KR20120059558A - 바이아릴 화합물 및 이의 사용 방법 - Google Patents
바이아릴 화합물 및 이의 사용 방법 Download PDFInfo
- Publication number
- KR20120059558A KR20120059558A KR1020127007076A KR20127007076A KR20120059558A KR 20120059558 A KR20120059558 A KR 20120059558A KR 1020127007076 A KR1020127007076 A KR 1020127007076A KR 20127007076 A KR20127007076 A KR 20127007076A KR 20120059558 A KR20120059558 A KR 20120059558A
- Authority
- KR
- South Korea
- Prior art keywords
- phenyl
- alkyl
- isoxazol
- tert
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 *c(c(Br)c1)nc(*=O)c1ICCI Chemical compound *c(c(Br)c1)nc(*=O)c1ICCI 0.000 description 3
- CJZPDDKKKYKXGN-UHFFFAOYSA-O CC(C)(C)C1=CCCCOC(NC(Cc(cc2)ccc2-c2ccc([NH3+])nc2)=O)=C1 Chemical compound CC(C)(C)C1=CCCCOC(NC(Cc(cc2)ccc2-c2ccc([NH3+])nc2)=O)=C1 CJZPDDKKKYKXGN-UHFFFAOYSA-O 0.000 description 1
- YCYUXDNKYCBTSE-UHFFFAOYSA-N CC(C)(C)c(cc1)n[n]1NC(Cc(cc1)ccc1-c1ccc(N)nc1)=O Chemical compound CC(C)(C)c(cc1)n[n]1NC(Cc(cc1)ccc1-c1ccc(N)nc1)=O YCYUXDNKYCBTSE-UHFFFAOYSA-N 0.000 description 1
- AFQMAGSFNWUQQD-UHFFFAOYSA-N CC(C)(C)c1cc(NC(Cc(cc2)ccc2-c2ccc(NCCS(C)(=O)=O)nc2)=O)n[o]1 Chemical compound CC(C)(C)c1cc(NC(Cc(cc2)ccc2-c2ccc(NCCS(C)(=O)=O)nc2)=O)n[o]1 AFQMAGSFNWUQQD-UHFFFAOYSA-N 0.000 description 1
- RKBPUPMHGKULMP-UHFFFAOYSA-N CC(C)(C)c1cc(NC(Cc(nc2)ccc2-c2cnc(N)nc2)=O)n[o]1 Chemical compound CC(C)(C)c1cc(NC(Cc(nc2)ccc2-c2cnc(N)nc2)=O)n[o]1 RKBPUPMHGKULMP-UHFFFAOYSA-N 0.000 description 1
- PQRLIKAZCMOXNP-UHFFFAOYSA-N CC(C)(C)c1ccn[n]1NC(Cc(cc1)ccc1-c1ccc(N)nc1)=O Chemical compound CC(C)(C)c1ccn[n]1NC(Cc(cc1)ccc1-c1ccc(N)nc1)=O PQRLIKAZCMOXNP-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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| Application Number | Priority Date | Filing Date | Title |
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| US23531609P | 2009-08-19 | 2009-08-19 | |
| US61/235,316 | 2009-08-19 | ||
| PCT/US2010/045876 WO2011022473A1 (en) | 2009-08-19 | 2010-08-18 | Biaryl compounds and methods of use thereof |
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| KR20120059558A true KR20120059558A (ko) | 2012-06-08 |
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Country Status (9)
| Country | Link |
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| US (1) | US20130035326A1 (https=) |
| EP (1) | EP2467137A1 (https=) |
| JP (1) | JP2013502429A (https=) |
| KR (1) | KR20120059558A (https=) |
| CN (1) | CN102470127A (https=) |
| BR (1) | BR112012003661A2 (https=) |
| CA (1) | CA2770454A1 (https=) |
| MX (1) | MX2012001974A (https=) |
| WO (1) | WO2011022473A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6097998B2 (ja) * | 2010-12-16 | 2017-03-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成のビアリールアミドインヒビター |
| CA2835835C (en) | 2011-05-13 | 2019-04-02 | Array Biopharma Inc. | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors |
| US8877763B2 (en) * | 2012-03-22 | 2014-11-04 | Genosco | Substituted pyridopyrimidine compounds and their use as FLT3 inhibitors |
| KR101529496B1 (ko) * | 2012-12-27 | 2015-06-22 | 한국과학기술원 | 낮은 열팽창 계수를 갖는 신규한 폴리아미드이미드 |
| SMT201700152T1 (it) | 2013-03-15 | 2017-05-08 | Glaxosmithkline Ip Dev Ltd | Derivati piridinici come inibitori della chinasi riarrangiata durante la trasfezione (ret) |
| AR095308A1 (es) | 2013-03-15 | 2015-10-07 | Glaxosmithkline Ip Dev Ltd | Compuesto de 2-piridona, composición farmacéutica que lo comprende y su uso para preparar un medicamento |
| KR20160055170A (ko) * | 2013-08-30 | 2016-05-17 | 암비트 바이오사이언시즈 코포레이션 | 바이아릴 아세트아미드 화합물 및 이의 사용 방법 |
| CN104513259B (zh) * | 2013-09-26 | 2017-06-16 | 广东东阳光药业有限公司 | 取代脲衍生物及其在药物中的应用 |
| CN104513253A (zh) | 2013-10-01 | 2015-04-15 | 南京波尔泰药业科技有限公司 | 用于治疗增殖性疾病的大环化合物 |
