SG11202011895VA - Muc16 specific chimeric antigen receptors and uses thereof - Google Patents

Muc16 specific chimeric antigen receptors and uses thereof

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Publication number
SG11202011895VA
SG11202011895VA SG11202011895VA SG11202011895VA SG11202011895VA SG 11202011895V A SG11202011895V A SG 11202011895VA SG 11202011895V A SG11202011895V A SG 11202011895VA SG 11202011895V A SG11202011895V A SG 11202011895VA SG 11202011895V A SG11202011895V A SG 11202011895VA
Authority
SG
Singapore
Prior art keywords
chimeric antigen
antigen receptors
specific chimeric
muc16
muc16 specific
Prior art date
Application number
SG11202011895VA
Inventor
Helen Sabzevari
Rutul R Shah
Original Assignee
Intrexon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Corp filed Critical Intrexon Corp
Publication of SG11202011895VA publication Critical patent/SG11202011895VA/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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SG11202011895VA 2018-06-04 2019-06-04 Muc16 specific chimeric antigen receptors and uses thereof SG11202011895VA (en)

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US201862680297P 2018-06-04 2018-06-04
PCT/US2019/035384 WO2019236577A2 (en) 2018-06-04 2019-06-04 Muc16 specific chimeric antigen receptors and uses thereof

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EP (1) EP3802615A4 (en)
JP (2) JP2021525534A (en)
KR (1) KR20210021493A (en)
CN (1) CN112533957A (en)
AU (1) AU2019282620A1 (en)
CA (1) CA3101641A1 (en)
IL (1) IL278976A (en)
SG (1) SG11202011895VA (en)
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ZA (1) ZA202008065B (en)

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EP3802615A2 (en) 2021-04-14
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