JP6500010B2 - 新規ピリジン誘導体 - Google Patents
新規ピリジン誘導体 Download PDFInfo
- Publication number
- JP6500010B2 JP6500010B2 JP2016504604A JP2016504604A JP6500010B2 JP 6500010 B2 JP6500010 B2 JP 6500010B2 JP 2016504604 A JP2016504604 A JP 2016504604A JP 2016504604 A JP2016504604 A JP 2016504604A JP 6500010 B2 JP6500010 B2 JP 6500010B2
- Authority
- JP
- Japan
- Prior art keywords
- cyclopropyl
- pyridin
- oxadiazole
- butyl
- tert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *c1ccncc1* Chemical compound *c1ccncc1* 0.000 description 10
- SHBBDXPJASJCHJ-UHFFFAOYSA-N CC(C)(C)C(CNC(c1ncc(C2CC2)c(OCC2CC2)c1)=O)O Chemical compound CC(C)(C)C(CNC(c1ncc(C2CC2)c(OCC2CC2)c1)=O)O SHBBDXPJASJCHJ-UHFFFAOYSA-N 0.000 description 1
- UAWJZDSNZLBNHZ-UHFFFAOYSA-N CC(C)(C)c1n[o]c(-c2ncc(C3CC3)c(OCC(F)F)c2)n1 Chemical compound CC(C)(C)c1n[o]c(-c2ncc(C3CC3)c(OCC(F)F)c2)n1 UAWJZDSNZLBNHZ-UHFFFAOYSA-N 0.000 description 1
- KFNKJSXISWPVMF-UHFFFAOYSA-N CC(C)(C)c1nc(-c(cc2OCC3CC3)ncc2Br)n[o]1 Chemical compound CC(C)(C)c1nc(-c(cc2OCC3CC3)ncc2Br)n[o]1 KFNKJSXISWPVMF-UHFFFAOYSA-N 0.000 description 1
- RESZPWREOKJYOD-UHFFFAOYSA-N CC(C)(C)c1nc(-c(cc2OCC3CC3)ncc2N(C2)CC2(F)F)n[o]1 Chemical compound CC(C)(C)c1nc(-c(cc2OCC3CC3)ncc2N(C2)CC2(F)F)n[o]1 RESZPWREOKJYOD-UHFFFAOYSA-N 0.000 description 1
- QKWJKWWGALDXLP-UHFFFAOYSA-N CC(C)(C)c1nc(-c2ncc(C3(COC3)F)c(Cl)c2)n[o]1 Chemical compound CC(C)(C)c1nc(-c2ncc(C3(COC3)F)c(Cl)c2)n[o]1 QKWJKWWGALDXLP-UHFFFAOYSA-N 0.000 description 1
- BZKCRABBWHSWAK-UHFFFAOYSA-N CC(C)(C)c1nc(-c2ncc(C3(COC3)F)c(OC3CCOCC3)c2)n[o]1 Chemical compound CC(C)(C)c1nc(-c2ncc(C3(COC3)F)c(OC3CCOCC3)c2)n[o]1 BZKCRABBWHSWAK-UHFFFAOYSA-N 0.000 description 1
- YUKWEOINOQTYRZ-UHFFFAOYSA-N CC(C)(C)c1nc(-c2ncc(C3CC3)c(OC3COCC3)c2)n[o]1 Chemical compound CC(C)(C)c1nc(-c2ncc(C3CC3)c(OC3COCC3)c2)n[o]1 YUKWEOINOQTYRZ-UHFFFAOYSA-N 0.000 description 1
- WBLXODPLAQULOQ-UHFFFAOYSA-N CC(C)(C)c1nc(-c2ncc(C3CC3)c(OC3COCCC3)c2)n[o]1 Chemical compound CC(C)(C)c1nc(-c2ncc(C3CC3)c(OC3COCCC3)c2)n[o]1 WBLXODPLAQULOQ-UHFFFAOYSA-N 0.000 description 1
- YYTFUINYIFJHFR-UHFFFAOYSA-N CC(C)(C)c1nc(-c2ncc(C3CC3)c(OCC3(COC3)F)c2)n[o]1 Chemical compound CC(C)(C)c1nc(-c2ncc(C3CC3)c(OCC3(COC3)F)c2)n[o]1 YYTFUINYIFJHFR-UHFFFAOYSA-N 0.000 description 1
- ZHJWBDVCTLEADE-UHFFFAOYSA-N CC(C)(C)c1nc(-c2ncc(C3CC3)c(OCc3c(C)[o]c(C)n3)c2)n[o]1 Chemical compound CC(C)(C)c1nc(-c2ncc(C3CC3)c(OCc3c(C)[o]c(C)n3)c2)n[o]1 ZHJWBDVCTLEADE-UHFFFAOYSA-N 0.000 description 1
