CN114302733B - 抗纽约食管鳞状细胞癌1(ny-eso-1)抗原结合蛋白及其使用方法 - Google Patents
抗纽约食管鳞状细胞癌1(ny-eso-1)抗原结合蛋白及其使用方法 Download PDFInfo
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- CN114302733B CN114302733B CN202080061474.0A CN202080061474A CN114302733B CN 114302733 B CN114302733 B CN 114302733B CN 202080061474 A CN202080061474 A CN 202080061474A CN 114302733 B CN114302733 B CN 114302733B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A—HUMAN NECESSITIES
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K40/4269—NY-ESO
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202510427533.6A CN120248123A (zh) | 2019-07-03 | 2020-07-02 | 抗纽约食管鳞状细胞癌1(ny-eso-1)抗原结合蛋白及其使用方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962870232P | 2019-07-03 | 2019-07-03 | |
| US62/870,232 | 2019-07-03 | ||
| US202063020177P | 2020-05-05 | 2020-05-05 | |
| US63/020,177 | 2020-05-05 | ||
| US202063021826P | 2020-05-08 | 2020-05-08 | |
| US63/021,826 | 2020-05-08 | ||
| PCT/US2020/040642 WO2021003357A1 (en) | 2019-07-03 | 2020-07-02 | Anti-new york esophageal squamous cell carcinoma 1 (ny-eso-1) antigen-binding proteins and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202510427533.6A Division CN120248123A (zh) | 2019-07-03 | 2020-07-02 | 抗纽约食管鳞状细胞癌1(ny-eso-1)抗原结合蛋白及其使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114302733A CN114302733A (zh) | 2022-04-08 |
| CN114302733B true CN114302733B (zh) | 2025-04-25 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080061474.0A Active CN114302733B (zh) | 2019-07-03 | 2020-07-02 | 抗纽约食管鳞状细胞癌1(ny-eso-1)抗原结合蛋白及其使用方法 |
| CN202510427533.6A Pending CN120248123A (zh) | 2019-07-03 | 2020-07-02 | 抗纽约食管鳞状细胞癌1(ny-eso-1)抗原结合蛋白及其使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202510427533.6A Pending CN120248123A (zh) | 2019-07-03 | 2020-07-02 | 抗纽约食管鳞状细胞癌1(ny-eso-1)抗原结合蛋白及其使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US12600783B2 (https=) |
| EP (1) | EP3993817A4 (https=) |
| JP (2) | JP7674278B2 (https=) |
| KR (1) | KR20220042137A (https=) |
| CN (2) | CN114302733B (https=) |
| AU (1) | AU2020301027A1 (https=) |
| BR (1) | BR112021026831A2 (https=) |
| CA (1) | CA3145857A1 (https=) |
| CL (1) | CL2021003550A1 (https=) |
| CO (1) | CO2022000804A2 (https=) |
| IL (1) | IL289573A (https=) |
| MA (1) | MA56468A (https=) |
| MX (1) | MX2022000081A (https=) |
| PH (1) | PH12021553306A1 (https=) |
| WO (1) | WO2021003357A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12022500012A1 (en) | 2020-03-30 | 2023-04-03 | Daiichi Sankyo Co Ltd | Bispecific antibody |
| US20250195645A1 (en) * | 2022-03-16 | 2025-06-19 | Daiichi Sankyo Company, Limited | Combination of multispecific molecule and immune checkpoint inhibitor |
| CN116970614A (zh) * | 2022-12-29 | 2023-10-31 | 达冕疫苗(广州)有限公司 | 编码ny-eso-1的核糖核酸疫苗的组合物和方法 |
| JP2026507123A (ja) | 2023-02-28 | 2026-02-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | T細胞活性化剤およびその使用方法 |
| CN117843794A (zh) * | 2023-12-01 | 2024-04-09 | 浙江大学 | 一种抗ny-eso-1的纳米抗体及其应用 |
| WO2026006794A1 (en) * | 2024-06-27 | 2026-01-02 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric antigen receptors and uses thereof |
| CN119161418B (zh) * | 2024-08-30 | 2025-11-21 | 天津大学 | 一种结合ny-eso-1抗原的蛋白 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005113595A2 (en) * | 2004-05-19 | 2005-12-01 | Avidex Ltd | High affinity ny-eso t cell receptor |
| WO2010106431A2 (en) * | 2009-03-20 | 2010-09-23 | Ludwig Institute For Cancer Research Ltd | High affinity t-cell receptor-like ny-eso-1 peptide antibodies, methods, and uses thereof |
| WO2016210365A2 (en) * | 2015-06-24 | 2016-12-29 | Eureka Therapeutics, Inc. | Constructs targeting ny-eso-1 peptide/mhc complexes and uses thereof |
| WO2018132739A2 (en) * | 2017-01-13 | 2018-07-19 | Agenus Inc. | T cell receptors that bind to ny-eso-1 and methods of use thereof |
| CN115023500A (zh) * | 2020-03-30 | 2022-09-06 | 国立大学法人三重大学 | 双特异性抗体 |
| CN115485303A (zh) * | 2020-05-05 | 2022-12-16 | 瑞泽恩制药公司 | 包含CD28ζ和CD3ζ的CAR |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1061623A (zh) * | 1990-06-01 | 1992-06-03 | 里珍纳龙药品有限公司 | 睫状神经营养性因子受体 |
