BRPI0713253A2 - método de inibição de pde4, método de tratamento de um doença mediada por pde4, composto e composição farmacêutica - Google Patents
método de inibição de pde4, método de tratamento de um doença mediada por pde4, composto e composição farmacêutica Download PDFInfo
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- BRPI0713253A2 BRPI0713253A2 BRPI0713253-0A BRPI0713253A BRPI0713253A2 BR PI0713253 A2 BRPI0713253 A2 BR PI0713253A2 BR PI0713253 A BRPI0713253 A BR PI0713253A BR PI0713253 A2 BRPI0713253 A2 BR PI0713253A2
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Classifications
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Public Health (AREA)
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- Rheumatology (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81950906P | 2006-07-07 | 2006-07-07 | |
| US60/819,509 | 2006-07-07 | ||
| US88682507P | 2007-01-26 | 2007-01-26 | |
| US60/886,825 | 2007-01-26 | ||
| PCT/US2007/072919 WO2008006050A2 (en) | 2006-07-07 | 2007-07-06 | Bicyclic heteroaryl inhibitors of pde4 |
Publications (1)
| Publication Number | Publication Date |
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| BRPI0713253A2 true BRPI0713253A2 (pt) | 2012-10-30 |
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| BRPI0713253-0A BRPI0713253A2 (pt) | 2006-07-07 | 2007-07-06 | método de inibição de pde4, método de tratamento de um doença mediada por pde4, composto e composição farmacêutica |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US20090291950A1 (enExample) |
| EP (1) | EP2037924A2 (enExample) |
| JP (2) | JP5280357B2 (enExample) |
| KR (2) | KR20150004441A (enExample) |
| CN (1) | CN104606194A (enExample) |
| AU (1) | AU2007269070B2 (enExample) |
| BR (1) | BRPI0713253A2 (enExample) |
| CA (1) | CA2657093A1 (enExample) |
| CO (1) | CO6190532A2 (enExample) |
| MX (1) | MX2009000148A (enExample) |
| WO (3) | WO2008006051A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| CA2477604A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
| MXPA04008070A (es) | 2003-03-10 | 2004-11-26 | Altana Pharma Ag | Novedoso proceso para la preparacion de roflumilasto. |
| EP1843734A4 (en) * | 2005-02-03 | 2008-09-10 | Signum Biosciences Inc | COMPOSITIONS AND METHOD FOR INTENSIFYING COGNITIVE FUNCTIONS |
| US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| US8663694B2 (en) | 2005-03-16 | 2014-03-04 | Takeda Gmbh | Taste masked dosage form containing roflumilast |
| US8138205B2 (en) * | 2006-07-07 | 2012-03-20 | Kalypsys, Inc. | Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 |
| EP2037924A2 (en) | 2006-07-07 | 2009-03-25 | Steven P. Govek | Bicyclic heteroaryl inhibitors of pde4 |
| CN102014897B (zh) | 2008-04-21 | 2015-08-05 | 西格纳姆生物科学公司 | 化合物、组合物和其制备方法 |
| CN101353338B (zh) * | 2008-07-10 | 2011-05-04 | 上海交通大学 | 糖胺改性的水溶性香豆素酮衍生物及其制备方法 |
| CA2773483A1 (en) * | 2009-10-01 | 2011-04-07 | Alcon Research, Ltd. | Olopatadine compositions and uses thereof |
| US8394829B2 (en) | 2010-05-10 | 2013-03-12 | Gilead Sciences, Inc. | Bi-functional quinoline analogs |
| US8367829B2 (en) | 2010-05-10 | 2013-02-05 | Gilead Sciences, Inc. | Bi-functional pyrazolopyridine compounds |
| US20130116279A1 (en) * | 2011-11-07 | 2013-05-09 | Kalypsys, Inc. | Bicyclic heteroaryl inhibitors of pde4 |
| HK1217092A1 (zh) | 2013-02-15 | 2016-12-23 | Kala Pharmaceuticals, Inc. | 治疗性化合物及其用途 |
