KR20130102534A - 히스티딜trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 - Google Patents
히스티딜trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 Download PDFInfo
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- KR20130102534A KR20130102534A KR1020137003454A KR20137003454A KR20130102534A KR 20130102534 A KR20130102534 A KR 20130102534A KR 1020137003454 A KR1020137003454 A KR 1020137003454A KR 20137003454 A KR20137003454 A KR 20137003454A KR 20130102534 A KR20130102534 A KR 20130102534A
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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- C12Y—ENZYMES
- C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
- C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/53—Ligases (6)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
- C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
- C12Y601/01021—Histidine-tRNA ligase (6.1.1.21)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/9015—Ligases (6)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36358710P | 2010-07-12 | 2010-07-12 | |
| US36358110P | 2010-07-12 | 2010-07-12 | |
| US36358510P | 2010-07-12 | 2010-07-12 | |
| US61/363,581 | 2010-07-12 | ||
| US61/363,585 | 2010-07-12 | ||
| US61/363,587 | 2010-07-12 | ||
| PCT/US2011/043758 WO2012021249A2 (en) | 2010-07-12 | 2011-07-12 | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187014755A Division KR20180059953A (ko) | 2010-07-12 | 2011-07-12 | 히스티딜trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20130102534A true KR20130102534A (ko) | 2013-09-17 |
Family
ID=45568116
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137003454A Ceased KR20130102534A (ko) | 2010-07-12 | 2011-07-12 | 히스티딜trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 |
| KR1020187014755A Ceased KR20180059953A (ko) | 2010-07-12 | 2011-07-12 | 히스티딜trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187014755A Ceased KR20180059953A (ko) | 2010-07-12 | 2011-07-12 | 히스티딜trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US20130202576A1 (enExample) |
| EP (1) | EP2593126B1 (enExample) |
| JP (3) | JP6177129B2 (enExample) |
| KR (2) | KR20130102534A (enExample) |
| CN (1) | CN103108649B (enExample) |
| AU (1) | AU2011289833C1 (enExample) |
| CA (1) | CA2804424C (enExample) |
| EA (1) | EA030418B1 (enExample) |
| ES (1) | ES2653718T3 (enExample) |
| NZ (1) | NZ603813A (enExample) |
| WO (1) | WO2012021249A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160125459A (ko) * | 2014-02-26 | 2016-10-31 | 시에이치알. 한센 에이/에스 | 개선된 응유 특성을 갖는 키모신 변이체 |
| KR20190133559A (ko) * | 2018-05-23 | 2019-12-03 | 주식회사 큐어바이오 | 단편화된 grs 폴리펩타이드, 이의 변이체 및 이들의 용도 |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010099477A2 (en) | 2009-02-27 | 2010-09-02 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
| DK3255146T3 (da) | 2009-03-16 | 2019-08-19 | Pangu Biopharma Ltd | Præparater og fremgangsmåder omfattende histidyl-tRNA-synthetasesplejsningsvarianter med ikke-kanoniske biologiske aktiviteter |
| ES2535951T3 (es) | 2009-12-11 | 2015-05-19 | Atyr Pharma, Inc. | Histidil ARNt sintetasas para reducir la inflamación |
| CA2797093C (en) | 2010-04-26 | 2019-10-29 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase |
| CN108165537A (zh) | 2010-04-27 | 2018-06-15 | Atyr医药公司 | 与苏氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| EP2563381B1 (en) | 2010-04-27 | 2017-08-09 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases |
| CN103097524B (zh) | 2010-04-28 | 2016-08-03 | Atyr医药公司 | 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| US9068177B2 (en) | 2010-04-29 | 2015-06-30 | Atyr Pharma, Inc | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases |
| JP5991963B2 (ja) | 2010-04-29 | 2016-09-14 | エータイアー ファーマ, インコーポレイテッド | バリルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| CN103097523B (zh) | 2010-04-29 | 2016-09-28 | Atyr医药公司 | 与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| JP6008841B2 (ja) | 2010-05-03 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | メチオニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| JP6008840B2 (ja) | 2010-05-03 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | フェニルアラニルαtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| US8961961B2 (en) | 2010-05-03 | 2015-02-24 | a Tyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases |
| WO2011139988A2 (en) | 2010-05-03 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases |
