Asp Thr Val Cys Ala Gly Cys Gly Leu Asp Leu 1 5 10 <210> 304 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 304 Gln Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 1 5 10 <210> 305 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 305 Asp Ala Ser Thr Leu Ala Ser 1 5 <210> 306 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 306 Gln Ser Thr Tyr Tyr Asn Asn Ile Ile Tyr Gly Ala Ala 1 5 10 <210> 307 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 307 Ser Asn Ala Ile Gly 1 5 <210> 308 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 308 Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 309 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 309 Gly Gly Tyr Ser Ser Asp Ile 1 5 <210> 310 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 310 Gln Ser Ser Gln Ser Val Ala Lys Asn Asn Asn Leu Ala 1 5 10 <210> 311 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 311 Ser Ala Ser Thr Leu Ala Ala 1 5 <210> 312 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 312 Ser Ala Arg Asp Ser Gly Asn Ile Gln Ser 1 5 10 <210> 313 <211> 329 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 313 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly 325 <210> 314 <211> 326 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 314 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 1 5 10 15 Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 65 70 75 80 Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 100 105 110 Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 115 120 125 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 130 135 140 Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 145 150 155 160 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 165 170 175 Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 180 185 190 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 195 200 205 Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 210 215 220 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 225 230 235 240 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 245 250 255 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 260 265 270 Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 275 280 285 Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 290 295 300 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 305 310 315 320 Leu Ser Leu Ser Leu Gly 325

Claims (30)

