KR20150059778A - 임의로 치환된 페닐 및 피리딜 피롤리딘의 제조 방법 - Google Patents
임의로 치환된 페닐 및 피리딜 피롤리딘의 제조 방법 Download PDFInfo
- Publication number
- KR20150059778A KR20150059778A KR1020157010339A KR20157010339A KR20150059778A KR 20150059778 A KR20150059778 A KR 20150059778A KR 1020157010339 A KR1020157010339 A KR 1020157010339A KR 20157010339 A KR20157010339 A KR 20157010339A KR 20150059778 A KR20150059778 A KR 20150059778A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- iii
- alkyl
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 *Cc1c(*)nc(*)c(*)c1C(*)=C Chemical compound *Cc1c(*)nc(*)c(*)c1C(*)=C 0.000 description 5
- UYBQBUZXULIDMQ-UHFFFAOYSA-N C=C(C(F)(F)F)c1cc(Cl)cc(Cl)c1 Chemical compound C=C(C(F)(F)F)c1cc(Cl)cc(Cl)c1 UYBQBUZXULIDMQ-UHFFFAOYSA-N 0.000 description 1
- ITLBXWCFLQWODC-QDEBKDIKSA-N CC(/C(/c1cc(N)cc(N)c1)=C\C)N Chemical compound CC(/C(/c1cc(N)cc(N)c1)=C\C)N ITLBXWCFLQWODC-QDEBKDIKSA-N 0.000 description 1
- TVZXRRNSGRTVGG-UHFFFAOYSA-N COCN(CC1=CC=CCC1)C[Si](C)(C)C Chemical compound COCN(CC1=CC=CCC1)C[Si](C)(C)C TVZXRRNSGRTVGG-UHFFFAOYSA-N 0.000 description 1
- ZMMHZDUDIMSDIB-WEVVVXLNSA-N CS(/C=C(/C(F)(F)F)\c1cc(Cl)cc(Cl)c1)(=O)=O Chemical compound CS(/C=C(/C(F)(F)F)\c1cc(Cl)cc(Cl)c1)(=O)=O ZMMHZDUDIMSDIB-WEVVVXLNSA-N 0.000 description 1
- JZMBROIBZYADMK-UITAMQMPSA-N CS/C=C(\C(F)(F)F)/c1cc(Cl)cc(Cl)c1 Chemical compound CS/C=C(\C(F)(F)F)/c1cc(Cl)cc(Cl)c1 JZMBROIBZYADMK-UITAMQMPSA-N 0.000 description 1
- GRAIWYLORMNQBX-UHFFFAOYSA-N CSC[P+](c1ccccc1)(c1ccccc1)c1ccccc1 Chemical compound CSC[P+](c1ccccc1)(c1ccccc1)c1ccccc1 GRAIWYLORMNQBX-UHFFFAOYSA-N 0.000 description 1
- JIDBBHUCJQHFPK-UKTHLTGXSA-N Cc1cc(/C(/C(F)(F)F)=C\[S+](c2ccccc2)O)cc(Cl)c1Cl Chemical compound Cc1cc(/C(/C(F)(F)F)=C\[S+](c2ccccc2)O)cc(Cl)c1Cl JIDBBHUCJQHFPK-UKTHLTGXSA-N 0.000 description 1
- SBVTWNLWCMSMGF-UHFFFAOYSA-N NC(C(c1cc(N)cc(N)c1)=O)(N)N Chemical compound NC(C(c1cc(N)cc(N)c1)=O)(N)N SBVTWNLWCMSMGF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
- C07C317/10—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
- C07C323/02—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/07—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/16—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12186243.7 | 2012-09-27 | ||
| EP12186243 | 2012-09-27 | ||
| PCT/EP2013/069919 WO2014048958A1 (en) | 2012-09-27 | 2013-09-25 | Process for the preparation of optionally substituted phenyl and pyridyl pyrrolidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20150059778A true KR20150059778A (ko) | 2015-06-02 |
Family
ID=47044827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157010339A Ceased KR20150059778A (ko) | 2012-09-27 | 2013-09-25 | 임의로 치환된 페닐 및 피리딜 피롤리딘의 제조 방법 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9447036B2 (https=) |
| EP (1) | EP2900634B1 (https=) |
| JP (1) | JP6251749B2 (https=) |
| KR (1) | KR20150059778A (https=) |
| CN (1) | CN104619683B (https=) |
| BR (1) | BR112015006825A2 (https=) |
| DK (1) | DK2900634T3 (https=) |
| ES (1) | ES2625547T3 (https=) |