| JP6008844B2 (ja) | 2010-05-04 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | p38MULTI−tRNA合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| US9062301B2 (en) | 2010-05-04 | 2015-06-23 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases |
| JP6396656B2 (ja) | 2010-05-14 | 2018-09-26 | エータイアー ファーマ, インコーポレイテッド | フェニルアラニルβtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| US9034598B2 (en) | 2010-05-17 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
| US8962560B2 (en) | 2010-06-01 | 2015-02-24 | Atyr Pharma Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases |
| AU2011289831C1 (en) | 2010-07-12 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| JP5991973B2 (ja) | 2010-07-12 | 2016-09-14 | エータイアー ファーマ, インコーポレイテッド | アスパルチルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| EP2593126B1 (en) | 2010-07-12 | 2017-09-20 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| AU2011293294B2 (en) | 2010-08-25 | 2016-03-24 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases |
| AU2011311956C1 (en) | 2010-10-06 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl tRNA synthetases |
| WO2013022982A2 (en) | 2011-08-09 | 2013-02-14 | Atyr Pharma, Inc. | Pegylated tyrosyl-trna synthetase polypeptides |
| WO2013086228A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Pegylated aspartyl-trna synthetase polypeptides |
| US9816084B2 (en) | 2011-12-06 | 2017-11-14 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetases |
| EP2797959A4 (en) | 2011-12-29 | 2015-08-26 | Atyr Pharma Inc | ASPARTYL-tRNA synthetase FC CONJUGATES |
| AU2013221317B2 (en) | 2012-02-16 | 2017-07-06 | Pangu Biopharma Limited | Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases |
| CA2907046C (en) | 2013-03-15 | 2021-04-20 | Atyr Pharma, Inc. | Histidyl-trna synthetase-fc conjugates |
| WO2018102589A2 (en) * | 2016-11-30 | 2018-06-07 | Atyr Pharma, Inc. | Anti-hrs antibodies and combination therapies for treating cancers |
| WO2018195338A1 (en) | 2017-04-20 | 2018-10-25 | Atyr Pharma, Inc. | Compositions and methods for treating lung inflammation |
| CN115960924A (zh) * | 2022-11-04 | 2023-04-14 | 广州达安基因股份有限公司 | 重组jo-1抗原的制备方法和应用 |
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| IL87737A (en) | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
| ATE131872T1 (de) | 1989-11-22 | 1996-01-15 | Genentech Inc | Latenz assoziierte peptide und deren verwendung |
| US5556645A (en) | 1990-01-12 | 1996-09-17 | Bockman; Richard | Methods of enhancing wound healing and tissue repair |
| US5981606A (en) | 1991-03-01 | 1999-11-09 | Warner-Lambert Company | Therapeutic TGF-beta-wound healing compositions and methods for preparing and using same |
| US5149691A (en) | 1991-03-12 | 1992-09-22 | Creative Biomolecules, Inc. | Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone |
| DE9115660U1 (de) | 1991-12-18 | 1992-07-30 | Aventis Research & Technologies GmbH & Co KG, 65929 Frankfurt | L-Phenylalanyl-tRNA-Synthetase mit erweiterter Substratselektivität aus Mikroorganismen |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160125459A (ko) * | 2014-02-26 | 2016-10-31 | 시에이치알. 한센 에이/에스 | 개선된 응유 특성을 갖는 키모신 변이체 |
| KR20220002714A (ko) * | 2014-02-26 | 2022-01-06 | 시에이치알. 한센 에이/에스 | 개선된 응유 특성을 갖는 키모신 변이체 |
| KR20190133559A (ko) * | 2018-05-23 | 2019-12-03 | 주식회사 큐어바이오 | 단편화된 grs 폴리펩타이드, 이의 변이체 및 이들의 용도 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012021249A3 (en) | 2012-04-26 |
| JP2017201993A (ja) | 2017-11-16 |
| NZ603813A (en) | 2015-03-27 |
| CA2804424C (en) | 2021-03-30 |
| EP2593126A2 (en) | 2013-05-22 |
| JP2015227379A (ja) | 2015-12-17 |
| US20170029800A1 (en) | 2017-02-02 |
| US9637730B2 (en) | 2017-05-02 |
| US20130202576A1 (en) | 2013-08-08 |
| AU2011289833C1 (en) | 2017-06-15 |
| US9422539B2 (en) | 2016-08-23 |
| AU2011289833A1 (en) | 2013-02-21 |
| US20150344866A1 (en) | 2015-12-03 |
| US20190264190A1 (en) | 2019-08-29 |
| JP6177129B2 (ja) | 2017-08-09 |
| US20170321206A1 (en) | 2017-11-09 |
| JP2013533750A (ja) | 2013-08-29 |
| CN103108649A (zh) | 2013-05-15 |
| EP2593126A4 (en) | 2014-08-06 |
| CN103108649B (zh) | 2016-10-12 |
| CA2804424A1 (en) | 2012-02-16 |
| EP2593126B1 (en) | 2017-09-20 |
| EA201390095A1 (ru) | 2013-06-28 |
| EA030418B1 (ru) | 2018-08-31 |
| KR20180059953A (ko) | 2018-06-05 |
| WO2012021249A2 (en) | 2012-02-16 |
| US10669533B2 (en) | 2020-06-02 |
| ES2653718T3 (es) | 2018-02-08 |
| AU2011289833B2 (en) | 2017-02-02 |
| US10196628B2 (en) | 2019-02-05 |
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