| LT3466955T (lt) | 2014-01-13 | 2021-02-25 | Aurigene Discovery Technologies Limited | Oksazol[4,5-b]piridino ir tiazol[4,5-b]piridino darinių, kaip irak4 inhibitorių, skirtų vėžio gydymui, gamybos būdas |
| WO2016038519A1 (en) * | 2014-09-08 | 2016-03-17 | Glaxosmithkline Intellectual Property Development Limited | Crystalline forms of 2-(4-(4-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)-n-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)acetamide |
| WO2016038552A1 (en) | 2014-09-10 | 2016-03-17 | Glaxosmithkline Intellectual Property Development Limited | Pyridone derivatives as rearranged during transfection (ret) kinase inhibitors |
| WO2016037578A1 (en) | 2014-09-10 | 2016-03-17 | Glaxosmithkline Intellectual Property Development Limited | Novel compounds as rearranged during transfection (ret) inhibitors |
| CN105461709B (zh) * | 2014-09-26 | 2020-01-21 | 广东东阳光药业有限公司 | 取代脲衍生物及其在药物中的应用 |
| CN104387331A (zh) * | 2014-10-27 | 2015-03-04 | 湖南华腾制药有限公司 | 一种吡嗪衍生物的制备方法 |
| CN105001172B (zh) * | 2015-06-30 | 2018-02-09 | 浙江大学 | 5,6‑二取代氮杂嘧啶酮类化合物及制备方法 |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| ES2904615T3 (es) * | 2016-03-16 | 2022-04-05 | Plexxikon Inc | Compuestos y métodos para la modulación de quinasas e indicaciones al respecto |
| JP2018052878A (ja) | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | ピリジン化合物 |
| EP3600270B1 (en) * | 2017-03-31 | 2023-06-14 | Aurigene Oncology Limited | Compounds and compositions for treating hematological disorders |
| EP3720436A4 (en) * | 2017-12-06 | 2021-06-02 | Lin Bioscience, Pty Ltd. | TUBULIN INHIBITORS |
| WO2019126731A1 (en) | 2017-12-22 | 2019-06-27 | Petra Pharma Corporation | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| AU2019215799B2 (en) * | 2018-02-01 | 2022-04-14 | The University Of Sydney | Anti-cancer compounds |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| WO2021144360A1 (en) * | 2020-01-17 | 2021-07-22 | F. Hoffmann-La Roche Ag | Small molecule csf-1r inhibitors in therapeutic and cosmetic uses |
| RS65962B1 (sr) | 2020-05-08 | 2024-10-31 | Halia Therapeutics Inc | Inhibitori nek7 kinaze |
| CN111840285A (zh) * | 2020-06-10 | 2020-10-30 | 苏州安康盟医疗科技有限公司 | Gpr17和/或csfr1受体抑制剂 |
| US20240116962A1 (en) * | 2020-12-31 | 2024-04-11 | Tsinghua University | Pyridine-2-amine derivative and pharmaceutical composition and use thereof |
| EP4319750A4 (en) | 2021-04-08 | 2025-02-26 | Curis, Inc. | COMBINATION THERAPIES FOR THE TREATMENT OF CANCER |
| WO2022236255A2 (en) * | 2021-05-03 | 2022-11-10 | Nuvation Bio Inc. | Heterocyclic compounds as kinase inhibitors |
| US20240158394A1 (en) | 2022-09-14 | 2024-05-16 | Halia Therapeutics, Inc. | Nek7 inhibitors |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| DE3209472C2 (de) | 1982-03-16 | 1984-05-17 | Degussa Ag, 6000 Frankfurt | Verfahren zur Herstellung von 3-Oxonitrilen sowie neue 3-Oxonitrile |
| US4657906A (en) * | 1982-06-05 | 1987-04-14 | Smith Kline & French Laboratories Ltd. | Heterocyclic compounds having inotropic activity |
| EP0096517A3 (en) * | 1982-06-05 | 1985-04-03 | Smith Kline & French Laboratories Limited | Aryl pyrazinones |
| ZA834032B (en) * | 1982-06-05 | 1984-04-25 | Smith Kline French Lab | Heterocyclic compounds |
| HU196714B (en) | 1984-10-04 | 1989-01-30 | Monsanto Co | Process for producing non-aqueous composition comprising somatotropin |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| JPS6296479A (ja) | 1985-10-23 | 1987-05-02 | Shionogi & Co Ltd | ポリフルオロアルキルイソオキサゾリルアミン類 |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| PH30995A (en) | 1989-07-07 | 1997-12-23 | Novartis Inc | Sustained release formulations of water soluble peptides. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
