KR20180122028A - 의약으로서의 아자인다졸 또는 디아자인다졸 유형의 유도체 - Google Patents

의약으로서의 아자인다졸 또는 디아자인다졸 유형의 유도체 Download PDF

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KR20180122028A
KR20180122028A KR1020187031264A KR20187031264A KR20180122028A KR 20180122028 A KR20180122028 A KR 20180122028A KR 1020187031264 A KR1020187031264 A KR 1020187031264A KR 20187031264 A KR20187031264 A KR 20187031264A KR 20180122028 A KR20180122028 A KR 20180122028A
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South Korea
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charom
compound
group
arom
formula
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Korean (ko)
Inventor
엘 바쉬르 깔롱
까렝 브드제귀에랄
레미 라뽀
앙나 끄뤼끄진스키
필리프 쉬미뜨
미셀 쁘레
니꼴라 라이엘
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피에르 파브르 메디카먼트
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Publication of KR20180122028A publication Critical patent/KR20180122028A/ko
Ceased legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020187031264A 2011-01-27 2012-01-27 의약으로서의 아자인다졸 또는 디아자인다졸 유형의 유도체 Ceased KR20180122028A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1150651 2011-01-27
FR1150651A FR2970967B1 (fr) 2011-01-27 2011-01-27 Derives de type azaindazole ou diazaindazole comme medicament
PCT/EP2012/051283 WO2012101239A1 (en) 2011-01-27 2012-01-27 Derivatives of azaindazole or diazaindazole type as medicament

Related Parent Applications (1)

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KR1020137022330A Division KR101923751B1 (ko) 2011-01-27 2012-01-27 의약으로서의 아자인다졸 또는 디아자인다졸 유형의 유도체

Publications (1)

Publication Number Publication Date
KR20180122028A true KR20180122028A (ko) 2018-11-09

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Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020137022330A Expired - Fee Related KR101923751B1 (ko) 2011-01-27 2012-01-27 의약으로서의 아자인다졸 또는 디아자인다졸 유형의 유도체
KR1020187031264A Ceased KR20180122028A (ko) 2011-01-27 2012-01-27 의약으로서의 아자인다졸 또는 디아자인다졸 유형의 유도체

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KR1020137022330A Expired - Fee Related KR101923751B1 (ko) 2011-01-27 2012-01-27 의약으로서의 아자인다졸 또는 디아자인다졸 유형의 유도체

Country Status (30)

Country Link
US (2) US20130172360A1 (OSRAM)
EP (1) EP2668184B1 (OSRAM)
JP (1) JP5931926B2 (OSRAM)
KR (2) KR101923751B1 (OSRAM)
CN (1) CN103339129B (OSRAM)
AR (1) AR084935A1 (OSRAM)
AU (1) AU2012210467B2 (OSRAM)
BR (1) BR112013018852B1 (OSRAM)
CA (1) CA2823824C (OSRAM)
CY (1) CY1120088T1 (OSRAM)
DK (1) DK2668184T3 (OSRAM)
ES (1) ES2661695T3 (OSRAM)
FR (1) FR2970967B1 (OSRAM)
HR (1) HRP20180524T1 (OSRAM)
HU (1) HUE037153T2 (OSRAM)
IL (2) IL227496B (OSRAM)
LT (1) LT2668184T (OSRAM)
MA (1) MA34903B1 (OSRAM)
MX (1) MX356411B (OSRAM)
MY (1) MY180666A (OSRAM)
PL (1) PL2668184T3 (OSRAM)
PT (1) PT2668184T (OSRAM)
RS (1) RS57101B1 (OSRAM)
RU (1) RU2600976C2 (OSRAM)
SI (1) SI2668184T1 (OSRAM)
TN (1) TN2013000293A1 (OSRAM)
TR (1) TR201802944T4 (OSRAM)
TW (1) TWI546303B (OSRAM)
UA (1) UA109698C2 (OSRAM)
WO (1) WO2012101239A1 (OSRAM)

