CN110430871A - 可压缩性改善的粒度受控的吡非尼酮的药物组合物及其制备方法 - Google Patents

可压缩性改善的粒度受控的吡非尼酮的药物组合物及其制备方法 Download PDF

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Publication number
CN110430871A
CN110430871A CN201880018876.5A CN201880018876A CN110430871A CN 110430871 A CN110430871 A CN 110430871A CN 201880018876 A CN201880018876 A CN 201880018876A CN 110430871 A CN110430871 A CN 110430871A
Authority
CN
China
Prior art keywords
pirfenidone
composition
tablet
preparation
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880018876.5A
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English (en)
Chinese (zh)
Inventor
尹良老
金正泌
崔墉焕
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yungjin Pharmaceutical Co Ltd
Original Assignee
Yungjin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yungjin Pharmaceutical Co Ltd filed Critical Yungjin Pharmaceutical Co Ltd
Publication of CN110430871A publication Critical patent/CN110430871A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201880018876.5A 2017-03-02 2018-02-28 可压缩性改善的粒度受控的吡非尼酮的药物组合物及其制备方法 Pending CN110430871A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2017-0027228 2017-03-02
KR1020170027228A KR20180100869A (ko) 2017-03-02 2017-03-02 피르페니돈의 입자크기 조절에 따른 타정성이 개선된 약제학적 조성물 및 이의 제조방법
PCT/KR2018/002484 WO2018160011A1 (ko) 2017-03-02 2018-02-28 피르페니돈의 입자크기 조절에 따른 타정성이 개선된 약제학적 조성물 및 이의 제조방법

Publications (1)

Publication Number Publication Date
CN110430871A true CN110430871A (zh) 2019-11-08

Family

ID=63370533

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880018876.5A Pending CN110430871A (zh) 2017-03-02 2018-02-28 可压缩性改善的粒度受控的吡非尼酮的药物组合物及其制备方法

Country Status (4)

Country Link
JP (2) JP2020509053A (ja)
KR (1) KR20180100869A (ja)
CN (1) CN110430871A (ja)
WO (1) WO2018160011A1 (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102199415B1 (ko) * 2019-02-18 2021-01-06 충북대학교 산학협력단 중합체 및 채널링제를 포함하는 피르페니돈 또는 이의 약학적으로 허용가능한 염의 지연 방출용 정제
US20230158004A1 (en) * 2020-04-22 2023-05-25 Yungjin Pharm. Co., Ltd. Enteric-coated preparation comprising pirfenidone having improved safety and stability, and method for preparing same

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002060446A1 (en) * 2001-01-29 2002-08-08 Shionogi & Co., Ltd. Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient
CN102552203A (zh) * 2010-12-21 2012-07-11 北京德众万全医药科技有限公司 一种吡非尼酮片及其制备方法
CN102846555A (zh) * 2012-04-09 2013-01-02 珠海亿邦制药股份有限公司 一种以吡非尼酮为活性成分的固体制剂及其应用
CN102846569A (zh) * 2012-09-06 2013-01-02 北京万全德众医药生物技术有限公司 一种含吡非尼酮的药物组合物及其制备方法
CN103271886A (zh) * 2013-05-29 2013-09-04 南京正大天晴制药有限公司 一种吡非尼酮片剂及其制备方法
CN103957892A (zh) * 2011-07-19 2014-07-30 细胞治疗技术合伙股份有限公司 以缓释片剂形式制备含有吡非尼酮的药物组合物的方法及其在人慢性肾功能衰竭、乳房包膜挛缩和肝纤维化的复原中的应用
CN106176641A (zh) * 2015-02-05 2016-12-07 保宁制药株式会社 片剂及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ591443A (en) * 2005-09-22 2013-04-26 Intermune Inc Granule formation of pirfenidone and pharmaceutically acceptable excipients
CA2937365C (en) * 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002060446A1 (en) * 2001-01-29 2002-08-08 Shionogi & Co., Ltd. Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient
CN102552203A (zh) * 2010-12-21 2012-07-11 北京德众万全医药科技有限公司 一种吡非尼酮片及其制备方法
CN103957892A (zh) * 2011-07-19 2014-07-30 细胞治疗技术合伙股份有限公司 以缓释片剂形式制备含有吡非尼酮的药物组合物的方法及其在人慢性肾功能衰竭、乳房包膜挛缩和肝纤维化的复原中的应用
CN102846555A (zh) * 2012-04-09 2013-01-02 珠海亿邦制药股份有限公司 一种以吡非尼酮为活性成分的固体制剂及其应用
CN102846569A (zh) * 2012-09-06 2013-01-02 北京万全德众医药生物技术有限公司 一种含吡非尼酮的药物组合物及其制备方法
CN103271886A (zh) * 2013-05-29 2013-09-04 南京正大天晴制药有限公司 一种吡非尼酮片剂及其制备方法
CN106176641A (zh) * 2015-02-05 2016-12-07 保宁制药株式会社 片剂及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
庄越等: "《实用药物制剂技术》", 31 January 1999, 人民卫生出版社 *
韦超等: "《药剂学》", 31 August 2012, 河南科学技术出版社 *

Also Published As

Publication number Publication date
WO2018160011A1 (ko) 2018-09-07
JP2020509053A (ja) 2020-03-26
JP2022031527A (ja) 2022-02-18
KR20180100869A (ko) 2018-09-12

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