KR20180023015A - 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도 - Google Patents

혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도 Download PDF

Info

Publication number
KR20180023015A
KR20180023015A KR1020187004862A KR20187004862A KR20180023015A KR 20180023015 A KR20180023015 A KR 20180023015A KR 1020187004862 A KR1020187004862 A KR 1020187004862A KR 20187004862 A KR20187004862 A KR 20187004862A KR 20180023015 A KR20180023015 A KR 20180023015A
Authority
KR
South Korea
Prior art keywords
dose
vegf antagonist
weeks
vegf
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020187004862A
Other languages
English (en)
Korean (ko)
Inventor
조지 디. 얀코풀로스
Original Assignee
리제너론 파아마슈티컬스, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45507924&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20180023015(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 리제너론 파아마슈티컬스, 인크. filed Critical 리제너론 파아마슈티컬스, 인크.
Publication of KR20180023015A publication Critical patent/KR20180023015A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
KR1020187004862A 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도 Ceased KR20180023015A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161432245P 2011-01-13 2011-01-13
US61/432,245 2011-01-13
US201161434836P 2011-01-21 2011-01-21
US61/434,836 2011-01-21
US201161561957P 2011-11-21 2011-11-21
US61/561,957 2011-11-21
PCT/US2012/020855 WO2012097019A1 (en) 2011-01-13 2012-01-11 Use of a vegf antagonist to treat angiogenic eye disorders

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020137018185A Division KR20140043313A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020197012536A Division KR20190049934A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도

Publications (1)

Publication Number Publication Date
KR20180023015A true KR20180023015A (ko) 2018-03-06

Family

ID=45507924

Family Applications (8)

Application Number Title Priority Date Filing Date
KR1020187004862A Ceased KR20180023015A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
KR1020257043583A Pending KR20260004598A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
KR1020247022007A Ceased KR20240110092A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
KR1020217007359A Ceased KR20210030510A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
KR1020227021482A Ceased KR20220097542A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
KR1020137018185A Ceased KR20140043313A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
KR1020197012536A Ceased KR20190049934A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
KR1020207018126A Ceased KR20200077622A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도

Family Applications After (7)

Application Number Title Priority Date Filing Date
KR1020257043583A Pending KR20260004598A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
KR1020247022007A Ceased KR20240110092A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
KR1020217007359A Ceased KR20210030510A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
KR1020227021482A Ceased KR20220097542A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
KR1020137018185A Ceased KR20140043313A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
KR1020197012536A Ceased KR20190049934A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
KR1020207018126A Ceased KR20200077622A (ko) 2011-01-13 2012-01-11 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도

Country Status (13)