| BR112015019276A2 (pt) | 2013-02-19 | 2017-07-18 | Pfizer | compostos de azabenzimidazol como inibidores de isoenzimas de pde4 para o tratamento de distúrbios do snc e outros distúrbios |
| US9353123B2 (en) | 2013-02-20 | 2016-05-31 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
| US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| NZ719185A (en) | 2013-11-01 | 2017-11-24 | Kala Pharmaceuticals Inc | Crystalline forms of therapeutic compounds and uses thereof |
| US10131669B2 (en) | 2014-07-24 | 2018-11-20 | Pfizer Inc. | Pyrazolopyrimidine compounds |
| EA031201B1 (ru) | 2014-08-06 | 2018-11-30 | Пфайзер Инк. | Соединения имидазопиридазина |
| BR112018006873A2 (pt) | 2015-10-05 | 2018-11-06 | The Trustees Of Columbia University In The City Of New York | ativadores do fluxo autofágico e fosfolipase d e depuração de agregados de proteína incluindo tau e tratamento de proteinopatias |
| KR102733897B1 (ko) * | 2015-12-24 | 2024-11-22 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Cftr 조절제 및 이의 사용방법 |
| WO2018048747A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CA3036340A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CA3036065A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CN106916104B (zh) * | 2017-02-28 | 2019-08-27 | 牡丹江医学院 | 用于治疗结肠炎的药物 |
| US12059404B2 (en) | 2017-07-26 | 2024-08-13 | Hg&H Pharmaceuticals (Pty) Ltd | Mesembrenol and/or mesembranol for prophylaxis and treatment of patients suffering from epilepsy and associated diseases |
| US11839616B2 (en) | 2017-08-24 | 2023-12-12 | The Regents Of The University Of California | Ocular pharmaceutical compositions |
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2007
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- 2007-07-06 US US12/307,738 patent/US20090291950A1/en not_active Abandoned
- 2007-07-06 WO PCT/US2007/072920 patent/WO2008006051A2/en not_active Ceased
- 2007-07-06 BR BRPI0713253-0A patent/BRPI0713253A2/pt not_active IP Right Cessation
- 2007-07-06 WO PCT/US2007/072919 patent/WO2008006050A2/en not_active Ceased
- 2007-07-06 MX MX2009000148A patent/MX2009000148A/es active IP Right Grant
- 2007-07-06 AU AU2007269070A patent/AU2007269070B2/en not_active Ceased
- 2007-07-06 CN CN201410768897.2A patent/CN104606194A/zh active Pending
- 2007-07-06 US US11/774,053 patent/US8258154B2/en not_active Expired - Fee Related
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2012
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| CN104606194A (zh) | 2015-05-13 |
| US20080027112A1 (en) | 2008-01-31 |
| WO2008006051A3 (en) | 2008-06-26 |
| CO6190532A2 (es) | 2010-08-19 |
| JP5705269B2 (ja) | 2015-04-22 |
| US8080563B2 (en) | 2011-12-20 |
| AU2007269070A1 (en) | 2008-01-10 |
| AU2007269070B2 (en) | 2013-03-21 |
| US7745646B2 (en) | 2010-06-29 |
| WO2008006050A2 (en) | 2008-01-10 |
| US9078887B2 (en) | 2015-07-14 |
| WO2008006050A3 (en) | 2008-06-26 |
| KR20090109527A (ko) | 2009-10-20 |
| US20130178498A1 (en) | 2013-07-11 |
| CA2657093A1 (en) | 2008-01-10 |
| US8258154B2 (en) | 2012-09-04 |
| US20080027099A1 (en) | 2008-01-31 |
| WO2008006052A2 (en) | 2008-01-10 |
| KR20150004441A (ko) | 2015-01-12 |
| JP2013177421A (ja) | 2013-09-09 |
| EP2037924A2 (en) | 2009-03-25 |
| JP2009542815A (ja) | 2009-12-03 |
| JP5280357B2 (ja) | 2013-09-04 |
| WO2008006051A2 (en) | 2008-01-10 |
| WO2008006052A3 (en) | 2008-11-20 |
| MX2009000148A (es) | 2009-10-26 |
| US20090291950A1 (en) | 2009-11-26 |
| US20100022586A1 (en) | 2010-01-28 |
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