  1. N-말단 및 C-말단을 갖는 다중특이적 항체 유사 단백질(multi-specific antibody-like protein)로서,
    N-말단으로부터 C-말단으로, 제1 결합 단량체, CH1 도메인, 제1 힌지(hinge), 제1 CH2 도메인, 및 제1 CH3 도메인을 포함하는 제1 단량체로서, 상기 제1 단량체가 임의로 N-말단에 연결된 제1 결합 도메인(D1), C-말단에 연결된 제4 결합 도메인(D4), 또는 둘 다를 포함하는, 제1 단량체,
    N-말단으로부터 C-말단으로, 제2 결합 단량체, CL 도메인, 제2 힌지, 제2 CH2 도메인, 및 제2 CH3 도메인을 포함하는 제2 단량체로서, 상기 제2 단량체가 임의로 N-말단에 연결된 제2 결합 도메인(D2), C-말단에 연결된 제5 결합 도메인(D5), 또는 둘 다를 포함하는, 제2 단량체를 포함하고,
    상기 제1 결합 단량체 및 제2 결합 단량체가 이량체(dimer)를 형성하도록 구성되며,
    상기 제1 단량체 및 상기 제2 단량체가 CH1 도메인과 CL 도메인 사이의 적어도 하나의 이황화 결합(disulfide bond) 및 제1 힌지와 제2 힌지 사이의 적어도 하나의 이황화 결합을 통해 공유적으로 쌍을 이루고,
    상기 다중특이적 항체 유사 단백질이 적어도 이중특이적인, 다중특이적 항체 유사 단백질.
  2. 제1항에 있어서, 상기 제1 결합 단량체가 VH 도메인을 포함하고, 제2 결합 단량체가 VL 도메인을 포함하고, 상기 VH, CH1, VL, CL 도메인이 제3 결합 도메인(D3)으로서 Fab 영역을 형성하는, 다중특이적 항체 유사 단백질.
  3. 제1항에 있어서, 상기 제1 결합 단량체 및 상기 제2 결합 단량체가 제3 결합 도메인(D3)으로서 NKG2D 수용체를 형성하는, 다중특이적 항체 유사 단백질.
  4. 제1항에 있어서, 상기 제1 CH3 도메인이 홀 구조(hole structure)를 형성하도록 구성되고, 상기 제2 CH3 도메인이 노브 구조(knob structure)를 형성하도록 구성되고, 상기 제1 CH2 및 CH3 도메인과 상기 제2 CH2 및 CH3 도메인이 이종이량체화(heterodimerizing)되어 상보성(complementary) Fc 도메인을 형성하도록 구성되는, 다중특이적 항체 유사 단백질.
  5. 제1항에 있어서, 상기 D1, D2, D4 및 D5가 독립적으로 scFv 도메인, VHH 도메인, 수용체 또는 리간드인, 다중 특이적 항체 유사 단백질.
  6. 제1항에 있어서, 상기 D1, D2, D3, D4 및 D5가 각각 독립적으로, 선택된 항원, EGFR, HER2, HER3, EGFRvIII, ROR1, CD3, CD28, CEA, LMP1, LMP2A, 메소텔린(Mesothelin), PSMA, EpCAM, 글리피칸-3, gpA33, GD2, TRP2, NKG2D, NKG2D 리간드, BCMA, CD19, CD20, CD33, CD123, CD22, CD30, PD-L1, PD1, 4-1BB, GITR, TIGIT, TIM-3, LAG-3, CTLA4, CD40, CD40L, VISTA, ICOS, BTLA, LIGHT, HVEM, CSF1R, CD73, CD39, CLDN18.2, DLL3, HLA-G, FcRH5, GPRC5D, LIV-1, MUC1, CD138, CD70, CD16, uPAR, Siglec-15, CD47, CD38, NKp46, PD-L2, CD160, LOX-1, SIRPα, CD27에 대한 결합 특이성(binding specificity)을 갖고, 상기 Fc 도메인이 인간 IgG Fc 도메인을 포함하는, 다중특이적 항체 유사 단백질.
  7. 제1항에 있어서, D1이 CD3, CD20, CEA, HER2, EGFR, 또는 NKG2D 리간드에 대한 결합 특이성을 갖는, 다중특이적 항체 유사 단백질.
  8. 제1항에 있어서, D2가 HER3, EGFR, CD3 또는 CD19에 대한 결합 특이성을 갖는, 다중특이적 항체 유사 단백질.
  9. 제1항에 있어서, D3이 HER3, EGFR, CD3 또는 NKG2D 리간드에 대한 결합 특이성을 갖는, 다중특이적 항체 유사 단백질.
  10. 제1항에 있어서, D4가 4-1BB 또는 EGFR에 대한 결합 특이성을 갖는, 다중특이적 항체 유사 단백질.
  11. 제1항에 있어서, D5가 PD-L1 또는 HER3에 대한 결합 특이성을 갖는, 다중특이적 항체 유사 단백질.
  12. 제1항에 있어서, 상기 항체가 EGFR, HER3 및 CD3에 대한 결합 특이성을 갖는 삼중특이적 항체(tri-specific antibody)인, 다중특이적 항체 유사 단백질.
  13. 제1항에 있어서, 상기 항체가 EGFR, HER3, CD3 및 4-1BB에 대한 결합 특이성을 갖는 사중특이적 항체인, 다중특이적 항체 유사 단백질.
  14. 제1항에 있어서, 상기 항체가 EGFR, HER3, CD3 및 PD-L1에 대한 결합 특이성을 갖는 사중특이적 항체인, 다중특이적 항체 유사 단백질.
  15. 제1항에 있어서, 상기 항체가 EGFR, HER3, CD3, 4-1BB 및 PD-L1에 대한 결합 특이성을 갖는 오중특이적 항체인, 다중특이적 항체 유사 단백질.
  16. 서열번호 301, 302, 303, 304, 305 또는 306과 적어도 80% 서열 동일성(sequence identity)을 갖는 아미노산 서열을 포함하는, CEA에 대한 친화성(affinity)을 갖는 상보성 결정 영역(CDR).
  17. 제16항의 CDR을 포함하는, CEA에 대한 친화성을 갖는 단백질.
  18. CEA에 대한 결합 친화성을 갖는 다중특이적 항체 유사 단백질로서, 상기 항체 유사 단백질이 서열번호 279, 280, 281 또는 282로부터 선택된 아미노산 서열과 적어도 98% 서열 동일성을 갖는 아미노산 서열을 포함하는, 다중특이적 항체 유사 단백질.
  19. 서열번호 307, 308, 309, 310, 311 또는 312와 적어도 80% 서열 동일성을 갖는 아미노산 서열을 포함하는, CD3에 대한 결합 친화성을 갖는 상보성 결정 영역(CDR).
  20. 제19항의 CDR을 포함하는, CD3에 대한 친화성을 갖는 단백질.
  21. CD3에 대한 결합 친화성을 갖는 다중특이적 항체 유사 단백질로서, 상기 항체 유사 단백질이 서열번호 227-230, 231-234, 235-238, 239-242 및 291-294로부터 선택된 아미노산 서열과 적어도 98% 서열 동일성을 갖는 아미노산 서열을 포함하는, 다중특이적 항체 유사 단백질.
  22. 제1항의 다중특이적 항체 유사 단백질을 인코딩(encoding)하는 단리된 핵산 서열.
  23. 제22항의 단리된 핵산 서열을 포함하는 발현 벡터(expression vector).
  24. 제22항의 단리된 핵산 서열을 포함하는 숙주 세포.
  25. 제1항의 다중특이적 항체 유사 단백질 및 세포독성제를 포함하는 면역접합체(immunoconjugate).
  26. 제1항의 다중특이적 항체 유사 단백질 및 약제학적으로 허용되는 담체를 포함하는 약제학적 조성물.
  27. 제25항의 면역접합체 및 약제학적으로 허용되는 담체를 포함하는 약제학적 조성물.
  28. 대상체(subject)에서 암, 자가면역 질환 또는 감염성 질환을 치료 또는 예방하는 방법으로서, 상기 방법이 제1항의 정제된 다중특이적 항체 유사 단백질을 포함하는 약제학적 조성물을 상기 대상체에게 투여하는 단계를 포함하는, 방법.
  29. 제1항의 다중특이적 항체 유사 단백질을 생산하는 방법으로서,
    제1항의 다중특이적 항체 유사 단백질을 인코딩하는 DNA 서열이 발현되도록 숙주 세포를 배양하는 단계, 및
    상기 다중특이적 항체 유사 단백질을 정제하는 단계를 포함하는, 방법.
  30. 제1항의 다중특이적 항체 유사 단백질의 유효 농도를 포함하는 용액으로서, 상기 용액이 대상체의 혈장인, 용액.
KR1020227033907A 2020-03-17 2021-03-17 소형 유도 및 항법 제어(miniGNC) 항체-유사 단백질 및 이의 제조 및 사용 방법 KR20220154710A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062991042P 2020-03-17 2020-03-17
US62/991,042 2020-03-17
PCT/US2021/022847 WO2021188736A1 (en) 2020-03-17 2021-03-17 MINIATURE GUIDANCE AND NAVIGATION CONTROL (miniGNC) ANTIBODY-LIKE PROTEINS AND METHODS OF MAKING AND USING THEREOF