Country Link
US (14) US9254338B2 (enExample)
EP (4) EP3222285A1 (enExample)
JP (6) JP2014503555A (enExample)
KR (8) KR20180023015A (enExample)
CN (1) CN103533950A (enExample)
AU (5) AU2012205599B2 (enExample)
BR (1) BR112013017752A8 (enExample)
CA (1) CA2824422A1 (enExample)
HK (1) HK1244693A1 (enExample)
IL (3) IL295359A (enExample)
MX (3) MX385629B (enExample)
SG (4) SG191334A1 (enExample)
WO (1) WO2012097019A1 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2828739T3 (es) 2006-04-07 2021-05-27 Aerpio Pharmaceuticals Inc Anticuerpos que se unen a la proteína tirosina fosfatasa beta humana (HPTP-beta) y sus usos
KR20180023015A (ko) 2011-01-13 2018-03-06 리제너론 파아마슈티컬스, 인크. 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
MX363351B (es) 2011-10-13 2019-03-20 Aerpio Therapeutics Inc Un agente de unión a hptp?-ecd para usarse en el tratamiento de síndrome de fuga vascular.
JO3405B1 (ar) 2013-01-09 2019-10-20 Regeneron Pharma الأجسام المضادة لمضاد مستقبل عامل النمو المشتق من الصفائح الدموية - بيتا واستخداماتها
WO2015200905A2 (en) 2014-06-28 2015-12-30 Oligasis, Llc Dual pdgf/vegf antagonists
WO2016005381A1 (en) * 2014-07-10 2016-01-14 Bayer Pharma Aktiengesellschaft Pdgfrbeta-fc fusion proteins and uses thereof
TWI806150B (zh) * 2014-11-07 2023-06-21 瑞士商諾華公司 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
US20160144025A1 (en) * 2014-11-25 2016-05-26 Regeneron Pharmaceuticals, Inc. Methods and formulations for treating vascular eye diseases
CN106999511A (zh) * 2014-12-11 2017-08-01 拜耳医药保健有限责任公司 具有小的活动性脉络膜新生血管病变的年龄相关性黄斑变性的治疗
US20180000816A1 (en) * 2015-02-06 2018-01-04 Unity Biotechnology, Inc. Use of a Heterocyclic Bcl-xL Inhibitor and Related Analogs for Removing Senescent Cells in the Treatment of Eye Diseases and Other Age-Related Conditions
AU2016224843B2 (en) * 2015-02-26 2019-12-05 Feramda Ltd. Compositions and combinations for the treatment of angiogenesis diseases and disorders
KR101808234B1 (ko) * 2015-06-23 2017-12-12 (주)알테오젠 IgG Fc 도메인을 가지는 융합 단백질의 안정한 액상 제제
WO2017046140A1 (en) * 2015-09-18 2017-03-23 Bayer Pharma Aktiengesellschaft Treatment regimens for dr and rvo in dependence of the extent of retinal ischemia
US20170087100A1 (en) 2015-09-30 2017-03-30 Novaliq Gmbh Semifluorinated compounds and their compositions
EP3380194B1 (en) 2015-11-24 2023-11-01 Indiana University Research & Technology Corporation Composition for blocking angiogenesis
KR20210157427A (ko) 2015-12-03 2021-12-28 리제너론 파마슈티칼스 인코포레이티드 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법
IL290457B2 (en) 2015-12-30 2025-02-01 Kodiak Sciences Inc Antibodies and their conjugates
KR101685532B1 (ko) * 2016-04-26 2016-12-13 한국프라임제약주식회사 혈관내피성장인자 수용체 융합단백질
EP3463349B1 (en) 2016-05-25 2021-08-04 Santen Pharmaceutical Co., Ltd. Use of sirolimus to treat exudative age-related macular degeneration with persistent edema
CN109937034B (zh) 2016-11-21 2022-09-16 济世-伊沃泰克生物制品有限公司 阿柏西普制剂及其用途
EP3573641A4 (en) * 2017-01-25 2020-11-11 Iconic Therapeutics, Inc. TREATMENT METHODS FOR DISORDERS ASSOCIATED WITH ANGIOGENESIS AND NEOVASCULARIZATION
CN111182893A (zh) 2017-10-04 2020-05-19 诺瓦利克有限责任公司 包含f6h8的眼用组合物
AU2018370135A1 (en) * 2017-11-16 2020-06-04 Iveric Bio, Inc. A method for treating or preventing idiopathic polypoidal choroidal vasculopathy (IPCV)
