KR20170118166A - 1-헤트(아릴)설폰일-(피롤리딘 또는 피페리딘)-2-카복스아마이드 유도체 및 trpa1 길항제로서의 이의 용도 - Google Patents

1-헤트(아릴)설폰일-(피롤리딘 또는 피페리딘)-2-카복스아마이드 유도체 및 trpa1 길항제로서의 이의 용도 Download PDF

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KR20170118166A
KR20170118166A KR1020177025946A KR20177025946A KR20170118166A KR 20170118166 A KR20170118166 A KR 20170118166A KR 1020177025946 A KR1020177025946 A KR 1020177025946A KR 20177025946 A KR20177025946 A KR 20177025946A KR 20170118166 A KR20170118166 A KR 20170118166A
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rti
alkyl
haloalkyl
cycloalkyl
membered
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Korean (ko)
Inventor
앤쏘니 에스트라다
매튜 볼그라프
후이펜 천
알렉산드르 콜레스니코프
엘리시아 빌무어
비샬 베르마
란 왕
다니엘 쇼어
스티븐 두
포-와이 위엔
바이후아 후
궈셩 우
싱위 린
아이쥔 루
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에프. 호프만-라 로슈 아게
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Publication of KR20170118166A publication Critical patent/KR20170118166A/ko
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65127—

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  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020177025946A 2015-02-15 2016-02-12 1-헤트(아릴)설폰일-(피롤리딘 또는 피페리딘)-2-카복스아마이드 유도체 및 trpa1 길항제로서의 이의 용도 Withdrawn KR20170118166A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CNPCT/CN2015/073102 2015-02-15
CN2015073102 2015-02-15
CNPCT/CN2015/076318 2015-04-10
CN2015076318 2015-04-10
CN2016071061 2016-01-15
CNPCT/CN2016/071061 2016-01-15
PCT/EP2016/052950 WO2016128529A1 (en) 2015-02-15 2016-02-12 1-(het)arylsulfonyl-(pyrrolidine or piperidine)-2-carboxamide derivatives and their use as trpa1 antagonists

Publications (1)

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KR20170118166A true KR20170118166A (ko) 2017-10-24

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KR1020177025946A Withdrawn KR20170118166A (ko) 2015-02-15 2016-02-12 1-헤트(아릴)설폰일-(피롤리딘 또는 피페리딘)-2-카복스아마이드 유도체 및 trpa1 길항제로서의 이의 용도

Country Status (20)

Country Link
US (1) US10179782B2 (OSRAM)
EP (1) EP3256463B1 (OSRAM)
JP (1) JP6700291B2 (OSRAM)
KR (1) KR20170118166A (OSRAM)
CN (1) CN107922392B (OSRAM)
AU (1) AU2016217851A1 (OSRAM)
BR (1) BR112017017052A2 (OSRAM)
CA (1) CA2975196A1 (OSRAM)
CL (1) CL2017001987A1 (OSRAM)
CO (1) CO2017007679A2 (OSRAM)
CR (1) CR20170367A (OSRAM)
EA (1) EA033497B1 (OSRAM)
IL (1) IL253478A0 (OSRAM)
MX (1) MX2017010300A (OSRAM)
PE (1) PE20180177A1 (OSRAM)
PH (1) PH12017501478A1 (OSRAM)
PT (1) PT3256463T (OSRAM)
SG (1) SG11201706451TA (OSRAM)
TW (1) TW201639829A (OSRAM)
WO (1) WO2016128529A1 (OSRAM)

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