Publications (1)

Publication Number Publication Date
KR20220154710A true KR20220154710A (ko) 2022-11-22

Family

ID=77771308

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227033907A KR20220154710A (ko) 2020-03-17 2021-03-17 소형 유도 및 항법 제어(miniGNC) 항체-유사 단백질 및 이의 제조 및 사용 방법

Country Status (12)

Country Link
US (2) US20230114801A1 (ko)
EP (2) EP4121458A1 (ko)
JP (2) JP2023518400A (ko)
KR (1) KR20220154710A (ko)
CN (2) CN115175941A (ko)
AU (1) AU2021238341A1 (ko)
BR (1) BR112022018495A2 (ko)
CA (1) CA3173883A1 (ko)
IL (2) IL295995A (ko)
MX (1) MX2022011529A (ko)
TW (2) TW202200619A (ko)
WO (2) WO2021188736A1 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023141713A1 (en) * 2022-01-26 2023-08-03 Zymeworks Bc Inc. Immunomodulatory trispecific t cell engager fusion proteins

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053202B2 (en) * 2001-10-19 2006-05-30 Millennium Pharmaceuticals, Inc. Immunoglobulin DNA cassette molecules, monobody constructs, methods of production, and methods of use therefor
US7560111B2 (en) * 2004-07-22 2009-07-14 Genentech, Inc. HER2 antibody composition
EP2195341B1 (en) * 2007-09-26 2017-03-22 UCB Biopharma SPRL Dual specificity antibody fusions
EP2643353A1 (en) * 2010-11-24 2013-10-02 Novartis AG Multispecific molecules
WO2013164325A1 (en) * 2012-05-02 2013-11-07 F. Hoffmann-La Roche Ag Multispecific antigen binding proteins
RS63152B1 (sr) * 2013-07-25 2022-05-31 Cytomx Therapeutics Inc Multispecifična antitela, multispecifična antitela koja mogu da se aktiviraju i postupci za njihovu upotrebu
UA117289C2 (uk) * 2014-04-02 2018-07-10 Ф. Хоффманн-Ля Рош Аг Мультиспецифічне антитіло
CN113512120A (zh) * 2014-12-22 2021-10-19 西雅图免疫公司 双特异性四价抗体及其制造和使用方法
CN107531784B (zh) * 2015-04-29 2021-08-27 生物医学研究所 通过多特异性抗体超强力地中和细胞因子和其用途
AU2016353231B2 (en) * 2015-11-13 2020-08-13 Dana-Farber Cancer Institute, Inc. An NKG2D-Ig fusion protein for cancer immunotherapy
TWI790206B (zh) * 2016-07-18 2023-01-21 法商賽諾菲公司 特異性結合至ｃｄ３和ｃｄ１２３的雙特異性抗體樣結合蛋白
CA3068049A1 (en) * 2017-06-25 2019-01-03 Systimmune, Inc. Multi-specific antibodies and methods of making and using thereof
KR20200118029A (ko) * 2018-01-04 2020-10-14 아이코닉 테라퓨틱스, 인코포레이티드 항-조직 인자 항체, 항체-약물 결합체, 및 관련 방법
CN111566127A (zh) * 2018-03-27 2020-08-21 西雅图免疫公司 制导和导航控制蛋白及其制备和使用方法

