KR20150004441A - Ｐｄｅ４의 바이사이클릭 헤테로아릴 억제제 - Google Patents
Ｐｄｅ４의 바이사이클릭 헤테로아릴 억제제 Download PDFInfo
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- KR20150004441A KR20150004441A KR1020147036033A KR20147036033A KR20150004441A KR 20150004441 A KR20150004441 A KR 20150004441A KR 1020147036033 A KR1020147036033 A KR 1020147036033A KR 20147036033 A KR20147036033 A KR 20147036033A KR 20150004441 A KR20150004441 A KR 20150004441A
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- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000004565 tumor cell growth Effects 0.000 description 1
- 230000006433 tumor necrosis factor production Effects 0.000 description 1
- 230000005951 type IV hypersensitivity Effects 0.000 description 1
- 208000027930 type IV hypersensitivity disease Diseases 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000002227 vasoactive effect Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81950906P | 2006-07-07 | 2006-07-07 | |
| US60/819,509 | 2006-07-07 | ||
| US88682507P | 2007-01-26 | 2007-01-26 | |
| US60/886,825 | 2007-01-26 | ||
| PCT/US2007/072919 WO2008006050A2 (en) | 2006-07-07 | 2007-07-06 | Bicyclic heteroaryl inhibitors of pde4 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| KR1020097002141A Division KR20090109527A (ko) | 2006-07-07 | 2007-07-06 | Ｐｄｅ４의 바이사이클릭 헤테로아릴 억제제 |
Publications (1)
| Publication Number | Publication Date |
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| KR20150004441A true KR20150004441A (ko) | 2015-01-12 |
Family
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| KR1020147036033A Ceased KR20150004441A (ko) | 2006-07-07 | 2007-07-06 | Ｐｄｅ４의 바이사이클릭 헤테로아릴 억제제 |
| KR1020097002141A Abandoned KR20090109527A (ko) | 2006-07-07 | 2007-07-06 | Ｐｄｅ４의 바이사이클릭 헤테로아릴 억제제 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| KR1020097002141A Abandoned KR20090109527A (ko) | 2006-07-07 | 2007-07-06 | Ｐｄｅ４의 바이사이클릭 헤테로아릴 억제제 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US20090291950A1 (enExample) |
| EP (1) | EP2037924A2 (enExample) |
| JP (2) | JP5280357B2 (enExample) |
| KR (2) | KR20150004441A (enExample) |
| CN (1) | CN104606194A (enExample) |
| AU (1) | AU2007269070B2 (enExample) |
| BR (1) | BRPI0713253A2 (enExample) |
| CA (1) | CA2657093A1 (enExample) |
| CO (1) | CO6190532A2 (enExample) |
| MX (1) | MX2009000148A (enExample) |
| WO (3) | WO2008006051A2 (enExample) |
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| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| CA2477604A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
| MXPA04008070A (es) | 2003-03-10 | 2004-11-26 | Altana Pharma Ag | Novedoso proceso para la preparacion de roflumilasto. |
| EP1843734A4 (en) * | 2005-02-03 | 2008-09-10 | Signum Biosciences Inc | COMPOSITIONS AND METHOD FOR INTENSIFYING COGNITIVE FUNCTIONS |
| US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| US8663694B2 (en) | 2005-03-16 | 2014-03-04 | Takeda Gmbh | Taste masked dosage form containing roflumilast |
| US8138205B2 (en) * | 2006-07-07 | 2012-03-20 | Kalypsys, Inc. | Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 |
| EP2037924A2 (en) | 2006-07-07 | 2009-03-25 | Steven P. Govek | Bicyclic heteroaryl inhibitors of pde4 |
| CN102014897B (zh) | 2008-04-21 | 2015-08-05 | 西格纳姆生物科学公司 | 化合物、组合物和其制备方法 |
| CN101353338B (zh) * | 2008-07-10 | 2011-05-04 | 上海交通大学 | 糖胺改性的水溶性香豆素酮衍生物及其制备方法 |
| CA2773483A1 (en) * | 2009-10-01 | 2011-04-07 | Alcon Research, Ltd. | Olopatadine compositions and uses thereof |
