KR20180067584A - 피롤로피리미딘 키나아제 억제제의 약학적 염, 물리적 형태 및 조성물, 및 이들의 제조 방법 - Google Patents

피롤로피리미딘 키나아제 억제제의 약학적 염, 물리적 형태 및 조성물, 및 이들의 제조 방법 Download PDF

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KR20180067584A
KR20180067584A KR1020187012886A KR20187012886A KR20180067584A KR 20180067584 A KR20180067584 A KR 20180067584A KR 1020187012886 A KR1020187012886 A KR 1020187012886A KR 20187012886 A KR20187012886 A KR 20187012886A KR 20180067584 A KR20180067584 A KR 20180067584A
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compound
pharmaceutical composition
pharmaceutically acceptable
alkyl
acceptable salt
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Korean (ko)
Inventor
롱 마오
지아 리유
일레 첸
유닝 화
콩겐 다이
이메이 바오
보지에 웽
샤오펑 모
지안 우
샤오 수
완홍 수
샤오보 왕
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아세아 테라퓨틱스 인코포레이티드
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Publication of KR20180067584A publication Critical patent/KR20180067584A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020187012886A 2015-10-09 2016-06-30 피롤로피리미딘 키나아제 억제제의 약학적 염, 물리적 형태 및 조성물, 및 이들의 제조 방법 Ceased KR20180067584A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2015/091536 2015-10-09
CN2015091536 2015-10-09
PCT/CN2016/087857 WO2017059702A1 (en) 2015-10-09 2016-06-30 Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same

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KR20180067584A true KR20180067584A (ko) 2018-06-20

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KR1020187012886A Ceased KR20180067584A (ko) 2015-10-09 2016-06-30 피롤로피리미딘 키나아제 억제제의 약학적 염, 물리적 형태 및 조성물, 및 이들의 제조 방법

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US (1) US10533011B2 (cg-RX-API-DMAC10.html)
EP (1) EP3359159B1 (cg-RX-API-DMAC10.html)
JP (1) JP6889494B2 (cg-RX-API-DMAC10.html)
KR (1) KR20180067584A (cg-RX-API-DMAC10.html)
CN (1) CN107949388B (cg-RX-API-DMAC10.html)
AR (1) AR106301A1 (cg-RX-API-DMAC10.html)
AU (1) AU2016334141B2 (cg-RX-API-DMAC10.html)
BR (1) BR112018006939A2 (cg-RX-API-DMAC10.html)
CA (1) CA3001744C (cg-RX-API-DMAC10.html)
MX (1) MX2018004332A (cg-RX-API-DMAC10.html)
RU (1) RU2018115334A (cg-RX-API-DMAC10.html)
TW (1) TW201722431A (cg-RX-API-DMAC10.html)
WO (1) WO2017059702A1 (cg-RX-API-DMAC10.html)

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BR112018006939A2 (en) 2018-10-16
CA3001744C (en) 2024-09-10
WO2017059702A1 (en) 2017-04-13
US20180312510A1 (en) 2018-11-01
RU2018115334A (ru) 2019-11-11
EP3359159A4 (en) 2019-06-05
EP3359159B1 (en) 2023-06-07
RU2018115334A3 (cg-RX-API-DMAC10.html) 2019-11-29
AU2016334141A1 (en) 2018-04-26
CN107949388A (zh) 2018-04-20
AR106301A1 (es) 2018-01-03
TW201722431A (zh) 2017-07-01
JP2018530610A (ja) 2018-10-18
CN107949388B (zh) 2021-10-26
CA3001744A1 (en) 2017-04-13
HK1253537A1 (en) 2019-06-21
MX2018004332A (es) 2019-01-10
JP6889494B2 (ja) 2021-06-18
EP3359159A1 (en) 2018-08-15
US10533011B2 (en) 2020-01-14
AU2016334141B2 (en) 2019-12-19

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