KR20140053026A - 폴리엔 살진균제와 비-리보솜 펩티드의 상승작용적 조합물 및 관련된 사용 방법 - Google Patents
폴리엔 살진균제와 비-리보솜 펩티드의 상승작용적 조합물 및 관련된 사용 방법 Download PDFInfo
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- KR20140053026A KR20140053026A KR20137033766A KR20137033766A KR20140053026A KR 20140053026 A KR20140053026 A KR 20140053026A KR 20137033766 A KR20137033766 A KR 20137033766A KR 20137033766 A KR20137033766 A KR 20137033766A KR 20140053026 A KR20140053026 A KR 20140053026A
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- lipopeptide
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- polyenophile
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- iturin
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Classifications
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/713—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
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- A—HUMAN NECESSITIES
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- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
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| US201161489640P | 2011-05-24 | 2011-05-24 | |
| US61/489,640 | 2011-05-24 | ||
| US201261615075P | 2012-03-23 | 2012-03-23 | |
| US61/615,075 | 2012-03-23 | ||
| PCT/US2012/039178 WO2012162412A2 (en) | 2011-05-24 | 2012-05-23 | Synergistic combinations of polyene fungicides and non-ribosomal peptides and related methods of use |
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| KR20140053026A true KR20140053026A (ko) | 2014-05-07 |
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| EP (1) | EP2713729A2 (enExample) |
| JP (1) | JP2014518878A (enExample) |
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| AU (1) | AU2012258776B2 (enExample) |
| BR (1) | BR112013029912A2 (enExample) |
| CA (1) | CA2836131A1 (enExample) |
| CL (1) | CL2013003349A1 (enExample) |
| CO (1) | CO6811811A2 (enExample) |
| MX (1) | MX347345B (enExample) |
| RU (1) | RU2013157207A (enExample) |
| WO (1) | WO2012162412A2 (enExample) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20190022381A (ko) * | 2017-08-24 | 2019-03-06 | 전남대학교산학협력단 | 3종의 리포펩타이드계 화합물을 생산하고, 항진균 활성을 가지는 바실러스 아밀로리퀘파시엔스 jck-12 균주 및 항진균성 합성농약을 유효성분으로 함유하는 식물병 방제용 조성물 |
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| EP3281526A1 (en) * | 2012-05-30 | 2018-02-14 | Bayer CropScience Aktiengesellschaft | Composition comprising a biological control agent and a fungicide |
| TW201438581A (zh) * | 2012-11-29 | 2014-10-16 | Bayer Cropscience Lp | 使用多烯殺真菌劑以控制真菌病原之方法 |
| JP6595761B2 (ja) * | 2014-12-19 | 2019-10-23 | 東亜薬品工業株式会社 | バチルスアミロリキファシエンス菌株及び該菌株を含む抗菌組成物 |
| CN104546663B (zh) * | 2014-12-26 | 2017-08-25 | 广州市植美化妆品有限公司 | 一种含类芽孢杆菌的防脱生发洗发水 |
| AR103287A1 (es) | 2014-12-29 | 2017-04-26 | Fmc Corp | Composiciones microbianas y métodos para usar para beneficiar el crecimiento de las plantas y tratar la enfermedad de las plantas |
| US11089785B2 (en) * | 2015-05-22 | 2021-08-17 | Institut National De U Recherche Scientifique | Bacterial and fungal metabolites possessing anti-microbial activity against Xanthomonas species, compositions, methods, kits and uses relating to same |
| ES2897886T3 (es) * | 2016-03-03 | 2022-03-03 | Bayer Cropscience Lp | Procedimiento de purificación de compuestos antifúngicos y exopolisacáridos a partir de un cultivo de células microbianas |
