KR20140099277A - 다중특이적 결합제의 자유 결합 파트너의 검출 방법 - Google Patents

다중특이적 결합제의 자유 결합 파트너의 검출 방법 Download PDF

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Publication number
KR20140099277A
KR20140099277A KR1020147016700A KR20147016700A KR20140099277A KR 20140099277 A KR20140099277 A KR 20140099277A KR 1020147016700 A KR1020147016700 A KR 1020147016700A KR 20147016700 A KR20147016700 A KR 20147016700A KR 20140099277 A KR20140099277 A KR 20140099277A
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South Korea
Prior art keywords
antibody
binding
antigen
multispecific
sample
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English (en)
Korean (ko)
Inventor
카이-군나르 슈튜벤라우흐
우베 베쎌스
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에프. 호프만-라 로슈 아게
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Publication of KR20140099277A publication Critical patent/KR20140099277A/ko
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
KR1020147016700A 2011-12-19 2012-12-18 다중특이적 결합제의 자유 결합 파트너의 검출 방법 Ceased KR20140099277A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11194350 2011-12-19
EP11194350.2 2011-12-19
PCT/EP2012/075991 WO2013092611A2 (en) 2011-12-19 2012-12-18 Method for the detection of free binding partner of a multispecific binder

Publications (1)

Publication Number Publication Date
KR20140099277A true KR20140099277A (ko) 2014-08-11

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KR1020147016700A Ceased KR20140099277A (ko) 2011-12-19 2012-12-18 다중특이적 결합제의 자유 결합 파트너의 검출 방법

Country Status (10)

Country Link
US (1) US9671394B2 (cg-RX-API-DMAC7.html)
EP (1) EP2795335B1 (cg-RX-API-DMAC7.html)
JP (1) JP6203747B2 (cg-RX-API-DMAC7.html)
KR (1) KR20140099277A (cg-RX-API-DMAC7.html)
CN (1) CN104040350B (cg-RX-API-DMAC7.html)
BR (1) BR112014011535A2 (cg-RX-API-DMAC7.html)
CA (1) CA2853917A1 (cg-RX-API-DMAC7.html)
MX (1) MX349003B (cg-RX-API-DMAC7.html)
RU (1) RU2633488C2 (cg-RX-API-DMAC7.html)
WO (1) WO2013092611A2 (cg-RX-API-DMAC7.html)

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BR112015000665A2 (pt) 2012-07-13 2017-06-27 Hoffmann La Roche método para a determinação da quantidade de um anticorpo
CA2926306C (en) * 2013-11-05 2022-12-06 F. Hoffmann-La Roche Ag A method for determining the total amount and/or concentration of an analyte in a sample
WO2015143277A1 (en) * 2014-03-20 2015-09-24 Wellstat Diagnostics, Llc Antibodies and methods for the detection of cell death
ES2761427T3 (es) 2014-12-18 2020-05-19 Hoffmann La Roche Procedimientos para reducir interferencias
AU2018304711B2 (en) 2017-07-20 2025-04-10 Cytomx Therapeutics, Inc. Methods of qualitatively and/or quantitatively analyzing properties of activatable antibodies and uses thereof
CN109358192B (zh) * 2018-02-08 2020-05-12 中国科学院上海药物研究所 一种去除抗药抗体检测样品中游离药物的装置和方法、该装置的制备方法及应用
EP3805757A4 (en) 2018-06-04 2022-03-23 Chugai Seiyaku Kabushiki Kaisha Method for detecting complex
WO2020229378A1 (en) * 2019-05-13 2020-11-19 F. Hoffmann-La Roche Ag Interference-suppressed pharmacokinetic immunoassay
KR20220007586A (ko) * 2019-05-13 2022-01-18 리제너론 파마슈티칼스 인코포레이티드 개선된 경쟁적 리간드 결합 검정
CN117805397A (zh) * 2024-02-29 2024-04-02 军科正源（北京）药物研究有限责任公司 检测游离vegf的方法

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Also Published As

Publication number Publication date
EP2795335A2 (en) 2014-10-29
BR112014011535A2 (pt) 2017-05-09
CA2853917A1 (en) 2013-06-27
RU2633488C2 (ru) 2017-10-12
JP2015502547A (ja) 2015-01-22
WO2013092611A3 (en) 2013-10-17
CN104040350B (zh) 2016-05-18
CN104040350A (zh) 2014-09-10
MX2014007095A (es) 2014-07-22
MX349003B (es) 2017-07-06
RU2014128510A (ru) 2016-02-10
US20150072359A1 (en) 2015-03-12
WO2013092611A2 (en) 2013-06-27
US9671394B2 (en) 2017-06-06
HK1201920A1 (zh) 2015-09-11
JP6203747B2 (ja) 2017-09-27
EP2795335B1 (en) 2017-09-06

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