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UA125503C2 (uk) 2012-06-13 2022-04-13 Інсайт Холдинґс Корпорейшн Заміщені трициклічні сполуки як інгібітори fgfr
EP2689779A1 (en) * 2012-07-27 2014-01-29 Pierre Fabre Medicament Derivatives of azaindazole or diazaindazole type for treating a cancer overexpressing trk
EP2689778A1 (en) * 2012-07-27 2014-01-29 Pierre Fabre Medicament Derivatives of azaindoles or diazaindoles for treating pain
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
MY181497A (en) 2013-04-19 2020-12-23 Incyte Holdings Corp Bicyclic heterocycles as fgfr inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
WO2016096709A1 (en) 2014-12-16 2016-06-23 Eudendron S.R.L. Heterocyclic derivatives modulating activity of certain protein kinases
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
CR20170390A (es) 2015-02-20 2017-10-23 Incyte Holdings Corp Heterociclos biciclicos como inhibidores de fgfr
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
US10211205B2 (en) * 2016-04-27 2019-02-19 International Business Machines Corporation Field effect transistor structure for reducing contact resistance
CN108570052A (zh) * 2017-03-13 2018-09-25 中国科学院上海药物研究所 五元杂环并吡嗪化合物、制备方法、中间体、组合和应用
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
CA3098988A1 (en) * 2018-05-02 2019-11-07 Jw Pharmaceutical Corporation Heterocycle derivative
BR112020022392A2 (pt) 2018-05-04 2021-02-02 Incyte Corporation formas sólidas de um inibidor de fgfr e processos para preparação das mesmas
PE20210919A1 (es) 2018-05-04 2021-05-19 Incyte Corp Sales de un inhibidor de fgfr
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
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PE20221504A1 (es) 2019-12-04 2022-09-30 Incyte Corp Derivados de un inhibidor de fgfr
WO2021138419A1 (en) * 2019-12-31 2021-07-08 Ifm Due, Inc, Compounds and compositions for treating conditions associated with sting activity
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WO2021197467A1 (zh) * 2020-04-02 2021-10-07 上海华汇拓医药科技有限公司 多靶点的抗肿瘤化合物及其制备方法和应用
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Also Published As

Publication number Publication date
MX356411B (es) 2018-05-24
PL2668184T3 (pl) 2018-06-29
JP5931926B2 (ja) 2016-06-08
DK2668184T3 (en) 2018-03-12
AR084935A1 (es) 2013-07-10
BR112013018852A2 (pt) 2017-08-15
CY1120088T1 (el) 2018-12-12
US20130085144A1 (en) 2013-04-04
MA34903B1 (fr) 2014-02-01
FR2970967B1 (fr) 2013-02-15
CA2823824A1 (en) 2012-08-02
RU2600976C2 (ru) 2016-10-27
MX2013008673A (es) 2013-12-02
NZ614432A (en) 2015-03-27
MY180666A (en) 2020-12-04
JP2014503574A (ja) 2014-02-13
US20130172360A1 (en) 2013-07-04
TWI546303B (zh) 2016-08-21
IL257748B (en) 2020-06-30
AU2012210467B2 (en) 2016-07-07
KR20140014147A (ko) 2014-02-05
EP2668184A1 (en) 2013-12-04
CA2823824C (en) 2018-12-11
WO2012101239A1 (en) 2012-08-02
LT2668184T (lt) 2018-04-10
US8883821B2 (en) 2014-11-11
HK1186737A1 (en) 2014-03-21
AU2012210467A1 (en) 2013-09-12
ES2661695T3 (es) 2018-04-03
TN2013000293A1 (en) 2015-01-20
RU2013138624A (ru) 2015-03-10
FR2970967A1 (fr) 2012-08-03
BR112013018852B1 (pt) 2021-12-21
HRP20180524T1 (hr) 2018-05-04
IL227496B (en) 2019-02-28
HUE037153T2 (hu) 2018-08-28
CN103339129A (zh) 2013-10-02
RS57101B1 (sr) 2018-06-29
TW201247664A (en) 2012-12-01
SI2668184T1 (en) 2018-06-29
PT2668184T (pt) 2018-03-13
TR201802944T4 (tr) 2018-03-21
IL227496A0 (en) 2013-09-30
EP2668184B1 (en) 2018-01-10
KR101923751B1 (ko) 2018-11-29
IL257748A (en) 2018-04-30
UA109698C2 (xx) 2015-09-25
CN103339129B (zh) 2015-07-29

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