| KR102151472B1 (ko) * | 2016-08-09 | 2020-09-03 | 가부시키가이샤 에스디에스 바이오텍크 | 농원예용 살균 조성물 및 식물 병해 방제 방법 |
| FR3061410B1 (fr) * | 2016-12-30 | 2020-07-10 | Lipofabrik | Composition biostimulante de la croissance des plantes obtenue a partir de surnageant de culture de souches bacillus sp. |
| CN106978457B (zh) * | 2017-04-24 | 2021-06-25 | 光明乳业股份有限公司 | 一种抗生素FusaricidinA的制备方法 |
| WO2019011630A1 (en) | 2017-07-10 | 2019-01-17 | Dsm Ip Assets B.V. | SEED TREATMENT WITH NATAMYCIN |
| FR3069155B1 (fr) | 2017-07-21 | 2020-07-10 | Lipofabrik | Composition comprenant une concentration elevee en lipopeptides ituriniques |
| CA3070711C (en) | 2017-07-27 | 2023-09-19 | Locus Ip Company, Llc | Compositions for enhancing bioavailability of pharmaceuticals, supplements and ingested substances |
| CN109576174A (zh) * | 2018-12-05 | 2019-04-05 | 青岛大学 | 枯草芽孢杆菌Bacillus subtilis CS30及其应用 |
| JP2022516797A (ja) * | 2019-01-10 | 2022-03-02 | エボニック オペレーションズ ゲーエムベーハー | 発酵ブロスおよびその使用 |
| CA3147349A1 (en) * | 2019-08-14 | 2021-02-18 | Sean Farmer | Drinkable supplement composition for improved health and hydration |
| WO2024186207A1 (en) | 2023-03-06 | 2024-09-12 | Ceradis Patent B.V. | Antifungal compositions comprising natamycin |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2664464B2 (ja) | 1989-03-13 | 1997-10-15 | 森永製菓株式会社 | アイツリン―aを用いるアフラトキシン汚染の防除方法 |
| US5902579A (en) | 1991-08-05 | 1999-05-11 | Bio-Technical Resources | Natamycin-containing streptomyces biomass and its use in animal feed |
| AU666415B2 (en) * | 1993-01-27 | 1996-02-08 | Dsm Ip Assets B.V. | A fungicide composition to prevent the growth of mould on foodstuff and agricultural products |
| JP2915296B2 (ja) * | 1993-08-30 | 1999-07-05 | 宇野 潤 | 抗真菌製剤 |
| CA2257864A1 (en) * | 1996-06-07 | 1997-12-18 | Gist-Brocades B.V. | Fungicidal composition for treatment of plant bulbs |
| US5895680A (en) | 1996-06-19 | 1999-04-20 | Thomas J. Lipton | Foodstuff preservation |
| EA002469B1 (ru) * | 1996-09-12 | 2002-06-27 | Мерк Энд Ко., Инк. | Способ лечения грибковой инфекции |
| US6103228A (en) | 1997-05-09 | 2000-08-15 | Agraquest, Inc. | Compositions and methods for controlling plant pests |
| IL132533A0 (en) | 1997-05-09 | 2001-03-19 | Agraquest Inc | A novel strain of bacillus for controlling plant diseases and corn rootworm |
| AUPQ066399A0 (en) * | 1999-05-31 | 1999-06-24 | Fujisawa Pharmaceutical Co., Ltd. | Antifungal combination use |
| EP1949789A1 (en) | 2001-05-11 | 2008-07-30 | Naturize, Inc. | Biological-chemical fungicide compositions and methods of use |
| EP1414306A1 (en) * | 2001-08-10 | 2004-05-06 | Showa Denko K.K. | Fungicidal and/or bactericidal composition |
| CA2491001A1 (en) * | 2002-06-28 | 2004-01-08 | Faculte Universitaire Des Sciences Agronomiques De Gembloux | Novel use of lipopeptide preparations |
| AU2005286540B2 (en) | 2004-09-23 | 2010-09-02 | Dsm Ip Assets B.V. | Antimicrobial composition |
| CA2695343C (en) | 2007-09-13 | 2015-07-07 | Laboratorios Miret, S.A. | Combinations of polyene fungicide with cationic surfactants |
| EA019915B1 (ru) | 2007-09-20 | 2014-07-30 | Басф Се | Фунгицидная композиция для борьбы с фитопатогенными вредными грибами |
| PE20091532A1 (es) | 2007-12-19 | 2009-10-03 | Dsm Ip Assets Bv | Tratamiento de plantas de platano y papa con una nueva composicion antifungica |
