KR20210021493A - Muc16 특이적 키메라 항원 수용체 및 그의 용도 - Google Patents

Muc16 특이적 키메라 항원 수용체 및 그의 용도 Download PDF

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KR20210021493A
KR20210021493A KR1020207038033A KR20207038033A KR20210021493A KR 20210021493 A KR20210021493 A KR 20210021493A KR 1020207038033 A KR1020207038033 A KR 1020207038033A KR 20207038033 A KR20207038033 A KR 20207038033A KR 20210021493 A KR20210021493 A KR 20210021493A
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cells
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car
vector
cell
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헬렌 삽제바리
루툴 알. 샤
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프레시전 인코포레이티드
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KR1020207038033A 2018-06-04 2019-06-04 Muc16 특이적 키메라 항원 수용체 및 그의 용도 Pending KR20210021493A (ko)

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US201862680297P 2018-06-04 2018-06-04
US62/680,297 2018-06-04
PCT/US2019/035384 WO2019236577A2 (en) 2018-06-04 2019-06-04 Muc16 specific chimeric antigen receptors and uses thereof

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US (4) US11319380B2 (https=)
EP (1) EP3802615A4 (https=)
JP (3) JP2021525534A (https=)
KR (1) KR20210021493A (https=)
CN (2) CN121852427A (https=)
AU (1) AU2019282620B2 (https=)
CA (1) CA3101641A1 (https=)
IL (1) IL278976A (https=)
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US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
EP3697438A4 (en) * 2017-10-18 2021-08-18 Intrexon Corporation POLYPEPTIDE COMPOSITIONS WITH SPACERS
SG11202104524YA (en) * 2018-11-01 2021-05-28 Gracell Biotechnologies Shanghai Co Ltd Compositions and methods for t cell engineering
CA3150224A1 (en) 2019-09-10 2021-03-18 Obsidian Therapeutics, Inc. Ca2 compositions and methods for tunable regulation
WO2021256522A1 (ja) * 2020-06-17 2021-12-23 国立大学法人京都大学 キメラ抗原受容体発現免疫担当細胞
WO2022140388A1 (en) * 2020-12-21 2022-06-30 Allogene Therapeutics, Inc. Protease-activating cd45-gate car
TW202233662A (zh) * 2020-12-31 2022-09-01 大陸商亘喜生物科技(上海)有限公司 膜融合蛋白及其在免疫細胞中的應用
JP2024504585A (ja) * 2021-01-19 2024-02-01 オブシディアン セラピューティクス, インコーポレイテッド T細胞及び腫瘍浸潤リンパ球の拡張のための組成物及び方法
KR20230147619A (ko) * 2021-02-26 2023-10-23 난징 레전드 바이오테크 씨오., 엘티디. 외인적으로 도입된 사이토카인을 발현하는 조작된 면역이펙터 세포
US20250145950A1 (en) * 2022-02-01 2025-05-08 Alaunos Therapeutics, Inc. Methods for Activation and Expansion of T Cells
CN115819613B (zh) * 2022-05-10 2023-10-20 四川大学华西医院 基于msln前体蛋白构建的嵌合抗原受体免疫细胞制备及其应用
CN116196402A (zh) * 2022-11-01 2023-06-02 山东大学齐鲁医院 表达双特异性抗体的溶瘤腺病毒联合cart在肿瘤治疗中的应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2491017A1 (en) 2002-07-03 2004-01-15 Immunogen, Inc. Antibodies to non-shed muc1 and muc16, and uses thereof
NZ563370A (en) 2005-06-20 2010-10-29 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor
EP2144628B1 (en) 2007-05-08 2012-10-17 Genentech, Inc. Cysteine engineered anti-muc16 antibodies and antibody drug conjugates
KR101597842B1 (ko) 2008-01-11 2016-02-25 가부시키가이샤 진 테크노 사이언스 인간화된 항-알파9 인테그린 항체 및 그의 용도
DK2496698T3 (en) * 2009-11-03 2019-04-15 Hope City TRUNCATED EPIDERIMAL GROWTH FACTOR RECEPTOR (EGFRt) FOR TRUNCATED T-CELL SELECTION
PT2552959T (pt) * 2010-03-26 2017-04-21 Memorial Sloan Kettering Cancer Center Anticorpos para muc16 e métodos de utilização dos mesmos
AU2014248119B2 (en) 2013-04-03 2019-06-20 Memorial Sloan-Kettering Cancer Center Effective generation of tumor-targeted T-cells derived from pluripotent stem cells
EP3783098A1 (en) * 2013-05-14 2021-02-24 Board Of Regents, The University Of Texas System Human application of engineered chimeric antigen receptor (car) t-cells
EP3126390B2 (en) * 2014-04-03 2026-01-07 Cellectis Cd33 specific chimeric antigen receptors for cancer immunotherapy
TWI750110B (zh) 2014-07-21 2021-12-21 瑞士商諾華公司 使用人類化抗-bcma嵌合抗原受體治療癌症
AU2016243124A1 (en) 2015-03-27 2017-11-02 University Of Southern California CAR T-cell therapy directed to LHR for the treatment of solid tumors
CN108064246A (zh) 2015-06-15 2018-05-22 基因泰克公司 抗体和免疫结合物
WO2017040945A1 (en) 2015-09-04 2017-03-09 Memorial Sloan Kettering Cancer Center Immune cell compositions and methods of use
WO2017172981A2 (en) * 2016-03-29 2017-10-05 University Of Southern California Chimeric antigen receptors targeting cancer
SG11201810640RA (en) 2016-06-08 2018-12-28 Intrexon Corp Cd33 specific chimeric antigen receptors
WO2018009811A1 (en) * 2016-07-08 2018-01-11 Genentech, Inc. Use of human epididymis protein 4 (he4) for assessing responsiveness of muc 16-positive cancer treatment
MA45779A (fr) 2016-07-29 2019-06-05 Juno Therapeutics Inc Polypeptides immunomdulateurs et compositions et procédés associés
EP3522933B1 (en) * 2016-10-05 2021-12-15 F. Hoffmann-La Roche AG Methods for preparing antibody drug conjugates
CN107557336B (zh) * 2017-09-15 2020-02-14 山东兴瑞生物科技有限公司 一种抗muc16安全型嵌合抗原受体修饰的免疫细胞及其应用

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