KR20150135458A - 신규한 피리딘 유도체 - Google Patents
신규한 피리딘 유도체 Download PDFInfo
- Publication number
- KR20150135458A KR20150135458A KR1020157030611A KR20157030611A KR20150135458A KR 20150135458 A KR20150135458 A KR 20150135458A KR 1020157030611 A KR1020157030611 A KR 1020157030611A KR 20157030611 A KR20157030611 A KR 20157030611A KR 20150135458 A KR20150135458 A KR 20150135458A
- Authority
- KR
- South Korea
- Prior art keywords
- cyclopropyl
- oxadiazole
- pyridin
- butyl
- tert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 *c1ccncc1* Chemical compound *c1ccncc1* 0.000 description 8
- HDASBCPGRAIAKQ-UHFFFAOYSA-N Brc(cncc1)c1OCC1CC1 Chemical compound Brc(cncc1)c1OCC1CC1 HDASBCPGRAIAKQ-UHFFFAOYSA-N 0.000 description 1
- HBERRWFKOWFTDM-UHFFFAOYSA-N CC(C)(C)C(NNC(c1ncc(C2CC2)c(OC2CCOCC2)c1)=O)=O Chemical compound CC(C)(C)C(NNC(c1ncc(C2CC2)c(OC2CCOCC2)c1)=O)=O HBERRWFKOWFTDM-UHFFFAOYSA-N 0.000 description 1
- DEXJMRNYBGYWGO-UHFFFAOYSA-N CC(C)(C)S(NC(C)(COCc1ccccc1)C#N)=O Chemical compound CC(C)(C)S(NC(C)(COCc1ccccc1)C#N)=O DEXJMRNYBGYWGO-UHFFFAOYSA-N 0.000 description 1
- KFNKJSXISWPVMF-UHFFFAOYSA-N CC(C)(C)c1nc(-c(cc2OCC3CC3)ncc2Br)n[o]1 Chemical compound CC(C)(C)c1nc(-c(cc2OCC3CC3)ncc2Br)n[o]1 KFNKJSXISWPVMF-UHFFFAOYSA-N 0.000 description 1
- RESZPWREOKJYOD-UHFFFAOYSA-N CC(C)(C)c1nc(-c(cc2OCC3CC3)ncc2N(C2)CC2(F)F)n[o]1 Chemical compound CC(C)(C)c1nc(-c(cc2OCC3CC3)ncc2N(C2)CC2(F)F)n[o]1 RESZPWREOKJYOD-UHFFFAOYSA-N 0.000 description 1
- BZKCRABBWHSWAK-UHFFFAOYSA-N CC(C)(C)c1nc(-c2ncc(C3(COC3)F)c(OC3CCOCC3)c2)n[o]1 Chemical compound CC(C)(C)c1nc(-c2ncc(C3(COC3)F)c(OC3CCOCC3)c2)n[o]1 BZKCRABBWHSWAK-UHFFFAOYSA-N 0.000 description 1
- BBYXUCNLCLZVKY-UHFFFAOYSA-N CC(C)(C)c1nc(-c2ncc(C3CC3)c(N(CC3)CC3(F)F)c2)n[o]1 Chemical compound CC(C)(C)c1nc(-c2ncc(C3CC3)c(N(CC3)CC3(F)F)c2)n[o]1 BBYXUCNLCLZVKY-UHFFFAOYSA-N 0.000 description 1
- IWDOHNFAQZIYQL-UHFFFAOYSA-N CC(C)(C)c1nc(-c2ncc(C3CC3)c(OCc3cccnc3)c2)n[o]1 Chemical compound CC(C)(C)c1nc(-c2ncc(C3CC3)c(OCc3cccnc3)c2)n[o]1 IWDOHNFAQZIYQL-UHFFFAOYSA-N 0.000 description 1
- MPEOFTYVDLQIHX-UHFFFAOYSA-N CC(C)(C)c1nc(-c2ncc(C3CC3)c(Oc(cc3)ccc3S(C)(=O)=O)c2)n[o]1 Chemical compound CC(C)(C)c1nc(-c2ncc(C3CC3)c(Oc(cc3)ccc3S(C)(=O)=O)c2)n[o]1 MPEOFTYVDLQIHX-UHFFFAOYSA-N 0.000 description 1
- VPMWTKZJXOPHMS-UHFFFAOYSA-N CC(C)(c1nc(-c2ncc(C3CC3)c(OCC3CC3)c2)n[o]1)O Chemical compound CC(C)(c1nc(-c2ncc(C3CC3)c(OCC3CC3)c2)n[o]1)O VPMWTKZJXOPHMS-UHFFFAOYSA-N 0.000 description 1
- UASAFNNTYJHQOD-UHFFFAOYSA-N CC1(c2n[o]c(C)n2)N=C(c2ncc(C3CC3)c(OCC(F)(F)F)c2)OC1 Chemical compound CC1(c2n[o]c(C)n2)N=C(c2ncc(C3CC3)c(OCC(F)(F)F)c2)OC1 UASAFNNTYJHQOD-UHFFFAOYSA-N 0.000 description 1
