KR20170117095A - 유전적으로 변형된 t 세포 선택 방법 - Google Patents

유전적으로 변형된 t 세포 선택 방법 Download PDF

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KR20170117095A
KR20170117095A KR1020177024195A KR20177024195A KR20170117095A KR 20170117095 A KR20170117095 A KR 20170117095A KR 1020177024195 A KR1020177024195 A KR 1020177024195A KR 20177024195 A KR20177024195 A KR 20177024195A KR 20170117095 A KR20170117095 A KR 20170117095A
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cells
dhfr
cell
tyms
gene
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데이비드 러쉬워쓰
로렌스 제이. 쿠퍼
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보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템
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KR1020177024195A 2015-02-24 2016-02-24 유전적으로 변형된 t 세포 선택 방법 Withdrawn KR20170117095A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562120329P 2015-02-24 2015-02-24
US62/120,329 2015-02-24
US201562120790P 2015-02-25 2015-02-25
US62/120,790 2015-02-25
US201562175794P 2015-06-15 2015-06-15
US62/175,794 2015-06-15
PCT/US2016/019288 WO2016138091A2 (en) 2015-02-24 2016-02-24 Selection methods for genetically-modified t cells

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KR20170117095A true KR20170117095A (ko) 2017-10-20

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220111143A (ko) 2021-02-01 2022-08-09 서울대학교산학협력단 형질전환 생식세포의 제조 방법 및 이를 이용한 형질전환 동물의 제조 방법

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102238226B1 (ko) 2013-05-14 2021-04-09 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 가공된 키메라 항원 수용체 (ｃａｒ) ｔ-세포의 인간 적용
KR102375998B1 (ko) 2014-02-14 2022-03-21 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 키메라 항원 수용체 및 제조방법
EP3215534B1 (en) 2014-11-05 2020-04-15 Board of Regents, The University of Texas System Chimeric antigen receptors (car) to selectively target protein complexes
CN107532174A (zh) 2015-03-11 2018-01-02 得克萨斯州大学系统董事会 转座酶多肽及其用途
KR20180042449A (ko) 2015-09-15 2018-04-25 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 T 세포 수용체(tcr) 결합 항체 및 이의 용도
US11059879B2 (en) 2015-10-27 2021-07-13 Board Of Regents, The University Of Texas System Chimeric antigen receptor molecules and uses thereof
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
US10780119B2 (en) 2017-05-24 2020-09-22 Effector Therapeutics Inc. Methods and compositions for cellular immunotherapy
CN109136282A (zh) * 2018-09-30 2019-01-04 北京鼎成肽源生物技术有限公司 一种hafft1细胞的构建方法
CN120555349A (zh) 2018-11-16 2025-08-29 拉帕治疗有限公司 使用诱导性调节性T（iTREG）细胞进行的ALS治疗
WO2020102726A1 (en) * 2018-11-16 2020-05-22 Rapa Therapeutics, Llc Method for manufacturing of human hybrid regulatory t/th2 cells (hybrid treg/th2 cells) from de-differentiated t cells
CA3234311A1 (en) * 2021-09-30 2023-04-06 University Of Southern California Human hepatocyte culture medium and conditioned medium of in vitro cultured human hepatocytes and uses thereof
CN114740196B (zh) * 2022-04-08 2023-04-18 中南大学湘雅二医院 标志物及其在制备评价机体免疫功能的产品中的应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012504959A (ja) * 2008-10-08 2012-03-01 イントレキソン コーポレーション 複数の免疫モジュレーターを発現する遺伝子操作された細胞およびその使用
EP3970736A1 (en) * 2009-11-02 2022-03-23 Emory University Drug resistant immunotherapy for treatment of a cancer
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
AU2012203048A1 (en) * 2011-05-24 2012-12-13 Agency For Science, Technology And Research IRES mediated multicistronic vectors
WO2013074916A1 (en) 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
JP6850528B2 (ja) * 2012-02-13 2021-03-31 シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート 二重特異性キメラ抗原受容体およびその治療的使用
KR102238226B1 (ko) 2013-05-14 2021-04-09 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 가공된 키메라 항원 수용체 (ｃａｒ) ｔ-세포의 인간 적용
WO2014190273A1 (en) 2013-05-24 2014-11-27 Board Of Regents, The University Of Texas System Chimeric antigen receptor-targeting monoclonal antibodies
CA2926859A1 (en) 2013-10-25 2015-04-30 Board Of Regents, The University Of Texas System Polyclonal gamma delta t cells for immunotherapy
WO2015075195A1 (en) 2013-11-22 2015-05-28 Cellectis Method of engineering chemotherapy drug resistant t-cells for immunotherapy
KR102375998B1 (ko) 2014-02-14 2022-03-21 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 키메라 항원 수용체 및 제조방법
SG11201608393TA (en) * 2014-04-10 2016-11-29 Seattle Children S Hospital Dba Seattle Children S Res Inst Transgene genetic tags and methods of use
KR20160145802A (ko) 2014-04-23 2016-12-20 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 요법에 사용하기 위한 키메라 항원 수용체 (car) 및 이의 제조 방법
CA2945393C (en) 2014-04-24 2021-03-23 Board Of Regents, The University Of Texas System Application of induced pluripotent stem cells to generate adoptive cell therapy products
HK1243441A1 (zh) 2014-11-05 2018-07-13 Board Of Regents, The University Of Texas System 基因修饰的免疫效应细胞和用於扩增免疫效应细胞的工程化细胞
EP3215534B1 (en) 2014-11-05 2020-04-15 Board of Regents, The University of Texas System Chimeric antigen receptors (car) to selectively target protein complexes
CN107532174A (zh) 2015-03-11 2018-01-02 得克萨斯州大学系统董事会 转座酶多肽及其用途
KR20180042449A (ko) 2015-09-15 2018-04-25 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 T 세포 수용체(tcr) 결합 항체 및 이의 용도
US11059879B2 (en) 2015-10-27 2021-07-13 Board Of Regents, The University Of Texas System Chimeric antigen receptor molecules and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220111143A (ko) 2021-02-01 2022-08-09 서울대학교산학협력단 형질전환 생식세포의 제조 방법 및 이를 이용한 형질전환 동물의 제조 방법

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