KR20190092618A - 세포 배양 배지의 바이러스 여과 - Google Patents

세포 배양 배지의 바이러스 여과 Download PDF

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Publication number
KR20190092618A
KR20190092618A KR1020197022413A KR20197022413A KR20190092618A KR 20190092618 A KR20190092618 A KR 20190092618A KR 1020197022413 A KR1020197022413 A KR 1020197022413A KR 20197022413 A KR20197022413 A KR 20197022413A KR 20190092618 A KR20190092618 A KR 20190092618A
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KR
South Korea
Prior art keywords
cell culture
culture medium
virus
filtration
filter
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Ceased
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KR1020197022413A
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English (en)
Korean (ko)
Inventor
볼프강 문트
아르투르 미테레르
만프레트 라이터
마인하르트 하슬라허
레오폴트 그릴베르거
토마스 크레일
Original Assignee
박스알타 인코퍼레이티드
박스앨타 게엠베하
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Publication of KR20190092618A publication Critical patent/KR20190092618A/ko
Ceased legal-status Critical Current

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    • A61L2/0017—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/022—Filtration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Filtering Materials (AREA)
KR1020197022413A 2012-06-21 2013-06-13 세포 배양 배지의 바이러스 여과 Ceased KR20190092618A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261662814P 2012-06-21 2012-06-21
US61/662,814 2012-06-21
PCT/US2013/045663 WO2013192009A1 (en) 2012-06-21 2013-06-13 Virus filtration of cell culture media

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020157001269A Division KR102008048B1 (ko) 2012-06-21 2013-06-13 세포 배양 배지의 바이러스 여과

Publications (1)

Publication Number Publication Date
KR20190092618A true KR20190092618A (ko) 2019-08-07

Family

ID=48672845

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020197022413A Ceased KR20190092618A (ko) 2012-06-21 2013-06-13 세포 배양 배지의 바이러스 여과
KR1020157001269A Active KR102008048B1 (ko) 2012-06-21 2013-06-13 세포 배양 배지의 바이러스 여과

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020157001269A Active KR102008048B1 (ko) 2012-06-21 2013-06-13 세포 배양 배지의 바이러스 여과

Country Status (27)

Country Link
US (3) US9670456B2 (https=)
EP (2) EP2732020B1 (https=)
JP (3) JP6220392B2 (https=)
KR (2) KR20190092618A (https=)
CN (2) CN104640969A (https=)
AR (1) AR092847A1 (https=)
AU (2) AU2013277532B2 (https=)
BR (1) BR112014031842B1 (https=)
CA (1) CA2876473C (https=)
CO (1) CO7151484A2 (https=)
DK (2) DK2732020T3 (https=)
EA (2) EA201990887A1 (https=)
ES (2) ES2829968T3 (https=)
HR (1) HRP20161435T1 (https=)
HU (1) HUE031601T2 (https=)
IL (2) IL236073B (https=)
IN (1) IN2014DN10441A (https=)
MX (2) MX386767B (https=)
MY (2) MY173835A (https=)
NZ (1) NZ629083A (https=)
PL (2) PL3103861T3 (https=)
PT (2) PT3103861T (https=)
SG (2) SG10201701721TA (https=)
SI (1) SI2732020T1 (https=)
TW (2) TWI609962B (https=)
WO (1) WO2013192009A1 (https=)
ZA (1) ZA201409253B (https=)

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BR112014031842B1 (pt) * 2012-06-21 2020-09-15 Baxalta GmbH Método para remover um contaminante viral de uma preparação
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
SG10201507931QA (en) * 2014-12-22 2016-07-28 Emd Millipore Corp Removal of microorganisms from cell culture media
JP7133925B2 (ja) 2015-03-23 2022-09-09 アレクシオン ファーマシューティカルズ インコーポレイテッド ウイルス濾過
EP3015542A1 (de) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes
TWI870789B (zh) 2015-08-04 2025-01-21 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
WO2017180814A1 (en) * 2016-04-15 2017-10-19 Boehringer Ingelheim International Gmbh Cell retention device and method
EP3535047A1 (en) * 2016-12-09 2019-09-11 Lonza Ltd Method for the reduction of viral titer in pharmaceuticals
BR112020000127A2 (pt) * 2017-07-06 2020-07-07 Regeneron Pharmaceuticals, Inc. método para selecionar um hidrolisado de soja, e, glicoproteína
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
US11504713B2 (en) 2019-03-11 2022-11-22 Genzyme Corporation Tangential viral filtration
US11912741B2 (en) * 2019-04-03 2024-02-27 Genzyme Corporation Continuous production of recombinant proteins
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
WO2021231956A1 (en) * 2020-05-14 2021-11-18 North Carolina State University Fast automated approach for the derivation of acellular extracellular matrix scaffolds from tissues
IL301774A (en) * 2020-10-02 2023-05-01 Regeneron Pharma Continuous retentive filtering of viruses
WO2025019797A2 (en) * 2023-07-19 2025-01-23 Hatchless Inc. System and method for low-cost sterilization of liquids

