KR20220042137A - 항-뉴욕 식도 편평 세포 암종 1 (ny-eso-1) 항원-결합 단백질 및 이의 사용 방법 - Google Patents

항-뉴욕 식도 편평 세포 암종 1 (ny-eso-1) 항원-결합 단백질 및 이의 사용 방법 Download PDF

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KR20220042137A
KR20220042137A KR1020227003658A KR20227003658A KR20220042137A KR 20220042137 A KR20220042137 A KR 20220042137A KR 1020227003658 A KR1020227003658 A KR 1020227003658A KR 20227003658 A KR20227003658 A KR 20227003658A KR 20220042137 A KR20220042137 A KR 20220042137A
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antigen
binding protein
eso
amino acid
binding
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Korean (ko)
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케빈 에이. 브레이
프랭크 델피노
데이비드 디릴로
매튜 씨. 프랭클린
제시카 커쉬너
더글라스 맥도널드
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리제너론 파아마슈티컬스, 인크.
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Application filed by 리제너론 파아마슈티컬스, 인크. filed Critical 리제너론 파아마슈티컬스, 인크.
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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KR1020227003658A 2019-07-03 2020-07-02 항-뉴욕 식도 편평 세포 암종 1 (ny-eso-1) 항원-결합 단백질 및 이의 사용 방법 Pending KR20220042137A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962870232P 2019-07-03 2019-07-03
US62/870,232 2019-07-03
US202063020177P 2020-05-05 2020-05-05
US63/020,177 2020-05-05
US202063021826P 2020-05-08 2020-05-08
US63/021,826 2020-05-08
PCT/US2020/040642 WO2021003357A1 (en) 2019-07-03 2020-07-02 Anti-new york esophageal squamous cell carcinoma 1 (ny-eso-1) antigen-binding proteins and methods of use thereof

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KR20220042137A true KR20220042137A (ko) 2022-04-04

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US (1) US12600783B2 (https=)
EP (1) EP3993817A4 (https=)
JP (2) JP7674278B2 (https=)
KR (1) KR20220042137A (https=)
CN (2) CN114302733B (https=)
AU (1) AU2020301027A1 (https=)
BR (1) BR112021026831A2 (https=)
CA (1) CA3145857A1 (https=)
CL (1) CL2021003550A1 (https=)
CO (1) CO2022000804A2 (https=)
IL (1) IL289573A (https=)
MA (1) MA56468A (https=)
MX (1) MX2022000081A (https=)
PH (1) PH12021553306A1 (https=)
WO (1) WO2021003357A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12022500012A1 (en) 2020-03-30 2023-04-03 Daiichi Sankyo Co Ltd Bispecific antibody
US20250195645A1 (en) * 2022-03-16 2025-06-19 Daiichi Sankyo Company, Limited Combination of multispecific molecule and immune checkpoint inhibitor
CN116970614A (zh) * 2022-12-29 2023-10-31 达冕疫苗(广州)有限公司 编码ny-eso-1的核糖核酸疫苗的组合物和方法
JP2026507123A (ja) 2023-02-28 2026-02-27 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｔ細胞活性化剤およびその使用方法
CN117843794A (zh) * 2023-12-01 2024-04-09 浙江大学 一种抗ny-eso-1的纳米抗体及其应用
WO2026006794A1 (en) * 2024-06-27 2026-01-02 The Board Of Trustees Of The Leland Stanford Junior University Chimeric antigen receptors and uses thereof
CN119161418B (zh) * 2024-08-30 2025-11-21 天津大学 一种结合ny-eso-1抗原的蛋白

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1061623A (zh) * 1990-06-01 1992-06-03 里珍纳龙药品有限公司 睫状神经营养性因子受体
AU2003217384A1 (en) * 2002-02-13 2003-09-04 Ludwig Institute For Cancer Research Isolated peptides which bind to hla molecules and uses thereof
US8193318B2 (en) * 2002-08-14 2012-06-05 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
ATE417065T1 (de) * 2004-05-19 2008-12-15 Medigene Ltd Hochaffiner ny-eso-t-zellen-rezeptor
EP2457928B1 (en) 2007-03-13 2017-05-10 Universität Zürich Monoclonal human tumor-specific antibody
WO2010106431A2 (en) * 2009-03-20 2010-09-23 Ludwig Institute For Cancer Research Ltd High affinity t-cell receptor-like ny-eso-1 peptide antibodies, methods, and uses thereof
WO2010141986A1 (en) * 2009-06-09 2010-12-16 Mabdesign Pty Ltd Novel antibodies and uses therefor
EP3404111A1 (en) * 2013-03-13 2018-11-21 Health Research, Inc. Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen
CN104450615B (zh) * 2013-09-25 2020-12-15 深圳市北科生物科技有限公司 一种具有双特异性抗体的细胞CTL(BiAT)及其制备方法与应用
TWI681969B (zh) * 2014-01-23 2020-01-11 美商再生元醫藥公司 針對ｐｄ-１的人類抗體
JP2017529841A (ja) 2014-09-19 2017-10-12 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． キメラ抗原受容体
AU2016274767B2 (en) * 2015-06-09 2022-05-19 Eureka Therapeutics, Inc. T cell receptor-like antibody agents specific for EBV latent membrane protein 2A peptide presented by human HLA
HK1248255A1 (zh) 2015-06-24 2018-10-12 优瑞科生物技术公司 靶向ny-eso-1肽/mhc复合物的构建体及其用途
CN106729698A (zh) * 2015-11-25 2017-05-31 宁波美丽人生医药生物科技发展有限公司 NY-ESO-1有作为增强Art v1(wtArt)过敏原免疫反应分子佐剂的作用
WO2017111862A1 (en) 2015-12-23 2017-06-29 Xiaolin Ai Multimode electromechanical variable speed transmission apparatus with smooth mode shifting and method of controlling the same
JP2018013957A (ja) * 2016-07-21 2018-01-25 東芝テック株式会社 読取装置、サーバ装置、及びプログラム
JP2020503883A (ja) * 2017-01-13 2020-02-06 アジェナス インコーポレイテッド Ｎｙ−ｅｓｏ−１に結合するｔ細胞受容体およびその使用方法
KR102104551B1 (ko) * 2017-05-11 2020-04-24 (주)온코태그디아그노스틱 Mrs에 특이적으로 결합하는 모노클로날 항체
EA202090149A1 (ru) * 2017-06-28 2020-05-31 Ридженерон Фармасьютикалз, Инк. Антигенсвязывающие белки против вируса папилломы человека (hpv) и способы их применения
WO2019084538A1 (en) 2017-10-27 2019-05-02 Board Of Regents, The University Of Texas System TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF
CN108383908A (zh) * 2018-02-05 2018-08-10 昆山百尔泰生物科技有限公司 识别人源ctla-4并阻断其功能的全人源单克隆抗体或抗体片段及其制备方法和用途
EP4004049A1 (en) 2019-07-24 2022-06-01 Regeneron Pharmaceuticals, Inc. Chimeric antigen receptors with mage-a4 specificity and uses thereof
PH12022500012A1 (en) * 2020-03-30 2023-04-03 Daiichi Sankyo Co Ltd Bispecific antibody
KR20230025662A (ko) * 2020-05-05 2023-02-22 리제너론 파마슈티칼스 인코포레이티드 Cd28 제타 및 cd3 제타를 포함하는 car

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