KR20180100869A - 피르페니돈의 입자크기 조절에 따른 타정성이 개선된 약제학적 조성물 및 이의 제조방법 - Google Patents

피르페니돈의 입자크기 조절에 따른 타정성이 개선된 약제학적 조성물 및 이의 제조방법 Download PDF

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Publication number
KR20180100869A
KR20180100869A KR1020170027228A KR20170027228A KR20180100869A KR 20180100869 A KR20180100869 A KR 20180100869A KR 1020170027228 A KR1020170027228 A KR 1020170027228A KR 20170027228 A KR20170027228 A KR 20170027228A KR 20180100869 A KR20180100869 A KR 20180100869A
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KR
South Korea
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composition
particle size
weight
tablet
prepared
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KR1020170027228A
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English (en)
Korean (ko)
Inventor
윤양노
김정필
최용환
Original Assignee
영진약품 주식회사
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Application filed by 영진약품 주식회사 filed Critical 영진약품 주식회사
Priority to KR1020170027228A priority Critical patent/KR20180100869A/ko
Priority to CN201880018876.5A priority patent/CN110430871A/zh
Priority to PCT/KR2018/002484 priority patent/WO2018160011A1/ko
Priority to JP2019547670A priority patent/JP2020509053A/ja
Publication of KR20180100869A publication Critical patent/KR20180100869A/ko
Priority to JP2021213391A priority patent/JP2022031527A/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020170027228A 2017-03-02 2017-03-02 피르페니돈의 입자크기 조절에 따른 타정성이 개선된 약제학적 조성물 및 이의 제조방법 KR20180100869A (ko)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1020170027228A KR20180100869A (ko) 2017-03-02 2017-03-02 피르페니돈의 입자크기 조절에 따른 타정성이 개선된 약제학적 조성물 및 이의 제조방법
CN201880018876.5A CN110430871A (zh) 2017-03-02 2018-02-28 可压缩性改善的粒度受控的吡非尼酮的药物组合物及其制备方法
PCT/KR2018/002484 WO2018160011A1 (ko) 2017-03-02 2018-02-28 피르페니돈의 입자크기 조절에 따른 타정성이 개선된 약제학적 조성물 및 이의 제조방법
JP2019547670A JP2020509053A (ja) 2017-03-02 2018-02-28 ピルフェニドンの粒子の大きさ調節による打錠性が改善された薬剤学的組成物およびその製造方法
JP2021213391A JP2022031527A (ja) 2017-03-02 2021-12-27 ピルフェニドンの粒子の大きさ調節による打錠性が改善された薬剤学的組成物およびその製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020170027228A KR20180100869A (ko) 2017-03-02 2017-03-02 피르페니돈의 입자크기 조절에 따른 타정성이 개선된 약제학적 조성물 및 이의 제조방법

Publications (1)

Publication Number Publication Date
KR20180100869A true KR20180100869A (ko) 2018-09-12

Family

ID=63370533

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020170027228A KR20180100869A (ko) 2017-03-02 2017-03-02 피르페니돈의 입자크기 조절에 따른 타정성이 개선된 약제학적 조성물 및 이의 제조방법

Country Status (4)

Country Link
JP (2) JP2020509053A (ja)
KR (1) KR20180100869A (ja)
CN (1) CN110430871A (ja)
WO (1) WO2018160011A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200100376A (ko) * 2019-02-18 2020-08-26 충북대학교 산학협력단 중합체 및 채널링제를 포함하는 피르페니돈 또는 이의 약학적으로 허용가능한 염의 지연 방출용 정제
WO2021215856A1 (ko) * 2020-04-22 2021-10-28 영진약품 주식회사 안전성과 안정성이 개선된 피르페니돈을 포함하는 장용성 제제 및 이의 제조방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4077320B2 (ja) * 2001-01-29 2008-04-16 塩野義製薬株式会社 ５−メチル−１−フェニル−２−（１ｈ）−ピリドンを有効成分として含有する医薬製剤
NZ591443A (en) * 2005-09-22 2013-04-26 Intermune Inc Granule formation of pirfenidone and pharmaceutically acceptable excipients
CN102552203A (zh) * 2010-12-21 2012-07-11 北京德众万全医药科技有限公司 一种吡非尼酮片及其制备方法
MX2011007675A (es) * 2011-07-19 2012-07-11 Cell Therapy And Technology S A De C V Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas.
CN102846555B (zh) * 2012-04-09 2014-06-25 珠海亿邦制药股份有限公司 一种以吡非尼酮为活性成分的固体制剂及其应用
CN102846569A (zh) * 2012-09-06 2013-01-02 北京万全德众医药生物技术有限公司 一种含吡非尼酮的药物组合物及其制备方法
CN103271886B (zh) * 2013-05-29 2014-08-13 南京正大天晴制药有限公司 一种吡非尼酮片剂及其制备方法
KR101545268B1 (ko) * 2015-02-05 2015-08-20 보령제약 주식회사 정제 및 이의 제조방법
CA2937365C (en) * 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200100376A (ko) * 2019-02-18 2020-08-26 충북대학교 산학협력단 중합체 및 채널링제를 포함하는 피르페니돈 또는 이의 약학적으로 허용가능한 염의 지연 방출용 정제
WO2021215856A1 (ko) * 2020-04-22 2021-10-28 영진약품 주식회사 안전성과 안정성이 개선된 피르페니돈을 포함하는 장용성 제제 및 이의 제조방법

Also Published As

Publication number Publication date
WO2018160011A1 (ko) 2018-09-07
JP2020509053A (ja) 2020-03-26
JP2022031527A (ja) 2022-02-18
CN110430871A (zh) 2019-11-08

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