AU2019282620B2 - MUC16 specific chimeric antigen receptors and uses thereof - Google Patents

MUC16 specific chimeric antigen receptors and uses thereof

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Publication number
AU2019282620B2
AU2019282620B2 AU2019282620A AU2019282620A AU2019282620B2 AU 2019282620 B2 AU2019282620 B2 AU 2019282620B2 AU 2019282620 A AU2019282620 A AU 2019282620A AU 2019282620 A AU2019282620 A AU 2019282620A AU 2019282620 B2 AU2019282620 B2 AU 2019282620B2
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cells
car
cell
domain
seq
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AU2019282620A1 (en
Inventor
Helen SABZEVARI
Rutul R. SHAH
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Precigen Inc
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Precigen Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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AU2019282620A 2018-06-04 2019-06-04 MUC16 specific chimeric antigen receptors and uses thereof Active AU2019282620B2 (en)

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US201862680297P 2018-06-04 2018-06-04
US62/680,297 2018-06-04
PCT/US2019/035384 WO2019236577A2 (en) 2018-06-04 2019-06-04 Muc16 specific chimeric antigen receptors and uses thereof

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AU2019282620A1 AU2019282620A1 (en) 2020-12-17
AU2019282620B2 true AU2019282620B2 (en) 2026-04-23

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US (4) US11319380B2 (https=)
EP (1) EP3802615A4 (https=)
JP (3) JP2021525534A (https=)
KR (1) KR20210021493A (https=)
CN (2) CN121852427A (https=)
AU (1) AU2019282620B2 (https=)
CA (1) CA3101641A1 (https=)
IL (1) IL278976A (https=)
SG (1) SG11202011895VA (https=)
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ZA (3) ZA202008065B (https=)

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US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
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