CA3001744C - Pharmaceutical salts, physical forms, and compositions of pyrolopyrimidine kinase inhibitors, and their preparation methods - Google Patents

Pharmaceutical salts, physical forms, and compositions of pyrolopyrimidine kinase inhibitors, and their preparation methods

Info

Publication number
CA3001744C
CA3001744C CA3001744A CA3001744A CA3001744C CA 3001744 C CA3001744 C CA 3001744C CA 3001744 A CA3001744 A CA 3001744A CA 3001744 A CA3001744 A CA 3001744A CA 3001744 C CA3001744 C CA 3001744C
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CA
Canada
Prior art keywords
pharmaceutical composition
compound
salt
pharmaceutically acceptable
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3001744A
Other languages
English (en)
French (fr)
Other versions
CA3001744A1 (en
Inventor
Long Mao
Jia Liu
Yile CHEN
Yuning HUA
Kongen DAI
Yimei BAO
Bojie WENG
Xiaopeng Mo
Jian Wu
Xiao Xu
Wanhong XU
Xiaobo Wang
Original Assignee
Acea Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Acea Therapeutics Inc filed Critical Acea Therapeutics Inc
Publication of CA3001744A1 publication Critical patent/CA3001744A1/en
Application granted granted Critical
Publication of CA3001744C publication Critical patent/CA3001744C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA3001744A 2015-10-09 2016-06-30 Pharmaceutical salts, physical forms, and compositions of pyrolopyrimidine kinase inhibitors, and their preparation methods Active CA3001744C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2015/091536 2015-10-09
CN2015091536 2015-10-09
PCT/CN2016/087857 WO2017059702A1 (en) 2015-10-09 2016-06-30 Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same

Publications (2)

Publication Number Publication Date
CA3001744A1 CA3001744A1 (en) 2017-04-13
CA3001744C true CA3001744C (en) 2024-09-10

Family

ID=58487279

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3001744A Active CA3001744C (en) 2015-10-09 2016-06-30 Pharmaceutical salts, physical forms, and compositions of pyrolopyrimidine kinase inhibitors, and their preparation methods

Country Status (13)

Country Link
US (1) US10533011B2 (cg-RX-API-DMAC10.html)
EP (1) EP3359159B1 (cg-RX-API-DMAC10.html)
JP (1) JP6889494B2 (cg-RX-API-DMAC10.html)
KR (1) KR20180067584A (cg-RX-API-DMAC10.html)
CN (1) CN107949388B (cg-RX-API-DMAC10.html)
AR (1) AR106301A1 (cg-RX-API-DMAC10.html)
AU (1) AU2016334141B2 (cg-RX-API-DMAC10.html)
BR (1) BR112018006939A2 (cg-RX-API-DMAC10.html)
CA (1) CA3001744C (cg-RX-API-DMAC10.html)
MX (1) MX2018004332A (cg-RX-API-DMAC10.html)
RU (1) RU2018115334A (cg-RX-API-DMAC10.html)
TW (1) TW201722431A (cg-RX-API-DMAC10.html)
WO (1) WO2017059702A1 (cg-RX-API-DMAC10.html)

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Also Published As

Publication number Publication date
BR112018006939A2 (en) 2018-10-16
WO2017059702A1 (en) 2017-04-13
US20180312510A1 (en) 2018-11-01
RU2018115334A (ru) 2019-11-11
EP3359159A4 (en) 2019-06-05
EP3359159B1 (en) 2023-06-07
KR20180067584A (ko) 2018-06-20
RU2018115334A3 (cg-RX-API-DMAC10.html) 2019-11-29
AU2016334141A1 (en) 2018-04-26
CN107949388A (zh) 2018-04-20
AR106301A1 (es) 2018-01-03
TW201722431A (zh) 2017-07-01
JP2018530610A (ja) 2018-10-18
CN107949388B (zh) 2021-10-26
CA3001744A1 (en) 2017-04-13
HK1253537A1 (en) 2019-06-21
MX2018004332A (es) 2019-01-10
JP6889494B2 (ja) 2021-06-18
EP3359159A1 (en) 2018-08-15
US10533011B2 (en) 2020-01-14
AU2016334141B2 (en) 2019-12-19

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