| IL (1) | IL237749A (https=) |
| IN (1) | IN2015DN02542A (https=) |
| MX (1) | MX350575B (https=) |
| TW (1) | TWI601713B (https=) |
| WO (1) | WO2014048958A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200037320A (ko) * | 2017-08-09 | 2020-04-08 | 론자 리미티드 | 4-(헵타플루오로-2-프로필) 아닐린의 제조 방법 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4092349A (en) | 1976-11-10 | 1978-05-30 | Pfizer Inc. | 11-Desoxy-15-thiaprostaglandins |
| US4173463A (en) | 1978-10-31 | 1979-11-06 | Shell Oil Company | Phosphonium salts as herbicides |
| EP0393424B1 (de) | 1989-04-17 | 1995-09-27 | Bayer Ag | Verfahren zur Herstellung von 2,7-Diazabicyclo(3.3.0)octanen |
| IT1274021B (it) | 1994-02-28 | 1997-07-14 | Italfarmaco Spa | Diesteri dell'acido carbonico ad attivita' antivirale ed antinfiammatoria |
| DE69624256T2 (de) | 1995-11-23 | 2003-09-18 | Rhodia Chimie, Courbevoie | Perfluoroalkylierungsverfahren und reagenz desselben |
| AU4064597A (en) * | 1996-08-16 | 1998-03-06 | Du Pont Pharmaceuticals Company | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof |
| HRP20041220A2 (hr) | 2002-05-28 | 2006-04-30 | 3-Dimensional Pharmaceuticals | Novi tiofen amidini, njihovi pripravci i postupci liječenja komplementom posredovanih bolesti i stanja |
| US7230119B2 (en) | 2004-08-25 | 2007-06-12 | Biocryst Pharmaceuticals, Inc. | Process for the preparation of substituted pyrrolidine derivatives and intermediates |
| US7521427B2 (en) | 2004-11-09 | 2009-04-21 | Georgia Tech Research Corporation | Peptidyl allyl sulfones |
| AR057032A1 (es) | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
| JP2009503048A (ja) | 2005-08-01 | 2009-01-29 | ファイザー・リミテッド | 尿路機能障害を治療するためのｍｃ４ｒ作動薬 |
| US7750167B2 (en) | 2006-07-05 | 2010-07-06 | N.V. Organon | Process for the preparation of asenapine and intermediate products used in said process |
| JP5164510B2 (ja) * | 2006-10-06 | 2013-03-21 | 日本曹達株式会社 | 含窒素複素環化合物および有害生物防除剤 |
| GB0623209D0 (en) | 2006-11-21 | 2007-01-03 | F2G Ltd | Antifungal agents |
| WO2008129811A1 (ja) | 2007-03-23 | 2008-10-30 | Panasonic Corporation | 無線送信装置及び無線受信装置 |
| JP2010116389A (ja) * | 2008-10-17 | 2010-05-27 | Bayer Cropscience Ag | 殺虫性アリールピロリジン類 |
| JP2008266230A (ja) * | 2007-04-23 | 2008-11-06 | Bayer Cropscience Ag | 殺虫性アリールピロリジン類 |
| WO2009087058A1 (en) | 2008-01-04 | 2009-07-16 | N.V. Organon | Process for the preparation of asenapine and intermediate products used in said process |
| CZ305085B6 (cs) | 2008-03-14 | 2015-04-29 | Zentiva, K.S. | Způsob přípravy dabigatranu |
| WO2010086820A1 (en) | 2009-02-02 | 2010-08-05 | Pfizer Inc. | 4-amino-5-oxo-7, 8-dihydropyrimido [5,4-f] [1,4] oxazepin-6 (5h) -yl) phenyl derivatives, pharmaceutical compositions and uses thereof |
| AR075633A1 (es) | 2009-02-27 | 2011-04-20 | Ambit Biosciences Corp | Compuestos moduladores de jak quinasa y sus metodos de uso |
| EP2424838A1 (en) | 2009-04-30 | 2012-03-07 | Bayer CropScience AG | Pesticidal arylpyrrolidines |
