KR20150023679A - 아미노산 치환을 갖는 인간화된 항-TrkA 항체 - Google Patents

아미노산 치환을 갖는 인간화된 항-TrkA 항체 Download PDF

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KR20150023679A
KR20150023679A KR20157000453A KR20157000453A KR20150023679A KR 20150023679 A KR20150023679 A KR 20150023679A KR 20157000453 A KR20157000453 A KR 20157000453A KR 20157000453 A KR20157000453 A KR 20157000453A KR 20150023679 A KR20150023679 A KR 20150023679A
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antibody
thr
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gly
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스타니슬래스 블랭
로맹 올리에
다코 스케그로
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그렌마크 파머수티칼스 에스. 아.
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Application filed by 그렌마크 파머수티칼스 에스. 아. filed Critical 그렌마크 파머수티칼스 에스. 아.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
KR20157000453A 2012-06-08 2013-06-07 아미노산 치환을 갖는 인간화된 항-TrkA 항체 Ceased KR20150023679A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261657184P 2012-06-08 2012-06-08
US61/657,184 2012-06-08
PCT/IB2013/054688 WO2013183032A2 (en) 2012-06-08 2013-06-07 Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof

Publications (1)

Publication Number Publication Date
KR20150023679A true KR20150023679A (ko) 2015-03-05

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ID=48906463

Family Applications (1)

Application Number Title Priority Date Filing Date
KR20157000453A Ceased KR20150023679A (ko) 2012-06-08 2013-06-07 아미노산 치환을 갖는 인간화된 항-TrkA 항체

Country Status (20)

Country Link
US (2) US20130344064A1 (enExample)
EP (1) EP2859019B1 (enExample)
JP (1) JP2015520182A (enExample)
KR (1) KR20150023679A (enExample)
CN (1) CN104520330A (enExample)
AP (1) AP2014008145A0 (enExample)
AU (1) AU2013273115B2 (enExample)
CA (1) CA2875703A1 (enExample)
CL (1) CL2014003339A1 (enExample)
CO (1) CO7240431A2 (enExample)
EA (1) EA201492163A1 (enExample)
ES (1) ES2666126T3 (enExample)
IL (1) IL235994A0 (enExample)
IN (1) IN2014MN02656A (enExample)
MX (1) MX362394B (enExample)
PE (1) PE20150212A1 (enExample)
PH (1) PH12014502722A1 (enExample)
SG (1) SG11201408037SA (enExample)
UA (1) UA113879C2 (enExample)
WO (1) WO2013183032A2 (enExample)

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US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
US9783601B2 (en) 2010-12-01 2017-10-10 Alderbio Holdings Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
MA41097A (fr) * 2014-12-05 2017-10-10 Glenmark Pharmaceuticals Sa Anticorps anti-trka à propriétés inhibitrices améliorées et dérivés desdits anticorps destinés à être utilisés pour traiter les douleurs osseuses
WO2016190263A1 (ja) 2015-05-22 2016-12-01 アステラス製薬株式会社 新規抗ヒトＮＧＦ抗体Ｆａｂフラグメント
TWI831365B (zh) * 2017-01-10 2024-02-01 國立大學法人山口大學 抗ｇｐｃ３抗體
MY202872A (en) 2017-11-20 2024-05-28 Just Evotec Biologics Inc Aflibercept formulations containing a lysine salt as tonicifying agent and uses thereof
AR114110A1 (es) 2018-02-28 2020-07-22 Lilly Co Eli Anticuerpo anti-trka
AU2020281378B2 (en) * 2019-05-30 2025-09-11 Sunshine Lake Pharma Co., Ltd. Anti-TrkA antibodies and uses thereof
CN116003590A (zh) * 2020-08-06 2023-04-25 熙源安健医药（上海）有限公司 抗ngf抗体及其抗原结合片段、其制备方法和应用
AU2021382828A1 (en) * 2020-11-20 2022-10-06 Sunshine Lake Pharma Co., Ltd. Humanized anti-TrkA antibodies and uses thereof
CN112961244B (zh) * 2021-02-28 2023-08-29 熙源安健医药（上海）有限公司 抗TrkA抗体或其抗原结合片段、其制备方法和应用
EP4716738A1 (en) * 2023-05-23 2026-04-01 4B Technologies (Shanghai) Co., Ltd Trka antibody and use thereof

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AU2013273115A1 (en) 2015-01-22
PE20150212A1 (es) 2015-02-27
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HK1209435A1 (en) 2016-04-01
US20170218087A1 (en) 2017-08-03
WO2013183032A2 (en) 2013-12-12
AP2014008145A0 (en) 2014-12-31
JP2015520182A (ja) 2015-07-16
US20130344064A1 (en) 2013-12-26
CA2875703A1 (en) 2013-12-12
PH12014502722A1 (en) 2015-02-02
EP2859019A2 (en) 2015-04-15
WO2013183032A3 (en) 2014-02-20
MX362394B (es) 2019-01-15
CO7240431A2 (es) 2015-04-17
MX2014015043A (es) 2015-02-20
SG11201408037SA (en) 2015-01-29
IN2014MN02656A (enExample) 2015-08-21
EP2859019B1 (en) 2018-02-21
EA201492163A1 (ru) 2015-08-31
CN104520330A (zh) 2015-04-15
ES2666126T3 (es) 2018-05-03
AU2013273115A2 (en) 2015-01-22
IL235994A0 (en) 2015-01-29
UA113879C2 (xx) 2017-03-27

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