MY202872A (en) 2017-11-20 2024-05-28 Just Evotec Biologics Inc Aflibercept formulations containing a lysine salt as tonicifying agent and uses thereof
KR20200093621A (ko) * 2017-11-30 2020-08-05 리제너론 파아마슈티컬스, 인크. 혈관형성 눈 장애를 치료하기 위한 vegf 길항제의 용도
US11524053B2 (en) 2018-01-26 2022-12-13 The Regents Of The University Of California Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents
CN111699004A (zh) 2018-02-06 2020-09-22 豪夫迈·罗氏有限公司 眼科疾病的治疗
CA3092588A1 (en) 2018-03-02 2019-09-06 Kodiak Sciences Inc. Il-6 antibodies and fusion constructs and conjugates thereof
MX2020009140A (es) * 2018-03-16 2020-09-28 Novartis Ag Metodos para el tratamiento de enfermedades oculares.
RS67656B1 (sr) 2018-05-10 2026-02-27 Regeneron Pharma Formulacije koje sadrže visoke koncentracije fuzionog proteina vegf receptora
US11519020B2 (en) 2018-05-25 2022-12-06 Regeneron Pharmaceuticals, Inc. Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF
EP3856245A4 (en) 2018-09-24 2022-10-26 EyePoint Pharmaceuticals, Inc. MULTISPECIFIC ANTIBODIES AGAINST HPTP - BETA (VE-PTP) AND VEGF
CN119033684A (zh) 2018-10-29 2024-11-29 豪夫迈·罗氏有限公司 抗体制剂
EP3923907B1 (en) 2019-02-13 2024-09-25 Novaliq GmbH Compositions and methods for the treatment of ocular neovascularization
WO2020241660A1 (ja) * 2019-05-28 2020-12-03 学校法人順天堂 糖尿病網膜症の予防又は治療薬
PE20240329A1 (es) 2019-06-05 2024-02-27 Regeneron Pharma Dispositivos y metodos para administracion de dosis de precision
AU2020345174A1 (en) * 2019-09-12 2022-03-31 Lupin Limited Modified dosing of VEGF inhibitors for ophthalmic use
CA3157509A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder
CN114867487A (zh) 2019-11-25 2022-08-05 加利福尼亚大学董事会 用于眼内新生血管的长效vegf抑制剂
IL309560B2 (en) 2019-12-06 2025-05-01 Regeneron Pharma Anti-VEGF protein preparations and methods for their production
MX2022006751A (es) 2019-12-06 2022-08-19 Regeneron Pharma Minitrampas de vegf y metodos de uso de las mismas.
KR102426802B1 (ko) * 2019-12-23 2022-07-28 한국프라임제약주식회사 혈관내피성장인자 수용체 융합단백질을 포함하는 신생혈관형성 관련 질환의 예방 및 치료를 위한 약학조성물
MX2022013812A (es) 2020-05-08 2022-12-15 Regeneron Pharma Trampas y mini-trampas de vegf y metodos para el tratamiento de trastornos oculares y cancer.
US12692301B2 (en) 2020-06-11 2026-07-28 Alkahest Inc. Methods of improving retina-associated disease outcome using CCR3-inhibitors
WO2022186335A1 (ja) * 2021-03-03 2022-09-09 学校法人自治医科大学 副作用の予測方法およびそのための装置
EP4323399A4 (en) * 2021-04-14 2025-04-09 Kodiak Sciences Inc. Methods of treating an eye disorder
FI4185318T3 (fi) * 2021-05-17 2025-10-13 Regeneron Pharma Pitkäaikaisia, suuren annoksen VEGF-antagonistihoitoja angiogeenisten silmäsairauksien hoitoon
JP2024526080A (ja) * 2021-06-23 2024-07-17 サイチューン ファーマ インターロイキン１５多様体
US12649031B2 (en) 2021-09-08 2026-06-09 Regeneron Pharmaceuticals, Inc. Methods for delivering agents with pre-filled syringes to minimize intraocular inflammation
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device
WO2024168252A2 (en) * 2023-02-10 2024-08-15 Yale University Use of inhibitors of vegf-c signaling for inhibiting immune responses and increasing gene therapy efficacy
CN121712520A (zh) * 2023-06-23 2026-03-20 瑞泽恩制药公司 用于治疗血管生成性眼病的延长的高剂量vegf拮抗剂方案
EP4761750A1 (en) * 2023-08-17 2026-06-24 Innovent Biologics (Suzhou) Co., Ltd. Methods of treating age-related macular degeneration and diabetic macular edema