- QVIXNVNASKMGFT-UHFFFAOYSA-N COCc1nc(-c2ncc(C3CC3)c(OCC3CC3)c2)n[o]1 Chemical compound COCc1nc(-c2ncc(C3CC3)c(OCC3CC3)c2)n[o]1 QVIXNVNASKMGFT-UHFFFAOYSA-N 0.000 description 1
- QISCIRQTNVSUMN-UHFFFAOYSA-N Cc1n[o]c(-c(cc2OCC(F)(F)F)ncc2N(C2)CC2(F)F)n1 Chemical compound Cc1n[o]c(-c(cc2OCC(F)(F)F)ncc2N(C2)CC2(F)F)n1 QISCIRQTNVSUMN-UHFFFAOYSA-N 0.000 description 1
- HMUPXUIISJZXTJ-UHFFFAOYSA-N FC(COc1cc(-c2n[o]c(C3CC3)n2)ncc1Cl)(F)F Chemical compound FC(COc1cc(-c2n[o]c(C3CC3)n2)ncc1Cl)(F)F HMUPXUIISJZXTJ-UHFFFAOYSA-N 0.000 description 1
- RXDXLMHEOFIOGX-UHFFFAOYSA-N FC(COc1cc(Cl)ncc1Cl)(F)F Chemical compound FC(COc1cc(Cl)ncc1Cl)(F)F RXDXLMHEOFIOGX-UHFFFAOYSA-N 0.000 description 1
- QDAXPZORUFWPDG-UHFFFAOYSA-N N#Cc(cc1OCC(F)(F)F)ncc1Br Chemical compound N#Cc(cc1OCC(F)(F)F)ncc1Br QDAXPZORUFWPDG-UHFFFAOYSA-N 0.000 description 1
- XKOGDTPSXRCIRC-UHFFFAOYSA-N N#Cc1ncc(C2(COC2)O)c(Cl)c1 Chemical compound N#Cc1ncc(C2(COC2)O)c(Cl)c1 XKOGDTPSXRCIRC-UHFFFAOYSA-N 0.000 description 1
- UOAUSPTZRKLEIB-UHFFFAOYSA-N [O-][n+](cc1Br)ccc1OCC(F)(F)F Chemical compound [O-][n+](cc1Br)ccc1OCC(F)(F)F UOAUSPTZRKLEIB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
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- A61K31/4245—Oxadiazoles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13161176 | 2013-03-26 | ||
| EP13161176.6 | 2013-03-26 | ||
| PCT/EP2014/055797 WO2014154612A1 (en) | 2013-03-26 | 2014-03-24 | Novel pyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20150135458A true KR20150135458A (ko) | 2015-12-02 |
Family
ID=47913322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157030611A Ceased KR20150135458A (ko) | 2013-03-26 | 2014-03-24 | 신규한 피리딘 유도체 |
Country Status (33)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9708341B2 (en) * | 2014-06-09 | 2017-07-18 | Sumitomo Chemical Company, Limited | Method for producing pyridine compound |
| PE20181203A1 (es) * | 2015-12-09 | 2018-07-23 | Hoffmann La Roche | Derivados de fenilo como agonistas de receptor de cannabinoides 2 |
| ES2847239T3 (es) * | 2016-07-07 | 2021-08-02 | Dow Agrosciences Llc | Procedimientos para la preparación de 4-alcoxi-3-(acil o alquil)oxipicolinamidas |
| TWI886480B (zh) | 2017-04-06 | 2025-06-11 | 美商富曼西公司 | 殺真菌之噁二唑 |
| AR112199A1 (es) | 2017-06-20 | 2019-10-02 | Hoffmann La Roche | Derivados de piridina como agonistas inversos del receptor cannabinoide 2 |
| WO2019003956A1 (ja) * | 2017-06-27 | 2019-01-03 | 住友化学株式会社 | オキサジアゾール化合物及びその用途 |
| CN108774220B (zh) * | 2018-05-27 | 2019-04-23 | 西安培华学院 | 用于治疗心肌缺血的化合物及其应用 |
