KR20210089716A - 질소 함유 축합 헤테로고리 shp2억제제 화합물, 제조방법 및 용도 - Google Patents

질소 함유 축합 헤테로고리 shp2억제제 화합물, 제조방법 및 용도 Download PDF

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KR20210089716A
KR20210089716A KR1020217017327A KR20217017327A KR20210089716A KR 20210089716 A KR20210089716 A KR 20210089716A KR 1020217017327 A KR1020217017327 A KR 1020217017327A KR 20217017327 A KR20217017327 A KR 20217017327A KR 20210089716 A KR20210089716 A KR 20210089716A
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membered
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후이신 완
지안펑 판
진구이 마
추안타오 차
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상하이 린진 바이오파마 씨오., 엘티디.
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020217017327A 2018-11-07 2019-11-07 질소 함유 축합 헤테로고리 shp2억제제 화합물, 제조방법 및 용도 Ceased KR20210089716A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN201811317588 2018-11-07
CN201811317588.8 2018-11-07
CN201811594644 2018-12-26
CN201811594644.2 2018-12-26
CN201910131491.6 2019-02-22
CN201910131491 2019-02-22
PCT/CN2019/116386 WO2020094104A1 (zh) 2018-11-07 2019-11-07 一类含氮稠杂环类shp2抑制剂化合物、制备方法和用途

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KR20210089716A true KR20210089716A (ko) 2021-07-16

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KR1020217017327A Ceased KR20210089716A (ko) 2018-11-07 2019-11-07 질소 함유 축합 헤테로고리 shp2억제제 화합물, 제조방법 및 용도

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US (1) US12281118B2 (https=)
EP (1) EP3878853A4 (https=)
JP (1) JP2022506887A (https=)
KR (1) KR20210089716A (https=)
CN (2) CN111153901B (https=)
WO (1) WO2020094104A1 (https=)

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