| IT1246382B (it) | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| TW333456B (en) | 1992-12-07 | 1998-06-11 | Takeda Pharm Ind Co Ltd | A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide. |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| US6274552B1 (en) | 1993-03-18 | 2001-08-14 | Cytimmune Sciences, Inc. | Composition and method for delivery of biologically-active factors |
| US5523092A (en) | 1993-04-14 | 1996-06-04 | Emory University | Device for local drug delivery and methods for using the same |
| US5985307A (en) | 1993-04-14 | 1999-11-16 | Emory University | Device and method for non-occlusive localized drug delivery |
| US6087324A (en) | 1993-06-24 | 2000-07-11 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
| US6004534A (en) | 1993-07-23 | 1999-12-21 | Massachusetts Institute Of Technology | Targeted polymerized liposomes for improved drug delivery |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| US5759542A (en) | 1994-08-05 | 1998-06-02 | New England Deaconess Hospital Corporation | Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases |
| US5660854A (en) | 1994-11-28 | 1997-08-26 | Haynes; Duncan H | Drug releasing surgical implant or dressing material |
| US6316652B1 (en) | 1995-06-06 | 2001-11-13 | Kosta Steliou | Drug mitochondrial targeting agents |
| AU6242096A (en) | 1995-06-27 | 1997-01-30 | Takeda Chemical Industries Ltd. | Method of producing sustained-release preparation |
| TW448055B (en) | 1995-09-04 | 2001-08-01 | Takeda Chemical Industries Ltd | Method of production of sustained-release preparation |
| JP2909418B2 (ja) | 1995-09-18 | 1999-06-23 | 株式会社資生堂 | 薬物の遅延放出型マイクロスフイア |
| US6039975A (en) | 1995-10-17 | 2000-03-21 | Hoffman-La Roche Inc. | Colon targeted delivery system |
| US5980945A (en) | 1996-01-16 | 1999-11-09 | Societe De Conseils De Recherches Et D'applications Scientifique S.A. | Sustained release drug formulations |
| TW345603B (en) | 1996-05-29 | 1998-11-21 | Gmundner Fertigteile Gmbh | A noise control device for tracks |
| US6264970B1 (en) | 1996-06-26 | 2001-07-24 | Takeda Chemical Industries, Ltd. | Sustained-release preparation |
| US6419961B1 (en) | 1996-08-29 | 2002-07-16 | Takeda Chemical Industries, Ltd. | Sustained release microcapsules of a bioactive substance and a biodegradable polymer |
| JP2000508339A (ja) | 1996-10-01 | 2000-07-04 | シーマ・ラブス・インコーポレイテッド | 味隠蔽マイクロカプセル組成物及び製造方法 |
| CA2217134A1 (en) | 1996-10-09 | 1998-04-09 | Sumitomo Pharmaceuticals Co., Ltd. | Sustained release formulation |
| PT839525E (pt) | 1996-10-31 | 2004-10-29 | Takeda Chemical Industries Ltd | Preparacao de libertacao prolongada |
| US6131570A (en) | 1998-06-30 | 2000-10-17 | Aradigm Corporation | Temperature controlling device for aerosol drug delivery |
| WO1998027980A2 (en) | 1996-12-20 | 1998-07-02 | Takeda Chemical Industries, Ltd. | Method of producing a sustained-release preparation |
| US5891474A (en) | 1997-01-29 | 1999-04-06 | Poli Industria Chimica, S.P.A. | Time-specific controlled release dosage formulations and method of preparing same |
| US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| US6060082A (en) | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
| ATE529109T1 (de) * | 1997-12-22 | 2011-11-15 | Bayer Healthcare Llc | Hemmung der p38 kinase aktivität durch substituierte heterocyclische harnstoffe |
| TR200002059T2 (tr) | 1998-01-16 | 2001-01-22 | Takeda Chemical Industries, Ltd. | Devamlı salınan bileşim, üretim yöntemi ve kullanımı. |
| US6613358B2 (en) | 1998-03-18 | 2003-09-02 | Theodore W. Randolph | Sustained-release composition including amorphous polymer |