| EP3814328A1 (en) | 2018-06-27 | 2021-05-05 | F. Hoffmann-La Roche AG | Novel azetidine-substituted pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2 |
| WO2020002314A1 (en) | 2018-06-27 | 2020-01-02 | F. Hoffmann-La Roche Ag | Radiolabeled cannabinoid receptor 2 ligand |
| SG11202009103WA (en) | 2018-06-27 | 2020-10-29 | Hoffmann La Roche | Novel pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2 |
| EP3814337B1 (en) * | 2018-06-27 | 2025-05-14 | F. Hoffmann-La Roche AG | Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists |
| CN114195759B (zh) * | 2021-08-26 | 2023-10-20 | 上海零诺生物科技有限公司 | 一种2-甲基-5-（1-甲基吡咯烷-2-基）吡啶制备方法 |
| WO2023069721A2 (en) * | 2021-10-22 | 2023-04-27 | Carmot Therapeutics, Inc. | Oxazole, oxadiazole, and indole derivatives for the inhibition of usp28 |
| CN115073366B (zh) * | 2022-06-08 | 2024-08-09 | 都创(重庆)医药科技有限公司 | 一种基于微通道技术快速制备3-氯吡啶-2-甲酸的方法 |
| WO2025104141A1 (en) * | 2023-11-16 | 2025-05-22 | F. Hoffmann-La Roche Ag | Novel reversible fluorescent probes for cb2 |
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| CA2479744A1 (en) * | 2002-03-28 | 2003-10-09 | Paul E. Finke | Substituted 2,3-diphenyl pyridines |
| EP2049520A4 (en) | 2006-08-07 | 2011-01-05 | Ironwood Pharmaceuticals Inc | indole compounds |
| EP2211619A1 (en) * | 2007-10-18 | 2010-08-04 | Merck Sharp & Dohme Corp. | Substituted 1,2,4-oxadiazoles and analogs thereof as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases |
| US9321727B2 (en) * | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
| UA111640C2 (uk) | 2011-11-08 | 2016-05-25 | Ф. Хоффманн-Ля Рош Аг | ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2 |
| MX2014015491A (es) | 2012-07-04 | 2015-03-06 | Hoffmann La Roche | Nuevos derivados de adamantilo como agonistas del receptor 2 del canabinoide. |
| US9512141B2 (en) | 2012-12-07 | 2016-12-06 | Hoffmann-La Roche Inc. | Pyrazine derivatives as CB2 receptor agonists |
| CN104837831B (zh) | 2012-12-07 | 2017-10-31 | 霍夫曼-拉罗奇有限公司 | 新的吡啶衍生物 |
| RS56424B1 (sr) | 2012-12-07 | 2018-01-31 | Hoffmann La Roche | Piridin-2-amidi korisni kao cb2-agonisti |
| CA2885987A1 (en) | 2012-12-07 | 2014-06-12 | F. Hoffmann-La Roche Ag | Pyridine-2-amides useful as cb2 agonists |
| PE20151539A1 (es) | 2013-03-07 | 2015-10-28 | Hoffmann La Roche | Nuevos derivados de pirazol |
| MA39843A (fr) | 2014-04-04 | 2017-02-08 | Hoffmann La Roche | Pyridine-2-amides utiles comme agonistes de cb2 |
| SG11201608246VA (en) | 2014-04-04 | 2016-10-28 | Hoffmann La Roche | 5,6-disubstituted pyridine-2-carboxamides as cannabinoid receptor agonists |
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