- MPEOFTYVDLQIHX-UHFFFAOYSA-N CC(C)(C)c1nc(-c2ncc(C3CC3)c(Oc(cc3)ccc3S(C)(=O)=O)c2)n[o]1 Chemical compound CC(C)(C)c1nc(-c2ncc(C3CC3)c(Oc(cc3)ccc3S(C)(=O)=O)c2)n[o]1 MPEOFTYVDLQIHX-UHFFFAOYSA-N 0.000 description 1
- QUNGTBASQFEHMV-UHFFFAOYSA-N CC1(CC1)c1nc(C2NC=C(C3CC3)C(OCC3CC3)=C2)n[o]1 Chemical compound CC1(CC1)c1nc(C2NC=C(C3CC3)C(OCC3CC3)=C2)n[o]1 QUNGTBASQFEHMV-UHFFFAOYSA-N 0.000 description 1
- RDDLATMPRZMXFU-UHFFFAOYSA-N N/C(/c1ncc(C2(COC2)F)c(Cl)c1)=N\O Chemical compound N/C(/c1ncc(C2(COC2)F)c(Cl)c1)=N\O RDDLATMPRZMXFU-UHFFFAOYSA-N 0.000 description 1
- ISEPHYSVKMWIQI-UHFFFAOYSA-N N/C(/c1ncc(C2CC2)c(OCC(F)(F)F)c1)=N\O Chemical compound N/C(/c1ncc(C2CC2)c(OCC(F)(F)F)c1)=N\O ISEPHYSVKMWIQI-UHFFFAOYSA-N 0.000 description 1
- LXSPVDZOENLDQG-UHFFFAOYSA-N OC(c(cc1OCC(F)(F)F)ncc1N(C1)CC1(F)F)=O Chemical compound OC(c(cc1OCC(F)(F)F)ncc1N(C1)CC1(F)F)=O LXSPVDZOENLDQG-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
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- A—HUMAN NECESSITIES
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13161176 | 2013-03-26 | ||
| EP13161176.6 | 2013-03-26 | ||
| PCT/EP2014/055797 WO2014154612A1 (en) | 2013-03-26 | 2014-03-24 | Novel pyridine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016516737A JP2016516737A (ja) | 2016-06-09 |
| JP6500010B2 true JP6500010B2 (ja) | 2019-04-10 |
Family
ID=47913322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016504604A Expired - Fee Related JP6500010B2 (ja) | 2013-03-26 | 2014-03-24 | 新規ピリジン誘導体 |
Country Status (33)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9708341B2 (en) * | 2014-06-09 | 2017-07-18 | Sumitomo Chemical Company, Limited | Method for producing pyridine compound |
| PE20181203A1 (es) * | 2015-12-09 | 2018-07-23 | Hoffmann La Roche | Derivados de fenilo como agonistas de receptor de cannabinoides 2 |
| ES2847239T3 (es) * | 2016-07-07 | 2021-08-02 | Dow Agrosciences Llc | Procedimientos para la preparación de 4-alcoxi-3-(acil o alquil)oxipicolinamidas |
| TWI886480B (zh) | 2017-04-06 | 2025-06-11 | 美商富曼西公司 | 殺真菌之噁二唑 |
| AR112199A1 (es) | 2017-06-20 | 2019-10-02 | Hoffmann La Roche | Derivados de piridina como agonistas inversos del receptor cannabinoide 2 |
| WO2019003956A1 (ja) * | 2017-06-27 | 2019-01-03 | 住友化学株式会社 | オキサジアゾール化合物及びその用途 |
| CN108774220B (zh) * | 2018-05-27 | 2019-04-23 | 西安培华学院 | 用于治疗心肌缺血的化合物及其应用 |
| EP3814328A1 (en) | 2018-06-27 | 2021-05-05 | F. Hoffmann-La Roche AG | Novel azetidine-substituted pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2 |