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2226575C (en) 1995-07-27 2011-10-18 Genentech, Inc. Stabile isotonic lyophilized protein formulation
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
US7303746B2 (en) 1999-06-08 2007-12-04 Regeneron Pharmaceuticals, Inc. Methods of treating eye disorders with modified chimeric polypeptides
US7070959B1 (en) 1999-06-08 2006-07-04 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
US6833349B2 (en) 1999-06-08 2004-12-21 Regeneron Pharmaceuticals, Inc. Methods of treating inflammatory skin diseases
US7396664B2 (en) * 1999-06-08 2008-07-08 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
CN101433715B (zh) * 1999-06-08 2013-04-17 里珍纳龙药品有限公司 具有改善的药物动力学特性的修饰嵌合多肽
US7306799B2 (en) * 1999-06-08 2007-12-11 Regeneron Pharmaceuticals, Inc. Use of VEGF inhibitors for treatment of eye disorders
ATE454137T1 (de) 2001-07-25 2010-01-15 Facet Biotech Corp Stabile lyophilisierte pharmazeutische formulierung des igg-antikörpers daclizumab
US20030138417A1 (en) 2001-11-08 2003-07-24 Kaisheva Elizabet A. Stable liquid pharmaceutical formulation of IgG antibodies
HRP20040406A2 (en) 2001-11-09 2005-02-28 Eyetech Pharmaceuticals Methods for treating ocular neovascular diseases
JP2003309411A (ja) 2002-04-17 2003-10-31 Alps Electric Co Ltd 複合アンテナ
US7300563B2 (en) 2003-02-07 2007-11-27 Pavco, Inc. Use of N-alllyl substituted amines and their salts as brightening agents in nickel plating baths
JP4730909B2 (ja) 2003-03-28 2011-07-20 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｖｅｇｆ媒介性活性を遮断することにより糖尿病を処置する方法
PT1610820E (pt) 2003-04-04 2010-12-16 Novartis Ag Formulações de elevada concentração de anticorpos e proteínas
US20040266688A1 (en) 2003-05-14 2004-12-30 Nayak Nihar R Methods for modulating endometrium
AU2004242586C1 (en) 2003-05-28 2011-02-24 Regeneron Pharmaceuticals, Inc. Method of treating corneal transplant rejection by using VEGF antagonists
AR046510A1 (es) 2003-07-25 2005-12-14 Regeneron Pharma Composicion de un antagonista de vegf y un agente anti-proliferativo
US7422741B2 (en) 2004-03-05 2008-09-09 Vegenics Limited VEGFR-3 fusion proteins
CN100361710C (zh) 2004-06-07 2008-01-16 成都康弘生物科技有限公司 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用
CN1304427C (zh) 2004-06-08 2007-03-14 成都康弘生物科技有限公司 抑制血管新生的融合蛋白质及其用途
ES2381014T3 (es) 2004-06-08 2012-05-22 Chengdu Kanghong Biotechnologies Co., Ltd. Proteína quimérica inhibidora de la angiogénesis y el uso
EP2583685A1 (en) 2004-06-10 2013-04-24 Regeneron Pharmaceuticals, Inc. Method of administering and using VEGF inhibitors for the treatment of human cancer
EP1755645A2 (en) 2004-06-18 2007-02-28 Regeneron Pharmaceuticals, Inc. Vegf inhibitors for the treatment of malignant pleural effusion
CN1997386B (zh) 2004-07-30 2012-05-30 瑞泽恩制药公司 通过阻断vegf介导的活性来治疗i型糖尿病的方法
PT1802334E (pt) * 2004-10-21 2012-11-28 Genentech Inc Método para tratamento de doenças neovasculares intraoculares
EP1877438A2 (en) * 2005-02-02 2008-01-16 Regeneron Pharmaceuticals, Inc. Method of treating eye injury with local administration of a vegf inhibitor
CA3142945A1 (en) 2005-03-25 2006-10-05 Regeneron Pharmaceuticals, Inc. Histidine-buffered formulations of vegf antagonist
AU2006279658A1 (en) 2005-08-12 2007-02-22 Regeneron Pharmaceuticals, Inc. Treatment of diseases by subcutaneous administration of a VEGF antagonist
CN100567325C (zh) 2006-03-31 2009-12-09 成都康弘生物科技有限公司 Vegf受体融合蛋白及其在制备治疗眼睛疾病的药物中的应用
CN100502945C (zh) 2006-03-31 2009-06-24 成都康弘生物科技有限公司 Vegf受体融合蛋白在治疗眼睛疾病中的应用
US8216575B2 (en) 2006-03-31 2012-07-10 Chengdu Kanghong Biotechnologies Co., Ltd. Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains
CA2654510C (en) 2006-06-16 2015-03-17 Regeneron Pharmaceuticals, Inc. Vegf antagonist formulations suitable for intravitreal administration
CA2666709A1 (en) 2006-11-10 2008-05-29 Genentech, Inc. Method for treating age-related macular degeneration
FR2918279B1 (fr) 2007-07-05 2010-10-22 Aventis Pharma Sa Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan
CN102233132B (zh) 2010-04-28 2013-10-23 成都康弘生物科技有限公司 Vegf受体融合蛋白在制备抑制眼表新生血管生长的药物中的应用
CN102380096B (zh) 2010-08-31 2014-04-30 成都康弘生物科技有限公司 一种含有抑制血管增生的融合蛋白的药物组合物及用途
KR20180023015A (ko) 2011-01-13 2018-03-06 리제너론 파아마슈티컬스, 인크. 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
CN107115294B (zh) 2012-01-19 2019-10-18 北京康弘生物医药有限公司 一种含有vegf拮抗剂的滴眼液
JP6071099B1 (ja) 2014-01-25 2017-02-01 ツェンドゥー カンホン バイオテクノロジーズ カンパニー リミテッド 血管の新生又は成長を抑制する融合タンパク質及びその用途
TWI806150B (zh) 2014-11-07 2023-06-21 瑞士商諾華公司 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
KR20200093621A (ko) 2017-11-30 2020-08-05 리제너론 파아마슈티컬스, 인크. 혈관형성 눈 장애를 치료하기 위한 vegf 길항제의 용도