| US6048736A (en) | 1998-04-29 | 2000-04-11 | Kosak; Kenneth M. | Cyclodextrin polymers for carrying and releasing drugs |
| KR19990085365A (ko) | 1998-05-16 | 1999-12-06 | 허영섭 | 지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법 |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6271359B1 (en) | 1999-04-14 | 2001-08-07 | Musc Foundation For Research Development | Tissue-specific and pathogen-specific toxic agents and ribozymes |
| WO2001012189A1 (en) * | 1999-08-12 | 2001-02-22 | Pharmacia Italia S.P.A. | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents |
| WO2003022273A1 (en) * | 2001-09-13 | 2003-03-20 | Boehringer Ingelheim Pharmaceuticals, Inc. | Methods of treating cytokine mediated diseases |
| DE10201764A1 (de) * | 2002-01-18 | 2003-07-31 | Bayer Cropscience Ag | Substituierte 4-Aminopyridin-Derivate |
| US7112435B1 (en) | 2002-08-07 | 2006-09-26 | Ambit Biosciences Corporation | Uncoupling of DNA insert propagation and expression of protein for phage display |
| DE10219294A1 (de) * | 2002-04-25 | 2003-11-13 | Schering Ag | Substituierte N-(1,4,5,6-Tetrahydro-cyclopentapyrazol-3-yl)-Derivate, deren Herstellung und Verwendung als Arzneimittel |
| DK1638941T3 (da) * | 2003-05-22 | 2010-10-11 | Abbott Lab | Indazol-, benzisoxazol- og benzisothiazolkinaseinhibitorer |
| GB0413955D0 (en) | 2004-06-22 | 2004-07-28 | Syngenta Participations Ag | Chemical compounds |
| US7709645B2 (en) * | 2004-07-27 | 2010-05-04 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| GB0502418D0 (en) | 2005-02-05 | 2005-03-16 | Astrazeneca Ab | Compounds |
| TW200800201A (en) | 2005-11-18 | 2008-01-01 | Lilly Co Eli | Pyrimidinyl benzothiophene compounds |
| KR20080075027A (ko) | 2005-12-05 | 2008-08-13 | 아피늄 파마슈티컬스, 인크. | Fabi 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물 |
| PE20070946A1 (es) | 2006-01-25 | 2007-10-16 | Smithkline Beecham Corp | COMPUESTOS DERIVADOS DE IMIDAZO[1,2-a]PIRIDINA COMO MODULADORES DEL RECEPTOR DE QUIMIOQUINA (CXCR4) |
| JP2009533327A (ja) * | 2006-03-22 | 2009-09-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | 増殖性疾患を処置するためのc−METキナーゼ阻害剤 |
| MX2009000044A (es) | 2006-06-30 | 2009-01-23 | Ambit Bios Corp | Etiqueta de acido nucleico detectable. |
| JP5468899B2 (ja) | 2006-07-20 | 2014-04-09 | アフィニウム ファーマシューティカルズ, インク. | Fabiインヒビターとしてのアクリルアミド誘導体 |
| WO2009011285A1 (ja) * | 2007-07-13 | 2009-01-22 | Taisho Pharmaceutical Co., Ltd. | ヘテロアリールベンゼン化合物 |
| LT2294072T (lt) * | 2008-05-23 | 2017-06-12 | Wyeth Llc | Triazino junginiai, kaip p13 kinazės ir mtor inhibitoriai |
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2010
- 2010-08-18 MX MX2012001974A patent/MX2012001974A/es not_active Application Discontinuation
- 2010-08-18 US US13/390,911 patent/US20130035326A1/en not_active Abandoned
- 2010-08-18 KR KR1020127007076A patent/KR20120059558A/ko not_active Withdrawn
- 2010-08-18 EP EP10745711A patent/EP2467137A1/en not_active Withdrawn
- 2010-08-18 JP JP2012525664A patent/JP2013502429A/ja active Pending
- 2010-08-18 WO PCT/US2010/045876 patent/WO2011022473A1/en not_active Ceased
- 2010-08-18 CN CN2010800366234A patent/CN102470127A/zh active Pending
- 2010-08-18 BR BR112012003661A patent/BR112012003661A2/pt not_active IP Right Cessation
- 2010-08-18 CA CA2770454A patent/CA2770454A1/en not_active Abandoned
Also Published As
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|---|---|
| EP2467137A1 (en) | 2012-06-27 |
| BR112012003661A2 (pt) | 2017-04-25 |
| MX2012001974A (es) | 2012-04-11 |
| WO2011022473A1 (en) | 2011-02-24 |
| CA2770454A1 (en) | 2011-02-24 |
| US20130035326A1 (en) | 2013-02-07 |
| JP2013502429A (ja) | 2013-01-24 |
| CN102470127A (zh) | 2012-05-23 |
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