KR20180004733A - 키나제 억제제로서의 헤테로시클릭 아미드 - Google Patents

키나제 억제제로서의 헤테로시클릭 아미드 Download PDF

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KR20180004733A
KR20180004733A KR1020177033029A KR20177033029A KR20180004733A KR 20180004733 A KR20180004733 A KR 20180004733A KR 1020177033029 A KR1020177033029 A KR 1020177033029A KR 20177033029 A KR20177033029 A KR 20177033029A KR 20180004733 A KR20180004733 A KR 20180004733A
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Prior art keywords
alkyl
optionally substituted
phenyl
membered heteroaryl
halo
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Korean (ko)
Inventor
니얼 앤드류 앤더슨
디파크 반디오파디야이
알랭 클로드-마리 도강
프레데릭 쥐. 돈쉐
패트릭 엠. 에이담
니콜라스 에릭 파우셔
니콜라스 에스. 조지
필립 안토니 하리스
재 유. 정
브라이언 더블유. 킹
클라크 에이. 세혼
젬마 빅토리아 화이트
데이빗 더프 위스노스키
Original Assignee
글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드
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Publication of KR20180004733A publication Critical patent/KR20180004733A/ko
Pending legal-status Critical Current

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/42—Oxazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
KR1020177033029A 2015-05-19 2016-05-19 키나제 억제제로서의 헤테로시클릭 아미드 Pending KR20180004733A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562163552P 2015-05-19 2015-05-19
US62/163,552 2015-05-19
US201562167359P 2015-05-28 2015-05-28
US62/167,359 2015-05-28
US201562197602P 2015-07-28 2015-07-28
US62/197,602 2015-07-28
PCT/IB2016/052948 WO2016185423A1 (en) 2015-05-19 2016-05-19 Heterocyclic amides as kinase inhibitors

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KR20220072857A (ko) * 2019-09-27 2022-06-02 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 질병 치료용 수용체 상호작용 단백질 키나아제 i 의 억제제

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