KR20210132007A - 피롤로피리미딘 화합물의 치료 용도 및 피롤로피리미딘 화합물의 고체 약학적 조성물 - Google Patents

피롤로피리미딘 화합물의 치료 용도 및 피롤로피리미딘 화합물의 고체 약학적 조성물 Download PDF

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Publication number
KR20210132007A
KR20210132007A KR1020217023608A KR20217023608A KR20210132007A KR 20210132007 A KR20210132007 A KR 20210132007A KR 1020217023608 A KR1020217023608 A KR 1020217023608A KR 20217023608 A KR20217023608 A KR 20217023608A KR 20210132007 A KR20210132007 A KR 20210132007A
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sodium
formula
compound
mixtures
pharmaceutical composition
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Korean (ko)
Inventor
동 왕
칭시아 리
준 다이
첸 리
주롄 장
옌칭 순
징징 첸
링링 진
준동 리우
치더 리
Original Assignee
치아타이 티안큉 파마수티컬 그룹 주식회사
롄윈강 룬종 파마슈티컬 컴퍼니, 리미티드
쇼우야오 홀딩스 (베이징) 코., 엘티디.
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Application filed by 치아타이 티안큉 파마수티컬 그룹 주식회사, 롄윈강 룬종 파마슈티컬 컴퍼니, 리미티드, 쇼우야오 홀딩스 (베이징) 코., 엘티디. filed Critical 치아타이 티안큉 파마수티컬 그룹 주식회사
Publication of KR20210132007A publication Critical patent/KR20210132007A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020217023608A 2018-12-24 2019-12-24 피롤로피리미딘 화합물의 치료 용도 및 피롤로피리미딘 화합물의 고체 약학적 조성물 Ceased KR20210132007A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201811581815.8 2018-12-24
CN201811581815 2018-12-24
CN201910679429 2019-07-26
CN201910679429.0 2019-07-26
PCT/CN2019/127837 WO2020135401A1 (zh) 2018-12-24 2019-12-24 吡咯并嘧啶化合物的治疗用途及其固体药物组合物

Publications (1)

Publication Number Publication Date
KR20210132007A true KR20210132007A (ko) 2021-11-03

Family

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Family Applications (1)

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KR1020217023608A Ceased KR20210132007A (ko) 2018-12-24 2019-12-24 피롤로피리미딘 화합물의 치료 용도 및 피롤로피리미딘 화합물의 고체 약학적 조성물

Country Status (8)

Country Link
US (1) US20220072002A1 (enExample)
EP (1) EP3904356A4 (enExample)
JP (2) JP2022515272A (enExample)
KR (1) KR20210132007A (enExample)
CN (2) CN113242859B (enExample)
AU (1) AU2019413421B9 (enExample)
CA (1) CA3123985A1 (enExample)
WO (1) WO2020135401A1 (enExample)

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JP2023548855A (ja) * 2020-11-05 2023-11-21 エグゼリクシス， インコーポレイテッド キナーゼ阻害剤の医薬組成物
CN118973582A (zh) * 2022-03-21 2024-11-15 正大天晴药业集团股份有限公司 吡咯并嘧啶化合物治疗中高危骨髓纤维化的用途
WO2024153148A1 (zh) * 2023-01-18 2024-07-25 北京普祺医药科技股份有限公司 一种杂环化合物、药物组合物及其用途
WO2024230727A1 (zh) * 2023-05-09 2024-11-14 正大天晴药业集团股份有限公司 一种吡咯并[2,3-c]吡啶酮化合物的联用药物组合物及其用途

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US20050130302A1 (en) * 2003-09-29 2005-06-16 Reprocell Inc. Method and composition for regulating expansion of stem cells
WO2007089926A2 (en) * 2006-01-31 2007-08-09 Teva Pharmaceutical Industries Ltd. Oxcarbazepine pharmaceutical formulation and its method of preparation, wherein oxcarbazepine has a broad and multi-modal particle size distribution
KR101566840B1 (ko) * 2007-03-12 2015-11-06 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 페닐 아미노 피리미딘 화합물 및 이의 용도
AR076794A1 (es) * 2009-05-22 2011-07-06 Incyte Corp Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen
EP3354652B1 (en) * 2010-03-10 2020-05-06 Incyte Holdings Corporation Piperidin-4-yl azetidine derivatives as jak1 inhibitors
PH12013502523A1 (en) * 2011-06-14 2019-10-11 Novartis Ag Combination of panobinostat and ruxolitinib in the treatment of cancer such as a myeloproliferative neoplasm
NZ714502A (en) * 2011-07-05 2017-04-28 Vertex Pharma Processes and intermediates for producing azaindoles
CN104418858B (zh) * 2013-08-30 2018-12-11 浙江医药股份有限公司新昌制药厂 2,6-二含氮取代的嘌呤衍生物及其制备方法和其药物组合物与应用
CN103585126A (zh) * 2013-11-18 2014-02-19 南京艾德凯腾生物医药有限责任公司 一种托法替尼组合物及制备方法
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CN107513069A (zh) * 2016-06-16 2017-12-26 正大天晴药业集团股份有限公司 手性吡咯并嘧啶化合物的制备方法
CN107513067A (zh) * 2016-06-16 2017-12-26 北京赛林泰医药技术有限公司 含有取代环戊基的吡咯并嘧啶化合物
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CA3123985A1 (en) 2020-07-02
US20220072002A1 (en) 2022-03-10
EP3904356A1 (en) 2021-11-03
CN113242859B (zh) 2023-04-14
CN116473973A (zh) 2023-07-25
WO2020135401A1 (zh) 2020-07-02
JP2022515272A (ja) 2022-02-17
AU2019413421B2 (en) 2025-02-13
JP2025032127A (ja) 2025-03-11
AU2019413421A1 (en) 2021-08-12
AU2019413421B9 (en) 2025-02-20
EP3904356A4 (en) 2022-09-21
CN113242859A (zh) 2021-08-10

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