| US8394829B2 (en) | 2010-05-10 | 2013-03-12 | Gilead Sciences, Inc. | Bi-functional quinoline analogs |
| US8367829B2 (en) | 2010-05-10 | 2013-02-05 | Gilead Sciences, Inc. | Bi-functional pyrazolopyridine compounds |
| US20130116279A1 (en) * | 2011-11-07 | 2013-05-09 | Kalypsys, Inc. | Bicyclic heteroaryl inhibitors of pde4 |
| HK1217092A1 (zh) | 2013-02-15 | 2016-12-23 | Kala Pharmaceuticals, Inc. | 治疗性化合物及其用途 |
| BR112015019276A2 (pt) | 2013-02-19 | 2017-07-18 | Pfizer | compostos de azabenzimidazol como inibidores de isoenzimas de pde4 para o tratamento de distúrbios do snc e outros distúrbios |
| US9353123B2 (en) | 2013-02-20 | 2016-05-31 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
| US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| NZ719185A (en) | 2013-11-01 | 2017-11-24 | Kala Pharmaceuticals Inc | Crystalline forms of therapeutic compounds and uses thereof |
| US10131669B2 (en) | 2014-07-24 | 2018-11-20 | Pfizer Inc. | Pyrazolopyrimidine compounds |
| EA031201B1 (ru) | 2014-08-06 | 2018-11-30 | Пфайзер Инк. | Соединения имидазопиридазина |
| BR112018006873A2 (pt) | 2015-10-05 | 2018-11-06 | The Trustees Of Columbia University In The City Of New York | ativadores do fluxo autofágico e fosfolipase d e depuração de agregados de proteína incluindo tau e tratamento de proteinopatias |
| KR102733897B1 (ko) * | 2015-12-24 | 2024-11-22 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Cftr 조절제 및 이의 사용방법 |
| WO2018048747A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CA3036340A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CA3036065A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CN106916104B (zh) * | 2017-02-28 | 2019-08-27 | 牡丹江医学院 | 用于治疗结肠炎的药物 |
| US12059404B2 (en) | 2017-07-26 | 2024-08-13 | Hg&H Pharmaceuticals (Pty) Ltd | Mesembrenol and/or mesembranol for prophylaxis and treatment of patients suffering from epilepsy and associated diseases |
| US11839616B2 (en) | 2017-08-24 | 2023-12-12 | The Regents Of The University Of California | Ocular pharmaceutical compositions |
| US20220098257A1 (en) * | 2019-01-23 | 2022-03-31 | Path Therapeutics, Inc. | Methods of Treating Epilepsy via Phosphodiesterase 4 (PDE4) Inhibition |
| EP4025559A4 (en) * | 2019-09-08 | 2023-05-10 | Hadasit Medical Research Services and Development Ltd. | ANTI-FIBROTIC COMPOUNDS AND THEIR USE |
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| US542104A (en) * | 1895-07-02 | Nut-sheller | ||
| AU639529B2 (en) | 1987-03-04 | 1993-07-29 | Higuchi, Yoshinari | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives |
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| JPH0772176B2 (ja) | 1991-04-03 | 1995-08-02 | コリア リサーチ インスティチュート オブ ケミカル テクノロジイ | ２―キノリノン誘導体 |
| EP0670833A1 (de) | 1992-11-27 | 1995-09-13 | Iovis Biomedical And Pharmaceutical Consultants | Nitroxyverbindungen mit pharmazeutischen eigenschaften |
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| FR2711992A1 (fr) | 1993-11-03 | 1995-05-12 | Lipha | Nouveaux dérivé hétérocycliques, procédé de préparation et composition pharmaceutique les contenant. |
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| DE10021256A1 (de) * | 2000-04-20 | 2001-10-31 | Forschungsverbund Berlin Ev | Neue, photolabile Cumarinylmethylester von cyclischen Nucleotiden, Verfahren zu deren Herstellung und ihre Verwendung |
