KR20220027271A - Btk 억제제의 염 및 고체 형태 - Google Patents

Btk 억제제의 염 및 고체 형태 Download PDF

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KR20220027271A
KR20220027271A KR1020227005455A KR20227005455A KR20220027271A KR 20220027271 A KR20220027271 A KR 20220027271A KR 1020227005455 A KR1020227005455 A KR 1020227005455A KR 20227005455 A KR20227005455 A KR 20227005455A KR 20220027271 A KR20220027271 A KR 20220027271A
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compound
salt
amorphous form
isomer
acid
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모하매드 레자 마세디자데
스티븐 고어레이
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프린시피아 바이오파마, 인코퍼레이티드
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
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KR1020227005455A 2014-02-21 2015-02-20 Btk 억제제의 염 및 고체 형태 Ceased KR20220027271A (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201461943262P 2014-02-21 2014-02-21
US61/943,262 2014-02-21
US201461946480P 2014-02-28 2014-02-28
US61/946,480 2014-02-28
US201462096468P 2014-12-23 2014-12-23
US62/096,468 2014-12-23
PCT/US2015/016963 WO2015127310A1 (en) 2014-02-21 2015-02-20 Salts and solid form of a btk inhibitor
KR1020167025774A KR20160117614A (ko) 2014-02-21 2015-02-20 Btk 억제제의 염 및 고체 형태

Related Parent Applications (1)

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KR1020167025774A Division KR20160117614A (ko) 2014-02-21 2015-02-20 Btk 억제제의 염 및 고체 형태

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Publication Number Publication Date
KR20220027271A true KR20220027271A (ko) 2022-03-07

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KR1020227005455A Ceased KR20220027271A (ko) 2014-02-21 2015-02-20 Btk 억제제의 염 및 고체 형태
KR1020167025774A Ceased KR20160117614A (ko) 2014-02-21 2015-02-20 Btk 억제제의 염 및 고체 형태

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KR1020167025774A Ceased KR20160117614A (ko) 2014-02-21 2015-02-20 Btk 억제제의 염 및 고체 형태

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US (5) US10092569B2 (enExample)
EP (2) EP3107544B1 (enExample)
JP (1) JP6504548B2 (enExample)
KR (2) KR20220027271A (enExample)
CN (2) CN112353806A (enExample)
AU (1) AU2015218713B2 (enExample)
BR (1) BR112016018948B1 (enExample)
CA (1) CA2939186C (enExample)
EA (1) EA033900B1 (enExample)
ES (1) ES2841248T3 (enExample)
IL (2) IL247215B (enExample)
MX (1) MX372673B (enExample)
PT (1) PT3107544T (enExample)
SG (2) SG11201606858RA (enExample)
WO (1) WO2015127310A1 (enExample)
ZA (2) ZA201605933B (enExample)

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TWI877239B (zh) 2019-10-14 2025-03-21 美商普林斯匹亞生物製藥公司 藉由投予(R)-2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧呾-3-基)哌-1-基]戊-2-烯腈來治療免疫血小板減少症之方法
MX2022007553A (es) 2019-12-20 2022-07-19 Principia Biopharma Inc Formas solidas de 2-[3-[4-amino-3-(2-fluoro-4-fenoxi-fenil)pirazol o[3,4-d]pirimidin-1-il]piperidina-1-carbonil]-4-metil-4-[4-(oxeta n-3-il)piperazin-1-il]pent-2-enenitrilo.
IL294447A (en) * 2020-01-06 2022-09-01 Principia Biopharma Inc Treatment of membranous nephropathy, IgG4-related diseases and antiphospholipid syndrome using the btk inhibitor 2-[(3r)-3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4 -d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile
TW202142237A (zh) * 2020-01-08 2021-11-16 美商普林斯匹亞生物製藥公司 包含2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)-1h-吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4,4-二甲基戊-2-烯腈之局部醫藥組成物
BR112022014149A2 (pt) * 2020-01-22 2022-09-27 Principia Biopharma Inc Formas cristalinas de 2-[3-[4-amino-3-(2-fluoro-4-fenóxi-fenil)-1h-pirazolo[3,4-d]pirimidina-1-il]piperidina-1-carbonil]-4-metil-4-[4-(oxetan-3-il)piperazin-1-il]pent-2-enenitrila
EP4322957A1 (en) 2021-04-16 2024-02-21 Principia Biopharma Inc. Methods for treating drug and vaccine induced immune thrombocytopenia by administering specific compounds
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JP7359457B2 (ja) * 2021-10-11 2023-10-11 タグシクス・バイオ株式会社 自己免疫性疾患治療薬
KR20250023505A (ko) 2022-06-14 2025-02-18 프린시피아 바이오파마, 인코퍼레이티드 2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-엔니트릴의결정질 형태
JP2024021164A (ja) * 2022-08-03 2024-02-16 タグシクス・バイオ株式会社 ＩＦＮ－γへ選択的に結合するＤＮＡオリゴヌクレオチドを含有するハンナ型間質性膀胱炎治療薬
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