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JPH0422874A (ja) * 1990-05-16 1992-01-27 Matsushita Electric Ind Co Ltd 波形表示装置
GB2352652A (en) 1999-08-06 2001-02-07 Fsm Technologies Ltd Pre-treating hollow fibre membranes for micro-organism detection
US6485686B1 (en) * 1999-09-17 2002-11-26 The United States Of America As Represented By The Secretary Of The Army Method and apparatus for counting submicron sized particles
WO2001040448A1 (en) 1999-12-02 2001-06-07 The General Hospital Corporation Methods for removal, purification, and concentration of viruses, and methods of therapy based thereupon
US6485688B1 (en) 2000-04-24 2002-11-26 General Electric Company On-line sparging sampling and monitoring systems and methods
US6835311B2 (en) 2002-01-31 2004-12-28 Koslow Technologies Corporation Microporous filter media, filtration systems containing same, and methods of making and using
US6630016B2 (en) * 2002-01-31 2003-10-07 Koslow Technologies Corp. Microporous filter media, filtration systems containing same, and methods of making and using
ES2214967B1 (es) 2003-03-06 2005-06-16 Probitas Pharma, S.A Procedimiento para la eliminacion de virus en soluciones de fibrinogeno y fibrinogeno obtenido por dicho procedimiento.
JP4874806B2 (ja) * 2003-12-01 2012-02-15 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 液体因子ｖｉｉ組成物のウイルス濾過
DE102005047301B4 (de) * 2005-09-30 2009-04-16 Sartorius Stedim Biotech Gmbh Verfahren zum Nachweis der Virenabreicherung für die Validierung von Filtern und Filtrationsprozessen
US20070084788A1 (en) * 2005-10-14 2007-04-19 Millipore Corporation Ultrafiltration membranes and methods of making and use of ultrafiltration membranes
US8309029B1 (en) * 2009-03-26 2012-11-13 The United States Of America As Represented By The Secretary Of The Army Virus and particulate separation from solution
US8945895B2 (en) * 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
DK2467399T3 (en) * 2009-08-20 2017-01-23 Baxalta Inc Purification of vWF for increased removal of non-lipid-enveloped viruses
BR112014031842B1 (pt) * 2012-06-21 2020-09-15 Baxalta GmbH Método para remover um contaminante viral de uma preparação

Also Published As

Publication number Publication date
AU2013277532B2 (en) 2017-06-15
IN2014DN10441A (https=) 2015-08-21
SI2732020T1 (sl) 2017-03-31
EA201590059A1 (ru) 2015-04-30
CO7151484A2 (es) 2014-12-29
US20170260498A1 (en) 2017-09-14
EP3103861A1 (en) 2016-12-14
TW201816105A (zh) 2018-05-01
AR092847A1 (es) 2015-05-06
TWI698522B (zh) 2020-07-11
TWI609962B (zh) 2018-01-01
WO2013192009A1 (en) 2013-12-27
PL2732020T3 (pl) 2017-06-30
US9670456B2 (en) 2017-06-06
HRP20161435T1 (hr) 2017-02-24
IL236073B (en) 2019-01-31
CN104640969A (zh) 2015-05-20
PT2732020T (pt) 2016-11-10
US20200277565A1 (en) 2020-09-03
KR20150032709A (ko) 2015-03-27
EP2732020B1 (en) 2016-08-10
JP2017184765A (ja) 2017-10-12
EP2732020A1 (en) 2014-05-21
JP2019022526A (ja) 2019-02-14
HK1231502A1 (en) 2017-12-22
TW201412986A (zh) 2014-04-01
DK2732020T3 (en) 2016-11-28
IL263479B (en) 2020-08-31
AU2017228547B2 (en) 2019-02-21
ES2829968T3 (es) 2021-06-02
CN108795724A (zh) 2018-11-13
ZA201409253B (en) 2022-05-25
BR112014031842B1 (pt) 2020-09-15
CA2876473A1 (en) 2013-12-27
HK1198335A1 (zh) 2015-04-02
SG10201701721TA (en) 2017-04-27
AU2017228547A1 (en) 2017-10-05
HUE031601T2 (hu) 2017-07-28
JP6557706B2 (ja) 2019-08-07
PT3103861T (pt) 2020-11-16
US20130344535A1 (en) 2013-12-26
CA2876473C (en) 2021-05-11
JP2015529447A (ja) 2015-10-08
DK3103861T3 (da) 2020-11-16
MX2014015950A (es) 2015-07-17
IL263479A (en) 2019-01-31
MX386767B (es) 2025-03-19
AU2013277532A1 (en) 2015-01-15
ES2601429T3 (es) 2017-02-15
MY173835A (en) 2020-02-24
BR112014031842A2 (pt) 2017-08-22
SG11201408490PA (en) 2015-01-29
US11421202B2 (en) 2022-08-23
PL3103861T3 (pl) 2021-03-22
EA201990887A1 (ru) 2019-08-30
EA033006B1 (ru) 2019-08-30
JP6220392B2 (ja) 2017-10-25
MY195362A (en) 2023-01-16
EP3103861B1 (en) 2020-09-30
IL236073A0 (en) 2015-01-29
KR102008048B1 (ko) 2019-08-06
MX347319B (es) 2017-04-21
NZ629083A (en) 2016-11-25

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