KR20130089157A - 신규 방법 - Google Patents

신규 방법 Download PDF

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Publication number
KR20130089157A
KR20130089157A KR20127032795A KR20127032795A KR20130089157A KR 20130089157 A KR20130089157 A KR 20130089157A KR 20127032795 A KR20127032795 A KR 20127032795A KR 20127032795 A KR20127032795 A KR 20127032795A KR 20130089157 A KR20130089157 A KR 20130089157A
Authority
KR
South Korea
Prior art keywords
formula
compound
alkyl
preparing
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR20127032795A
Other languages
English (en)
Korean (ko)
Inventor
케빈 스튜어트 카드웰
클레어 프랜시스 크로포드
수잔 헬렌 데이비스
찰스 에드워드 웨이드
Original Assignee
글락소 그룹 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44992024&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20130089157(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 글락소 그룹 리미티드 filed Critical 글락소 그룹 리미티드
Publication of KR20130089157A publication Critical patent/KR20130089157A/ko
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR20127032795A 2010-05-17 2011-05-17 신규 방법 Abandoned KR20130089157A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34522410P 2010-05-17 2010-05-17
US61/345,224 2010-05-17
PCT/US2011/036821 WO2011146494A1 (en) 2010-05-17 2011-05-17 Novel processes

Publications (1)

Publication Number Publication Date
KR20130089157A true KR20130089157A (ko) 2013-08-09

Family

ID=44992024

Family Applications (1)

Application Number Title Priority Date Filing Date
KR20127032795A Abandoned KR20130089157A (ko) 2010-05-17 2011-05-17 신규 방법

Country Status (25)

Country Link
US (2) US9447052B2 (https=)
EP (1) EP2571857B1 (https=)
JP (1) JP6027529B2 (https=)
KR (1) KR20130089157A (https=)
CN (2) CN105837520A (https=)
AR (1) AR081399A1 (https=)
AU (1) AU2011256270B2 (https=)
BR (1) BR112012030532A2 (https=)
CA (1) CA2799520C (https=)
CL (1) CL2012003206A1 (https=)
CO (1) CO6630197A2 (https=)
CR (1) CR20120630A (https=)
DO (1) DOP2012000289A (https=)
EA (1) EA026569B1 (https=)
IL (1) IL223068A0 (https=)
MA (1) MA34301B1 (https=)
MX (1) MX2012013387A (https=)
NZ (1) NZ603672A (https=)
PE (1) PE20130318A1 (https=)
PH (1) PH12012502247A1 (https=)
SG (1) SG185559A1 (https=)
TW (1) TW201209043A (https=)
UY (1) UY33388A (https=)
WO (1) WO2011146494A1 (https=)
ZA (1) ZA201208631B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201209043A (en) * 2010-05-17 2012-03-01 Glaxo Group Ltd Novel processes
WO2015087239A1 (en) 2013-12-11 2015-06-18 Ranbaxy Laboratories Limited Processes for the preparation of darapladib and its intermediates
WO2015092687A2 (en) 2013-12-17 2015-06-25 Ranbaxy Laboratories Limited Process for the purification of darapladib
EP3687980B1 (en) 2017-09-26 2022-01-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Radiolabeled darapladib, analogs thereof and their use as imaging compounds
US10866963B2 (en) * 2017-12-28 2020-12-15 Dropbox, Inc. File system authentication
TWI896037B (zh) 2023-07-17 2025-09-01 大陸商上海樞境生物科技有限公司 雙環[5,6]咪唑嘧啶酮類衍生物、其製備方法和應用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1143516B (de) * 1961-04-27 1963-02-14 Bayer Ag Verfahren zur Herstellung von Peptiden
US4277465A (en) 1978-08-26 1981-07-07 Kyoto Yakuhin Kogyo Kabushiki Kaisha Adjuvant for promoting absorption of therapeutically active substances through the digestive tract
US4235776A (en) * 1979-03-15 1980-11-25 Eli Lilly And Company Tetrahydro-2H-benzo[c]pyrroles
DE2941597A1 (de) * 1979-10-13 1981-04-23 Basf Ag, 6700 Ludwigshafen Piperidinderivate von 4,5-dialkyl-3-hydroxy-pyrrol-2-carbonsaeureestern, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
US4619941A (en) * 1984-11-19 1986-10-28 American Cyanamid Company N-[(1H-imidazol-1-yl)alkyl]-1H-indolecarboxamides useful as thromboxane synthetase inhibitors and antihypertensive agents
WO1999024420A1 (en) 1997-11-06 1999-05-20 Smithkline Beecham Plc Pyrimidinone compounds and pharmaceutical compositions containing them
US6750228B1 (en) * 1997-11-14 2004-06-15 Pharmacia Corporation Aromatic sulfone hydroxamic acid metalloprotease inhibitor
WO2000028328A1 (en) 1998-11-05 2000-05-18 Biocryst Pharmaceuticals, Inc. New cyclopentane and cyclopentene compounds and use for detecting influenza virus
HUP0201122A3 (en) * 1999-05-01 2003-11-28 Smithkline Beecham Plc Pyrimidinone compounds, process for their preparation and pharmaceutical compositions containing them
EP1686119B1 (en) * 2000-02-16 2009-07-29 Smithkline Beecham Plc Pyrimidine-5-one derivatives as LDL-PLA2 inhibitors
GB0119795D0 (en) 2001-08-14 2001-10-03 Smithkline Beecham Plc Novel process
TW201209043A (en) * 2010-05-17 2012-03-01 Glaxo Group Ltd Novel processes

Also Published As

Publication number Publication date
EA026569B1 (ru) 2017-04-28
EP2571857A4 (en) 2013-11-20
CA2799520A1 (en) 2011-11-24
JP6027529B2 (ja) 2016-11-16
EP2571857B1 (en) 2017-08-23
CN103003249B (zh) 2016-04-27
CN105837520A (zh) 2016-08-10
AU2011256270A1 (en) 2012-12-20
TW201209043A (en) 2012-03-01
CA2799520C (en) 2016-09-13
DOP2012000289A (es) 2013-04-15
UY33388A (es) 2011-12-01
CR20120630A (es) 2013-02-15
CL2012003206A1 (es) 2013-01-25
PH12012502247A1 (en) 2013-02-04
BR112012030532A2 (pt) 2015-09-29
CN103003249A (zh) 2013-03-27
AR081399A1 (es) 2012-08-29
US20130060028A1 (en) 2013-03-07
NZ603672A (en) 2015-01-30
AU2011256270B2 (en) 2015-11-26
PE20130318A1 (es) 2013-04-11
EA201291235A1 (ru) 2013-04-30
MA34301B1 (fr) 2013-06-01
MX2012013387A (es) 2012-12-10
CO6630197A2 (es) 2013-03-01
EP2571857A1 (en) 2013-03-27
ZA201208631B (en) 2013-09-25
SG185559A1 (en) 2012-12-28
US20160347720A1 (en) 2016-12-01
JP2013530948A (ja) 2013-08-01
IL223068A0 (en) 2013-02-03
US9725420B2 (en) 2017-08-08
WO2011146494A1 (en) 2011-11-24
US9447052B2 (en) 2016-09-20

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Legal Events

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PA0105 International application

Patent event date: 20121214

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
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PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20160516

Comment text: Request for Examination of Application

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PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20170210

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20170703

NORF Unpaid initial registration fee
PC1904 Unpaid initial registration fee