Also Published As

Publication number Publication date
US11975045B2 (en) 2024-05-07
JP2017061467A (ja) 2017-03-30
US20190247463A1 (en) 2019-08-15
AU2024204677A1 (en) 2024-07-25
US10130681B2 (en) 2018-11-20
AU2019202260A1 (en) 2019-04-18
NZ612593A (en) 2015-03-27
US12268730B2 (en) 2025-04-08
US11707506B2 (en) 2023-07-25
US9669069B2 (en) 2017-06-06
US20210121524A1 (en) 2021-04-29
CA2824422A1 (en) 2012-07-19
IL295359A (en) 2022-10-01
KR20200077622A (ko) 2020-06-30
EP3222285A1 (en) 2017-09-27
SG191334A1 (en) 2013-08-30
KR20210030510A (ko) 2021-03-17
SG10201509193UA (en) 2015-12-30
AU2017200290B2 (en) 2019-01-03
EP2663325A1 (en) 2013-11-20
BR112013017752A2 (pt) 2017-08-29
US10857205B2 (en) 2020-12-08
KR20190049934A (ko) 2019-05-09
JP2025169389A (ja) 2025-11-12
US20210308217A1 (en) 2021-10-07
US20180339018A1 (en) 2018-11-29
IL260167A (en) 2018-07-31
SG10201802789VA (en) 2018-05-30
US20130295094A1 (en) 2013-11-07
US20170202911A1 (en) 2017-07-20
US11730794B2 (en) 2023-08-22
US20250152669A1 (en) 2025-05-15
MX349901B (es) 2017-08-18
KR20140043313A (ko) 2014-04-09
BR112013017752A8 (pt) 2018-01-09
US20160101152A1 (en) 2016-04-14
US10888601B2 (en) 2021-01-12
EP3763379A1 (en) 2021-01-13
JP7733706B2 (ja) 2025-09-03
US20210308216A1 (en) 2021-10-07
MX385629B (es) 2025-03-18
JP2021193115A (ja) 2021-12-23
KR20220097542A (ko) 2022-07-07
US9254338B2 (en) 2016-02-09
JP2024001190A (ja) 2024-01-09
HK1244693A1 (en) 2018-08-17
US20210085753A1 (en) 2021-03-25
KR20260004598A (ko) 2026-01-08
WO2012097019A1 (en) 2012-07-19
JP2019167366A (ja) 2019-10-03
KR20240110092A (ko) 2024-07-12
AU2012205599B2 (en) 2016-10-20
AU2021200935A1 (en) 2021-03-11
US20220273764A1 (en) 2022-09-01
US11559564B2 (en) 2023-01-24
MX2013007847A (es) 2013-07-29
US20190046609A1 (en) 2019-02-14
CN103533950A (zh) 2014-01-22
JP2014503555A (ja) 2014-02-13
US11986511B2 (en) 2024-05-21
US20240123030A1 (en) 2024-04-18
MX2021006092A (es) 2022-05-18
IL227160B (en) 2019-02-28
SG10202111177VA (en) 2021-11-29
US10828345B2 (en) 2020-11-10
US11253572B2 (en) 2022-02-22
AU2012205599A1 (en) 2013-07-18
US20210023173A1 (en) 2021-01-28
AU2017200290A1 (en) 2017-02-02
EP4360709A2 (en) 2024-05-01
EP4360709A3 (en) 2024-07-03

