CA3101641A1 - Muc16 specific chimeric antigen receptors and uses thereof - Google Patents

Muc16 specific chimeric antigen receptors and uses thereof Download PDF

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Publication number
CA3101641A1
CA3101641A1 CA3101641A CA3101641A CA3101641A1 CA 3101641 A1 CA3101641 A1 CA 3101641A1 CA 3101641 A CA3101641 A CA 3101641A CA 3101641 A CA3101641 A CA 3101641A CA 3101641 A1 CA3101641 A1 CA 3101641A1
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Prior art keywords
cells
seq
car
vector
cell
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CA3101641A
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English (en)
French (fr)
Inventor
Helen SABZEVARI
Rutul R. SHAH
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Precigen Inc
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Intrexon Corp
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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CA3101641A 2018-06-04 2019-06-04 Muc16 specific chimeric antigen receptors and uses thereof Pending CA3101641A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862680297P 2018-06-04 2018-06-04
US62/680,297 2018-06-04
PCT/US2019/035384 WO2019236577A2 (en) 2018-06-04 2019-06-04 Muc16 specific chimeric antigen receptors and uses thereof

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CA3101641A1 true CA3101641A1 (en) 2019-12-12

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CA3101641A Pending CA3101641A1 (en) 2018-06-04 2019-06-04 Muc16 specific chimeric antigen receptors and uses thereof

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US (4) US11319380B2 (https=)
EP (1) EP3802615A4 (https=)
JP (3) JP2021525534A (https=)
KR (1) KR20210021493A (https=)
CN (2) CN121852427A (https=)
AU (1) AU2019282620B2 (https=)
CA (1) CA3101641A1 (https=)
IL (1) IL278976A (https=)
SG (1) SG11202011895VA (https=)
WO (1) WO2019236577A2 (https=)
ZA (3) ZA202008065B (https=)

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Publication number Priority date Publication date Assignee Title
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
EP3697438A4 (en) * 2017-10-18 2021-08-18 Intrexon Corporation POLYPEPTIDE COMPOSITIONS WITH SPACERS
SG11202104524YA (en) * 2018-11-01 2021-05-28 Gracell Biotechnologies Shanghai Co Ltd Compositions and methods for t cell engineering
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