| SG176100A1 (en) * | 2009-05-22 | 2011-12-29 | Abbott Lab | Modulators of 5-ht receptors and methods of use thereof |
| BR112012001078A8 (pt) | 2009-07-16 | 2016-05-03 | Bayer Cropscience Ag | Processo para preparação de derivados de sulfóxido de 3-triazolila quirais |
| JP2011136928A (ja) * | 2009-12-28 | 2011-07-14 | Bayer Cropscience Ag | 殺虫性アリールピロリジン類 |
| JP2012082186A (ja) | 2010-09-15 | 2012-04-26 | Bayer Cropscience Ag | 殺虫性アリールピロリジン類 |
| HK1210472A1 (en) * | 2012-09-07 | 2016-04-22 | Zoetis Services Llc | Spirocyclic derivatives as antiparasitic agents |
-
2013
- 2013-09-25 JP JP2015533567A patent/JP6251749B2/ja not_active Expired - Fee Related
- 2013-09-25 KR KR1020157010339A patent/KR20150059778A/ko not_active Ceased
- 2013-09-25 IN IN2542DEN2015 patent/IN2015DN02542A/en unknown
- 2013-09-25 BR BR112015006825A patent/BR112015006825A2/pt not_active Application Discontinuation
- 2013-09-25 US US14/430,607 patent/US9447036B2/en not_active Expired - Fee Related
- 2013-09-25 WO PCT/EP2013/069919 patent/WO2014048958A1/en not_active Ceased
- 2013-09-25 ES ES13766333.2T patent/ES2625547T3/es active Active
- 2013-09-25 EP EP13766333.2A patent/EP2900634B1/en not_active Not-in-force
- 2013-09-25 CN CN201380048737.4A patent/CN104619683B/zh not_active Expired - Fee Related
- 2013-09-25 DK DK13766333.2T patent/DK2900634T3/en active
- 2013-09-25 MX MX2015003902A patent/MX350575B/es active IP Right Grant
- 2013-09-26 TW TW102134666A patent/TWI601713B/zh not_active IP Right Cessation
-
2015
- 2015-03-16 IL IL237749A patent/IL237749A/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200037320A (ko) * | 2017-08-09 | 2020-04-08 | 론자 리미티드 | 4-(헵타플루오로-2-프로필) 아닐린의 제조 방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104619683A (zh) | 2015-05-13 |
| JP2015535835A (ja) | 2015-12-17 |
| EP2900634A1 (en) | 2015-08-05 |
| DK2900634T3 (en) | 2017-05-22 |
| MX350575B (es) | 2017-09-11 |
| EP2900634B1 (en) | 2017-02-22 |
| BR112015006825A2 (pt) | 2017-08-08 |
| IL237749A (en) | 2017-09-28 |
| US20150246880A1 (en) | 2015-09-03 |
| ES2625547T3 (es) | 2017-07-19 |
| US9447036B2 (en) | 2016-09-20 |
| CN104619683B (zh) | 2017-05-10 |
| JP6251749B2 (ja) | 2017-12-20 |
| MX2015003902A (es) | 2015-07-17 |
| WO2014048958A1 (en) | 2014-04-03 |
| TWI601713B (zh) | 2017-10-11 |
| TW201418215A (zh) | 2014-05-16 |
| IN2015DN02542A (https=) | 2015-09-11 |
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Legal Events
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| PA0105 | International application |
Patent event date: 20150422 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20180921 Comment text: Request for Examination of Application |
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| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20200120 Patent event code: PE09021S01D |
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| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20200323 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20200120 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |