CA2657093A1 - Bicyclic heteroaryl inhibitors of pde4 - Google Patents
Bicyclic heteroaryl inhibitors of pde4 Download PDFInfo
- Publication number
- CA2657093A1 CA2657093A1 CA002657093A CA2657093A CA2657093A1 CA 2657093 A1 CA2657093 A1 CA 2657093A1 CA 002657093 A CA002657093 A CA 002657093A CA 2657093 A CA2657093 A CA 2657093A CA 2657093 A1 CA2657093 A1 CA 2657093A1
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- CA
- Canada
- Prior art keywords
- nc3c
- group
- ccc2c
- ncl2
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
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| US81950906P | 2006-07-07 | 2006-07-07 | |
| US60/819,509 | 2006-07-07 | ||
| US88682507P | 2007-01-26 | 2007-01-26 | |
| US60/886,825 | 2007-01-26 | ||
| PCT/US2007/072919 WO2008006050A2 (en) | 2006-07-07 | 2007-07-06 | Bicyclic heteroaryl inhibitors of pde4 |
Publications (1)
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| CA2657093A1 true CA2657093A1 (en) | 2008-01-10 |
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| Country | Link |
|---|---|
| US (5) | US20090291950A1 (enExample) |
| EP (1) | EP2037924A2 (enExample) |
| JP (2) | JP5280357B2 (enExample) |
| KR (2) | KR20150004441A (enExample) |
| CN (1) | CN104606194A (enExample) |
| AU (1) | AU2007269070B2 (enExample) |
| BR (1) | BRPI0713253A2 (enExample) |
| CA (1) | CA2657093A1 (enExample) |
| CO (1) | CO6190532A2 (enExample) |
| MX (1) | MX2009000148A (enExample) |
| WO (3) | WO2008006051A2 (enExample) |
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| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| CA2477604A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
| MXPA04008070A (es) | 2003-03-10 | 2004-11-26 | Altana Pharma Ag | Novedoso proceso para la preparacion de roflumilasto. |
| WO2006084033A1 (en) * | 2005-02-03 | 2006-08-10 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| JP5383183B2 (ja) | 2005-03-16 | 2014-01-08 | タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロフルミラストを含有する矯味された剤形 |
| WO2008006051A2 (en) | 2006-07-07 | 2008-01-10 | Govek Steven P | Bicyclic heteroaryl inhibitors of pde4 |
| US8138205B2 (en) * | 2006-07-07 | 2012-03-20 | Kalypsys, Inc. | Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 |
| WO2009132051A1 (en) | 2008-04-21 | 2009-10-29 | Signum Biosciences, Inc. | Compounds, compositions and methods for making the same |
| CN101353338B (zh) * | 2008-07-10 | 2011-05-04 | 上海交通大学 | 糖胺改性的水溶性香豆素酮衍生物及其制备方法 |
| EP2482798A1 (en) * | 2009-10-01 | 2012-08-08 | Alcon Research, Ltd. | Olopatadine compositions and uses thereof |
| WO2011143106A1 (en) | 2010-05-10 | 2011-11-17 | Gilead Sciences, Inc. | Bi - functional pyrazolopyridine compounds |
| EP2569285A1 (en) | 2010-05-10 | 2013-03-20 | Gilead Sciences, Inc. | Bifunctional quinoline derivatives |
| US20130116279A1 (en) * | 2011-11-07 | 2013-05-09 | Kalypsys, Inc. | Bicyclic heteroaryl inhibitors of pde4 |
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- 2007-07-06 WO PCT/US2007/072919 patent/WO2008006050A2/en not_active Ceased
- 2007-07-06 JP JP2009519604A patent/JP5280357B2/ja not_active Expired - Fee Related
- 2007-07-06 US US12/307,738 patent/US20090291950A1/en not_active Abandoned
- 2007-07-06 US US11/774,058 patent/US7745646B2/en not_active Expired - Fee Related
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- 2007-07-06 US US11/774,053 patent/US8258154B2/en not_active Expired - Fee Related
- 2007-07-06 US US12/307,730 patent/US8080563B2/en not_active Expired - Fee Related
- 2007-07-06 CA CA002657093A patent/CA2657093A1/en not_active Abandoned
- 2007-07-06 AU AU2007269070A patent/AU2007269070B2/en not_active Ceased
- 2007-07-06 KR KR1020147036033A patent/KR20150004441A/ko not_active Ceased
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- 2007-07-06 BR BRPI0713253-0A patent/BRPI0713253A2/pt not_active IP Right Cessation
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| US8258154B2 (en) | 2012-09-04 |
| JP2013177421A (ja) | 2013-09-09 |
| US20080027112A1 (en) | 2008-01-31 |
| US20080027099A1 (en) | 2008-01-31 |
| MX2009000148A (es) | 2009-10-26 |
| AU2007269070A1 (en) | 2008-01-10 |
| CO6190532A2 (es) | 2010-08-19 |
| WO2008006051A2 (en) | 2008-01-10 |
| US7745646B2 (en) | 2010-06-29 |
| US8080563B2 (en) | 2011-12-20 |
| WO2008006051A3 (en) | 2008-06-26 |
| CN104606194A (zh) | 2015-05-13 |
| WO2008006050A2 (en) | 2008-01-10 |
| KR20150004441A (ko) | 2015-01-12 |
| BRPI0713253A2 (pt) | 2012-10-30 |
| JP2009542815A (ja) | 2009-12-03 |
| EP2037924A2 (en) | 2009-03-25 |
| US20130178498A1 (en) | 2013-07-11 |
| AU2007269070B2 (en) | 2013-03-21 |
| WO2008006052A2 (en) | 2008-01-10 |
| US20090291950A1 (en) | 2009-11-26 |
| JP5280357B2 (ja) | 2013-09-04 |
| KR20090109527A (ko) | 2009-10-20 |
| WO2008006052A3 (en) | 2008-11-20 |
| US20100022586A1 (en) | 2010-01-28 |
| WO2008006050A3 (en) | 2008-06-26 |
| US9078887B2 (en) | 2015-07-14 |
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