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| CN1506359A (zh) * | 2002-12-05 | 2004-06-23 | �й�ҽѧ��ѧԺҩ���о��� | 新的香豆素酰胺衍生物及其制法和其药物组合物与用途 |
| ITMI20022739A1 (it) * | 2002-12-23 | 2004-06-24 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4. |
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| JP4584990B2 (ja) * | 2004-05-18 | 2010-11-24 | シェーリング コーポレイション | Ｐｄｅ４インヒビターとして有用な置換２−キノリル−オキサゾール |
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| NL1028569C2 (nl) | 2005-03-18 | 2006-09-20 | Rademaker Holding B V | Toepassing van een coumarine-groep omvattende derivaten voor de bereiding van een antiviraal middel, alsmede kattenvoer. |
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| EP2037924A2 (en) * | 2006-07-07 | 2009-03-25 | Steven P. Govek | Bicyclic heteroaryl inhibitors of pde4 |
| US20130116279A1 (en) * | 2011-11-07 | 2013-05-09 | Kalypsys, Inc. | Bicyclic heteroaryl inhibitors of pde4 |
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2007
- 2007-07-06 EP EP07812666A patent/EP2037924A2/en not_active Withdrawn
- 2007-07-06 US US12/307,738 patent/US20090291950A1/en not_active Abandoned
- 2007-07-06 WO PCT/US2007/072920 patent/WO2008006051A2/en not_active Ceased
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- 2007-07-06 MX MX2009000148A patent/MX2009000148A/es active IP Right Grant
- 2007-07-06 AU AU2007269070A patent/AU2007269070B2/en not_active Ceased
- 2007-07-06 CN CN201410768897.2A patent/CN104606194A/zh active Pending
- 2007-07-06 US US11/774,053 patent/US8258154B2/en not_active Expired - Fee Related
- 2007-07-06 JP JP2009519604A patent/JP5280357B2/ja not_active Expired - Fee Related
- 2007-07-06 CA CA002657093A patent/CA2657093A1/en not_active Abandoned
- 2007-07-06 US US11/774,058 patent/US7745646B2/en not_active Expired - Fee Related
- 2007-07-06 WO PCT/US2007/072924 patent/WO2008006052A2/en not_active Ceased
- 2007-07-06 KR KR1020147036033A patent/KR20150004441A/ko not_active Ceased
- 2007-07-06 KR KR1020097002141A patent/KR20090109527A/ko not_active Abandoned
- 2007-07-06 US US12/307,730 patent/US8080563B2/en not_active Expired - Fee Related
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2009
- 2009-02-04 CO CO09010461A patent/CO6190532A2/es active IP Right Grant
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2012
- 2012-06-28 US US13/536,716 patent/US9078887B2/en not_active Expired - Fee Related
-
2013
- 2013-05-22 JP JP2013107844A patent/JP5705269B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN104606194A (zh) | 2015-05-13 |
| US20080027112A1 (en) | 2008-01-31 |
| WO2008006051A3 (en) | 2008-06-26 |
| CO6190532A2 (es) | 2010-08-19 |
| JP5705269B2 (ja) | 2015-04-22 |
| US8080563B2 (en) | 2011-12-20 |
| AU2007269070A1 (en) | 2008-01-10 |
| AU2007269070B2 (en) | 2013-03-21 |
| BRPI0713253A2 (pt) | 2012-10-30 |
| US7745646B2 (en) | 2010-06-29 |
| WO2008006050A2 (en) | 2008-01-10 |
| US9078887B2 (en) | 2015-07-14 |
| WO2008006050A3 (en) | 2008-06-26 |
| KR20090109527A (ko) | 2009-10-20 |
| US20130178498A1 (en) | 2013-07-11 |
| CA2657093A1 (en) | 2008-01-10 |
| US8258154B2 (en) | 2012-09-04 |
| US20080027099A1 (en) | 2008-01-31 |
| WO2008006052A2 (en) | 2008-01-10 |
| JP2013177421A (ja) | 2013-09-09 |
| EP2037924A2 (en) | 2009-03-25 |
| JP2009542815A (ja) | 2009-12-03 |
| JP5280357B2 (ja) | 2013-09-04 |
| WO2008006051A2 (en) | 2008-01-10 |
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| MX2009000148A (es) | 2009-10-26 |
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