Similar Documents

Publication Publication Date Title
KR20210030510A (ko) 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도
AU2019265005B2 (en) High concentration VEGF receptor fusion protein containing formulations
KR20240074890A (ko) 혈관형성 눈 장애를 치료하기 위한 vegf 길항제의 용도
KR20240008821A (ko) 혈관신생성 눈 장애 치료를 위한 연장된 고용량 vegf 길항제 요법
KR20190037228A (ko) Aav2 변이체를 아플리베르셉트와 함께 사용하는 amd의 치료
KR20230135012A (ko) 혈관형성 눈 장애의 치료를 위한 연장된 고 용량 vegf 길항제 용법
KR20230135013A (ko) 혈관형성 눈 장애의 치료를 위한 연장된 고 용량 vegf 길항제 용법
KR20220062352A (ko) 아플리베르셉트를 코딩하는 aav2 변이체를 사용하여 안구 신생혈관 질환을 치료하는 방법
CN117642175A (zh) 用于治疗血管生成性眼病的延长的高剂量vegf拮抗剂方案
HK40044750A (en) Use of a vegf antagonist to treat angiogenic eye disorders
NZ612593B2 (en) Use of a vegf antagonist to treat angiogenic eye disorders
HK40109837A (en) Use of a vegf antagonist to treat angiogenic eye disorders

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20180219

Application number text: 1020137018185

Filing date: 20130711

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20180321

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20180517

Patent event code: PE09021S01D

AMND Amendment
E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20181026

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20180517

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

X091 Application refused [patent]
AMND Amendment
PX0901 Re-examination

Patent event code: PX09011S01I

Patent event date: 20181026

Comment text: Decision to Refuse Application

Patent event code: PX09012R01I

Patent event date: 20180814

Comment text: Amendment to Specification, etc.

PX0601 Decision of rejection after re-examination

Comment text: Decision to Refuse Application

Patent event code: PX06014S01D

Patent event date: 20190129

Comment text: Amendment to Specification, etc.

Patent event code: PX06012R01I

Patent event date: 20181228

Comment text: Decision to Refuse Application

Patent event code: PX06011S01I

Patent event date: 20181026

Comment text: Amendment to Specification, etc.

Patent event code: PX06012R01I

Patent event date: 20180814

Comment text: Notification of reason for refusal

Patent event code: PX06013S01I

Patent event date: 20180517

X601 Decision of rejection after re-examination
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20190430

Application number text: 1020137018185

Filing date: 20130711