AU2012205599B2 - Use of a VEGF antagonist to treat angiogenic eye disorders - Google Patents

Use of a VEGF antagonist to treat angiogenic eye disorders Download PDF

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Publication number
AU2012205599B2
AU2012205599B2 AU2012205599A AU2012205599A AU2012205599B2 AU 2012205599 B2 AU2012205599 B2 AU 2012205599B2 AU 2012205599 A AU2012205599 A AU 2012205599A AU 2012205599 A AU2012205599 A AU 2012205599A AU 2012205599 B2 AU2012205599 B2 AU 2012205599B2
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Prior art keywords
vegf antagonist
administered
dose
doses
vegf
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AU2012205599A1 (en
Inventor
George D. Yancopoulos
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Priority to AU2017200290A priority Critical patent/AU2017200290B2/en
Priority to AU2019202260A priority patent/AU2019202260A1/en
Priority to AU2021200935A priority patent/AU2021200935A1/en
Priority to AU2024204677A priority patent/AU2024204677A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AU2012205599A 2011-01-13 2012-01-11 Use of a VEGF antagonist to treat angiogenic eye disorders Active AU2012205599B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2017200290A AU2017200290B2 (en) 2011-01-13 2017-01-17 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2019202260A AU2019202260A1 (en) 2011-01-13 2019-04-02 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2021200935A AU2021200935A1 (en) 2011-01-13 2021-02-12 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2024204677A AU2024204677A1 (en) 2011-01-13 2024-07-05 Use of a VEGF antagonist to treat angiogenic eye disorders

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161432245P 2011-01-13 2011-01-13
US61/432,245 2011-01-13
US201161434836P 2011-01-21 2011-01-21
US61/434,836 2011-01-21
US201161561957P 2011-11-21 2011-11-21
US61/561,957 2011-11-21
PCT/US2012/020855 WO2012097019A1 (en) 2011-01-13 2012-01-11 Use of a vegf antagonist to treat angiogenic eye disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017200290A Division AU2017200290B2 (en) 2011-01-13 2017-01-17 Use of a VEGF antagonist to treat angiogenic eye disorders

Publications (2)

Publication Number Publication Date
AU2012205599A1 AU2012205599A1 (en) 2013-07-18
AU2012205599B2 true AU2012205599B2 (en) 2016-10-20

Family

ID=45507924

Family Applications (5)

Application Number Title Priority Date Filing Date
AU2012205599A Active AU2012205599B2 (en) 2011-01-13 2012-01-11 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2017200290A Active AU2017200290B2 (en) 2011-01-13 2017-01-17 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2019202260A Abandoned AU2019202260A1 (en) 2011-01-13 2019-04-02 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2021200935A Abandoned AU2021200935A1 (en) 2011-01-13 2021-02-12 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2024204677A Pending AU2024204677A1 (en) 2011-01-13 2024-07-05 Use of a VEGF antagonist to treat angiogenic eye disorders

Family Applications After (4)

Application Number Title Priority Date Filing Date
AU2017200290A Active AU2017200290B2 (en) 2011-01-13 2017-01-17 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2019202260A Abandoned AU2019202260A1 (en) 2011-01-13 2019-04-02 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2021200935A Abandoned AU2021200935A1 (en) 2011-01-13 2021-02-12 Use of a VEGF antagonist to treat angiogenic eye disorders
AU2024204677A Pending AU2024204677A1 (en) 2011-01-13 2024-07-05 Use of a VEGF antagonist to treat angiogenic eye disorders

Country Status (13)

Country Link
US (14) US9254338B2 (enExample)
EP (4) EP3222285A1 (enExample)
JP (6) JP2014503555A (enExample)
KR (8) KR20180023015A (enExample)
CN (1) CN103533950A (enExample)
AU (5) AU2012205599B2 (enExample)
BR (1) BR112013017752A8 (enExample)
CA (1) CA2824422A1 (enExample)
HK (1) HK1244693A1 (enExample)
IL (3) IL295359A (enExample)
MX (3) MX385629B (enExample)
SG (4) SG191334A1 (enExample)
WO (1) WO2012097019A1 (enExample)

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