Also Published As

Publication number Publication date
WO2021188737A1 (en) 2021-09-23
CA3173883A1 (en) 2021-09-23
US20230114801A1 (en) 2023-04-13
IL295995A (en) 2022-10-01
MX2022011529A (es) 2022-10-13
US20230113563A1 (en) 2023-04-13
JP2023518400A (ja) 2023-05-01
TW202200619A (zh) 2022-01-01
CN115175938A (zh) 2022-10-11
WO2021188736A1 (en) 2021-09-23
EP4121458A1 (en) 2023-01-25
JP2023518241A (ja) 2023-04-28
CN115175941A (zh) 2022-10-11
TW202200618A (zh) 2022-01-01
BR112022018495A2 (pt) 2022-12-20
AU2021238341A1 (en) 2022-10-06
EP4121461A1 (en) 2023-01-25
IL295996A (en) 2022-10-01

Similar Documents

Publication Publication Date Title
US20230340160A1 (en) Bispecific t cell activating antigen binding molecules
CN110869389B (zh) 抗ror1抗体及其制备和使用方法
DK2519543T3 (en) HETERODIMER BINDING PROTEINS AND USE THEREOF
RU2761115C1 (ru) Биспецифические антитела, специфические в отношении костимуляторного tnf-рецептора
RU2753902C2 (ru) Комбинированная терапия на основе активирующих т-клетки биспецифических антигенсвязывающих молекул против cd3 и фолатного рецептора 1 (folr1) и антагонистов, связывающихся с осью pd-1
KR102182485B1 (ko) 단백질 약물의 불활성화를 위한 항체 로커
AU2021254602A1 (en) Humanized anti-MUC1* antibodies
KR102361237B1 (ko) 코일드 코일 면역글로불린 융합 단백질 및 이것의 조성물
KR20210134300A (ko) 항-sars-cov-2 스파이크 당단백질 항체 및 항원-결합 단편
AU2021203876A1 (en) Anti-CD3 antibodies, activatable anti-CD3 antibodies, multispecific anti-CD3 antibodies, multispecific activatable anti-CD3 antibodies, and methods of using the same
CN111954680B (zh) IL2Rβ/共同γ链抗体
KR20180081532A (ko) 암 치료용 조성물 및 방법
KR20180099723A (ko) 항-tl1a/항-tnf-알파 이중특이적 항원 결합 단백질 및 그의 용도
KR20150122761A (ko) Ｔ 세포 활성화 항원 결합 분자
KR20180054877A (ko) 공자극 tnf 수용체에 대해 4가를 갖는 이중특이적 항체
KR20150122203A (ko) T 세포 활성화 이중특이적 항원 결합 분자
KR20210013156A (ko) 항-cd33 항체, 항-cd33/항-cd3 이중특이성 항체, 및 이의 용도
KR20200003367A (ko) 암 치료용 조성물 및 방법
KR20200135935A (ko) 유도 및 네비게이션 제어 단백질 및 이의 제조 및 사용 방법
KR20190141655A (ko) 종양 형질도입용 조성물 및 방법
CN107949575B (zh) Cys80缀合型免疫球蛋白
CN113646328B (zh) 一种免疫细胞因子及其制备与用途
TW202216743A (zh) Ｉｌ－１０突變蛋白及其融合蛋白
KR20220154710A (ko) 소형 유도 및 항법 제어(miniGNC) 항체-유사 단백질 및 이의 제조 및 사용 방법
CN113316587B (zh) 一种双特异性分子及其制备与用途