| WO2020002314A1 (en) | 2018-06-27 | 2020-01-02 | F. Hoffmann-La Roche Ag | Radiolabeled cannabinoid receptor 2 ligand |
| SG11202009103WA (en) | 2018-06-27 | 2020-10-29 | Hoffmann La Roche | Novel pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2 |
| EP3814337B1 (en) * | 2018-06-27 | 2025-05-14 | F. Hoffmann-La Roche AG | Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists |
| CN114195759B (zh) * | 2021-08-26 | 2023-10-20 | 上海零诺生物科技有限公司 | 一种2-甲基-5-（1-甲基吡咯烷-2-基）吡啶制备方法 |
| WO2023069721A2 (en) * | 2021-10-22 | 2023-04-27 | Carmot Therapeutics, Inc. | Oxazole, oxadiazole, and indole derivatives for the inhibition of usp28 |
| CN115073366B (zh) * | 2022-06-08 | 2024-08-09 | 都创(重庆)医药科技有限公司 | 一种基于微通道技术快速制备3-氯吡啶-2-甲酸的方法 |
| WO2025104141A1 (en) * | 2023-11-16 | 2025-05-22 | F. Hoffmann-La Roche Ag | Novel reversible fluorescent probes for cb2 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2479744A1 (en) * | 2002-03-28 | 2003-10-09 | Paul E. Finke | Substituted 2,3-diphenyl pyridines |
| EP2049520A4 (en) | 2006-08-07 | 2011-01-05 | Ironwood Pharmaceuticals Inc | indole compounds |
| EP2211619A1 (en) * | 2007-10-18 | 2010-08-04 | Merck Sharp & Dohme Corp. | Substituted 1,2,4-oxadiazoles and analogs thereof as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases |
| US9321727B2 (en) * | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
| UA111640C2 (uk) | 2011-11-08 | 2016-05-25 | Ф. Хоффманн-Ля Рош Аг | ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2 |
| MX2014015491A (es) | 2012-07-04 | 2015-03-06 | Hoffmann La Roche | Nuevos derivados de adamantilo como agonistas del receptor 2 del canabinoide. |
| US9512141B2 (en) | 2012-12-07 | 2016-12-06 | Hoffmann-La Roche Inc. | Pyrazine derivatives as CB2 receptor agonists |
| CN104837831B (zh) | 2012-12-07 | 2017-10-31 | 霍夫曼-拉罗奇有限公司 | 新的吡啶衍生物 |
| RS56424B1 (sr) | 2012-12-07 | 2018-01-31 | Hoffmann La Roche | Piridin-2-amidi korisni kao cb2-agonisti |
| CA2885987A1 (en) | 2012-12-07 | 2014-06-12 | F. Hoffmann-La Roche Ag | Pyridine-2-amides useful as cb2 agonists |
| PE20151539A1 (es) | 2013-03-07 | 2015-10-28 | Hoffmann La Roche | Nuevos derivados de pirazol |
| MA39843A (fr) | 2014-04-04 | 2017-02-08 | Hoffmann La Roche | Pyridine-2-amides utiles comme agonistes de cb2 |
| SG11201608246VA (en) | 2014-04-04 | 2016-10-28 | Hoffmann La Roche | 5,6-disubstituted pyridine-2-carboxamides as cannabinoid receptor agonists |
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