| AU2003217384A1 (en) * | 2002-02-13 | 2003-09-04 | Ludwig Institute For Cancer Research | Isolated peptides which bind to hla molecules and uses thereof |
| US8193318B2 (en) * | 2002-08-14 | 2012-06-05 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
| EP2457928B1 (en) | 2007-03-13 | 2017-05-10 | Universität Zürich | Monoclonal human tumor-specific antibody |
| WO2010141986A1 (en) * | 2009-06-09 | 2010-12-16 | Mabdesign Pty Ltd | Novel antibodies and uses therefor |
| EP3404111A1 (en) * | 2013-03-13 | 2018-11-21 | Health Research, Inc. | Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen |
| CN104450615B (zh) * | 2013-09-25 | 2020-12-15 | 深圳市北科生物科技有限公司 | 一种具有双特异性抗体的细胞CTL(BiAT)及其制备方法与应用 |
| TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
| JP2017529841A (ja) | 2014-09-19 | 2017-10-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | キメラ抗原受容体 |
| AU2016274767B2 (en) * | 2015-06-09 | 2022-05-19 | Eureka Therapeutics, Inc. | T cell receptor-like antibody agents specific for EBV latent membrane protein 2A peptide presented by human HLA |
| CN106729698A (zh) * | 2015-11-25 | 2017-05-31 | 宁波美丽人生医药生物科技发展有限公司 | NY-ESO-1有作为增强Art v1(wtArt)过敏原免疫反应分子佐剂的作用 |
| WO2017111862A1 (en) | 2015-12-23 | 2017-06-29 | Xiaolin Ai | Multimode electromechanical variable speed transmission apparatus with smooth mode shifting and method of controlling the same |
| JP2018013957A (ja) * | 2016-07-21 | 2018-01-25 | 東芝テック株式会社 | 読取装置、サーバ装置、及びプログラム |
| KR102104551B1 (ko) * | 2017-05-11 | 2020-04-24 | (주)온코태그디아그노스틱 | Mrs에 특이적으로 결합하는 모노클로날 항체 |
| EA202090149A1 (ru) * | 2017-06-28 | 2020-05-31 | Ридженерон Фармасьютикалз, Инк. | Антигенсвязывающие белки против вируса папилломы человека (hpv) и способы их применения |
| WO2019084538A1 (en) | 2017-10-27 | 2019-05-02 | Board Of Regents, The University Of Texas System | TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF |
| CN108383908A (zh) * | 2018-02-05 | 2018-08-10 | 昆山百尔泰生物科技有限公司 | 识别人源ctla-4并阻断其功能的全人源单克隆抗体或抗体片段及其制备方法和用途 |
| EP4004049A1 (en) | 2019-07-24 | 2022-06-01 | Regeneron Pharmaceuticals, Inc. | Chimeric antigen receptors with mage-a4 specificity and uses thereof |
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2020
- 2020-07-02 JP JP2021578186A patent/JP7674278B2/ja active Active
- 2020-07-02 CN CN202080061474.0A patent/CN114302733B/zh active Active
- 2020-07-02 BR BR112021026831A patent/BR112021026831A2/pt unknown
- 2020-07-02 US US17/622,307 patent/US12600783B2/en active Active
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- 2020-07-02 MA MA056468A patent/MA56468A/fr unknown
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005113595A2 (en) * | 2004-05-19 | 2005-12-01 | Avidex Ltd | High affinity ny-eso t cell receptor |
| WO2010106431A2 (en) * | 2009-03-20 | 2010-09-23 | Ludwig Institute For Cancer Research Ltd | High affinity t-cell receptor-like ny-eso-1 peptide antibodies, methods, and uses thereof |
| WO2016210365A2 (en) * | 2015-06-24 | 2016-12-29 | Eureka Therapeutics, Inc. | Constructs targeting ny-eso-1 peptide/mhc complexes and uses thereof |
| WO2018132739A2 (en) * | 2017-01-13 | 2018-07-19 | Agenus Inc. | T cell receptors that bind to ny-eso-1 and methods of use thereof |
| CN115023500A (zh) * | 2020-03-30 | 2022-09-06 | 国立大学法人三重大学 | 双特异性抗体 |
| CN115485303A (zh) * | 2020-05-05 | 2022-12-16 | 瑞泽恩制药公司 | 包含CD28ζ和CD3ζ的CAR |
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| CL2021003550A1 (es) | 2022-08-19 |
| KR20220042137A (ko) | 2022-04-04 |
| WO2021003357A1 (en) | 2021-01-07 |
| PH12021553306A1 (en) | 2022-08-01 |
| JP7674278B2 (ja) | 2025-05-09 |
| IL289573A (en) | 2022-03-01 |
| JP2022538475A (ja) | 2022-09-02 |
| MX2022000081A (es) | 2022-04-27 |
| BR112021026831A2 (pt) | 2022-02-22 |
| CA3145857A1 (en) | 2021-01-07 |
| EP3993817A4 (en) | 2023-08-30 |
| AU2020301027A1 (en) | 2022-02-24 |
| MA56468A (fr) | 2022-05-11 |
| EP3993817A1 (en) | 2022-05-11 |
| JP2025156298A (ja) | 2025-10-14 |
| US12600783B2 (en) | 2026-04-14 |
| US20220251215A1 (en) | 2022-08-11 |
| CN114302733A (zh) | 2022-04-08 |
| CN120248123A (zh) | 2025-07-04 |
| CO2022000804A2 (es) | 2022-02-07 |
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