| PE20120074A1 (es) | 2008-09-17 | 2012-02-26 | Agraquest Inc | Composicion que comprende cepa de bacillus subtilis para alimentar animales |
| KR101737138B1 (ko) | 2009-03-26 | 2017-05-17 | 바이엘 크롭사이언스 엘피 | 유해 진균을 방제하기 위한 합성 및 생물학적 살진균제의 용도 |
| ES2719721T3 (es) | 2009-05-06 | 2019-07-12 | Bayer Cropscience Lp | Un procedimiento para aumentar el rendimiento de cultivo de plantas agrícolas bajo presión por patógenos esencialmente no existente |
| BRPI1008143A2 (pt) | 2009-06-05 | 2015-08-25 | Basf Se | Mistura composição agroquimica metodo para o combatre de fungos novicios fitopatogenicos e material de propagação de planta |
| DK2547348T3 (da) | 2010-03-17 | 2015-08-24 | Bayer Cropscience Lp | Fremgangsmåde til anvendelse af en bacillus subtilis-stamme til profylakse og behandling af mave-tarm-tilstande |
| EP2654433B1 (en) | 2010-12-21 | 2017-08-30 | Bayer Cropscience LP | Sandpaper mutants of bacillus and methods of their use to enhance plant growth, promote plant health and control diseases and pests |
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2012
- 2012-05-23 JP JP2014512079A patent/JP2014518878A/ja not_active Ceased
- 2012-05-23 CA CA2836131A patent/CA2836131A1/en not_active Abandoned
- 2012-05-23 AU AU2012258776A patent/AU2012258776B2/en not_active Ceased
- 2012-05-23 MX MX2013013709A patent/MX347345B/es active IP Right Grant
- 2012-05-23 KR KR20137033766A patent/KR20140053026A/ko not_active Withdrawn
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- 2012-05-23 CN CN201280025177.6A patent/CN103732064A/zh active Pending
- 2012-05-23 WO PCT/US2012/039178 patent/WO2012162412A2/en not_active Ceased
- 2012-05-23 RU RU2013157207/13A patent/RU2013157207A/ru not_active Application Discontinuation
- 2012-05-23 EP EP12725977.8A patent/EP2713729A2/en not_active Withdrawn
- 2012-05-23 BR BR112013029912A patent/BR112013029912A2/pt not_active Application Discontinuation
- 2012-05-24 AR ARP120101847 patent/AR090019A1/es unknown
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2013
- 2013-08-07 US US13/961,874 patent/US20130331311A1/en not_active Abandoned
- 2013-11-21 CL CL2013003349A patent/CL2013003349A1/es unknown
- 2013-11-22 ZA ZA2013/08820A patent/ZA201308820B/en unknown
- 2013-11-22 CO CO13275266A patent/CO6811811A2/es unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190022381A (ko) * | 2017-08-24 | 2019-03-06 | 전남대학교산학협력단 | 3종의 리포펩타이드계 화합물을 생산하고, 항진균 활성을 가지는 바실러스 아밀로리퀘파시엔스 jck-12 균주 및 항진균성 합성농약을 유효성분으로 함유하는 식물병 방제용 조성물 |
| WO2019039878A3 (ko) * | 2017-08-24 | 2019-04-25 | 전남대학교산학협력단 | 3종의 리포펩타이드계 화합물을 생산하고, 항진균 활성을 가지는 바실러스 아밀로리퀘파시엔스 jck-12 균주 및 항진균성 합성농약을 유효성분으로 함유하는 식물병 방제용 조성물 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2713729A2 (en) | 2014-04-09 |
| US20120302494A1 (en) | 2012-11-29 |
| JP2014518878A (ja) | 2014-08-07 |
| AR090019A1 (es) | 2014-10-15 |
| CA2836131A1 (en) | 2012-11-29 |
| ZA201308820B (en) | 2016-02-24 |
| US20130331311A1 (en) | 2013-12-12 |
| MX347345B (es) | 2017-04-21 |
| MX2013013709A (es) | 2014-02-27 |
| US8623813B2 (en) | 2014-01-07 |
| WO2012162412A2 (en) | 2012-11-29 |
| CN103732064A (zh) | 2014-04-16 |
| BR112013029912A2 (pt) | 2016-08-09 |
| RU2013157207A (ru) | 2015-06-27 |
| CO6811811A2 (es) | 2013-12-16 |
| WO2012162412A3 (en) | 2013-04-25 |
| AU2012258776B2 (en) | 2016-08-04 |
| CL2013003349A1 (es) | 2014-06-06 |
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